Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | cont |
GeneSet | GO|GO:0044437 |
Enrichment Score (ES) | -0.64099467 |
Normalized Enrichment Score (NES) | -1.5835198 |
Nominal p-value | 0.0 |
FDR q-value | 0.29513928 |
FWER p-Value | 1.0 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 81567 | TXNDC5 (thioredoxin domain containing 5) | 657 | 51.606 | 0.0040 | No | ||
2 | 54978 | C2orf18 (chromosome 2 open reading frame 18) | 1496 | 25.436 | -0.0194 | No | ||
3 | 6845 | VAMP7 (vesicle-associated membrane protein 7) | 1702 | 22.357 | -0.0137 | No | ||
4 | 162 | "AP1B1 (adaptor-related protein complex 1, beta 1 subunit)" | 2020 | 18.565 | -0.0163 | No | ||
5 | 121260 | "SLC15A4 (solute carrier family 15, member 4)" | 2152 | 17.461 | -0.0104 | No | ||
6 | 8905 | "AP1S2 (adaptor-related protein complex 1, sigma 2 subunit)" | 2240 | 16.745 | -0.0029 | No | ||
7 | 9296 | "ATP6V1F (ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F)" | 2288 | 16.117 | 0.0062 | No | ||
8 | 5641 | LGMN (legumain) | 2296 | 16.079 | 0.0172 | No | ||
9 | 10058 | "ABCB6 (ATP-binding cassette, sub-family B (MDR/TAP), member 6)" | 2316 | 15.892 | 0.0275 | No | ||
10 | 3123 | "HLA-DRB1 (major histocompatibility complex, class II, DR beta 1)" | 2579 | 13.655 | 0.0242 | No | ||
11 | 51361 | HOOK1 (hook homolog 1 (Drosophila)) | 2757 | 12.442 | 0.0243 | No | ||
12 | 8907 | "AP1M1 (adaptor-related protein complex 1, mu 1 subunit)" | 3145 | 10.205 | 0.0124 | No | ||
13 | 53373 | TPCN1 (two pore segment channel 1) | 3471 | 8.854 | 0.0026 | No | ||
14 | 284129 | "SLC26A11 (solute carrier family 26, member 11)" | 3711 | 7.893 | -0.0037 | No | ||
15 | 219931 | TPCN2 (two pore segment channel 2) | 3747 | 7.716 | 0.0001 | No | ||
16 | 130340 | "AP1S3 (adaptor-related protein complex 1, sigma 3 subunit)" | 3774 | 7.615 | 0.0042 | No | ||
17 | 1203 | "CLN5 (ceroid-lipofuscinosis, neuronal 5)" | 4102 | 6.430 | -0.0074 | No | ||
18 | 57617 | VPS18 (vacuolar protein sorting 18 homolog (S. cerevisiae)) | 4349 | 5.628 | -0.0156 | No | ||
19 | 3126 | "HLA-DRB4 (major histocompatibility complex, class II, DR beta 4)" | 4371 | 5.560 | -0.0127 | No | ||
20 | 23457 | "ABCB9 (ATP-binding cassette, sub-family B (MDR/TAP), member 9)" | 4553 | 5.110 | -0.0180 | No | ||
21 | 1174 | "AP1S1 (adaptor-related protein complex 1, sigma 1 subunit)" | 4682 | 4.756 | -0.0210 | No | ||
22 | 408 | "ARRB1 (arrestin, beta 1)" | 4928 | 4.173 | -0.0302 | No | ||
23 | 27072 | VPS41 (vacuolar protein sorting 41 homolog (S. cerevisiae)) | 5323 | 3.359 | -0.0472 | No | ||
24 | 3127 | "HLA-DRB5 (major histocompatibility complex, class II, DR beta 5)" | 6078 | 2.255 | -0.0829 | No | ||
25 | 84376 | HOOK3 (hook homolog 3 (Drosophila)) | 6416 | 1.860 | -0.0982 | No | ||
26 | 63894 | C14orf133 (chromosome 14 open reading frame 133) | 7324 | 1.116 | -0.1422 | No | ||
27 | 1538 | "CYLC1 (cylicin, basic protein of sperm head cytoskeleton 1)" | 7325 | 1.115 | -0.1414 | No | ||
28 | 245972 | "ATP6V0D2 (ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2)" | 7589 | 0.949 | -0.1538 | No | ||
29 | 49 | ACR (acrosin) | 7697 | 0.890 | -0.1584 | No | ||
30 | 4948 | OCA2 (oculocutaneous albinism II) | 8053 | 0.708 | -0.1754 | No | ||
31 | 51296 | "SLC15A3 (solute carrier family 15, member 3)" | 9322 | 0.299 | -0.2378 | No | ||
32 | 358 | AQP1 (aquaporin 1 (Colton blood group)) | 10226 | 0.078 | -0.2824 | No | ||
33 | 55016 | MARCH1 (membrane-associated ring finger (C3HC4) 1) | 10672 | -0.020 | -0.3043 | No | ||
34 | 2638 | GC (group-specific component (vitamin D binding protein)) | 11511 | -0.216 | -0.3456 | No | ||
35 | 525 | "ATP6V1B1 (ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1)" | 11564 | -0.227 | -0.3480 | No | ||
36 | 4935 | GPR143 (G protein-coupled receptor 143) | 12434 | -0.440 | -0.3906 | No | ||
37 | 9525 | VPS4B (vacuolar protein sorting 4 homolog B (S. cerevisiae)) | 13180 | -0.662 | -0.4269 | No | ||
38 | 4647 | MYO7A (myosin VIIA) | 13917 | -0.960 | -0.4626 | No | ||
39 | 9725 | TMEM63A (transmembrane protein 63A) | 14038 | -1.014 | -0.4678 | No | ||
40 | 8029 | CUBN (cubilin (intrinsic factor-cobalamin receptor)) | 14416 | -1.188 | -0.4856 | No | ||
41 | 64601 | VPS16 (vacuolar protein sorting 16 homolog (S. cerevisiae)) | 15648 | -2.096 | -0.5449 | No | ||
42 | 65082 | VPS33A (vacuolar protein sorting 33 homolog A (S. cerevisiae)) | 15667 | -2.113 | -0.5443 | No | ||
43 | 138050 | HGSNAT (heparan-alpha-glucosaminide N-acetyltransferase) | 16006 | -2.509 | -0.5592 | No | ||
44 | 1497 | "CTNS (cystinosis, nephropathic)" | 16959 | -4.140 | -0.6033 | No | ||
45 | 23339 | VPS39 (vacuolar protein sorting 39 homolog (S. cerevisiae)) | 17133 | -4.592 | -0.6086 | No | ||
46 | 11342 | RNF13 (ring finger protein 13) | 17465 | -5.513 | -0.6210 | No | ||
47 | 10053 | "AP1M2 (adaptor-related protein complex 1, mu 2 subunit)" | 17870 | -7.186 | -0.6359 | Yes | ||
48 | 26276 | VPS33B (vacuolar protein sorting 33 homolog B (yeast)) | 17902 | -7.377 | -0.6322 | Yes | ||
49 | 55062 | "WIPI1 (WD repeat domain, phosphoinositide interacting 1)" | 17994 | -7.878 | -0.6312 | Yes | ||
50 | 3122 | "HLA-DRA (major histocompatibility complex, class II, DR alpha)" | 17997 | -7.888 | -0.6257 | Yes | ||
51 | 5664 | PSEN2 (presenilin 2 (Alzheimer disease 4)) | 18005 | -7.937 | -0.6204 | Yes | ||
52 | 4891 | "SLC11A2 (solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2)" | 18016 | -7.985 | -0.6153 | Yes | ||
53 | 11337 | GABARAP (GABA(A) receptor-associated protein) | 18240 | -9.216 | -0.6198 | Yes | ||
54 | 373 | TRIM23 (tripartite motif-containing 23) | 18300 | -9.614 | -0.6159 | Yes | ||
55 | 26503 | "SLC17A5 (solute carrier family 17 (anion/sugar transporter), member 5)" | 18347 | -9.886 | -0.6112 | Yes | ||
56 | 83547 | RILP (Rab interacting lysosomal protein) | 18383 | -10.168 | -0.6057 | Yes | ||
57 | 2647 | "BLOC1S1 (biogenesis of lysosomal organelles complex-1, subunit 1)" | 18593 | -11.970 | -0.6076 | Yes | ||
58 | 50617 | "ATP6V0A4 (ATPase, H+ transporting, lysosomal V0 subunit a4)" | 18596 | -11.995 | -0.5992 | Yes | ||
59 | 2629 | "GBA (glucosidase, beta; acid (includes glucosylceramidase))" | 18623 | -12.262 | -0.5918 | Yes | ||
60 | 51606 | "ATP6V1H (ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H)" | 18782 | -13.854 | -0.5899 | Yes | ||
61 | 1200 | TPP1 (tripeptidyl peptidase I) | 19050 | -17.858 | -0.5904 | Yes | ||
62 | 55315 | "SLC29A3 (solute carrier family 29 (nucleoside transporters), member 3)" | 19100 | -18.778 | -0.5796 | Yes | ||
63 | 29911 | HOOK2 (hook homolog 2 (Drosophila)) | 19137 | -19.542 | -0.5675 | Yes | ||
64 | 55823 | VPS11 (vacuolar protein sorting 11 homolog (S. cerevisiae)) | 19149 | -19.713 | -0.5542 | Yes | ||
65 | 9114 | "ATP6V0D1 (ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1)" | 19347 | -24.177 | -0.5468 | Yes | ||
66 | 51092 | "SIDT2 (SID1 transmembrane family, member 2)" | 19507 | -28.505 | -0.5345 | Yes | ||
67 | 5663 | PSEN1 (presenilin 1) | 19728 | -38.379 | -0.5183 | Yes | ||
68 | 10437 | "IFI30 (interferon, gamma-inducible protein 30)" | 19766 | -40.310 | -0.4916 | Yes | ||
69 | 164 | "AP1G1 (adaptor-related protein complex 1, gamma 1 subunit)" | 19805 | -42.696 | -0.4633 | Yes | ||
70 | 64400 | AKTIP (AKT interacting protein) | 19904 | -51.459 | -0.4318 | Yes | ||
71 | 26100 | "WIPI2 (WD repeat domain, phosphoinositide interacting 2)" | 19912 | -52.575 | -0.3950 | Yes | ||
72 | 1201 | "CLN3 (ceroid-lipofuscinosis, neuronal 3)" | 19985 | -61.160 | -0.3554 | Yes | ||
73 | 5660 | PSAP (prosaposin) | 19990 | -61.664 | -0.3120 | Yes | ||
74 | 3920 | LAMP2 (lysosomal-associated membrane protein 2) | 20061 | -70.710 | -0.2655 | Yes | ||
75 | 950 | "SCARB2 (scavenger receptor class B, member 2)" | 20115 | -83.041 | -0.2094 | Yes | ||
76 | 51382 | "ATP6V1D (ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D)" | 20158 | -96.933 | -0.1430 | Yes | ||
77 | 11345 | GABARAPL2 (GABA(A) receptor-associated protein-like 2) | 20300 | -214.017 | 0.0012 | Yes |