Neurobiological Gene-sets

Phenotypes and Expression Specificity

• ExpHsBr: Human Specific Brain Expression

• PhMmAll: Mouse Neurological Phenotype converted to Human

• PhHsPsy: Human Neuropsychiatric

• PhHsDev: Human Neurodevelopmental and Intellectual Disability

• PhHsMsc: Human Other Neurological

Details

• ID System: human Entrez-Gene

• Documentation

  • PDF

  • pptx

• Notes on use
  • All gene-sets have good quality with respect to enrichment in neuropsychological functions and phenotypes

  • ExpHsBr and PhMmAll are the ones I found of higher quality when overlapping with my autism gene-set analysis results

  • PhHsPsy probably includes several genes from candidate gene studies, but is otherwise of good quality

  • The distinction between PhHsPsy and PhHsDev is a bit loose, these two gene-sets could be collapsed

  • PhMmAll is not completely unbiased, as investigators will make KO mouse models for genes of interest

  • ExpHsBr may be partially biased towards well characterized genes