OICR Cancer Stem Cell Program

Experimental Design and Statistical Analysis

Changjiang Xu, Gary Bader

• OICR CSC Projects: Biostatistical Part (PI's name and/or project title listed below)
  • Aaron Schimmer

    • AS02 (Some points in the reviewed paper to be addressed): Association between ClpP expression and known AML mutations

    • AS03-06: Gene expression of protein import / the cardiolipin pathway / HTRA2 / MTCH2 in AMLs

    • AS04_import_proteins_Danny: Gene expression of the mitochondrial import proteins MPPbeta in AML and HSC

  • Laurie Ailles

    • LA02 (LA02_CAF_ovarian_Laurie): Crosstalk between CAFs and ovarian cancer cells

      1. Differential expression analysis

      2. TCGA OV data analysis

  • Peter Dirks

    • PD03: Role of dopamine D4 receptor in glioblastoma stem cells

      1. Part2: normal cells

      2. Part3: TCGA GBM data analysis

      3. Comparison of TCGA GBM Affymetrix and RNAseq data

  • John Dick
    • HALT02/JAK2

      1. Differential expression analysis of SRC high vs low (negative) sub-populations

      2. Comparison of the pathways for XG-R/PF-R, XG-NR/PF-NR, and XG-R/PF-NR

    • JD12_relapsedAML_Liran: Clustering and pathway analysis of patients with relapsed AML

    • JD13_Itgb7_Peter: ITGb7+ and ITGb7– hematopoietic stem cells

    • JD14_Sasan_FL_BM: Differential expression analysis and gene-set enrichment analysis on hematopoietic stem cells derived from bone marrow or fetal liver

  • Bret Pearson

    • BP03: Spatial Organization of the planarian transcriptome

    • BP04: Mechanisms driving asymmetric cell fate outcomes in planarian adult stem cell lineages

  • Cyndi Guidos

  • oPOSSUM

• Biostatistics service

  1. Affymetrix microarray data analysis

  2. Illumina’s BeadChip microarray data analysis

  3. RNA-seq data analysis

  4. Flow cytometry data analysis

  5. Survival analysis