Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | cont |
GeneSet | GO|GO:0007179 |
Enrichment Score (ES) | -0.62338775 |
Normalized Enrichment Score (NES) | -1.5709131 |
Nominal p-value | 0.009868421 |
FDR q-value | 0.3081151 |
FWER p-Value | 1.0 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 23089 | PEG10 (paternally expressed 10) | 519 | 61.228 | 0.0168 | No | ||
2 | 7071 | KLF10 (Kruppel-like factor 10) | 545 | 59.103 | 0.0566 | No | ||
3 | 3622 | "ING2 (inhibitor of growth family, member 2)" | 1786 | 21.288 | 0.0101 | No | ||
4 | 7057 | THBS1 (thrombospondin 1) | 1837 | 20.662 | 0.0220 | No | ||
5 | 80139 | ZNF703 (zinc finger protein 703) | 2033 | 18.476 | 0.0252 | No | ||
6 | 657 | "BMPR1A (bone morphogenetic protein receptor, type IA)" | 2168 | 17.378 | 0.0306 | No | ||
7 | 58533 | SNX6 (sorting nexin 6) | 2367 | 15.407 | 0.0315 | No | ||
8 | 5300 | "PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1)" | 2371 | 15.381 | 0.0420 | No | ||
9 | 4087 | SMAD2 (SMAD family member 2) | 3208 | 9.912 | 0.0076 | No | ||
10 | 7040 | "TGFB1 (transforming growth factor, beta 1)" | 3665 | 8.104 | -0.0093 | No | ||
11 | 3725 | JUN (jun oncogene) | 3700 | 7.938 | -0.0055 | No | ||
12 | 2353 | FOS (v-fos FBJ murine osteosarcoma viral oncogene homolog) | 3938 | 6.979 | -0.0124 | No | ||
13 | 409 | "ARRB2 (arrestin, beta 2)" | 4205 | 6.074 | -0.0213 | No | ||
14 | 4092 | SMAD7 (SMAD family member 7) | 4318 | 5.717 | -0.0229 | No | ||
15 | 90 | "ACVR1 (activin A receptor, type I)" | 4352 | 5.625 | -0.0206 | No | ||
16 | 6868 | ADAM17 (ADAM metallopeptidase domain 17) | 4493 | 5.266 | -0.0238 | No | ||
17 | 23592 | LEMD3 (LEM domain containing 3) | 4495 | 5.262 | -0.0202 | No | ||
18 | 6794 | STK11 (serine/threonine kinase 11) | 4786 | 4.524 | -0.0314 | No | ||
19 | 57154 | SMURF1 (SMAD specific E3 ubiquitin protein ligase 1) | 4836 | 4.388 | -0.0308 | No | ||
20 | 4090 | SMAD5 (SMAD family member 5) | 4982 | 4.072 | -0.0351 | No | ||
21 | 5155 | PDGFB (platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)) | 5374 | 3.286 | -0.0522 | No | ||
22 | 51701 | NLK (nemo-like kinase) | 5699 | 2.752 | -0.0663 | No | ||
23 | 1149 | CIDEA (cell death-inducing DFFA-like effector a) | 5979 | 2.399 | -0.0784 | No | ||
24 | 2339 | "FNTA (farnesyltransferase, CAAX box, alpha)" | 6425 | 1.852 | -0.0991 | No | ||
25 | 7321 | "UBE2D1 (ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast))" | 6480 | 1.793 | -0.1005 | No | ||
26 | 2331 | FMOD (fibromodulin) | 6521 | 1.765 | -0.1013 | No | ||
27 | 64750 | SMURF2 (SMAD specific E3 ubiquitin protein ligase 2) | 6820 | 1.493 | -0.1150 | No | ||
28 | 9719 | ADAMTSL2 (ADAMTS-like 2) | 6984 | 1.352 | -0.1221 | No | ||
29 | 4053 | LTBP2 (latent transforming growth factor beta binding protein 2) | 7037 | 1.320 | -0.1237 | No | ||
30 | 8425 | LTBP4 (latent transforming growth factor beta binding protein 4) | 7161 | 1.220 | -0.1290 | No | ||
31 | 2200 | FBN1 (fibrillin 1) | 7364 | 1.088 | -0.1382 | No | ||
32 | 112744 | IL17F (interleukin 17F) | 7746 | 0.868 | -0.1564 | No | ||
33 | 2122 | EVI1 (ecotropic viral integration site 1) | 7765 | 0.856 | -0.1567 | No | ||
34 | 7044 | LEFTY2 (left-right determination factor 2) | 7817 | 0.826 | -0.1587 | No | ||
35 | 7080 | NKX2-1 (NK2 homeobox 1) | 7829 | 0.819 | -0.1586 | No | ||
36 | 63976 | PRDM16 (PR domain containing 16) | 7895 | 0.786 | -0.1613 | No | ||
37 | 2022 | ENG (endoglin (Osler-Rendu-Weber syndrome 1)) | 8423 | 0.570 | -0.1870 | No | ||
38 | 9392 | "TGFBRAP1 (transforming growth factor, beta receptor associated protein 1)" | 8577 | 0.521 | -0.1941 | No | ||
39 | 7041 | TGFB1I1 (transforming growth factor beta 1 induced transcript 1) | 8659 | 0.493 | -0.1978 | No | ||
40 | 4086 | SMAD1 (SMAD family member 1) | 8706 | 0.479 | -0.1997 | No | ||
41 | 163126 | EID2 (EP300 interacting inhibitor of differentiation 2) | 8781 | 0.451 | -0.2031 | No | ||
42 | 2201 | FBN2 (fibrillin 2) | 9529 | 0.247 | -0.2398 | No | ||
43 | 2488 | "FSHB (follicle stimulating hormone, beta polypeptide)" | 9725 | 0.201 | -0.2493 | No | ||
44 | 3248 | HPGD (hydroxyprostaglandin dehydrogenase 15-(NAD)) | 9791 | 0.184 | -0.2524 | No | ||
45 | 4089 | SMAD4 (SMAD family member 4) | 10664 | -0.017 | -0.2955 | No | ||
46 | 1278 | "COL1A2 (collagen, type I, alpha 2)" | 11598 | -0.234 | -0.3414 | No | ||
47 | 54829 | ASPN (asporin) | 11654 | -0.249 | -0.3440 | No | ||
48 | 7042 | "TGFB2 (transforming growth factor, beta 2)" | 11675 | -0.254 | -0.3448 | No | ||
49 | 7048 | "TGFBR2 (transforming growth factor, beta receptor II (70/80kDa))" | 12260 | -0.389 | -0.3734 | No | ||
50 | 6664 | SOX11 (SRY (sex determining region Y)-box 11) | 12616 | -0.488 | -0.3906 | No | ||
51 | 2662 | GDF10 (growth differentiation factor 10) | 12662 | -0.501 | -0.3924 | No | ||
52 | 8287 | "USP9Y (ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila))" | 12913 | -0.580 | -0.4044 | No | ||
53 | 1028 | "CDKN1C (cyclin-dependent kinase inhibitor 1C (p57, Kip2))" | 13428 | -0.754 | -0.4293 | No | ||
54 | 10637 | LEFTY1 (left-right determination factor 1) | 14022 | -1.005 | -0.4579 | No | ||
55 | 8928 | FOXH1 (forkhead box H1) | 14288 | -1.128 | -0.4702 | No | ||
56 | 1281 | "COL3A1 (collagen, type III, alpha 1)" | 14434 | -1.202 | -0.4765 | No | ||
57 | 2661 | GDF9 (growth differentiation factor 9) | 14854 | -1.454 | -0.4962 | No | ||
58 | 6498 | SKIL (SKI-like oncogene) | 14890 | -1.481 | -0.4969 | No | ||
59 | 7049 | "TGFBR3 (transforming growth factor, beta receptor III)" | 14997 | -1.561 | -0.5011 | No | ||
60 | 8200 | GDF5 (growth differentiation factor 5) | 15809 | -2.265 | -0.5396 | No | ||
61 | 4435 | "CITED1 (Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1)" | 15894 | -2.354 | -0.5421 | No | ||
62 | 607 | BCL9 (B-cell CLL/lymphoma 9) | 16190 | -2.744 | -0.5547 | No | ||
63 | 56940 | DUSP22 (dual specificity phosphatase 22) | 16775 | -3.739 | -0.5810 | No | ||
64 | 94 | ACVRL1 (activin A receptor type II-like 1) | 16780 | -3.748 | -0.5786 | No | ||
65 | 4052 | LTBP1 (latent transforming growth factor beta binding protein 1) | 17501 | -5.649 | -0.6103 | No | ||
66 | 5494 | "PPM1A (protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform)" | 17598 | -6.003 | -0.6108 | No | ||
67 | 5045 | FURIN (furin (paired basic amino acid cleaving enzyme)) | 17734 | -6.604 | -0.6129 | No | ||
68 | 4221 | MEN1 (multiple endocrine neoplasia I) | 17921 | -7.493 | -0.6169 | No | ||
69 | 7046 | "TGFBR1 (transforming growth factor, beta receptor 1)" | 18051 | -8.147 | -0.6176 | Yes | ||
70 | 7043 | "TGFB3 (transforming growth factor, beta 3)" | 18102 | -8.466 | -0.6142 | Yes | ||
71 | 51592 | TRIM33 (tripartite motif-containing 33) | 18150 | -8.757 | -0.6105 | Yes | ||
72 | 9372 | "ZFYVE9 (zinc finger, FYVE domain containing 9)" | 18308 | -9.670 | -0.6115 | Yes | ||
73 | 8754 | ADAM9 (ADAM metallopeptidase domain 9 (meltrin gamma)) | 18549 | -11.504 | -0.6154 | Yes | ||
74 | 4091 | SMAD6 (SMAD family member 6) | 18569 | -11.753 | -0.6082 | Yes | ||
75 | 4088 | SMAD3 (SMAD family member 3) | 18573 | -11.772 | -0.6002 | Yes | ||
76 | 8239 | "USP9X (ubiquitin specific peptidase 9, X-linked)" | 18719 | -13.272 | -0.5981 | Yes | ||
77 | 5796 | "PTPRK (protein tyrosine phosphatase, receptor type, K)" | 18768 | -13.761 | -0.5910 | Yes | ||
78 | 6497 | SKI (v-ski sarcoma viral oncogene homolog (avian)) | 18818 | -14.221 | -0.5835 | Yes | ||
79 | 1030 | "CDKN2B (cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4))" | 18830 | -14.350 | -0.5741 | Yes | ||
80 | 283149 | BCL9L (B-cell CLL/lymphoma 9-like) | 19472 | -27.591 | -0.5866 | Yes | ||
81 | 9518 | GDF15 (growth differentiation factor 15) | 19802 | -42.423 | -0.5734 | Yes | ||
82 | 7323 | "UBE2D3 (ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast))" | 19877 | -49.242 | -0.5429 | Yes | ||
83 | 10755 | "GIPC1 (GIPC PDZ domain containing family, member 1)" | 19891 | -50.423 | -0.5086 | Yes | ||
84 | 28996 | HIPK2 (homeodomain interacting protein kinase 2) | 20050 | -69.317 | -0.4683 | Yes | ||
85 | 10370 | "CITED2 (Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2)" | 20070 | -71.972 | -0.4193 | Yes | ||
86 | 3397 | "ID1 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein)" | 20316 | -310.355 | -0.2161 | Yes | ||
87 | 25805 | BAMBI (BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)) | 20317 | -312.036 | 0.0004 | Yes |