|
Size: 2585
Comment:
|
← Revision 71 as of 2019-01-22 19:51:50 ⇥
Size: 4815
Comment:
|
| Deletions are marked like this. | Additions are marked like this. |
| Line 6: | Line 6: |
| Shirley is a Research Associate in the Bader Lab at the University of Toronto in the Department of Molecular Genetics. | Shirley is a Research Associate in the Bader Lab at the University of Toronto. |
| Line 13: | Line 13: |
| === Current === * [[/../MedicalDecisionMakingProject|Medical decision making]] * Progress [[/../MedicalDecisionMakingProject/Log| Log]] === Past === * [[/../DomainSpecificityPredictionProject|PDZ domain specificity prediction]] * Thesis: [[http://hdl.handle.net/1807/43599|Computational Prediction of PDZ mediated Protein-Protein Interactions]] * Supervisory Committee: [[http://www.utoronto.ca/boonelab/|Charlie Boone]], [[http://morrislab.med.utoronto.ca/|Quaid Morris]], [[http://pawsonlab.mshri.on.ca/|Tony Pawson]] |
* Current * RCC single cell genomics project * [[/RCCscRNAProject/Weekly|Weekly Update]] ## *Breast Cancer GSEA Projects ## * Progess [[http://baderlab.org/ShirleyHui/BreastCancerGSEAProjects|Log]] * Past * Breast Cancer Pathway GSEA Project * [[attachment:BreastCancerPathwayGSEA-2017.pdf|PDF]] * Precision Medicine Projects * [[/../MedicalDecisionMakingProject/Log| Progress Log]] * [[/../DomainSpecificityPredictionProject|PDZ domain interaction prediction]] * Thesis: [[http://hdl.handle.net/1807/43599|Computational Prediction of PDZ mediated Protein-Protein Interactions]] * Supervisory Committee: [[http://www.utoronto.ca/boonelab/|Charlie Boone]], [[http://morrislab.med.utoronto.ca/|Quaid Morris]], [[http://pawsonlab.mshri.on.ca/|Tony Pawson]] * POW! Website: http://webservice.baderlab.org/domains/POW/ |
| Line 29: | Line 37: |
| * 2002 - 2005 [[http://www.cs.uwaterloo.ca/|University of Waterloo]] - M.Math focusing on applications in Bioinformatics * 1996 - 2001 [[http://www.cs.uwaterloo.ca/|University of Waterloo]] - B.Math Hons Computer Science Co-op |
* 2002 - 2005 [[http://www.cs.uwaterloo.ca/|University of Waterloo]] - M.Math, focus on Computational Biology * 1996 - 2001 [[http://www.cs.uwaterloo.ca/|University of Waterloo]] - B.Math, Honours Computer Science Co-op |
| Line 33: | Line 41: |
| * Association analysis identifies 65 new breast cancer risk loci, Michailidou K, Lindström S, Dennis J, Beesley J, '''Hui S''', et al.<<BR>> [[https://www.nature.com/articles/nature24284|Nature (2017) Nov 2;551(7678):92-94. Epub 2017 Oct 23]] * Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer, Milne RL, Kuchenbaecker KB, Michailidou K, Beesley J, Kar S, Lindström S, '''Hui S''', et al.<<BR>> [[https://www.nature.com/articles/ng.3785|Nat Genet. (2017) Dec;49(12):1767-1778. Epub 2017 Oct 23]] * Predicting PDZ domain mediated protein interactions from structure, '''Hui S''', Xing X, Bader GD<<BR>>[[http://www.biomedcentral.com/1471-2105/14/27/abstract|BMC Bioinformatics (2013) doi:10.1186/1471-2105-14-27]] [[http://www.ncbi.nlm.nih.gov/pubmed/23336252|PubMed Abstract]] [[attachment:pdz-struct-2013.pdf|PDF]] * Domain-mediated protein interaction prediction: From genome to network, Reimand J, '''Hui S''', Jain S, Law B, Bader GD<<BR>> [[http://www.sciencedirect.com/science/article/pii/S001457931200316X|FEBS Lett. 2012 May 3]][[http://www.ncbi.nlm.nih.gov/pubmed/22561014|PubMed Abstract]] [[attachment:Genome2NetworkReview.pdf|PDF]] * Proteome scanning to predict PDZ domain interactions using support vector machines, '''Hui S''', Bader GD<<BR>> [[http://www.biomedcentral.com/1471-2105/11/507|BMC Bioinformatics. 2010 Oct 12;11(1):50]] [[http://www.ncbi.nlm.nih.gov/pubmed/20939902|PubMed Abstract]] [[attachment:2010_HuiBader-ProteomeScanningPDZ_BMCBioinformatics.pdf|PDF]] * Rapid evolution of functional complexity in a domain family, Ernst A, Sazinsky SL, '''Hui S''', Currell B, Dharsee M, Seshagiri S, Bader GD, Sidhu SS<<BR>> [[http://stke.sciencemag.org/cgi/content/full/sigtrans;2/87/ra50|Science Signaling 2009 Sep 8;2(87):ra50]] [[http://www.ncbi.nlm.nih.gov/pubmed/19738200|PubMed Abstract]] [[attachment:2009_Ernst_PDZEvolution_ScienceSignaling_Sep.pdf|PDF]] == Work == * 2006 * Toronto (Sunnybrook Hospital - Medical Imaging) - Research Analyst * 2001 - 2006 * Waterloo (AGFA Healthcare) - Software Development * 1996 - 2001 (Co-op work terms - Software Development) * Ottawa (Corel) * Mississauga (Pervasive Software, Platform Computing) * San fransisco (Evolve Digital Consulting) |
|
| Line 50: | Line 78: |
| ## * 1996 - 2001 (Co-op work terms - Software Development) ## * Ottawa (Corel) ## * Mississauga (Pervasive Software, Platform Computing) ## * San fransisco (Evolve Digital Consulting) ## * 2001 - 2006 ## * Waterloo (AGFA Healthcare) - Software Development ## * 2006 ## * Toronto (Sunnybrook Hospital - Medical Imaging) - Research Analyst |
Shirley Hui
Shirley is a Research Associate in the Bader Lab at the University of Toronto.
Email: <shirley.hui AT SPAMFREE utoronto DOT ca>
Supervisor: Gary Bader
Research Projects
- Current
- RCC single cell genomics project
- Past
- Breast Cancer Pathway GSEA Project
- Precision Medicine Projects
PDZ domain interaction prediction
Thesis: Computational Prediction of PDZ mediated Protein-Protein Interactions
Supervisory Committee: Charlie Boone, Quaid Morris, Tony Pawson
POW! Website: http://webservice.baderlab.org/domains/POW/
Education
2007 - 2013 University of Toronto - Ph.D. Department of Molecular Genetics
2002 - 2005 University of Waterloo - M.Math, focus on Computational Biology
1996 - 2001 University of Waterloo - B.Math, Honours Computer Science Co-op
Publications
Association analysis identifies 65 new breast cancer risk loci, Michailidou K, Lindström S, Dennis J, Beesley J, Hui S, et al.
Nature (2017) Nov 2;551(7678):92-94. Epub 2017 Oct 23Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer, Milne RL, Kuchenbaecker KB, Michailidou K, Beesley J, Kar S, Lindström S, Hui S, et al.
Nat Genet. (2017) Dec;49(12):1767-1778. Epub 2017 Oct 23Predicting PDZ domain mediated protein interactions from structure, Hui S, Xing X, Bader GD
BMC Bioinformatics (2013) doi:10.1186/1471-2105-14-27 PubMed Abstract PDFDomain-mediated protein interaction prediction: From genome to network, Reimand J, Hui S, Jain S, Law B, Bader GD
FEBS Lett. 2012 May 3PubMed Abstract PDFProteome scanning to predict PDZ domain interactions using support vector machines, Hui S, Bader GD
BMC Bioinformatics. 2010 Oct 12;11(1):50 PubMed Abstract PDFRapid evolution of functional complexity in a domain family, Ernst A, Sazinsky SL, Hui S, Currell B, Dharsee M, Seshagiri S, Bader GD, Sidhu SS
Science Signaling 2009 Sep 8;2(87):ra50 PubMed Abstract PDF
Work
- 2006
- Toronto (Sunnybrook Hospital - Medical Imaging) - Research Analyst
- 2001 - 2006
- Waterloo (AGFA Healthcare) - Software Development
- 1996 - 2001 (Co-op work terms - Software Development)
- Ottawa (Corel)
- Mississauga (Pervasive Software, Platform Computing)
- San fransisco (Evolve Digital Consulting)