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| }}} Describe CSCBiostatService/GSEA here. |
= Summary of Gene Set Enrichment Analysis (GSEA) = == GSEA goal == The below description is cited from [[http://www.pnas.org/content/102/43/15545.full | Subramanian et al. (2005)]]: * The goal of GSEA is to determine whether members of a gene set S tend to occur toward the top (or bottom) of the ranked gene list L, in which case the gene set is correlated with the phenotypic class distinction. * Given an a priori defined set of genes S (e.g., genes encoding products in a metabolic pathway, located in the same cytogenetic band, or sharing the same GO category), the goal of GSEA is to determine whether the members of S are randomly distributed throughout L or primarily found at the top or bottom. We expect that sets related to the phenotypic distinction will tend to show the latter distribution. |
Summary of Gene Set Enrichment Analysis (GSEA)
GSEA goal
The below description is cited from Subramanian et al. (2005):
- The goal of GSEA is to determine whether members of a gene set S tend to occur toward the top (or bottom) of the ranked gene list L, in which case the gene set is correlated with the phenotypic class distinction.
- Given an a priori defined set of genes S (e.g., genes encoding products in a metabolic pathway, located in the same cytogenetic band, or sharing the same GO category), the goal of GSEA is to determine whether the members of S are randomly distributed throughout L or primarily found at the top or bottom. We expect that sets related to the phenotypic distinction will tend to show the latter distribution.