Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | treated |
GeneSet | REACTOME|REACT_6256.3 |
Enrichment Score (ES) | 0.7160201 |
Normalized Enrichment Score (NES) | 1.6139944 |
Nominal p-value | 0.0 |
FDR q-value | 0.04644718 |
FWER p-Value | 0.967 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 5901 | "RAN (RAN, member RAS oncogene family)" | 27 | 250.127 | 0.0871 | Yes | ||
2 | 5902 | RANBP1 (RAN binding protein 1) | 172 | 109.952 | 0.1189 | Yes | ||
3 | 5431 | "POLR2B (polymerase (RNA) II (DNA directed) polypeptide B, 140kDa)" | 248 | 93.705 | 0.1484 | Yes | ||
4 | 57122 | NUP107 (nucleoporin 107kDa) | 276 | 89.588 | 0.1787 | Yes | ||
5 | 7520 | XRCC5 (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | 300 | 85.797 | 0.2079 | Yes | ||
6 | 2547 | XRCC6 (X-ray repair complementing defective repair in Chinese hamster cells 6) | 307 | 84.412 | 0.2375 | Yes | ||
7 | 8480 | RAE1 (RAE1 RNA export 1 homolog (S. pombe)) | 322 | 83.312 | 0.2663 | Yes | ||
8 | 2966 | "GTF2H2 (general transcription factor IIH, polypeptide 2, 44kDa)" | 337 | 80.980 | 0.2942 | Yes | ||
9 | 2237 | FEN1 (flap structure-specific endonuclease 1) | 348 | 79.316 | 0.3218 | Yes | ||
10 | 6921 | "TCEB1 (transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C))" | 377 | 75.377 | 0.3471 | Yes | ||
11 | 8815 | BANF1 (barrier to autointegration factor 1) | 405 | 71.738 | 0.3711 | Yes | ||
12 | 5436 | POLR2G (polymerase (RNA) II (DNA directed) polypeptide G) | 439 | 67.768 | 0.3934 | Yes | ||
13 | 11198 | SUPT16H (suppressor of Ty 16 homolog (S. cerevisiae)) | 484 | 63.469 | 0.4137 | Yes | ||
14 | 129401 | NUP35 (nucleoporin 35kDa) | 502 | 61.873 | 0.4348 | Yes | ||
15 | 5435 | POLR2F (polymerase (RNA) II (DNA directed) polypeptide F) | 531 | 60.346 | 0.4547 | Yes | ||
16 | 902 | CCNH (cyclin H) | 536 | 59.543 | 0.4756 | Yes | ||
17 | 7514 | "XPO1 (exportin 1 (CRM1 homolog, yeast))" | 539 | 59.462 | 0.4965 | Yes | ||
18 | 5441 | "POLR2L (polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa)" | 655 | 51.833 | 0.5092 | Yes | ||
19 | 6923 | "TCEB2 (transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B))" | 707 | 48.699 | 0.5239 | Yes | ||
20 | 79023 | NUP37 (nucleoporin 37kDa) | 770 | 46.189 | 0.5371 | Yes | ||
21 | 6882 | "TAF11 (TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa)" | 854 | 42.429 | 0.5480 | Yes | ||
22 | 4686 | "NCBP1 (nuclear cap binding protein subunit 1, 80kDa)" | 860 | 42.266 | 0.5627 | Yes | ||
23 | 9972 | NUP153 (nucleoporin 153kDa) | 924 | 39.672 | 0.5737 | Yes | ||
24 | 23636 | NUP62 (nucleoporin 62kDa) | 980 | 37.692 | 0.5843 | Yes | ||
25 | 22916 | "NCBP2 (nuclear cap binding protein subunit 2, 20kDa)" | 986 | 37.528 | 0.5973 | Yes | ||
26 | 10762 | NUP50 (nucleoporin 50kDa) | 1132 | 32.860 | 0.6018 | Yes | ||
27 | 23165 | NUP205 (nucleoporin 205kDa) | 1143 | 32.605 | 0.6128 | Yes | ||
28 | 4927 | NUP88 (nucleoporin 88kDa) | 1149 | 32.455 | 0.6240 | Yes | ||
29 | 5438 | "POLR2I (polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa)" | 1157 | 32.249 | 0.6351 | Yes | ||
30 | 6878 | "TAF6 (TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa)" | 1223 | 30.555 | 0.6427 | Yes | ||
31 | 2967 | "GTF2H3 (general transcription factor IIH, polypeptide 3, 34kDa)" | 1273 | 29.625 | 0.6507 | Yes | ||
32 | 5434 | "POLR2E (polymerase (RNA) II (DNA directed) polypeptide E, 25kDa)" | 1328 | 28.268 | 0.6581 | Yes | ||
33 | 6880 | "TAF9 (TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa)" | 1501 | 25.350 | 0.6585 | Yes | ||
34 | 53371 | NUP54 (nucleoporin 54kDa) | 1604 | 23.859 | 0.6619 | Yes | ||
35 | 6917 | "TCEA1 (transcription elongation factor A (SII), 1)" | 1635 | 23.406 | 0.6687 | Yes | ||
36 | 9631 | NUP155 (nucleoporin 155kDa) | 1641 | 23.360 | 0.6768 | Yes | ||
37 | 2957 | "GTF2A1 (general transcription factor IIA, 1, 19/37kDa)" | 1679 | 22.708 | 0.6830 | Yes | ||
38 | 5433 | POLR2D (polymerase (RNA) II (DNA directed) polypeptide D) | 1747 | 21.711 | 0.6873 | Yes | ||
39 | 6874 | "TAF4 (TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa)" | 1759 | 21.509 | 0.6944 | Yes | ||
40 | 5432 | "POLR2C (polymerase (RNA) II (DNA directed) polypeptide C, 33kDa)" | 1772 | 21.389 | 0.7014 | Yes | ||
41 | 23279 | NUP160 (nucleoporin 160kDa) | 1804 | 20.988 | 0.7073 | Yes | ||
42 | 6749 | SSRP1 (structure specific recognition protein 1) | 1943 | 19.577 | 0.7074 | Yes | ||
43 | 2963 | "GTF2F2 (general transcription factor IIF, polypeptide 2, 30kDa)" | 2056 | 18.264 | 0.7083 | Yes | ||
44 | 5903 | RANBP2 (RAN binding protein 2) | 2164 | 17.399 | 0.7091 | Yes | ||
45 | 905 | CCNT2 (cyclin T2) | 2429 | 14.880 | 0.7014 | Yes | ||
46 | 23511 | NUP188 (nucleoporin 188kDa) | 2623 | 13.256 | 0.6965 | Yes | ||
47 | 6881 | "TAF10 (TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa)" | 2681 | 12.963 | 0.6983 | Yes | ||
48 | 1104 | RCC1 (regulator of chromosome condensation 1) | 2700 | 12.870 | 0.7019 | Yes | ||
49 | 9688 | NUP93 (nucleoporin 93kDa) | 2709 | 12.814 | 0.7061 | Yes | ||
50 | 2961 | "GTF2E2 (general transcription factor IIE, polypeptide 2, beta 34kDa)" | 2730 | 12.640 | 0.7096 | Yes | ||
51 | 55746 | NUP133 (nucleoporin 133kDa) | 2787 | 12.281 | 0.7111 | Yes | ||
52 | 6877 | "TAF5 (TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa)" | 2921 | 11.505 | 0.7086 | Yes | ||
53 | 5905 | RANGAP1 (Ran GTPase activating protein 1) | 2997 | 11.060 | 0.7088 | Yes | ||
54 | 6827 | SUPT4H1 (suppressor of Ty 4 homolog 1 (S. cerevisiae)) | 3058 | 10.669 | 0.7096 | Yes | ||
55 | 7936 | RDBP (RD RNA binding protein) | 3086 | 10.515 | 0.7120 | Yes | ||
56 | 6875 | "TAF4B (TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa)" | 3216 | 9.871 | 0.7091 | Yes | ||
57 | 79902 | NUP85 (nucleoporin 85kDa) | 3289 | 9.586 | 0.7090 | Yes | ||
58 | 9150 | "CTDP1 (CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1)" | 3303 | 9.518 | 0.7117 | Yes | ||
59 | 348995 | NUP43 (nucleoporin 43kDa) | 3355 | 9.350 | 0.7125 | Yes | ||
60 | 23225 | NUP210 (nucleoporin 210kDa) | 3396 | 9.169 | 0.7137 | Yes | ||
61 | 2968 | "GTF2H4 (general transcription factor IIH, polypeptide 4, 52kDa)" | 3416 | 9.103 | 0.7160 | Yes | ||
62 | 6872 | "TAF1 (TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa)" | 3510 | 8.705 | 0.7145 | No | ||
63 | 4331 | "MNAT1 (menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis))" | 3583 | 8.417 | 0.7139 | No | ||
64 | 5430 | "POLR2A (polymerase (RNA) II (DNA directed) polypeptide A, 220kDa)" | 3626 | 8.231 | 0.7148 | No | ||
65 | 7518 | XRCC4 (X-ray repair complementing defective repair in Chinese hamster cells 4) | 3942 | 6.975 | 0.7016 | No | ||
66 | 904 | CCNT1 (cyclin T1) | 4046 | 6.653 | 0.6989 | No | ||
67 | 5437 | POLR2H (polymerase (RNA) II (DNA directed) polypeptide H) | 4596 | 5.000 | 0.6735 | No | ||
68 | 6908 | TBP (TATA box binding protein) | 4690 | 4.739 | 0.6706 | No | ||
69 | 9883 | POM121 (POM121 membrane glycoprotein (rat)) | 5027 | 3.978 | 0.6554 | No | ||
70 | 3981 | "LIG4 (ligase IV, DNA, ATP-dependent)" | 5053 | 3.915 | 0.6556 | No | ||
71 | 2068 | "ERCC2 (excision repair cross-complementing rodent repair deficiency, complementation group 2)" | 5159 | 3.702 | 0.6517 | No | ||
72 | 2071 | "ERCC3 (excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing))" | 5944 | 2.439 | 0.6138 | No | ||
73 | 2965 | "GTF2H1 (general transcription factor IIH, polypeptide 1, 62kDa)" | 6155 | 2.163 | 0.6042 | No | ||
74 | 7469 | WHSC2 (Wolf-Hirschhorn syndrome candidate 2) | 6278 | 2.021 | 0.5989 | No | ||
75 | 5440 | "POLR2K (polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa)" | 6321 | 1.970 | 0.5975 | No | ||
76 | 2962 | "GTF2F1 (general transcription factor IIF, polypeptide 1, 74kDa)" | 6388 | 1.894 | 0.5949 | No | ||
77 | 1234 | CCR5 (chemokine (C-C motif) receptor 5) | 8760 | 0.457 | 0.4778 | No | ||
78 | 6924 | "TCEB3 (transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A))" | 10319 | 0.059 | 0.4008 | No | ||
79 | 1025 | CDK9 (cyclin-dependent kinase 9) | 10418 | 0.034 | 0.3960 | No | ||
80 | 3978 | "LIG1 (ligase I, DNA, ATP-dependent)" | 10691 | -0.024 | 0.3826 | No | ||
81 | 920 | CD4 (CD4 molecule) | 12457 | -0.446 | 0.2955 | No | ||
82 | 6884 | "TAF13 (TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa)" | 13077 | -0.630 | 0.2651 | No | ||
83 | 8178 | ELL (elongation factor RNA polymerase II) | 14520 | -1.254 | 0.1942 | No | ||
84 | 2958 | "GTF2A2 (general transcription factor IIA, 2, 12kDa)" | 14627 | -1.311 | 0.1895 | No | ||
85 | 2960 | "GTF2E1 (general transcription factor IIE, polypeptide 1, alpha 56kDa)" | 16002 | -2.503 | 0.1224 | No | ||
86 | 8021 | NUP214 (nucleoporin 214kDa) | 16014 | -2.513 | 0.1228 | No | ||
87 | 8732 | RNGTT (RNA guanylyltransferase and 5'-phosphatase) | 16653 | -3.499 | 0.0925 | No | ||
88 | 8731 | RNMT (RNA (guanine-7-) methyltransferase) | 16887 | -3.967 | 0.0823 | No | ||
89 | 8086 | "AAAS (achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A))" | 16985 | -4.211 | 0.0790 | No | ||
90 | 6883 | "TAF12 (TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa)" | 17252 | -4.858 | 0.0676 | No | ||
91 | 7175 | TPR (translocated promoter region (to activated MET oncogene)) | 17416 | -5.336 | 0.0614 | No | ||
92 | 5439 | "POLR2J (polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa)" | 18134 | -8.661 | 0.0291 | No | ||
93 | 11097 | NUPL2 (nucleoporin like 2) | 18164 | -8.850 | 0.0308 | No | ||
94 | 2959 | GTF2B (general transcription factor IIB) | 18273 | -9.429 | 0.0288 | No | ||
95 | 25920 | COBRA1 (cofactor of BRCA1) | 19016 | -17.134 | -0.0019 | No | ||
96 | 51497 | TH1L (TH1-like (Drosophila)) | 19618 | -32.568 | -0.0201 | No | ||
97 | 1022 | CDK7 (cyclin-dependent kinase 7) | 19757 | -39.600 | -0.0129 | No | ||
98 | 5478 | PPIA (peptidylprolyl isomerase A (cyclophilin A)) | 20198 | -115.647 | 0.0063 | No |