= Signing of Regulatory Networks (SIREN) =
 

'''Discrimination of Interaction Type in Biological Networks''' 

Signing of Regulatory Networks (SIREN) algorithm needs two kinds of data for making inference. As the first source, it needs the presence of an interaction network. This network shows the existing linkages among nodes; and can be directed or undirected. As the second source, SIREN algorithm needs transcriptome data of related biological network. With having these, this new algorithm infers the underlying interaction type between each pair of interacting nodes in the network.

SIREN is an efficient algorithm with low computational complexity; hence, it is applicable to huge biological networks with a large number of genes. It can be considered as a complementary for a wide range of network reconstruction methods which do not provide any information about the nature of interaction type.


[[attachment:SIREN.zip]]