Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | treated |
GeneSet | GO|GO:0006399 |
Enrichment Score (ES) | 0.78943497 |
Normalized Enrichment Score (NES) | 1.7156017 |
Nominal p-value | 0.0 |
FDR q-value | 0.0093294205 |
FWER p-Value | 0.112 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 3735 | KARS (lysyl-tRNA synthetase) | 40 | 210.715 | 0.0960 | Yes | ||
2 | 3376 | IARS (isoleucyl-tRNA synthetase) | 127 | 127.806 | 0.1512 | Yes | ||
3 | 4677 | NARS (asparaginyl-tRNA synthetase) | 181 | 107.344 | 0.1986 | Yes | ||
4 | 2617 | GARS (glycyl-tRNA synthetase) | 210 | 101.532 | 0.2444 | Yes | ||
5 | 6301 | SARS (seryl-tRNA synthetase) | 294 | 86.383 | 0.2805 | Yes | ||
6 | 5464 | PPA1 (pyrophosphatase (inorganic) 1) | 305 | 84.801 | 0.3194 | Yes | ||
7 | 9255 | "SCYE1 (small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating))" | 384 | 74.806 | 0.3504 | Yes | ||
8 | 6741 | SSB (Sjogren syndrome antigen B (autoantigen La)) | 390 | 73.858 | 0.3845 | Yes | ||
9 | 2193 | "FARSA (phenylalanyl-tRNA synthetase, alpha subunit)" | 417 | 70.567 | 0.4160 | Yes | ||
10 | 55699 | "IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial)" | 453 | 66.112 | 0.4451 | Yes | ||
11 | 79731 | "NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial (putative))" | 467 | 64.859 | 0.4746 | Yes | ||
12 | 7965 | JTV1 (JTV1 gene) | 485 | 63.450 | 0.5033 | Yes | ||
13 | 10056 | "FARSB (phenylalanyl-tRNA synthetase, beta subunit)" | 493 | 62.388 | 0.5319 | Yes | ||
14 | 6897 | TARS (threonyl-tRNA synthetase) | 568 | 57.505 | 0.5550 | Yes | ||
15 | 9521 | EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1) | 662 | 51.393 | 0.5743 | Yes | ||
16 | 51095 | "TRNT1 (tRNA nucleotidyl transferase, CCA-adding, 1)" | 664 | 51.205 | 0.5981 | Yes | ||
17 | 3035 | HARS (histidyl-tRNA synthetase) | 720 | 48.241 | 0.6178 | Yes | ||
18 | 283989 | TSEN54 (tRNA splicing endonuclease 54 homolog (S. cerevisiae)) | 890 | 40.918 | 0.6285 | Yes | ||
19 | 4234 | METTL1 (methyltransferase like 1) | 913 | 40.202 | 0.6461 | Yes | ||
20 | 8565 | YARS (tyrosyl-tRNA synthetase) | 1057 | 35.065 | 0.6554 | Yes | ||
21 | 80324 | PUS1 (pseudouridylate synthase 1) | 1066 | 34.689 | 0.6711 | Yes | ||
22 | 7453 | WARS (tryptophanyl-tRNA synthetase) | 1069 | 34.581 | 0.6871 | Yes | ||
23 | 54888 | "NSUN2 (NOL1/NOP2/Sun domain family, member 2)" | 1161 | 32.054 | 0.6975 | Yes | ||
24 | 51520 | LARS (leucyl-tRNA synthetase) | 1194 | 31.242 | 0.7105 | Yes | ||
25 | 51493 | C22orf28 (chromosome 22 open reading frame 28) | 1390 | 27.185 | 0.7135 | Yes | ||
26 | 5917 | RARS (arginyl-tRNA synthetase) | 1440 | 26.395 | 0.7234 | Yes | ||
27 | 283459 | "GATC (glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial))" | 1551 | 24.661 | 0.7294 | Yes | ||
28 | 124454 | "EARS2 (glutamyl-tRNA synthetase 2, mitochondrial (putative))" | 1556 | 24.557 | 0.7406 | Yes | ||
29 | 81605 | URM1 (ubiquitin related modifier 1 homolog (S. cerevisiae)) | 1657 | 23.136 | 0.7465 | Yes | ||
30 | 10785 | WDR4 (WD repeat domain 4) | 1732 | 21.974 | 0.7530 | Yes | ||
31 | 1615 | DARS (aspartyl-tRNA synthetase) | 1784 | 21.311 | 0.7604 | Yes | ||
32 | 23536 | "ADAT1 (adenosine deaminase, tRNA-specific 1)" | 1874 | 20.196 | 0.7654 | Yes | ||
33 | 80746 | TSEN2 (tRNA splicing endonuclease 2 homolog (S. cerevisiae)) | 1913 | 19.842 | 0.7728 | Yes | ||
34 | 16 | AARS (alanyl-tRNA synthetase) | 2027 | 18.529 | 0.7758 | Yes | ||
35 | 10667 | "FARS2 (phenylalanyl-tRNA synthetase 2, mitochondrial)" | 2158 | 17.446 | 0.7775 | Yes | ||
36 | 54974 | THG1L (tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)) | 2266 | 16.410 | 0.7799 | Yes | ||
37 | 51067 | "YARS2 (tyrosyl-tRNA synthetase 2, mitochondrial)" | 2381 | 15.282 | 0.7813 | Yes | ||
38 | 2058 | EPRS (glutamyl-prolyl-tRNA synthetase) | 2422 | 14.958 | 0.7863 | Yes | ||
39 | 4141 | MARS (methionyl-tRNA synthetase) | 2495 | 14.313 | 0.7894 | Yes | ||
40 | 348180 | C16orf84 (chromosome 16 open reading frame 84) | 2643 | 13.127 | 0.7883 | No | ||
41 | 57038 | "RARS2 (arginyl-tRNA synthetase 2, mitochondrial)" | 2948 | 11.340 | 0.7786 | No | ||
42 | 79691 | QTRTD1 (queuine tRNA-ribosyltransferase domain containing 1) | 2983 | 11.100 | 0.7820 | No | ||
43 | 27304 | MOCS3 (molybdenum cofactor synthesis 3) | 3135 | 10.257 | 0.7794 | No | ||
44 | 79587 | "CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial (putative))" | 3215 | 9.880 | 0.7801 | No | ||
45 | 10352 | "WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial)" | 3226 | 9.823 | 0.7841 | No | ||
46 | 7407 | VARS (valyl-tRNA synthetase) | 3266 | 9.660 | 0.7867 | No | ||
47 | 57176 | "VARS2 (valyl-tRNA synthetase 2, mitochondrial (putative))" | 3342 | 9.381 | 0.7874 | No | ||
48 | 10940 | "POP1 (processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae))" | 3570 | 8.468 | 0.7801 | No | ||
49 | 27068 | PPA2 (pyrophosphatase (inorganic) 2) | 3948 | 6.964 | 0.7647 | No | ||
50 | 55157 | "DARS2 (aspartyl-tRNA synthetase 2, mitochondrial)" | 3973 | 6.877 | 0.7667 | No | ||
51 | 23395 | "LARS2 (leucyl-tRNA synthetase 2, mitochondrial)" | 4609 | 4.948 | 0.7377 | No | ||
52 | 81890 | QTRT1 (queuine tRNA-ribosyltransferase 1) | 5438 | 3.176 | 0.6983 | No | ||
53 | 80222 | "TARS2 (threonyl-tRNA synthetase 2, mitochondrial (putative))" | 5509 | 3.050 | 0.6963 | No | ||
54 | 10978 | "CLP1 (CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae))" | 5783 | 2.637 | 0.6840 | No | ||
55 | 57505 | "AARS2 (alanyl-tRNA synthetase 2, mitochondrial (putative))" | 5849 | 2.552 | 0.6820 | No | ||
56 | 55278 | QRSL1 (glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1) | 6154 | 2.165 | 0.6680 | No | ||
57 | 92935 | "MARS2 (methionyl-tRNA synthetase 2, mitochondrial)" | 6332 | 1.957 | 0.6602 | No | ||
58 | 55687 | TRMU (tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase) | 6683 | 1.607 | 0.6436 | No | ||
59 | 54802 | TRIT1 (tRNA isopentenyltransferase 1) | 7032 | 1.324 | 0.6271 | No | ||
60 | 129450 | C2orf60 (chromosome 2 open reading frame 60) | 12356 | -0.416 | 0.3645 | No | ||
61 | 91801 | "ALKBH8 (alkB, alkylation repair homolog 8 (E. coli))" | 15416 | -1.885 | 0.2144 | No | ||
62 | 25973 | "PARS2 (prolyl-tRNA synthetase 2, mitochondrial (putative))" | 15762 | -2.223 | 0.1984 | No | ||
63 | 54938 | "SARS2 (seryl-tRNA synthetase 2, mitochondrial)" | 16128 | -2.672 | 0.1816 | No | ||
64 | 5188 | PET112L (PET112-like (yeast)) | 16674 | -3.549 | 0.1564 | No | ||
65 | 23438 | "HARS2 (histidyl-tRNA synthetase 2, mitochondrial (putative))" | 17469 | -5.523 | 0.1198 | No | ||
66 | 833 | CARS (cysteinyl-tRNA synthetase) | 19280 | -22.411 | 0.0408 | No | ||
67 | 5859 | QARS (glutaminyl-tRNA synthetase) | 19303 | -22.978 | 0.0504 | No |