Neurobiological Gene-sets

Phenotypes and Expression Specificity

Last update: May 2011
Text files

• ExpHsBr: Human Brain-Specific Expression

• PhMmAll: Mouse Neurological Phenotypes converted to Human

• PhHsPsy: Human Neuropsychiatric Disorders

• PhHsDev: Human Neurodevelopmental Disorders and Intellectual Disability

• PhHsMsc: Human Other Neurological Disorders

R Workspace

• All gene-sets Rws

Details

• ID System: human Entrez-Gene

• Documentation

  • PDF

  • pptx

• Notes on use

  • All gene-sets have good quality with respect to enrichment in neuropsychological functions and phenotypes

  • ExpHsBr and PhMmAll are the ones I found of higher quality when overlapping with my autism gene-set analysis results

  • PhHsPsy probably includes several genes from candidate gene studies, but is otherwise of good quality

  • The distinction between PhHsPsy and PhHsDev is a bit loose, these two gene-sets could be collapsed

  • PhHsMsc is quite heterogeneous, and its neurovascular and neurodegenerative auto-immune components are probably source of bad candidates for researchers working on autism, schizophrenia or ADHD

  • PhMmAll is not completely unbiased, as investigators will make KO mouse models for genes of interest

  • ExpHsBr may be partially biased towards well characterized genes

From Gene Ontology

Last update: April 2011
Text files

• Human Nervous System Development (GO:0007399)

• Human Nervous System Process (without sensory receptors)

  • Cognition (GO:0050890), Neuronal action potential propagation (GO:0019227), Transmission of nerve impulse (GO:0019226)