Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | treated |
GeneSet | GO|GO:0034660 |
Enrichment Score (ES) | 0.705282 |
Normalized Enrichment Score (NES) | 1.694809 |
Nominal p-value | 0.0 |
FDR q-value | 0.01517902 |
FWER p-Value | 0.246 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 55651 | "NOLA2 (nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs))" | 16 | 288.767 | 0.0436 | Yes | ||
2 | 3735 | KARS (lysyl-tRNA synthetase) | 40 | 210.715 | 0.0748 | Yes | ||
3 | 6635 | SNRPE (small nuclear ribonucleoprotein polypeptide E) | 43 | 207.433 | 0.1066 | Yes | ||
4 | 6636 | SNRPF (small nuclear ribonucleoprotein polypeptide F) | 93 | 154.388 | 0.1279 | Yes | ||
5 | 51602 | NOP5/NOP58 (nucleolar protein NOP5/NOP58) | 106 | 143.574 | 0.1494 | Yes | ||
6 | 10436 | EMG1 (EMG1 nucleolar protein homolog (S. cerevisiae)) | 107 | 143.252 | 0.1714 | Yes | ||
7 | 9221 | NOLC1 (nucleolar and coiled-body phosphoprotein 1) | 110 | 140.415 | 0.1929 | Yes | ||
8 | 6209 | RPS15 (ribosomal protein S15) | 122 | 130.517 | 0.2124 | Yes | ||
9 | 3376 | IARS (isoleucyl-tRNA synthetase) | 127 | 127.806 | 0.2319 | Yes | ||
10 | 25929 | GEMIN5 (gem (nuclear organelle) associated protein 5) | 175 | 109.063 | 0.2463 | Yes | ||
11 | 4677 | NARS (asparaginyl-tRNA synthetase) | 181 | 107.344 | 0.2625 | Yes | ||
12 | 6634 | SNRPD3 (small nuclear ribonucleoprotein D3 polypeptide 18kDa) | 196 | 103.434 | 0.2777 | Yes | ||
13 | 2617 | GARS (glycyl-tRNA synthetase) | 210 | 101.532 | 0.2927 | Yes | ||
14 | 87178 | PNPT1 (polyribonucleotide nucleotidyltransferase 1) | 225 | 98.251 | 0.3071 | Yes | ||
15 | 6135 | RPL11 (ribosomal protein L11) | 247 | 93.709 | 0.3205 | Yes | ||
16 | 92856 | "IMP4 (IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast))" | 255 | 92.309 | 0.3343 | Yes | ||
17 | 6301 | SARS (seryl-tRNA synthetase) | 294 | 86.383 | 0.3457 | Yes | ||
18 | 5464 | PPA1 (pyrophosphatase (inorganic) 1) | 305 | 84.801 | 0.3582 | Yes | ||
19 | 6201 | RPS7 (ribosomal protein S7) | 321 | 83.359 | 0.3703 | Yes | ||
20 | 6632 | SNRPD1 (small nuclear ribonucleoprotein D1 polypeptide 16kDa) | 352 | 78.903 | 0.3810 | Yes | ||
21 | 10528 | NOL5A (nucleolar protein 5A (56kDa with KKE/D repeat)) | 353 | 78.890 | 0.3931 | Yes | ||
22 | 84365 | MKI67IP (MKI67 (FHA domain) interacting nucleolar phosphoprotein) | 378 | 75.370 | 0.4035 | Yes | ||
23 | 9255 | "SCYE1 (small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating))" | 384 | 74.806 | 0.4147 | Yes | ||
24 | 6741 | SSB (Sjogren syndrome antigen B (autoantigen La)) | 390 | 73.858 | 0.4258 | Yes | ||
25 | 55759 | WDR12 (WD repeat domain 12) | 395 | 72.865 | 0.4368 | Yes | ||
26 | 10419 | PRMT5 (protein arginine methyltransferase 5) | 413 | 71.043 | 0.4469 | Yes | ||
27 | 2193 | "FARSA (phenylalanyl-tRNA synthetase, alpha subunit)" | 417 | 70.567 | 0.4576 | Yes | ||
28 | 55699 | "IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial)" | 453 | 66.112 | 0.4660 | Yes | ||
29 | 23246 | BOP1 (block of proliferation 1) | 462 | 65.015 | 0.4756 | Yes | ||
30 | 6217 | RPS16 (ribosomal protein S16) | 466 | 64.909 | 0.4855 | Yes | ||
31 | 79731 | "NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial (putative))" | 467 | 64.859 | 0.4954 | Yes | ||
32 | 7965 | JTV1 (JTV1 gene) | 485 | 63.450 | 0.5043 | Yes | ||
33 | 10056 | "FARSB (phenylalanyl-tRNA synthetase, beta subunit)" | 493 | 62.388 | 0.5136 | Yes | ||
34 | 6633 | SNRPD2 (small nuclear ribonucleoprotein D2 polypeptide 16.5kDa) | 528 | 60.471 | 0.5212 | Yes | ||
35 | 6129 | RPL7 (ribosomal protein L7) | 543 | 59.190 | 0.5296 | Yes | ||
36 | 9045 | RPL14 (ribosomal protein L14) | 557 | 58.201 | 0.5379 | Yes | ||
37 | 6897 | TARS (threonyl-tRNA synthetase) | 568 | 57.505 | 0.5462 | Yes | ||
38 | 6229 | RPS24 (ribosomal protein S24) | 632 | 53.340 | 0.5513 | Yes | ||
39 | 9521 | EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1) | 662 | 51.393 | 0.5578 | Yes | ||
40 | 51095 | "TRNT1 (tRNA nucleotidyl transferase, CCA-adding, 1)" | 664 | 51.205 | 0.5656 | Yes | ||
41 | 6628 | SNRPB (small nuclear ribonucleoprotein polypeptides B and B1) | 697 | 49.717 | 0.5716 | Yes | ||
42 | 3035 | HARS (histidyl-tRNA synthetase) | 720 | 48.241 | 0.5780 | Yes | ||
43 | 113802 | C1orf59 (chromosome 1 open reading frame 59) | 807 | 44.513 | 0.5805 | Yes | ||
44 | 4686 | "NCBP1 (nuclear cap binding protein subunit 1, 80kDa)" | 860 | 42.266 | 0.5845 | Yes | ||
45 | 283989 | TSEN54 (tRNA splicing endonuclease 54 homolog (S. cerevisiae)) | 890 | 40.918 | 0.5893 | Yes | ||
46 | 4234 | METTL1 (methyltransferase like 1) | 913 | 40.202 | 0.5944 | Yes | ||
47 | 79084 | WDR77 (WD repeat domain 77) | 950 | 38.449 | 0.5985 | Yes | ||
48 | 79833 | GEMIN6 (gem (nuclear organelle) associated protein 6) | 967 | 37.974 | 0.6036 | Yes | ||
49 | 22916 | "NCBP2 (nuclear cap binding protein subunit 2, 20kDa)" | 986 | 37.528 | 0.6084 | Yes | ||
50 | 23405 | "DICER1 (dicer 1, ribonuclease type III)" | 995 | 37.181 | 0.6138 | Yes | ||
51 | 23481 | "PES1 (pescadillo homolog 1, containing BRCT domain (zebrafish))" | 1025 | 36.027 | 0.6179 | Yes | ||
52 | 8565 | YARS (tyrosyl-tRNA synthetase) | 1057 | 35.065 | 0.6217 | Yes | ||
53 | 80324 | PUS1 (pseudouridylate synthase 1) | 1066 | 34.689 | 0.6266 | Yes | ||
54 | 7453 | WARS (tryptophanyl-tRNA synthetase) | 1069 | 34.581 | 0.6319 | Yes | ||
55 | 88745 | C6orf153 (chromosome 6 open reading frame 153) | 1103 | 33.619 | 0.6354 | Yes | ||
56 | 51119 | SBDS (Shwachman-Bodian-Diamond syndrome) | 1120 | 33.204 | 0.6397 | Yes | ||
57 | 54888 | "NSUN2 (NOL1/NOP2/Sun domain family, member 2)" | 1161 | 32.054 | 0.6426 | Yes | ||
58 | 1207 | "CLNS1A (chloride channel, nucleotide-sensitive, 1A)" | 1186 | 31.453 | 0.6463 | Yes | ||
59 | 54512 | EXOSC4 (exosome component 4) | 1189 | 31.293 | 0.6510 | Yes | ||
60 | 51520 | LARS (leucyl-tRNA synthetase) | 1194 | 31.242 | 0.6556 | Yes | ||
61 | 6606 | "SMN1 (survival of motor neuron 1, telomeric)" | 1233 | 30.350 | 0.6584 | Yes | ||
62 | 56915 | EXOSC5 (exosome component 5) | 1353 | 27.771 | 0.6567 | Yes | ||
63 | 6165 | RPL35A (ribosomal protein L35a) | 1357 | 27.702 | 0.6608 | Yes | ||
64 | 29960 | FTSJ2 (FtsJ homolog 2 (E. coli)) | 1385 | 27.290 | 0.6637 | Yes | ||
65 | 51493 | C22orf28 (chromosome 22 open reading frame 28) | 1390 | 27.185 | 0.6677 | Yes | ||
66 | 5393 | EXOSC9 (exosome component 9) | 1391 | 27.161 | 0.6719 | Yes | ||
67 | 11218 | DDX20 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 20) | 1420 | 26.719 | 0.6746 | Yes | ||
68 | 5917 | RARS (arginyl-tRNA synthetase) | 1440 | 26.395 | 0.6777 | Yes | ||
69 | 57508 | INTS2 (integrator complex subunit 2) | 1449 | 26.216 | 0.6813 | Yes | ||
70 | 23517 | SKIV2L2 (superkiller viralicidic activity 2-like 2 (S. cerevisiae)) | 1529 | 24.894 | 0.6812 | Yes | ||
71 | 283459 | "GATC (glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial))" | 1551 | 24.661 | 0.6840 | Yes | ||
72 | 124454 | "EARS2 (glutamyl-tRNA synthetase 2, mitochondrial (putative))" | 1556 | 24.557 | 0.6876 | Yes | ||
73 | 50628 | GEMIN4 (gem (nuclear organelle) associated protein 4) | 1589 | 24.086 | 0.6897 | Yes | ||
74 | 81605 | URM1 (ubiquitin related modifier 1 homolog (S. cerevisiae)) | 1657 | 23.136 | 0.6899 | Yes | ||
75 | 51808 | "RNUXA (RNA U, small nuclear RNA export adaptor (phosphorylation regulated))" | 1660 | 23.100 | 0.6934 | Yes | ||
76 | 8602 | NOL14 (nucleolar protein 14) | 1686 | 22.595 | 0.6956 | Yes | ||
77 | 10785 | WDR4 (WD repeat domain 4) | 1732 | 21.974 | 0.6967 | Yes | ||
78 | 1615 | DARS (aspartyl-tRNA synthetase) | 1784 | 21.311 | 0.6975 | Yes | ||
79 | 201164 | "PLD6 (phospholipase D family, member 6)" | 1827 | 20.783 | 0.6986 | Yes | ||
80 | 23536 | "ADAT1 (adenosine deaminase, tRNA-specific 1)" | 1874 | 20.196 | 0.6994 | Yes | ||
81 | 55656 | INTS8 (integrator complex subunit 8) | 1885 | 20.124 | 0.7020 | Yes | ||
82 | 80746 | TSEN2 (tRNA splicing endonuclease 2 homolog (S. cerevisiae)) | 1913 | 19.842 | 0.7037 | Yes | ||
83 | 16 | AARS (alanyl-tRNA synthetase) | 2027 | 18.529 | 0.7010 | Yes | ||
84 | 79760 | GEMIN7 (gem (nuclear organelle) associated protein 7) | 2057 | 18.256 | 0.7023 | Yes | ||
85 | 51010 | EXOSC3 (exosome component 3) | 2073 | 18.099 | 0.7044 | Yes | ||
86 | 10667 | "FARS2 (phenylalanyl-tRNA synthetase 2, mitochondrial)" | 2158 | 17.446 | 0.7029 | Yes | ||
87 | 6895 | TARBP2 (TAR (HIV-1) RNA binding protein 2) | 2251 | 16.637 | 0.7009 | Yes | ||
88 | 27340 | "UTP20 (UTP20, small subunit (SSU) processome component, homolog (yeast))" | 2257 | 16.525 | 0.7032 | Yes | ||
89 | 54974 | THG1L (tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)) | 2266 | 16.410 | 0.7053 | Yes | ||
90 | 51067 | "YARS2 (tyrosyl-tRNA synthetase 2, mitochondrial)" | 2381 | 15.282 | 0.7020 | No | ||
91 | 2058 | EPRS (glutamyl-prolyl-tRNA synthetase) | 2422 | 14.958 | 0.7023 | No | ||
92 | 4141 | MARS (methionyl-tRNA synthetase) | 2495 | 14.313 | 0.7009 | No | ||
93 | 65123 | INTS3 (integrator complex subunit 3) | 2550 | 13.883 | 0.7004 | No | ||
94 | 10200 | MPHOSPH6 (M-phase phosphoprotein 6) | 2628 | 13.231 | 0.6986 | No | ||
95 | 348180 | C16orf84 (chromosome 16 open reading frame 84) | 2643 | 13.127 | 0.6999 | No | ||
96 | 80789 | INTS5 (integrator complex subunit 5) | 2645 | 13.114 | 0.7019 | No | ||
97 | 55174 | INTS10 (integrator complex subunit 10) | 2673 | 12.998 | 0.7025 | No | ||
98 | 79050 | NOC4L (nucleolar complex associated 4 homolog (S. cerevisiae)) | 2848 | 11.962 | 0.6957 | No | ||
99 | 57038 | "RARS2 (arginyl-tRNA synthetase 2, mitochondrial)" | 2948 | 11.340 | 0.6926 | No | ||
100 | 79691 | QTRTD1 (queuine tRNA-ribosyltransferase domain containing 1) | 2983 | 11.100 | 0.6926 | No | ||
101 | 162989 | DEDD2 (death effector domain containing 2) | 3132 | 10.276 | 0.6868 | No | ||
102 | 27304 | MOCS3 (molybdenum cofactor synthesis 3) | 3135 | 10.257 | 0.6883 | No | ||
103 | 65083 | NOL6 (nucleolar protein family 6 (RNA-associated)) | 3192 | 9.999 | 0.6871 | No | ||
104 | 4087 | SMAD2 (SMAD family member 2) | 3208 | 9.912 | 0.6878 | No | ||
105 | 79587 | "CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial (putative))" | 3215 | 9.880 | 0.6891 | No | ||
106 | 10352 | "WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial)" | 3226 | 9.823 | 0.6901 | No | ||
107 | 54464 | XRN1 (5'-3' exoribonuclease 1) | 3263 | 9.667 | 0.6898 | No | ||
108 | 7407 | VARS (valyl-tRNA synthetase) | 3266 | 9.660 | 0.6912 | No | ||
109 | 79707 | NOL9 (nucleolar protein 9) | 3284 | 9.605 | 0.6918 | No | ||
110 | 57176 | "VARS2 (valyl-tRNA synthetase 2, mitochondrial (putative))" | 3342 | 9.381 | 0.6904 | No | ||
111 | 96764 | TGS1 (trimethylguanosine synthase homolog (S. cerevisiae)) | 3388 | 9.200 | 0.6896 | No | ||
112 | 90459 | THEX1 (three prime histone mRNA exonuclease 1) | 3481 | 8.803 | 0.6864 | No | ||
113 | 10940 | "POP1 (processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae))" | 3570 | 8.468 | 0.6833 | No | ||
114 | 22894 | DIS3 (DIS3 mitotic control homolog (S. cerevisiae)) | 3783 | 7.577 | 0.6740 | No | ||
115 | 27068 | PPA2 (pyrophosphatase (inorganic) 2) | 3948 | 6.964 | 0.6669 | No | ||
116 | 55157 | "DARS2 (aspartyl-tRNA synthetase 2, mitochondrial)" | 3973 | 6.877 | 0.6668 | No | ||
117 | 55756 | INTS9 (integrator complex subunit 9) | 4162 | 6.216 | 0.6584 | No | ||
118 | 8487 | SIP1 (survival of motor neuron protein interacting protein 1) | 4233 | 6.009 | 0.6558 | No | ||
119 | 10438 | C1D (nuclear DNA-binding protein) | 4326 | 5.700 | 0.6521 | No | ||
120 | 115752 | DIS3L (DIS3 mitotic control homolog (S. cerevisiae)-like) | 4430 | 5.430 | 0.6479 | No | ||
121 | 26512 | INTS6 (integrator complex subunit 6) | 4439 | 5.404 | 0.6483 | No | ||
122 | 57117 | INTS12 (integrator complex subunit 12) | 4571 | 5.063 | 0.6426 | No | ||
123 | 23395 | "LARS2 (leucyl-tRNA synthetase 2, mitochondrial)" | 4609 | 4.948 | 0.6415 | No | ||
124 | 54487 | DGCR8 (DiGeorge syndrome critical region gene 8) | 4931 | 4.166 | 0.6262 | No | ||
125 | 81890 | QTRT1 (queuine tRNA-ribosyltransferase 1) | 5438 | 3.176 | 0.6016 | No | ||
126 | 25896 | INTS7 (integrator complex subunit 7) | 5452 | 3.162 | 0.6014 | No | ||
127 | 80222 | "TARS2 (threonyl-tRNA synthetase 2, mitochondrial (putative))" | 5509 | 3.050 | 0.5991 | No | ||
128 | 27161 | "EIF2C2 (eukaryotic translation initiation factor 2C, 2)" | 5539 | 3.005 | 0.5982 | No | ||
129 | 10978 | "CLP1 (CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae))" | 5783 | 2.637 | 0.5865 | No | ||
130 | 57505 | "AARS2 (alanyl-tRNA synthetase 2, mitochondrial (putative))" | 5849 | 2.552 | 0.5837 | No | ||
131 | 55278 | QRSL1 (glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1) | 6154 | 2.165 | 0.5689 | No | ||
132 | 5394 | EXOSC10 (exosome component 10) | 6276 | 2.023 | 0.5632 | No | ||
133 | 92935 | "MARS2 (methionyl-tRNA synthetase 2, mitochondrial)" | 6332 | 1.957 | 0.5608 | No | ||
134 | 55687 | TRMU (tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase) | 6683 | 1.607 | 0.5437 | No | ||
135 | 54802 | TRIT1 (tRNA isopentenyltransferase 1) | 7032 | 1.324 | 0.5266 | No | ||
136 | 4086 | SMAD1 (SMAD family member 1) | 8706 | 0.479 | 0.4437 | No | ||
137 | 6125 | RPL5 (ribosomal protein L5) | 8741 | 0.465 | 0.4421 | No | ||
138 | 56165 | TDRD1 (tudor domain containing 1) | 9179 | 0.339 | 0.4204 | No | ||
139 | 389421 | LIN28B (lin-28 homolog B (C. elegans)) | 9943 | 0.148 | 0.3826 | No | ||
140 | 143689 | PIWIL4 (piwi-like 4 (Drosophila)) | 10500 | 0.014 | 0.3550 | No | ||
141 | 79727 | LIN28 (lin-28 homolog (C. elegans)) | 11232 | -0.150 | 0.3188 | No | ||
142 | 122402 | TDRD9 (tudor domain containing 9) | 12182 | -0.368 | 0.2717 | No | ||
143 | 129450 | C2orf60 (chromosome 2 open reading frame 60) | 12356 | -0.416 | 0.2632 | No | ||
144 | 136991 | "ASZ1 (ankyrin repeat, SAM and basic leucine zipper domain containing 1)" | 12989 | -0.602 | 0.2319 | No | ||
145 | 84944 | MAEL (maelstrom homolog (Drosophila)) | 13360 | -0.726 | 0.2137 | No | ||
146 | 91801 | "ALKBH8 (alkB, alkylation repair homolog 8 (E. coli))" | 15416 | -1.885 | 0.1120 | No | ||
147 | 55124 | PIWIL2 (piwi-like 2 (Drosophila)) | 15626 | -2.071 | 0.1020 | No | ||
148 | 25973 | "PARS2 (prolyl-tRNA synthetase 2, mitochondrial (putative))" | 15762 | -2.223 | 0.0956 | No | ||
149 | 10595 | ERN2 (endoplasmic reticulum to nucleus signaling 2) | 16031 | -2.538 | 0.0827 | No | ||
150 | 54938 | "SARS2 (seryl-tRNA synthetase 2, mitochondrial)" | 16128 | -2.672 | 0.0784 | No | ||
151 | 5303 | "PIN4 (protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin))" | 16171 | -2.721 | 0.0767 | No | ||
152 | 6202 | RPS8 (ribosomal protein S8) | 16179 | -2.728 | 0.0768 | No | ||
153 | 5188 | PET112L (PET112-like (yeast)) | 16674 | -3.549 | 0.0528 | No | ||
154 | 23318 | "ZCCHC11 (zinc finger, CCHC domain containing 11)" | 16916 | -4.026 | 0.0415 | No | ||
155 | 92105 | INTS4 (integrator complex subunit 4) | 16949 | -4.118 | 0.0405 | No | ||
156 | 64852 | "TUT1 (terminal uridylyl transferase 1, U6 snRNA-specific)" | 16954 | -4.129 | 0.0409 | No | ||
157 | 10073 | SNUPN (snurportin 1) | 16960 | -4.145 | 0.0413 | No | ||
158 | 26173 | INTS1 (integrator complex subunit 1) | 17371 | -5.197 | 0.0218 | No | ||
159 | 23438 | "HARS2 (histidyl-tRNA synthetase 2, mitochondrial (putative))" | 17469 | -5.523 | 0.0178 | No | ||
160 | 54853 | WDR55 (WD repeat domain 55) | 18030 | -8.043 | -0.0087 | No | ||
161 | 4088 | SMAD3 (SMAD family member 3) | 18573 | -11.772 | -0.0338 | No | ||
162 | 6637 | SNRPG (small nuclear ribonucleoprotein polypeptide G) | 19107 | -18.986 | -0.0573 | No | ||
163 | 6227 | RPS21 (ribosomal protein S21) | 19135 | -19.508 | -0.0557 | No | ||
164 | 833 | CARS (cysteinyl-tRNA synthetase) | 19280 | -22.411 | -0.0594 | No | ||
165 | 5859 | QARS (glutaminyl-tRNA synthetase) | 19303 | -22.978 | -0.0569 | No | ||
166 | 3921 | RPSA (ribosomal protein SA) | 19315 | -23.344 | -0.0539 | No | ||
167 | 51593 | ARS2 (arsenate resistance protein 2) | 19417 | -26.154 | -0.0549 | No | ||
168 | 6194 | RPS6 (ribosomal protein S6) | 20091 | -76.100 | -0.0766 | No | ||
169 | 6208 | RPS14 (ribosomal protein S14) | 20109 | -82.199 | -0.0648 | No | ||
170 | 6234 | RPS28 (ribosomal protein S28) | 20178 | -103.480 | -0.0523 | No | ||
171 | 6218 | RPS17 (ribosomal protein S17) | 20283 | -190.183 | -0.0282 | No | ||
172 | 6223 | RPS19 (ribosomal protein S19) | 20288 | -196.680 | 0.0018 | No |