Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | cont |
GeneSet | GO|GO:0051222 |
Enrichment Score (ES) | -0.6839749 |
Normalized Enrichment Score (NES) | -1.6766028 |
Nominal p-value | 0.0035587188 |
FDR q-value | 0.17720422 |
FWER p-Value | 0.98 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 999 | "CDH1 (cadherin 1, type 1, E-cadherin (epithelial))" | 597 | 55.288 | 0.0201 | No | ||
2 | 94121 | SYTL4 (synaptotagmin-like 4) | 1883 | 20.129 | -0.0253 | No | ||
3 | 657 | "BMPR1A (bone morphogenetic protein receptor, type IA)" | 2168 | 17.378 | -0.0237 | No | ||
4 | 4282 | MIF (macrophage migration inhibitory factor (glycosylation-inhibiting factor)) | 2375 | 15.341 | -0.0201 | No | ||
5 | 8877 | SPHK1 (sphingosine kinase 1) | 2474 | 14.588 | -0.0119 | No | ||
6 | 23705 | CADM1 (cell adhesion molecule 1) | 2561 | 13.762 | -0.0038 | No | ||
7 | 11030 | RBPMS (RNA binding protein with multiple splicing) | 3232 | 9.780 | -0.0281 | No | ||
8 | 2010 | EMD (emerin) | 3549 | 8.598 | -0.0360 | No | ||
9 | 64127 | NOD2 (nucleotide-binding oligomerization domain containing 2) | 3594 | 8.389 | -0.0307 | No | ||
10 | 7040 | "TGFB1 (transforming growth factor, beta 1)" | 3665 | 8.104 | -0.0268 | No | ||
11 | 24145 | PANX1 (pannexin 1) | 4362 | 5.589 | -0.0562 | No | ||
12 | 1956 | "EGFR (epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian))" | 5292 | 3.407 | -0.0990 | No | ||
13 | 43 | ACHE (acetylcholinesterase (Yt blood group)) | 5645 | 2.852 | -0.1139 | No | ||
14 | 2150 | F2RL1 (coagulation factor II (thrombin) receptor-like 1) | 5923 | 2.465 | -0.1253 | No | ||
15 | 7293 | "TNFRSF4 (tumor necrosis factor receptor superfamily, member 4)" | 6266 | 2.038 | -0.1404 | No | ||
16 | 6289 | SAA2 (serum amyloid A2) | 6670 | 1.616 | -0.1589 | No | ||
17 | 7545 | "ZIC1 (Zic family member 1 (odd-paired homolog, Drosophila))" | 6735 | 1.562 | -0.1606 | No | ||
18 | 22900 | "CARD8 (caspase recruitment domain family, member 8)" | 6768 | 1.538 | -0.1608 | No | ||
19 | 3479 | IGF1 (insulin-like growth factor 1 (somatomedin C)) | 7098 | 1.270 | -0.1759 | No | ||
20 | 340061 | TMEM173 (transmembrane protein 173) | 7361 | 1.090 | -0.1879 | No | ||
21 | 8740 | "TNFSF14 (tumor necrosis factor (ligand) superfamily, member 14)" | 7733 | 0.873 | -0.2054 | No | ||
22 | 3357 | HTR2B (5-hydroxytryptamine (serotonin) receptor 2B) | 7872 | 0.797 | -0.2116 | No | ||
23 | 2932 | GSK3B (glycogen synthase kinase 3 beta) | 8018 | 0.725 | -0.2181 | No | ||
24 | 163882 | C1orf71 (chromosome 1 open reading frame 71) | 8114 | 0.686 | -0.2221 | No | ||
25 | 7097 | TLR2 (toll-like receptor 2) | 8386 | 0.583 | -0.2350 | No | ||
26 | 22861 | "NLRP1 (NLR family, pyrin domain containing 1)" | 8879 | 0.422 | -0.2589 | No | ||
27 | 192683 | SCAMP5 (secretory carrier membrane protein 5) | 9000 | 0.386 | -0.2645 | No | ||
28 | 55801 | IL26 (interleukin 26) | 9311 | 0.302 | -0.2796 | No | ||
29 | 5950 | "RBP4 (retinol binding protein 4, plasma)" | 9448 | 0.266 | -0.2860 | No | ||
30 | 939 | CD27 (CD27 molecule) | 9453 | 0.264 | -0.2860 | No | ||
31 | 27159 | "CHIA (chitinase, acidic)" | 9661 | 0.218 | -0.2960 | No | ||
32 | 3569 | "IL6 (interleukin 6 (interferon, beta 2))" | 9770 | 0.188 | -0.3012 | No | ||
33 | 101 | ADAM8 (ADAM metallopeptidase domain 8) | 9784 | 0.185 | -0.3017 | No | ||
34 | 3586 | IL10 (interleukin 10) | 9801 | 0.182 | -0.3023 | No | ||
35 | 727 | C5 (complement component 5) | 9925 | 0.151 | -0.3082 | No | ||
36 | 10626 | TRIM16 (tripartite motif-containing 16) | 9953 | 0.146 | -0.3094 | No | ||
37 | 7474 | "WNT5A (wingless-type MMTV integration site family, member 5A)" | 10164 | 0.093 | -0.3197 | No | ||
38 | 5319 | "PLA2G1B (phospholipase A2, group IB (pancreas))" | 10369 | 0.046 | -0.3298 | No | ||
39 | 51284 | TLR7 (toll-like receptor 7) | 10492 | 0.016 | -0.3358 | No | ||
40 | 4089 | SMAD4 (SMAD family member 4) | 10664 | -0.017 | -0.3442 | No | ||
41 | 56253 | CRTAM (cytotoxic and regulatory T cell molecule) | 11311 | -0.166 | -0.3760 | No | ||
42 | 90865 | IL33 (interleukin 33) | 11364 | -0.182 | -0.3784 | No | ||
43 | 3593 | "IL12B (interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40))" | 11374 | -0.185 | -0.3786 | No | ||
44 | 3630 | INS (insulin) | 11442 | -0.201 | -0.3818 | No | ||
45 | 7292 | "TNFSF4 (tumor necrosis factor (ligand) superfamily, member 4)" | 11460 | -0.205 | -0.3824 | No | ||
46 | 7042 | "TGFB2 (transforming growth factor, beta 2)" | 11675 | -0.254 | -0.3928 | No | ||
47 | 7098 | TLR3 (toll-like receptor 3) | 11911 | -0.304 | -0.4041 | No | ||
48 | 3553 | "IL1B (interleukin 1, beta)" | 11912 | -0.304 | -0.4038 | No | ||
49 | 260434 | PYDC1 (PYD (pyrin domain) containing 1) | 12140 | -0.355 | -0.4147 | No | ||
50 | 5027 | "P2RX7 (purinergic receptor P2X, ligand-gated ion channel, 7)" | 12248 | -0.386 | -0.4197 | No | ||
51 | 1950 | EGF (epidermal growth factor (beta-urogastrone)) | 12439 | -0.441 | -0.4287 | No | ||
52 | 55655 | "NLRP2 (NLR family, pyrin domain containing 2)" | 12539 | -0.465 | -0.4331 | No | ||
53 | 2149 | F2R (coagulation factor II (thrombin) receptor) | 12636 | -0.496 | -0.4374 | No | ||
54 | 7124 | "TNF (tumor necrosis factor (TNF superfamily, member 2))" | 12777 | -0.537 | -0.4439 | No | ||
55 | 6363 | CCL19 (chemokine (C-C motif) ligand 19) | 12834 | -0.556 | -0.4461 | No | ||
56 | 5460 | POU5F1 (POU class 5 homeobox 1) | 13341 | -0.718 | -0.4705 | No | ||
57 | 3552 | "IL1A (interleukin 1, alpha)" | 13376 | -0.731 | -0.4715 | No | ||
58 | 114548 | "NLRP3 (NLR family, pyrin domain containing 3)" | 13741 | -0.872 | -0.4887 | No | ||
59 | 7099 | TLR4 (toll-like receptor 4) | 14032 | -1.010 | -0.5021 | No | ||
60 | 23086 | EXPH5 (exophilin 5) | 15077 | -1.621 | -0.5522 | No | ||
61 | 90070 | LACRT (lacritin) | 15089 | -1.628 | -0.5513 | No | ||
62 | 54106 | TLR9 (toll-like receptor 9) | 15160 | -1.682 | -0.5533 | No | ||
63 | 91662 | "NLRP12 (NLR family, pyrin domain containing 12)" | 15825 | -2.282 | -0.5840 | No | ||
64 | 11146 | "GLMN (glomulin, FKBP associated protein)" | 17334 | -5.100 | -0.6539 | No | ||
65 | 283 | "ANG (angiogenin, ribonuclease, RNase A family, 5)" | 17573 | -5.893 | -0.6604 | No | ||
66 | 7046 | "TGFBR1 (transforming growth factor, beta receptor 1)" | 18051 | -8.147 | -0.6767 | Yes | ||
67 | 7043 | "TGFB3 (transforming growth factor, beta 3)" | 18102 | -8.466 | -0.6715 | Yes | ||
68 | 7205 | TRIP6 (thyroid hormone receptor interactor 6) | 18141 | -8.698 | -0.6656 | Yes | ||
69 | 29108 | PYCARD (PYD and CARD domain containing) | 18363 | -9.973 | -0.6676 | Yes | ||
70 | 652 | BMP4 (bone morphogenetic protein 4) | 18378 | -10.143 | -0.6592 | Yes | ||
71 | 8754 | ADAM9 (ADAM metallopeptidase domain 9 (meltrin gamma)) | 18549 | -11.504 | -0.6572 | Yes | ||
72 | 4088 | SMAD3 (SMAD family member 3) | 18573 | -11.772 | -0.6478 | Yes | ||
73 | 51561 | "IL23A (interleukin 23, alpha subunit p19)" | 19029 | -17.353 | -0.6547 | Yes | ||
74 | 2316 | "FLNA (filamin A, alpha (actin binding protein 280))" | 19138 | -19.560 | -0.6425 | Yes | ||
75 | 23586 | DDX58 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 58) | 19385 | -25.182 | -0.6321 | Yes | ||
76 | 51366 | UBR5 (ubiquitin protein ligase E3 component n-recognin 5) | 19390 | -25.318 | -0.6096 | Yes | ||
77 | 387 | "RHOA (ras homolog gene family, member A)" | 19574 | -30.675 | -0.5911 | Yes | ||
78 | 57506 | VISA (virus-induced signaling adapter) | 19622 | -32.677 | -0.5641 | Yes | ||
79 | 6934 | "TCF7L2 (transcription factor 7-like 2 (T-cell specific, HMG-box))" | 19726 | -38.340 | -0.5348 | Yes | ||
80 | 3728 | JUP (junction plakoglobin) | 19987 | -61.273 | -0.4926 | Yes | ||
81 | 2625 | GATA3 (GATA binding protein 3) | 20312 | -255.499 | -0.2794 | Yes | ||
82 | 25805 | BAMBI (BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)) | 20317 | -312.036 | 0.0004 | Yes |