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== Signing of Regulatory Networks (SIREN) ==

Discrimination of Interaction Type in Biological Networks

The Signing of Regulatory Networks (SIREN) algorithm can infer the regulatory type (positive or negative regulation) of interactions in a known gene regulatory network given corresponding genome-wide gene expression data.

SIREN is an efficient algorithm with low computational complexity; hence, it is applicable to large biological networks. It is a complementary approach for a wide range of network reconstruction methods that do not provide information about the interaction type.

[[attachment:SIREN.zip]]