Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classtreated
GeneSetGO|GO:0060249
Enrichment Score (ES)0.70717853
Normalized Enrichment Score (NES)1.625557
Nominal p-value0.0027173914
FDR q-value0.043987695
FWER p-Value0.923
Table: GSEA Results Summary



Fig 1: Enrichment plot: GO|GO:0060249   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
15111PCNA (proliferating cell nuclear antigen)102146.2210.0733Yes
28364"HIST1H4C (histone cluster 1, H4c)"141122.9000.1372Yes
31736"DKC1 (dyskeratosis congenita 1, dyskerin)"177108.9490.1938Yes
44609MYC (v-myc myelocytomatosis viral oncogene homolog (avian))186106.8540.2507Yes
55983"RFC3 (replication factor C (activator 1) 3, 38kDa)"215100.3380.3030Yes
6226"ALDOA (aldolase A, fructose-bisphosphate)"22997.3590.3545Yes
77520XRCC5 (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))30085.7970.3970Yes
82547XRCC6 (X-ray repair complementing defective repair in Chinese hamster cells 6)30784.4120.4419Yes
92237FEN1 (flap structure-specific endonuclease 1)34879.3160.4824Yes
1012"SERPINA3 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3)"55658.3250.5034Yes
115557"PRIM1 (primase, DNA, polypeptide 1 (49kDa))"75647.0790.5188Yes
125425"POLD2 (polymerase (DNA directed), delta 2, regulatory subunit 50kDa)"91240.2180.5327Yes
136584"SLC22A5 (solute carrier family 22 (organic cation/carnitine transporter), member 5)"111333.3320.5406Yes
145982"RFC2 (replication factor C (activator 1) 2, 40kDa)"128829.3030.5477Yes
156119"RPA3 (replication protein A3, 14kDa)"128929.2970.5634Yes
165213"PFKM (phosphofructokinase, muscle)"132928.2520.5766Yes
1723649"POLA2 (polymerase (DNA directed), alpha 2 (70kD subunit))"159823.9760.5762Yes
185985"RFC5 (replication factor C (activator 1) 5, 36.5kDa)"161723.6760.5880Yes
194763NF1 (neurofibromin 1)165623.1470.5985Yes
204683NBN (nibrin)170622.3160.6080Yes
21580BARD1 (BRCA1 associated RING domain 1)175621.5560.6172Yes
2265057ACD (adrenocortical dysplasia homolog (mouse))178821.2550.6270Yes
2354386"TERF2IP (telomeric repeat binding factor 2, interacting protein)"184520.5480.6352Yes
245424"POLD1 (polymerase (DNA directed), delta 1, catalytic subunit 125kDa)"186620.3340.6451Yes
2510728PTGES3 (prostaglandin E synthase 3 (cytosolic))200018.7710.6486Yes
265558"PRIM2 (primase, DNA, polypeptide 2 (58kDa))"203118.4850.6570Yes
276118"RPA2 (replication protein A2, 32kDa)"204818.3550.6661Yes
287486WRN (Werner syndrome)216617.3860.6696Yes
295427"POLE2 (polymerase (DNA directed), epsilon 2 (p59 subunit))"217617.3320.6784Yes
305984"RFC4 (replication factor C (activator 1) 4, 37kDa)"233515.7350.6790Yes
3110111RAD50 (RAD50 homolog (S. cerevisiae))239615.1880.6842Yes
324361MRE11A (MRE11 meiotic recombination 11 homolog A (S. cerevisiae))245714.7160.6891Yes
335981"RFC1 (replication factor C (activator 1) 1, 145kDa)"251914.0980.6937Yes
345422"POLA1 (polymerase (DNA directed), alpha 1, catalytic subunit)"254313.9450.7000Yes
356117"RPA1 (replication protein A1, 70kDa)"254913.8880.7072Yes
3655277FGGY (FGGY carbohydrate kinase domain containing)271012.8130.7061No
3779738BBS10 (Bardet-Biedl syndrome 10)297311.1360.6991No
3810714"POLD3 (polymerase (DNA-directed), delta 3, accessory subunit)"309710.4490.6986No
3964858"DCLRE1B (DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae))"33629.3200.6906No
4026272FBXO4 (F-box protein 4)34568.9090.6907No
416647"SOD1 (superoxide dismutase 1, soluble)"38147.4630.6771No
422072"ERCC4 (excision repair cross-complementing rodent repair deficiency, complementation group 4)"39706.8950.6731No
4385456"TNKS1BP1 (tankyrase 1 binding protein 1, 182kDa)"39836.8580.6762No
449215LARGE (like-glycosyltransferase)43215.7120.6626No
45120071GYLTL1B (glycosyltransferase-like 1B)43395.6520.6648No
4679991OBFC1 (oligonucleotide/oligosaccharide-binding fold containing 1)45385.1340.6577No
476662SOX9 (SRY (sex determining region Y)-box 9)52043.5990.6268No
4825861"DFNB31 (deafness, autosomal recessive 31)"57542.6770.6010No
495426"POLE (polymerase (DNA directed), epsilon)"58782.5200.5963No
50171392ZNF675 (zinc finger protein 675)59292.4570.5951No
518360"HIST1H4D (histone cluster 1, H4d)"60452.3140.5907No
521763DNA2 (DNA replication helicase 2 homolog (yeast))60492.3100.5918No
539290GPR55 (G protein-coupled receptor 55)66631.6200.5623No
549607CARTPT (CART prepropeptide)67011.5930.5613No
558363"HIST1H4J (histone cluster 1, H4j)"67661.5390.5590No
567013TERF1 (telomeric repeat binding factor (NIMA-interacting) 1)74121.0590.5277No
578366"HIST1H4B (histone cluster 1, H4b)"74341.0450.5272No
588359"HIST1H4A (histone cluster 1, H4a)"78070.8320.5092No
591134"CHRNA1 (cholinergic receptor, nicotinic, alpha 1 (muscle))"83810.5840.4812No
605950"RBP4 (retinol binding protein 4, plasma)"94480.2660.4286No
618290"HIST3H3 (histone cluster 3, H3)"95240.2490.4250No
628600"TNFSF11 (tumor necrosis factor (ligand) superfamily, member 11)"96080.2270.4211No
63101ADAM8 (ADAM metallopeptidase domain 8)97840.1850.4125No
64201516ZSCAN4 (zinc finger and SCAN domain containing 4)99030.1570.4067No
6525913POT1 (POT1 protection of telomeres 1 homolog (S. pombe))103940.0400.3825No
663978"LIG1 (ligase I, DNA, ATP-dependent)"10691-0.0240.3679No
676714SRC (v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian))11110-0.1240.3473No
688294"HIST1H4I (histone cluster 1, H4i)"11396-0.1900.3333No
69137868SGCZ (sarcoglycan zeta)11428-0.1990.3319No
705027"P2RX7 (purinergic receptor P2X, ligand-gated ion channel, 7)"12248-0.3860.2916No
7151750RTEL1 (regulator of telomere elongation helicase 1)12358-0.4160.2864No
725741PTH (parathyroid hormone)12607-0.4850.2744No
7357876"MUC3B (mucin 3B, cell surface associated)"12647-0.4980.2727No
743574IL7 (interleukin 7)13019-0.6120.2547No
758368"HIST1H4L (histone cluster 1, H4l)"13315-0.7100.2405No
764160MC4R (melanocortin 4 receptor)13545-0.7930.2296No
77585BBS4 (Bardet-Biedl syndrome 4)13612-0.8220.2268No
787099TLR4 (toll-like receptor 4)14032-1.0100.2066No
796441SFTPD (surfactant protein D)14068-1.0330.2054No
8080119PIF1 (PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae))14116-1.0570.2036No
814760NEUROD1 (neurogenic differentiation 1)14137-1.0650.2032No
825025"P2RX4 (purinergic receptor P2X, ligand-gated ion channel, 4)"14139-1.0660.2037No
838029CUBN (cubilin (intrinsic factor-cobalamin receptor))14416-1.1880.1907No
846722SRF (serum response factor (c-fos serum response element-binding transcription factor))14565-1.2760.1841No
857128"TNFAIP3 (tumor necrosis factor, alpha-induced protein 3)"14654-1.3310.1804No
8623498"HAAO (3-hydroxyanthranilate 3,4-dioxygenase)"14801-1.4220.1740No
878370"HIST2H4A (histone cluster 2, H4a)"15149-1.6730.1577No
8854106TLR9 (toll-like receptor 9)15160-1.6820.1581No
898361"HIST1H4F (histone cluster 1, H4f)"15444-1.9110.1451No
908367"HIST1H4E (histone cluster 1, H4e)"15478-1.9390.1445No
917011TEP1 (telomerase-associated protein 1)15540-2.0050.1426No
927015TERT (telomerase reverse transcriptase)15612-2.0630.1402No
933690"ITGB3 (integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61))"15709-2.1590.1366No
94796CALCA (calcitonin-related polypeptide alpha)16176-2.7250.1150No
958658"TNKS (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase)"16951-4.1200.0789No
9657804"POLD4 (polymerase (DNA-directed), delta 4)"17078-4.4470.0751No
972185PTK2B (PTK2B protein tyrosine kinase 2 beta)17444-5.4520.0599No
9880169C17orf68 (chromosome 17 open reading frame 68)17913-7.4410.0408No
994584"MUC3A (mucin 3A, cell surface associated)"17916-7.4620.0447No
100582BBS1 (Bardet-Biedl syndrome 1)17978-7.8050.0458No
10123293"SMG6 (Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans))"18036-8.0670.0473No
1028362"HIST1H4K (histone cluster 1, H4k)"18125-8.6150.0476No
1037014TERF2 (telomeric repeat binding factor 2)18350-9.9210.0418No
1044588"MUC6 (mucin 6, oligomeric mucus/gel-forming)"18361-9.9570.0467No
1055371PML (promyelocytic leukemia)18450-10.7970.0481No
1062067"ERCC1 (excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence))"18551-11.5300.0493No
10780351"TNKS2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2)"18583-11.8680.0542No
1088365"HIST1H4H (histone cluster 1, H4h)"18949-16.0290.0447No
1091200TPP1 (tripeptidyl peptidase I)19050-17.8580.0493No
11026277TINF2 (TERF1 (TRF1)-interacting nuclear factor 2)19397-25.6020.0459No
Table: GSEA details [plain text format]



Fig 2: GO|GO:0060249   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: GO|GO:0060249: Random ES distribution   
Gene set null distribution of ES for GO|GO:0060249