Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classtreated
GeneSetGO|GO:0000375
Enrichment Score (ES)0.7023061
Normalized Enrichment Score (NES)1.7197064
Nominal p-value0.0
FDR q-value0.01005316
FWER p-Value0.089
Table: GSEA Results Summary



Fig 1: Enrichment plot: GO|GO:0000375   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
16432"SFRS7 (splicing factor, arginine/serine-rich 7, 35kDa)"38213.9760.0300Yes
26635SNRPE (small nuclear ribonucleoprotein polypeptide E)43207.4330.0607Yes
34904YBX1 (Y box binding protein 1)52184.1770.0877Yes
46434"SFRS10 (splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila))"63174.6510.1133Yes
56627SNRPA1 (small nuclear ribonucleoprotein polypeptide A')87156.3830.1354Yes
63187HNRNPH1 (heterogeneous nuclear ribonucleoprotein H1 (H))89155.6030.1586Yes
76636SNRPF (small nuclear ribonucleoprotein polypeptide F)93154.3880.1814Yes
83184"HNRNPD (heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa))"114136.8580.2008Yes
96426"SFRS1 (splicing factor, arginine/serine-rich 1)"119133.0170.2204Yes
1010189THOC4 (THO complex 4)158117.0780.2360Yes
114809NHP2L1 (NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae))162113.7000.2528Yes
1225929GEMIN5 (gem (nuclear organelle) associated protein 5)175109.0630.2684Yes
132521FUS (fusion (involved in t(12;16) in malignant liposarcoma))182107.3020.2841Yes
146634SNRPD3 (small nuclear ribonucleoprotein D3 polypeptide 18kDa)196103.4340.2989Yes
159939RBM8A (RNA binding motif protein 8A)201102.6130.3140Yes
1651639"SF3B14 (splicing factor 3B, 14 kDa subunit)"23296.6860.3269Yes
175431"POLR2B (polymerase (RNA) II (DNA directed) polypeptide B, 140kDa)"24893.7050.3401Yes
186427"SFRS2 (splicing factor, arginine/serine-rich 2)"27390.1070.3523Yes
1910907TXNL4A (thioredoxin-like 4A)28388.4840.3651Yes
2010286BCAS2 (breast carcinoma amplified sequence 2)29286.8780.3776Yes
216428"SFRS3 (splicing factor, arginine/serine-rich 3)"30285.6640.3899Yes
226632SNRPD1 (small nuclear ribonucleoprotein D1 polypeptide 16kDa)35278.9030.3992Yes
2310492"SYNCRIP (synaptotagmin binding, cytoplasmic RNA interacting protein)"39672.7550.4079Yes
2410419PRMT5 (protein arginine methyltransferase 5)41371.0430.4177Yes
256629SNRPB2 (small nuclear ribonucleoprotein polypeptide B'')42169.8440.4278Yes
265436POLR2G (polymerase (RNA) II (DNA directed) polypeptide G)43967.7680.4370Yes
273192HNRNPU (heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A))45066.4000.4464Yes
2827339PRPF19 (PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae))49562.3700.4535Yes
297307U2AF1 (U2 small nuclear RNA auxiliary factor 1)50961.5550.4621Yes
3051645PPIL1 (peptidylprolyl isomerase (cyclophilin)-like 1)51061.5150.4712Yes
3110772FUSIP1 (FUS interacting protein (serine/arginine-rich) 1)51161.4190.4804Yes
326633SNRPD2 (small nuclear ribonucleoprotein D2 polypeptide 16.5kDa)52860.4710.4886Yes
335435POLR2F (polymerase (RNA) II (DNA directed) polypeptide F)53160.3460.4975Yes
349128PRPF4 (PRP4 pre-mRNA processing factor 4 homolog (yeast))55858.1800.5049Yes
3527258"LSM3 (LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae))"56157.8750.5134Yes
363189HNRNPH3 (heterogeneous nuclear ribonucleoprotein H3 (2H9))56357.7910.5219Yes
3751690"LSM7 (LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae))"56957.4700.5303Yes
3883443"SF3B5 (splicing factor 3b, subunit 5, 10kDa)"60554.8530.5367Yes
3984844PHF5A (PHD finger protein 5A)61654.0600.5443Yes
405441"POLR2L (polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa)"65551.8330.5501Yes
416628SNRPB (small nuclear ribonucleoprotein polypeptides B and B1)69749.7170.5555Yes
4223450"SF3B3 (splicing factor 3b, subunit 3, 130kDa)"71148.6050.5621Yes
431479"CSTF3 (cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa)"76746.2720.5662Yes
4410236HNRNPR (heterogeneous nuclear ribonucleoprotein R)80344.7120.5711Yes
459775"EIF4A3 (eukaryotic translation initiation factor 4A, isoform 3)"82943.5000.5764Yes
466421SFPQ (splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated))85842.2920.5813Yes
474686"NCBP1 (nuclear cap binding protein subunit 1, 80kDa)"86042.2660.5875Yes
4810262"SF3B4 (splicing factor 3b, subunit 4, 49kDa)"88241.2580.5926Yes
496626SNRPA (small nuclear ribonucleoprotein polypeptide A)92040.0410.5968Yes
5079084WDR77 (WD repeat domain 77)95038.4490.6010Yes
5179833GEMIN6 (gem (nuclear organelle) associated protein 6)96737.9740.6059Yes
5222916"NCBP2 (nuclear cap binding protein subunit 2, 20kDa)"98637.5280.6106Yes
534116"MAGOH (mago-nashi homolog, proliferation-associated (Drosophila))"100936.6190.6150Yes
549295"SFRS11 (splicing factor, arginine/serine-rich 11)"104235.3880.6187Yes
5529896TRA2A (transformer-2 alpha)109233.9950.6213Yes
5610921"RNPS1 (RNA binding protein S1, serine-rich domain)"110733.5360.6256Yes
5711338U2AF2 (U2 small nuclear RNA auxiliary factor 2)111233.3720.6304Yes
5827316"RBMX (RNA binding motif protein, X-linked)"114232.6050.6338Yes
595438"POLR2I (polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa)"115732.2490.6379Yes
601207"CLNS1A (chloride channel, nucleotide-sensitive, 1A)"118631.4530.6412Yes
6111168PSIP1 (PC4 and SFRS1 interacting protein 1)118831.4040.6458Yes
623185HNRNPF (heterogeneous nuclear ribonucleoprotein F)121730.7320.6490Yes
636606"SMN1 (survival of motor neuron 1, telomeric)"123330.3500.6528Yes
643188HNRNPH2 (heterogeneous nuclear ribonucleoprotein H2 (H'))126529.7600.6557Yes
6510199MPHOSPH10 (M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein))128529.3800.6591Yes
665434"POLR2E (polymerase (RNA) II (DNA directed) polypeptide E, 25kDa)"132828.2680.6612Yes
6751503CWC15 (CWC15 homolog (S. cerevisiae))133928.0130.6649Yes
6851428DDX41 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 41)134527.8800.6688Yes
6910465PPIH (peptidylprolyl isomerase H (cyclophilin H))136427.5840.6720Yes
7027257"LSM1 (LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae))"136927.5240.6759Yes
7111218DDX20 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 20)142026.7190.6774Yes
7258517RBM25 (RNA binding motif protein 25)142626.5940.6811Yes
7323517SKIV2L2 (superkiller viralicidic activity 2-like 2 (S. cerevisiae))152924.8940.6798Yes
7450628GEMIN4 (gem (nuclear organelle) associated protein 4)158924.0860.6804Yes
758243SMC1A (structural maintenance of chromosomes 1A)159723.9870.6836Yes
767072TIA1 (TIA1 cytotoxic granule-associated RNA binding protein)164623.2600.6847Yes
7751808"RNUXA (RNA U, small nuclear RNA export adaptor (phosphorylation regulated))"166023.1000.6875Yes
785433POLR2D (polymerase (RNA) II (DNA directed) polypeptide D)174721.7110.6865Yes
791653DDX1 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 1)175421.6030.6894Yes
805432"POLR2C (polymerase (RNA) II (DNA directed) polypeptide C, 33kDa)"177221.3890.6917Yes
8165109UPF3B (UPF3 regulator of nonsense transcripts homolog B (yeast))177821.3410.6947Yes
826631SNRPC (small nuclear ribonucleoprotein polypeptide C)187120.2400.6931Yes
836429"SFRS4 (splicing factor, arginine/serine-rich 4)"197019.1040.6911Yes
8451319RSRC1 (arginine/serine-rich coiled-coil 1)204318.4080.6903Yes
852963"GTF2F2 (general transcription factor IIF, polypeptide 2, 30kDa)"205618.2640.6924Yes
8679760GEMIN7 (gem (nuclear organelle) associated protein 7)205718.2560.6951Yes
8751362CDC40 (cell division cycle 40 homolog (S. cerevisiae))209817.9420.6958Yes
886431"SFRS6 (splicing factor, arginine/serine-rich 6)"211317.8000.6977Yes
896625SNRP70 (small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen))215917.4430.6981Yes
9010285SMNDC1 (survival motor neuron domain containing 1)221017.0430.6982Yes
915356"PLRG1 (pleiotropic regulator 1 (PRL1 homolog, Arabidopsis))"223916.7590.6993Yes
921660DHX9 (DEAH (Asp-Glu-Ala-His) box polypeptide 9)225816.5210.7008Yes
9324144TFIP11 (tuftelin interacting protein 11)227816.2070.7023Yes
949410WDR57 (WD repeat domain 57 (U5 snRNP specific))243414.8490.6968No
9510283SDCCAG10 (serologically defined colon cancer antigen 10)245414.7280.6981No
968570KHSRP (KH-type splicing regulatory protein)246014.7000.7000No
9723210JMJD6 (jumonji domain containing 6)248714.4200.7009No
985093PCBP1 (poly(rC) binding protein 1)260613.4290.6970No
999416DDX23 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 23)265313.0870.6967No
10055749CCAR1 (cell division cycle and apoptosis regulator 1)268412.9530.6971No
10129894"CPSF1 (cleavage and polyadenylation specific factor 1, 160kDa)"272012.7110.6973No
1028220DGCR14 (DiGeorge syndrome critical region gene 14)280812.1670.6947No
10351163DBR1 (debranching enzyme homolog 1 (S. cerevisiae))285411.9380.6943No
10423398PPWD1 (peptidylprolyl isomerase domain and WD repeat containing 1)287211.8290.6952No
10510946"SF3A3 (splicing factor 3a, subunit 3, 60kDa)"290611.6230.6953No
1065936RBM4 (RNA binding motif protein 4)294111.3800.6953No
1072483FRG1 (FSHD region gene 1)310710.3980.6887No
10857819"LSM2 (LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae))"313610.2510.6888No
10911051NUDT21 (nudix (nucleoside diphosphate linked moiety X)-type motif 21)313910.2330.6902No
11051692"CPSF3 (cleavage and polyadenylation specific factor 3, 73kDa)"32999.5330.6837No
11196764TGS1 (trimethylguanosine synthase homolog (S. cerevisiae))33889.2000.6807No
11210450PPIE (peptidylprolyl isomerase E (cyclophilin E))34259.0670.6803No
1136733SRPK2 (SFRS protein kinase 2)34768.8310.6791No
11479869"FLJ12529 (pre-mRNA cleavage factor I, 59 kDa subunit)"34828.7990.6802No
11510250SRRM1 (serine/arginine repetitive matrix 1)34848.7950.6814No
1166433"SFRS8 (splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot homolog, Drosophila))"35748.4570.6783No
11710291"SF3A1 (splicing factor 3a, subunit 1, 120kDa)"35978.3600.6784No
1189343EFTUD2 (elongation factor Tu GTP binding domain containing 2)36178.2800.6787No
11911193WBP4 (WW domain binding protein 4 (formin binding protein 21))36208.2670.6799No
1205430"POLR2A (polymerase (RNA) II (DNA directed) polypeptide A, 220kDa)"36268.2310.6808No
1219716AQR (aquarius homolog (mouse))37227.8600.6773No
12210914PAPOLA (poly(A) polymerase alpha)38757.1870.6708No
1239129PRPF3 (PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae))39117.0550.6701No
1243191HNRNPL (heterogeneous nuclear ribonucleoprotein L)40066.7660.6664No
1258487SIP1 (survival of motor neuron protein interacting protein 1)42336.0090.6561No
12657461ISY1 (ISY1 splicing factor homolog (S. cerevisiae))43855.5050.6494No
12784081CCDC55 (coiled-coil domain containing 55)44055.4720.6493No
12884292MORG1 (mitogen-activated protein kinase organizer 1)44365.4090.6486No
12958509C19orf29 (chromosome 19 open reading frame 29)44435.3910.6491No
1305437POLR2H (polymerase (RNA) II (DNA directed) polypeptide H)45965.0000.6423No
1319092SART1 (squamous cell carcinoma antigen recognized by T cells)47074.7030.6375No
132988CDC5L (CDC5 cell division cycle 5-like (S. pombe))49154.2040.6279No
13355696RBM22 (RNA binding motif protein 22)50373.9490.6225No
13422938SNW1 (SNW domain containing 1)50773.8810.6211No
13510421CD2BP2 (CD2 (cytoplasmic tail) binding protein 2)53573.3070.6077No
1361478"CSTF2 (cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa)"54943.0740.6014No
13757703KIAA1604 (KIAA1604 protein)55702.9610.5981No
13810978"CLP1 (CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae))"57832.6370.5880No
13923543RBM9 (RNA binding motif protein 9)59802.3990.5786No
1405440"POLR2K (polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa)"63211.9700.5620No
1412962"GTF2F1 (general transcription factor IIF, polypeptide 1, 74kDa)"63881.8940.5590No
142652147"LOC652147 (similar to U5 snRNP-specific protein, 200 kDa)"65321.7500.5522No
14360625DHX35 (DEAH (Asp-Glu-Ala-His) box polypeptide 35)66641.6200.5459No
14457794SF4 (splicing factor 4)66911.5970.5448No
14510569SLU7 (SLU7 splicing factor homolog (S. cerevisiae))74241.0510.5086No
14610658"CUGBP1 (CUG triplet repeat, RNA binding protein 1)"74271.0480.5087No
14710713USP39 (ubiquitin specific peptidase 39)78090.8320.4899No
14810949HNRNPA0 (heterogeneous nuclear ribonucleoprotein A0)79900.7410.4810No
1495940"RBMY1A1 (RNA binding motif protein, Y-linked, family 1, member A1)"88360.4320.4391No
1507536SF1 (splicing factor 1)92850.3090.4169No
1519169"SFRS2IP (splicing factor, arginine/serine-rich 2, interacting protein)"95340.2470.4046No
1528106"PABPN1 (poly(A) binding protein, nuclear 1)"98660.1670.3882No
15360677"BRUNOL6 (bruno-like 6, RNA binding protein (Drosophila))"12006-0.3240.2819No
15410212DDX39 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 39)12643-0.4970.2504No
155135295SRrp35 (serine-arginine repressor protein (35 kDa))12746-0.5270.2454No
15656853"BRUNOL4 (bruno-like 4, RNA binding protein (Drosophila))"13321-0.7110.2170No
1573181HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1)13361-0.7270.2151No
1589785DHX38 (DEAH (Asp-Glu-Ala-His) box polypeptide 38)14908-1.4910.1385No
15953981"CPSF2 (cleavage and polyadenylation specific factor 2, 100kDa)"15120-1.6540.1283No
16056949XAB2 (XPA binding protein 2)15293-1.7870.1200No
1618175"SF3A2 (splicing factor 3a, subunit 2, 66kDa)"15425-1.8930.1138No
16222913"RALY (RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse)))"15765-2.2250.0973No
16323451"SF3B1 (splicing factor 3b, subunit 1, 155kDa)"15886-2.3480.0917No
16451691"LSM8 (LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae))"15943-2.4250.0892No
1658899PRPF4B (PRP4 pre-mRNA processing factor 4 homolog B (yeast))16019-2.5210.0859No
16654960GEMIN8 (gem (nuclear organelle) associated protein 8)16351-2.9920.0699No
16754496PRMT7 (protein arginine methyltransferase 7)16473-3.1760.0643No
16826121PRPF31 (PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae))16741-3.6920.0516No
16910073SNUPN (snurportin 1)16960-4.1450.0414No
17029890RBM15B (RNA binding motif protein 15B)17097-4.5170.0353No
1711659DHX8 (DEAH (Asp-Glu-Ala-His) box polypeptide 8)17140-4.6100.0339No
17211189TNRC4 (trinucleotide repeat containing 4)17169-4.6670.0332No
17311100HNRNPUL1 (heterogeneous nuclear ribonucleoprotein U-like 1)17403-5.3000.0224No
17455094GPATCH1 (G patch domain containing 1)17675-6.3240.0099No
17510181RBM5 (RNA binding motif protein 5)17795-6.8970.0050No
17610594PRPF8 (PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae))17881-7.2460.0019No
1774670HNRNPM (heterogeneous nuclear ribonucleoprotein M)17936-7.5870.0003No
1781477"CSTF1 (cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa)"18059-8.190-0.0045No
1795439"POLR2J (polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa)"18134-8.661-0.0069No
1803178HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)18139-8.691-0.0058No
1818233"ZRSR2 (zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2)"18162-8.812-0.0056No
1823190HNRNPK (heterogeneous nuclear ribonucleoprotein K)18557-11.620-0.0234No
18323524SRRM2 (serine/arginine repetitive matrix 2)18558-11.635-0.0217No
18455596"ZCCHC8 (zinc finger, CCHC domain containing 8)"18579-11.840-0.0209No
18524148PRPF6 (PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae))18644-12.510-0.0223No
18622826"DNAJC8 (DnaJ (Hsp40) homolog, subfamily C, member 8)"18654-12.595-0.0208No
18725949"SYF2 (SYF2 homolog, RNA splicing factor (S. cerevisiae))"18657-12.624-0.0190No
18853938PPIL3 (peptidylprolyl isomerase (cyclophilin)-like 3)18919-15.513-0.0297No
18951340CRNKL1 (crooked neck pre-mRNA splicing factor-like 1 (Drosophila))18946-16.005-0.0286No
1908683"SFRS9 (splicing factor, arginine/serine-rich 9)"18964-16.250-0.0270No
19110992"SF3B2 (splicing factor 3b, subunit 2, 145kDa)"19037-17.576-0.0280No
1921655DDX5 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 5)19052-17.892-0.0260No
1936637SNRPG (small nuclear ribonucleoprotein polypeptide G)19107-18.986-0.0259No
1948621CDC2L5 (cell division cycle 2-like 5 (cholinesterase-related cell division controller))19181-20.200-0.0265No
1955725PTBP1 (polypyrimidine tract binding protein 1)19275-22.290-0.0278No
19651585"PCF11 (PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae))"19324-23.584-0.0267No
1977919BAT1 (HLA-B associated transcript 1)19345-24.118-0.0241No
19823020ASCC3L1 (activating signal cointegrator 1 complex subunit 3-like 1)19614-32.261-0.0326No
199220988HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3)19789-41.609-0.0350No
2003183HNRNPC (heterogeneous nuclear ribonucleoprotein C (C1/C2))19797-42.022-0.0291No
2016430"SFRS5 (splicing factor, arginine/serine-rich 5)"19923-53.636-0.0273No
20226986"PABPC1 (poly(A) binding protein, cytoplasmic 1)"20057-70.422-0.0235No
2035094PCBP2 (poly(rC) binding protein 2)20076-73.183-0.0134No
2045411"PNN (pinin, desmosome associated protein)"20269-172.9900.0028No
Table: GSEA details [plain text format]



Fig 2: GO|GO:0000375   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: GO|GO:0000375: Random ES distribution   
Gene set null distribution of ES for GO|GO:0000375