The Bader Lab is involved in a number of collaborative open-source bioinformatics projects designed to make biological pathway data easy to visualize and analyze.

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Biological Network Analysis and Visualization Software

Cytoscape

Cytoscape is a bioinformatics software platform for visualizing molecular interaction networks and integrating these interactions with gene expression profiles and other state data. Additional features are available as plugins. Plugins are available for network and molecular profiling analyses, new layouts, additional file format support and connection with databases. Plugins may be developed using the Cytoscape open Java software architecture by anyone and plugin community development is encouraged.

http://www.cytoscape.org

Cytoscape was originally developed at the [http://systemsbiology.org/ Institute of Systems Biology] and is now a collaborative effort involving many different academic and commercial groups.

NetMatch

NetMatch is a Cytoscape plugin that finds user defined network motifs in any Cytoscape network. Node and edge attributes of any type and paths of unknown length can be specified in the search.

Released by: Ferro, Giugno, Pulvirenti group, University of Catania, Bader group, University of Toronto and Shasha group, New York University.

[:/NetMatch:Available from the Bader Lab mirror of the NetMatch homepage]

MCODE

MCODE is a Cytoscape plugin that finds clusters (highly interconnected regions) in a network. Clusters mean different things in different types of networks. For instance, clusters in a protein-protein interaction network are often protein complexes and parts of pathways, while clusters in a protein similarity network represent protein families.

[:/MCODE:Available from the MCODE homepage]

BRAIN

LOLA (LOgos Look Amazing) is a tool for generating sequence logos using Position Weight Matrix based protein profiles. LOLA allows you to generate custom sequence logos by setting parameters such as logo height, trim percentage, and residue colour scheme. You can also generate "logo trees" based on clustered protein profiles to analyze binding motif classes. Sequence logos and logo trees can be saved in various formats including PDF, PNG, and JPEG.

[:/BRAIN:Available from the BRAIN homepage]

LOLA

LOLA (LOgos Look Amazing) is a tool for generating sequence logos using Position Weight Matrix based protein profiles. LOLA allows you to generate custom sequence logos by setting parameters such as logo height, trim percentage, and residue colour scheme. You can also generate "logo trees" based on clustered protein profiles to analyze binding motif classes. Sequence logos and logo trees can be saved in various formats including PDF, PNG, and JPEG.

[:/LOLA:Available from the LOLA homepage]

Biological Pathway and Network Database Software

cPath

cPath, an open source database and web application for collecting, storing, browsing and querying biological pathway data. cPath makes it easy to aggregate custom pathway data sets available in standard exchange formats from multiple databases, present pathway data to biologists via a customizable web interface, and easily export pathway data via a web service to third-party software for visualization and analysis. cPath is software only, and does not include new pathway information. Key features include: a built-in identity and reference service for identifying and annotating interactors; built-in support for PSI-MI and BioPAX standard pathway exchange formats; and a web service interface for searching and retrieving pathway data sets. Thorough documentation is available for all aspects of cPath. The cPath software is freely available under the LGPL open source license for academic and commercial use.

http://cbio.mskcc.org/dev_site/cpath/ BR Demo: http://cbio.mskcc.org/cpath/ (Protein-protein interactions) BR Demo: http://cancer.cellmap.org (Pathways) BR

This work is done in collaboration with the Sander group of the [http://cbio.mskcc.org/ Computational Biology Center] at Memorial Sloan-Kettering Cancer Center in New York City.

Pathway and Network Data

The Cancer Cell Map

The Cancer Cell Map contains selected cancer related signaling pathways which you can browse or search. Biologists can browse and search the Cancer Cell Map pathways. View gene expression data on any pathway. Computational biologists can download all pathways in BioPAX format for global analysis. Software developers can build software on top of the Cancer Cell Map using the web service API. Download and install the cPath software to create a local mirror.

http://cancer.cellmap.org

This work is done in collaboration with the Sander group of the [http://cbio.mskcc.org/ Computational Biology Center] at Memorial Sloan-Kettering Cancer Center in New York City.

Pathway Commons

Pathway Commons is a convenient point of access to biological pathway information collected from public pathway databases, which you can browse or search. Pathways include biochemical reactions, complex assembly, transport and catalysis events, and physical interactions involving proteins, DNA, RNA, small molecules and complexes.

http://www.pathwaycommons.org/

This work is done in collaboration with the Sander group of the [http://cbio.mskcc.org/ Computational Biology Center] at Memorial Sloan-Kettering Cancer Center in New York City.

Pathway Data Exchange Standards

BioPAX

BioPAX (Biological Pathway Exchange) is a collaborative effort to create a data exchange format for biological pathway data. BioPAX covers metabolic pathways, molecular interactions and protein post-translational modifications. Future versions will expand support for signaling pathways, gene regulatory networks and genetic interactions.

http://www.biopax.org/

PSI-MI

PSI-MI (The Proteomics Standards Initiative Molecular Interactions) format allows exchange of molecular interaction data, focusing on protein-protein interactions.

http://psidev.sourceforge.net/

Both of these projects are large international collaborative efforts involving many different academic and commercial groups.

Community Web Sites

Pathguide

Pathguide, the Pathway Resource List, contains information about hundreds of online biological pathway resources. Databases that are free and those supporting BioPAX, CellML, PSI-MI or SBML standards are highlighted.

http://www.pathguide.org/

Vision

The above software support a vision for easy, seamless access to all public pathway information for visualization and interpretation in biological research.

attachment:pathways.png