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| Shirley is a Research Associate in the Bader Lab at the University of Toronto in the Department of Molecular Genetics. | |
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| Email: [[MailTo(shirleyh AT SPAMFREE gmail DOT com)]] | '''Email''': <<MailTo(shirley.hui AT SPAMFREE utoronto DOT ca)>> |
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| Shirley is a graduate student in the Bader Lab at the University of Toronto in the Department of Molecular Genetics. * Supervisor: Gary Bader * Supervisory Committee: Tony Pawson, Quaid Morris, Charlie Boone |
'''Supervisor''': Gary Bader |
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| == Research Project == * [wiki:/DomainSpecificityPredictionProject Computational prediction of protein domain-peptide interactions using machine learning methods] * [wiki:/Log Progress] |
== Research Projects == === Current === * [[/../MedicalDecisionMakingProject|Medical decision making]] * Progress [[/../MedicalDecisionMakingProject/Log| Log]] === Past === * [[/../DomainSpecificityPredictionProject|PDZ domain specificity prediction]] * Thesis: [[http://hdl.handle.net/1807/43599|Computational Prediction of PDZ mediated Protein-Protein Interactions]] * Supervisory Committee: [[http://www.utoronto.ca/boonelab/|Charlie Boone]], [[http://morrislab.med.utoronto.ca/|Quaid Morris]], [[http://pawsonlab.mshri.on.ca/|Tony Pawson]] |
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| == Current Interests == * Algorithms: Machine Learning - Support Vector Machines * Protein-protein interaction prediction |
## * [wiki:/../DomainSpecificityPredictionProject/Log Progress] ##== Current Interests == ## * Algorithms: Machine Learning - Support Vector Machines ## * Peptide Recognition Domains: PDZ Domain |
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| * 1996 - 2001 University of Waterloo - B.Math Hons Computer Science Co-op * 2002 - 2005 University of Waterloo - M.Math focusing on applications in Bioinformatics |
* 2007 - 2013 [[http://www.utoronto.ca|University of Toronto]] - Ph.D. Department of Molecular Genetics * 2002 - 2005 [[http://www.cs.uwaterloo.ca/|University of Waterloo]] - M.Math focusing on applications in Bioinformatics * 1996 - 2001 [[http://www.cs.uwaterloo.ca/|University of Waterloo]] - B.Math Hons Computer Science Co-op |
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| == Skills == * Technical: * Programming Languages: Java, C++ * Numerical Analysis Software: Matlab * Non-Technical: * Play the Piano/Read Music (Gr 10 Royal Conservatory Hons) |
== Publications == 1. '''Predicting PDZ domain mediated protein interactions from structure'''<<BR>>'''Hui S, Xing X, Bader GD'''<<BR>> [[http://www.biomedcentral.com/1471-2105/14/27/abstract|BMC Bioinformatics (2013) doi:10.1186/1471-2105-14-27]] <<BR>>[[http://www.ncbi.nlm.nih.gov/pubmed/23336252|PubMed Abstract]] [[attachment:pdz-struct-2013.pdf|PDF]] <<BR>>'''PROTEIN INTERACTION PREDICTION''' 1. '''Domain-mediated protein interaction prediction: From genome to network'''<<BR>>'''Reimand J, Hui S, Jain S, Law B, Bader GD'''<<BR>> [[http://www.sciencedirect.com/science/article/pii/S001457931200316X|FEBS Lett. 2012 May 3]]<<BR>>[[http://www.ncbi.nlm.nih.gov/pubmed/22561014|PubMed Abstract]] [[attachment:Genome2NetworkReview.pdf|PDF]]<<BR>>'''PROTEIN INTERACTIONS''' 1. '''Proteome scanning to predict PDZ domain interactions using support vector machines'''<<BR>>'''Hui S''', '''Bader GD'''<<BR>>[[http://www.biomedcentral.com/1471-2105/11/507|BMC Bioinformatics. 2010 Oct 12;11(1):50]]<<BR>>[[http://www.ncbi.nlm.nih.gov/pubmed/20939902|PubMed Abstract]] -[[attachment:2010_HuiBader-ProteomeScanningPDZ_BMCBioinformatics.pdf|PDF]]<<BR>>'''PROTEIN INTERACTION PREDICTION''' 1. '''Rapid evolution of functional complexity in a domain family'''<<BR>>Ernst A, Sazinsky SL, '''Hui S''', Currell B, '''Dharsee M''', Seshagiri S, '''Bader GD''', Sidhu SS<<BR>>[[http://stke.sciencemag.org/cgi/content/full/sigtrans;2/87/ra50|Science Signaling 2009 Sep 8;2(87):ra50]]<<BR>>[[http://www.ncbi.nlm.nih.gov/pubmed/19738200|PubMed Abstract]] - [[attachment:2009_Ernst_PDZEvolution_ScienceSignaling_Sep.pdf|PDF]]<<BR>>'''PROTEIN INTERACTION NETWORK EVOLUTION''' |
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| == Things I Support == * Cancer Research and Related Fundraisers * [http://convio.cancer.ca/site/PageServer?pagename=RFL_ON_about_relay Canadian Cancer Society Relay For Life - Team Steven Hui] * Last year we raised $4030 * Earth Hour * [http://www.earthhour.org/] * WWF CN Tower Climb * [http://wwfcentral.ca/NetCommunity/Page.aspx?pid=503&srcid=500] * Sporting Life 10K - Easiest 10K! * [http://www.canadarunningseries.com/sportinglife/] |
== Work == * 1996 - 2001 (Co-op work terms - Software Development) * Ottawa (Corel) * Mississauga (Pervasive Software, Platform Computing) * San fransisco (Evolve Digital Consulting) * 2001 - 2006 * Waterloo (AGFA Healthcare) - Software Development * 2006 * Toronto (Sunnybrook Hospital - Medical Imaging) - Research Analyst |
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| == Things I Like (With Top 3 - or more - Recommends) == || i || Interest || #(1 + 3i) || #(2 + 3i) || #(3 + 3i) || || 0 || Snowboarding || Snowbird, UT || Vail, CO || Whistler/Blackcomb, BC || || 0 || Leisure reading || The Time Traveler's Wife, Niffeneger || Kite Runner, Hosseini || The Curious Incident of The Dog in The Night Time, Haddon || || 0 || Traveling || Munich, Germany || Guilin, China || Rockies, BC || || 0 || Camping/Hiking || West Coast Trail, BC (Challenging!!!) || Moab, UT *haven't been but want to go || Algonquin Park, ON || || 0 || Natural Wonders || Rockies, BC || Grand Canyon, CO || Athabasca Glacier, BC || || 1 || || Ben Nevis, UK || Guilin Landscape, China || Owen's Point, BC || || 2 || || Mt. St. Helen, WA || Badlands, AB || ... || || 0 || Man Made "Wonders" || Great Wall, China || Neuschwanstein, Germany || Edinburgh Castle, UK || || 0 || Favourite Foods || Sushi || Seafood (crab, lobster) || Veggies || || 0 || Places I Want to Travel to || Japan || Australia || Spain/Egypt/Morocco || || 0 || Favourite Coffee || Guatemala, Starbucks || Belgium Chocolate, Second Cup || || |
## == Skills == ## * Technical: ## * Programming Languages: Java ## * Numerical Analysis Software: Matlab, R ## * Non-Technical: ## * Piano/Read Music (Gr 10 [[http://www.rcmusic.ca/html|Toronto Royal Conservatory]]) |
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| == Places I Have Worked == * 1996 - 2001 (Co-op work terms - Software Development) * Ottawa (Corel) * Mississauga (Pervasive Software, Platform Computing) * San fransisco (Evolve Digital Consulting) * 2001 - 2006 * Waterloo (AGFA Healthcare) - Software Development * 2006 * Toronto (Sunnybrook Hospital - Medical Imaging) - Research Analyst |
## == Things I Support == ## * [[http://convio.cancer.ca/site/PageServer?pagename=RFL_ON_about_relay|Canadian Cancer Society Relay For Life - Team Steven Hui]] ## * [[http://www.ottawanrf.com/2007/our_kids.htm|Ottawa Neuroblastoma Fund]] ## * [[http://www.earthhour.org/|Earth Hour]] ## * [[http://wwfcentral.ca/NetCommunity/Page.aspx?pid=503&srcid=500|WWF CN Tower Climb]] ## * [[http://www.canadarunningseries.com/sportinglife/|Sporting Life 10K - Easiest 10K!]] ## == Places I Have Worked == |
Shirley Hui
Shirley is a Research Associate in the Bader Lab at the University of Toronto in the Department of Molecular Genetics.
Email: <shirley.hui AT SPAMFREE utoronto DOT ca>
Supervisor: Gary Bader
Research Projects
Current
Progress Log
Past
PDZ domain specificity prediction
Thesis: Computational Prediction of PDZ mediated Protein-Protein Interactions
Supervisory Committee: Charlie Boone, Quaid Morris, Tony Pawson
Education
2007 - 2013 University of Toronto - Ph.D. Department of Molecular Genetics
2002 - 2005 University of Waterloo - M.Math focusing on applications in Bioinformatics
1996 - 2001 University of Waterloo - B.Math Hons Computer Science Co-op
Publications
1. Predicting PDZ domain mediated protein interactions from structure
Hui S, Xing X, Bader GD
BMC Bioinformatics (2013) doi:10.1186/1471-2105-14-27
PubMed Abstract PDF
PROTEIN INTERACTION PREDICTION 1. Domain-mediated protein interaction prediction: From genome to network
Reimand J, Hui S, Jain S, Law B, Bader GD
FEBS Lett. 2012 May 3
PubMed Abstract PDF
PROTEIN INTERACTIONS 1. Proteome scanning to predict PDZ domain interactions using support vector machines
Hui S, Bader GD
BMC Bioinformatics. 2010 Oct 12;11(1):50
PubMed Abstract -PDF
PROTEIN INTERACTION PREDICTION 1. Rapid evolution of functional complexity in a domain family
Ernst A, Sazinsky SL, Hui S, Currell B, Dharsee M, Seshagiri S, Bader GD, Sidhu SS
Science Signaling 2009 Sep 8;2(87):ra50
PubMed Abstract - PDF
PROTEIN INTERACTION NETWORK EVOLUTION
Work
- 1996 - 2001 (Co-op work terms - Software Development)
- Ottawa (Corel)
- Mississauga (Pervasive Software, Platform Computing)
- San fransisco (Evolve Digital Consulting)
- 2001 - 2006
- Waterloo (AGFA Healthcare) - Software Development
- 2006
- Toronto (Sunnybrook Hospital - Medical Imaging) - Research Analyst