Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | treated |
GeneSet | GO|GO:0050658 |
Enrichment Score (ES) | 0.76992816 |
Normalized Enrichment Score (NES) | 1.6813257 |
Nominal p-value | 0.0 |
FDR q-value | 0.016261848 |
FWER p-Value | 0.378 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 5901 | "RAN (RAN, member RAS oncogene family)" | 27 | 250.127 | 0.0901 | Yes | ||
2 | 6432 | "SFRS7 (splicing factor, arginine/serine-rich 7, 35kDa)" | 38 | 213.976 | 0.1679 | Yes | ||
3 | 1984 | EIF5A (eukaryotic translation initiation factor 5A) | 68 | 172.120 | 0.2294 | Yes | ||
4 | 6426 | "SFRS1 (splicing factor, arginine/serine-rich 1)" | 119 | 133.017 | 0.2755 | Yes | ||
5 | 10189 | THOC4 (THO complex 4) | 158 | 117.078 | 0.3165 | Yes | ||
6 | 9939 | RBM8A (RNA binding motif protein 8A) | 201 | 102.613 | 0.3519 | Yes | ||
7 | 87178 | PNPT1 (polyribonucleotide nucleotidyltransferase 1) | 225 | 98.251 | 0.3867 | Yes | ||
8 | 80145 | THOC7 (THO complex 7 homolog (Drosophila)) | 243 | 94.098 | 0.4202 | Yes | ||
9 | 29074 | MRPL18 (mitochondrial ribosomal protein L18) | 262 | 91.261 | 0.4527 | Yes | ||
10 | 6427 | "SFRS2 (splicing factor, arginine/serine-rich 2)" | 273 | 90.107 | 0.4852 | Yes | ||
11 | 57122 | NUP107 (nucleoporin 107kDa) | 276 | 89.588 | 0.5178 | Yes | ||
12 | 6428 | "SFRS3 (splicing factor, arginine/serine-rich 3)" | 302 | 85.664 | 0.5479 | Yes | ||
13 | 1977 | EIF4E (eukaryotic translation initiation factor 4E) | 306 | 84.641 | 0.5787 | Yes | ||
14 | 8480 | RAE1 (RAE1 RNA export 1 homolog (S. pombe)) | 322 | 83.312 | 0.6084 | Yes | ||
15 | 11260 | "XPOT (exportin, tRNA (nuclear export receptor for tRNAs))" | 367 | 76.844 | 0.6344 | Yes | ||
16 | 7307 | U2AF1 (U2 small nuclear RNA auxiliary factor 1) | 509 | 61.555 | 0.6499 | Yes | ||
17 | 10772 | FUSIP1 (FUS interacting protein (serine/arginine-rich) 1) | 511 | 61.419 | 0.6723 | Yes | ||
18 | 8563 | THOC5 (THO complex 5) | 620 | 53.822 | 0.6867 | Yes | ||
19 | 4686 | "NCBP1 (nuclear cap binding protein subunit 1, 80kDa)" | 860 | 42.266 | 0.6903 | Yes | ||
20 | 7884 | SLBP (stem-loop binding protein) | 966 | 37.985 | 0.6990 | Yes | ||
21 | 22916 | "NCBP2 (nuclear cap binding protein subunit 2, 20kDa)" | 986 | 37.528 | 0.7118 | Yes | ||
22 | 4116 | "MAGOH (mago-nashi homolog, proliferation-associated (Drosophila))" | 1009 | 36.619 | 0.7241 | Yes | ||
23 | 9295 | "SFRS11 (splicing factor, arginine/serine-rich 11)" | 1042 | 35.388 | 0.7355 | Yes | ||
24 | 10921 | "RNPS1 (RNA binding protein S1, serine-rich domain)" | 1107 | 33.536 | 0.7446 | Yes | ||
25 | 11338 | U2AF2 (U2 small nuclear RNA auxiliary factor 2) | 1112 | 33.372 | 0.7566 | Yes | ||
26 | 10657 | "KHDRBS1 (KH domain containing, RNA binding, signal transduction associated 1)" | 1396 | 27.053 | 0.7525 | Yes | ||
27 | 7263 | TST (thiosulfate sulfurtransferase (rhodanese)) | 1644 | 23.301 | 0.7488 | Yes | ||
28 | 51808 | "RNUXA (RNA U, small nuclear RNA export adaptor (phosphorylation regulated))" | 1660 | 23.100 | 0.7565 | Yes | ||
29 | 65109 | UPF3B (UPF3 regulator of nonsense transcripts homolog B (yeast)) | 1778 | 21.341 | 0.7585 | Yes | ||
30 | 23279 | NUP160 (nucleoporin 160kDa) | 1804 | 20.988 | 0.7650 | Yes | ||
31 | 6429 | "SFRS4 (splicing factor, arginine/serine-rich 4)" | 1970 | 19.104 | 0.7638 | Yes | ||
32 | 51362 | CDC40 (cell division cycle 40 homolog (S. cerevisiae)) | 2098 | 17.942 | 0.7641 | Yes | ||
33 | 6431 | "SFRS6 (splicing factor, arginine/serine-rich 6)" | 2113 | 17.800 | 0.7699 | Yes | ||
34 | 11269 | DDX19B (DEAD (Asp-Glu-Ala-As) box polypeptide 19B) | 2524 | 14.080 | 0.7548 | No | ||
35 | 29894 | "CPSF1 (cleavage and polyadenylation specific factor 1, 160kDa)" | 2720 | 12.711 | 0.7499 | No | ||
36 | 55746 | NUP133 (nucleoporin 133kDa) | 2787 | 12.281 | 0.7511 | No | ||
37 | 10482 | NXF1 (nuclear RNA export factor 1) | 2811 | 12.145 | 0.7544 | No | ||
38 | 57187 | THOC2 (THO complex 2) | 3035 | 10.817 | 0.7473 | No | ||
39 | 9984 | THOC1 (THO complex 1) | 3123 | 10.355 | 0.7468 | No | ||
40 | 23049 | SMG1 (PI-3-kinase-related kinase SMG-1) | 3211 | 9.906 | 0.7462 | No | ||
41 | 51692 | "CPSF3 (cleavage and polyadenylation specific factor 3, 73kDa)" | 3299 | 9.533 | 0.7453 | No | ||
42 | 10250 | SRRM1 (serine/arginine repetitive matrix 1) | 3484 | 8.795 | 0.7395 | No | ||
43 | 5976 | UPF1 (UPF1 regulator of nonsense transcripts homolog (yeast)) | 4148 | 6.283 | 0.7090 | No | ||
44 | 79228 | THOC6 (THO complex 6 homolog (Drosophila)) | 4206 | 6.072 | 0.7084 | No | ||
45 | 23381 | "SMG5 (Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans))" | 4285 | 5.861 | 0.7067 | No | ||
46 | 3087 | HHEX (hematopoietically expressed homeobox) | 6095 | 2.232 | 0.6182 | No | ||
47 | 56001 | NXF2 (nuclear RNA export factor 2) | 6582 | 1.692 | 0.5949 | No | ||
48 | 23144 | ZC3H3 (zinc finger CCCH-type containing 3) | 7516 | 0.986 | 0.5492 | No | ||
49 | 55998 | NXF5 (nuclear RNA export factor 5) | 8043 | 0.713 | 0.5234 | No | ||
50 | 56000 | NXF3 (nuclear RNA export factor 3) | 8688 | 0.482 | 0.4918 | No | ||
51 | 8106 | "PABPN1 (poly(A) binding protein, nuclear 1)" | 9866 | 0.167 | 0.4338 | No | ||
52 | 7248 | TSC1 (tuberous sclerosis 1) | 10179 | 0.089 | 0.4184 | No | ||
53 | 29118 | DDX25 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 25) | 11315 | -0.167 | 0.3624 | No | ||
54 | 10212 | DDX39 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 39) | 12643 | -0.497 | 0.2971 | No | ||
55 | 3181 | HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1) | 13361 | -0.727 | 0.2620 | No | ||
56 | 9785 | DHX38 (DEAH (Asp-Glu-Ala-His) box polypeptide 38) | 14908 | -1.491 | 0.1862 | No | ||
57 | 26019 | UPF2 (UPF2 regulator of nonsense transcripts homolog (yeast)) | 14958 | -1.532 | 0.1843 | No | ||
58 | 53981 | "CPSF2 (cleavage and polyadenylation specific factor 2, 100kDa)" | 15120 | -1.654 | 0.1770 | No | ||
59 | 3267 | HRB (HIV-1 Rev binding protein) | 15546 | -2.007 | 0.1567 | No | ||
60 | 2733 | GLE1 (GLE1 RNA export mediator homolog (yeast)) | 16723 | -3.644 | 0.1000 | No | ||
61 | 54715 | A2BP1 (ataxin 2-binding protein 1) | 16837 | -3.836 | 0.0958 | No | ||
62 | 6311 | ATXN2 (ataxin 2) | 17202 | -4.748 | 0.0796 | No | ||
63 | 23293 | "SMG6 (Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans))" | 18036 | -8.067 | 0.0414 | No | ||
64 | 3178 | HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) | 18139 | -8.691 | 0.0395 | No | ||
65 | 9887 | "SMG7 (Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans))" | 18182 | -8.946 | 0.0407 | No | ||
66 | 8683 | "SFRS9 (splicing factor, arginine/serine-rich 9)" | 18964 | -16.250 | 0.0081 | No | ||
67 | 9793 | CKAP5 (cytoskeleton associated protein 5) | 18973 | -16.388 | 0.0137 | No | ||
68 | 11163 | NUDT4 (nudix (nucleoside diphosphate linked moiety X)-type motif 4) | 19126 | -19.371 | 0.0133 | No | ||
69 | 3921 | RPSA (ribosomal protein SA) | 19315 | -23.344 | 0.0125 | No | ||
70 | 84248 | FYTTD1 (forty-two-three domain containing 1) | 19338 | -23.934 | 0.0202 | No | ||
71 | 7919 | BAT1 (HLA-B associated transcript 1) | 19345 | -24.118 | 0.0287 | No | ||
72 | 6430 | "SFRS5 (splicing factor, arginine/serine-rich 5)" | 19923 | -53.636 | 0.0198 | No |