Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classtreated
GeneSetGO|GO:0006260
Enrichment Score (ES)0.67524165
Normalized Enrichment Score (NES)1.620769
Nominal p-value0.0
FDR q-value0.04296846
FWER p-Value0.943
Table: GSEA Results Summary



Fig 1: Enrichment plot: GO|GO:0006260   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
16241RRM2 (ribonucleotide reductase M2 polypeptide)66172.7900.0366Yes
24175MCM6 (minichromosome maintenance complex component 6)78163.8120.0739Yes
35111PCNA (proliferating cell nuclear antigen)102146.2210.1065Yes
44176MCM7 (minichromosome maintenance complex component 7)145121.4390.1325Yes
51736"DKC1 (dyskeratosis congenita 1, dyskerin)"177108.9490.1561Yes
67298TYMS (thymidylate synthetase)202102.5060.1786Yes
75983"RFC3 (replication factor C (activator 1) 3, 38kDa)"215100.3380.2011Yes
88099CDK2AP1 (CDK2-associated protein 1)23197.1750.2228Yes
9374AREG (amphiregulin)23596.1250.2449Yes
104171MCM2 (minichromosome maintenance complex component 2)25991.9010.2649Yes
1151053"GMNN (geminin, DNA replication inhibitor)"34180.4410.2795Yes
122237FEN1 (flap structure-specific endonuclease 1)34879.3160.2975Yes
1354107"POLE3 (polymerase (DNA directed), epsilon 3 (p17 subunit))"42269.6810.3100Yes
1451659GINS2 (GINS complex subunit 2 (Psf2 homolog))42469.2840.3259Yes
1581542TXNDC1 (thioredoxin domain containing 1)47564.1270.3382Yes
1655388MCM10 (minichromosome maintenance complex component 10)51461.3110.3505Yes
178883NAE1 (NEDD8 activating enzyme E1 subunit 1)52160.9010.3643Yes
1855035NOL8 (nucleolar protein 8)54858.8730.3766Yes
196418SET (SET nuclear oncogene)59255.6710.3873Yes
2079075DSCC1 (defective in sister chromatid cohesion 1 homolog (S. cerevisiae))59555.4040.4000Yes
21811CALR (calreticulin)64452.3600.4097Yes
2279892C10orf119 (chromosome 10 open reading frame 119)66151.4060.4208Yes
2323560GTPBP4 (GTP binding protein 4)72248.1680.4289Yes
249837GINS1 (GINS complex subunit 1 (Psf1 homolog))73147.8330.4396Yes
255557"PRIM1 (primase, DNA, polypeptide 1 (49kDa))"75647.0790.4492Yes
264172MCM3 (minichromosome maintenance complex component 3)81643.8920.4564Yes
27545ATR (ataxia telangiectasia and Rad3 related)84642.9640.4649Yes
2810926DBF4 (DBF4 homolog (S. cerevisiae))85042.7050.4746Yes
295425"POLD2 (polymerase (DNA directed), delta 2, regulatory subunit 50kDa)"91240.2180.4809Yes
3054962TIPIN (TIMELESS interacting protein)92739.5320.4893Yes
3110432RBM14 (RNA binding motif protein 14)92839.5110.4984Yes
324174MCM5 (minichromosome maintenance complex component 5)95438.3410.5061Yes
337884SLBP (stem-loop binding protein)96637.9850.5143Yes
349126SMC3 (structural maintenance of chromosomes 3)99837.0970.5213Yes
35990CDC6 (cell division cycle 6 homolog (S. cerevisiae))109833.8170.5242Yes
3611177"BAZ1A (bromodomain adjacent to zinc finger domain, 1A)"110033.7300.5319Yes
3723594"ORC6L (origin recognition complex, subunit 6 like (yeast))"114832.4560.5371Yes
3810535"RNASEH2A (ribonuclease H2, subunit A)"120530.9920.5415Yes
397019"TFAM (transcription factor A, mitochondrial)"126729.7270.5453Yes
405982"RFC2 (replication factor C (activator 1) 2, 40kDa)"128829.3030.5511Yes
416119"RPA3 (replication protein A3, 14kDa)"128929.2970.5578Yes
425810RAD1 (RAD1 homolog (S. pombe))131428.6720.5633Yes
434673NAP1L1 (nucleosome assembly protein 1-like 1)133628.1280.5687Yes
441854DUT (deoxyuridine triphosphatase)141926.7300.5708Yes
458243SMC1A (structural maintenance of chromosomes 1A)159723.9870.5676Yes
4623649"POLA2 (polymerase (DNA directed), alpha 2 (70kD subunit))"159823.9760.5731Yes
475985"RFC5 (replication factor C (activator 1) 5, 36.5kDa)"161723.6760.5777Yes
4823244"PDS5A (PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae))"162923.4440.5825Yes
494998"ORC1L (origin recognition complex, subunit 1-like (yeast))"165823.1330.5865Yes
504683NBN (nibrin)170622.3160.5893Yes
513265HRAS (v-Ha-ras Harvey rat sarcoma viral oncogene homolog)172322.0730.5936Yes
52993CDC25A (cell division cycle 25 homolog A (S. pombe))174221.8190.5978Yes
5365057ACD (adrenocortical dysplasia homolog (mouse))178821.2550.6004Yes
5481620CDT1 (chromatin licensing and DNA replication factor 1)179021.2050.6053Yes
555888"RAD51 (RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae))"182220.7980.6085Yes
564999"ORC2L (origin recognition complex, subunit 2-like (yeast))"183020.7700.6130Yes
5754386"TERF2IP (telomeric repeat binding factor 2, interacting protein)"184520.5480.6170Yes
585424"POLD1 (polymerase (DNA directed), delta 1, catalytic subunit 125kDa)"186620.3340.6207Yes
596464SHC1 (SHC (Src homology 2 domain containing) transforming protein 1)189320.0450.6241Yes
604173MCM4 (minichromosome maintenance complex component 4)193819.6300.6264Yes
6184515MCM8 (minichromosome maintenance complex component 8)194919.4440.6304Yes
6256897WRNIP1 (Werner helicase interacting protein 1)202818.5010.6308Yes
635001"ORC5L (origin recognition complex, subunit 5-like (yeast))"203018.4860.6350Yes
645558"PRIM2 (primase, DNA, polypeptide 2 (58kDa))"203118.4850.6393Yes
656118"RPA2 (replication protein A2, 32kDa)"204818.3550.6428Yes
661017CDK2 (cyclin-dependent kinase 2)212217.7310.6432Yes
678318CDC45L (CDC45 cell division cycle 45-like (S. cerevisiae))215117.4750.6459Yes
687486WRN (Werner syndrome)216617.3860.6492Yes
695427"POLE2 (polymerase (DNA directed), epsilon 2 (p59 subunit))"217617.3320.6527Yes
709401RECQL4 (RecQ protein-like 4)219717.1770.6557Yes
715515"PPP2CA (protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform)"226416.4270.6562Yes
725984"RFC4 (replication factor C (activator 1) 4, 37kDa)"233515.7350.6564Yes
735154PDGFA (platelet-derived growth factor alpha polypeptide)234515.5510.6595Yes
7410111RAD50 (RAD50 homolog (S. cerevisiae))239615.1880.6606Yes
755884RAD17 (RAD17 homolog (S. pombe))240115.1500.6639Yes
764361MRE11A (MRE11 meiotic recombination 11 homolog A (S. cerevisiae))245714.7160.6645Yes
7756652C10orf2 (chromosome 10 open reading frame 2)246614.6760.6675Yes
785981"RFC1 (replication factor C (activator 1) 1, 145kDa)"251914.0980.6682Yes
795422"POLA1 (polymerase (DNA directed), alpha 1, catalytic subunit)"254313.9450.6703Yes
806117"RPA1 (replication protein A1, 70kDa)"254913.8880.6732Yes
81222229LRWD1 (leucine-rich repeats and WD repeat domain containing 1)257313.6950.6752Yes
8290381C15orf42 (chromosome 15 open reading frame 42)276912.3700.6684No
8323063WAPAL (wings apart-like homolog (Drosophila))290411.6280.6644No
8423411SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae))293311.4200.6657No
8510714"POLD3 (polymerase (DNA-directed), delta 3, accessory subunit)"309710.4490.6600No
8623054NCOA6 (nuclear receptor coactivator 6)311210.3910.6617No
878317CDC7 (cell division cycle 7 homolog (S. cerevisiae))317810.0560.6608No
8879736C17orf42 (chromosome 17 open reading frame 42)33319.4270.6554No
894771NF2 (neurofibromin 2 (merlin))33519.3610.6567No
905813PURA (purine-rich element binding protein A)33729.2740.6578No
9111232"POLG2 (polymerase (DNA directed), gamma 2, accessory subunit)"34279.0640.6572No
9223595"ORC3L (origin recognition complex, subunit 3-like (yeast))"35388.6260.6537No
93641BLM (Bloom syndrome)35528.5830.6551No
947040"TGFB1 (transforming growth factor, beta 1)"36658.1040.6514No
953364HUS1 (HUS1 checkpoint homolog (S. pombe))36688.0980.6532No
961111CHEK1 (CHK1 checkpoint homolog (S. pombe))36738.0780.6548No
9755294FBXW7 (F-box and WD repeat domain containing 7)37507.6970.6528No
985883RAD9A (RAD9 homolog A (S. pombe))37987.5320.6522No
9984897TBRG1 (transforming growth factor beta regulator 1)39686.9040.6454No
10085456"TNKS1BP1 (tankyrase 1 binding protein 1, 182kDa)"39836.8580.6463No
1014678NASP (nuclear autoantigenic sperm protein (histone-binding))40116.7480.6466No
1025937"RBMS1 (RNA binding motif, single stranded interacting protein 1)"40616.5800.6456No
1035976UPF1 (UPF1 regulator of nonsense transcripts homolog (yeast))41486.2830.6428No
10484268RPAIN (RPA interacting protein)42126.0530.6411No
105157570ESCO2 (establishment of cohesion 1 homolog 2 (S. cerevisiae))42415.9950.6411No
10684296GINS4 (GINS complex subunit 4 (Sld5 homolog))44135.4610.6339No
1076282S100A11 (S100 calcium binding protein A11)44765.3020.6320No
10879991OBFC1 (oligonucleotide/oligosaccharide-binding fold containing 1)45385.1340.6302No
1094796NFKBIL2 (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2)48444.3710.6160No
11084289"ING5 (inhibitor of growth family, member 5)"49544.1150.6116No
1113508IGHMBP2 (immunoglobulin mu binding protein 2)50783.8790.6063No
1125980"REV3L (REV3-like, catalytic subunit of DNA polymerase zeta (yeast))"51453.7210.6039No
11384126ATRIP (ATR interacting protein)52793.4330.5981No
1145155PDGFB (platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog))53743.2860.5942No
11543ACHE (acetylcholinesterase (Yt blood group))56452.8520.5815No
1164928NUP98 (nucleoporin 98kDa)57212.7160.5784No
1175763PTMS (parathymosin)58512.5490.5726No
1185426"POLE (polymerase (DNA directed), epsilon)"58782.5200.5718No
1191890TYMP (thymidine phosphorylase)59432.4430.5692No
1201763DNA2 (DNA replication helicase 2 homolog (yeast))60492.3100.5645No
12192797HELB (helicase (DNA) B)63861.8950.5483No
12254617INO80 (INO80 homolog (S. cerevisiae))68341.4760.5265No
12310638SPHAR (S-phase response (cyclin-related))69771.3580.5197No
1242658GDF2 (growth differentiation factor 2)69831.3530.5198No
1253479IGF1 (insulin-like growth factor 1 (somatomedin C))70981.2700.5144No
12656953"NT5M (5',3'-nucleotidase, mitochondrial)"72031.1910.5095No
127253980KCTD13 (potassium channel tetramerisation domain containing 13)72351.1710.5083No
1281437CSF2 (colony stimulating factor 2 (granulocyte-macrophage))73781.0800.5015No
1297013TERF1 (telomeric repeat binding factor (NIMA-interacting) 1)74121.0590.5001No
130339221ENPP7 (ectonucleotide pyrophosphatase/phosphodiesterase 7)76210.9340.4899No
13129935"RPA4 (replication protein A4, 34kDa)"81200.6840.4654No
1323562"IL3 (interleukin 3 (colony-stimulating factor, multiple))"83050.6130.4564No
13363967CLSPN (claspin homolog (Xenopus laevis))86690.4890.4385No
1342735GLI1 (glioma-associated oncogene homolog 1 (zinc finger protein))87710.4540.4336No
13556034PDGFC (platelet derived growth factor C)88250.4360.4310No
1362069EREG (epiregulin)91560.3440.4147No
137144715RAD9B (RAD9 homolog B (S. cerevisiae))94650.2610.3995No
1382255FGF10 (fibroblast growth factor 10)95610.2390.3948No
1395319"PLA2G1B (phospholipase A2, group IB (pancreas))"103690.0460.3548No
14025913POT1 (POT1 protection of telomeres 1 homolog (S. pombe))103940.0400.3536No
1413978"LIG1 (ligase I, DNA, ATP-dependent)"10691-0.0240.3389No
1425428"POLG (polymerase (DNA directed), gamma)"10805-0.0480.3333No
14355704CCDC88A (coiled-coil domain containing 88A)11023-0.0980.3226No
1445156"PDGFRA (platelet-derived growth factor receptor, alpha polypeptide)"11208-0.1440.3135No
1453630INS (insulin)11442-0.2010.3019No
146727738AREGB (amphiregulin B)12425-0.4370.2533No
1471950EGF (epidermal growth factor (beta-urogastrone))12439-0.4410.2527No
148340533KIAA2022 (KIAA2022)13859-0.9270.1825No
14911143MYST2 (MYST histone acetyltransferase 2)14419-1.1890.1550No
15022944"KIN (KIN, antigenic determinant of recA protein homolog (mouse))"14422-1.1930.1552No
1512736GLI2 (GLI-Kruppel family member GLI2)14561-1.2730.1486No
15211277TREX1 (three prime repair exonuclease 1)14986-1.5540.1279No
1535423"POLB (polymerase (DNA directed), beta)"15243-1.7500.1156No
1547015TERT (telomerase reverse transcriptase)15612-2.0630.0978No
1553643INSR (insulin receptor)15941-2.4230.0821No
1562056EPO (erythropoietin)16718-3.6320.0444No
15794ACVRL1 (activin A receptor type II-like 1)16780-3.7480.0423No
1583159HMGA1 (high mobility group AT-hook 1)16865-3.9170.0390No
1598658"TNKS (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase)"16951-4.1200.0357No
16057804"POLD4 (polymerase (DNA-directed), delta 4)"17078-4.4470.0305No
16127343"POLL (polymerase (DNA directed), lambda)"17158-4.6450.0276No
162114799ESCO1 (establishment of cohesion 1 homolog 1 (S. cerevisiae))17533-5.7530.0104No
16311284PNKP (polynucleotide kinase 3'-phosphatase)17615-6.0770.0078No
164997CDC34 (cell division cycle 34 homolog (S. cerevisiae))17810-6.960-0.0002No
16580169C17orf68 (chromosome 17 open reading frame 68)17913-7.441-0.0036No
166995CDC25C (cell division cycle 25 homolog C (S. pombe))18014-7.979-0.0067No
1677043"TGFB3 (transforming growth factor, beta 3)"18102-8.466-0.0091No
16851147"ING4 (inhibitor of growth family, member 4)"18169-8.877-0.0103No
1697014TERF2 (telomeric repeat binding factor 2)18350-9.921-0.0169No
1706240RRM1 (ribonucleotide reductase M1)18380-10.148-0.0160No
1715371PML (promyelocytic leukemia)18450-10.797-0.0170No
17264061TSPYL2 (TSPY-like 2)18530-11.340-0.0183No
17380351"TNKS2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2)"18583-11.868-0.0181No
1747126"TNFAIP1 (tumor necrosis factor, alpha-induced protein 1 (endothelial))"18604-12.063-0.0163No
1755000"ORC4L (origin recognition complex, subunit 4-like (yeast))"18666-12.706-0.0164No
1763855KRT7 (keratin 7)18820-14.254-0.0207No
1778888MCM3AP (minichromosome maintenance complex component 3 associated protein)18873-14.883-0.0199No
1783480IGF1R (insulin-like growth factor 1 receptor)18931-15.644-0.0191No
1797153TOP2A (topoisomerase (DNA) II alpha 170kDa)19279-22.386-0.0312No
18026277TINF2 (TERF1 (TRF1)-interacting nuclear factor 2)19397-25.602-0.0311No
1817155TOP2B (topoisomerase (DNA) II beta 180kDa)19771-40.621-0.0402No
1825518"PPP2R1A (protein phosphatase 2 (formerly 2A), regulatory subunit A , alpha isoform)"19806-42.722-0.0320No
18310735STAG2 (stromal antigen 2)19852-46.380-0.0235No
1844254KITLG (KIT ligand)20130-87.603-0.0171No
1855478PPIA (peptidylprolyl isomerase A (cyclophilin A))20198-115.6470.0063No
Table: GSEA details [plain text format]



Fig 2: GO|GO:0006260   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: GO|GO:0006260: Random ES distribution   
Gene set null distribution of ES for GO|GO:0006260