Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classcont
GeneSetKEGG|HSA00980
Enrichment Score (ES)-0.6908179
Normalized Enrichment Score (NES)-1.6147039
Nominal p-value0.00952381
FDR q-value0.24705234
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: KEGG|HSA00980   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
17366"UGT2B15 (UDP glucuronosyltransferase 2 family, polypeptide B15)"49961.9540.0554No
21545"CYP1B1 (cytochrome P450, family 1, subfamily B, polypeptide 1)"140126.9850.0458No
354490"UGT2B28 (UDP glucuronosyltransferase 2 family, polypeptide B28)"277012.347-0.0057No
4119391GSTO2 (glutathione S-transferase omega 2)300011.041-0.0027No
5373156GSTK1 (glutathione S-transferase kappa 1)34878.792-0.0154No
62941GSTA4 (glutathione S-transferase A4)62092.113-0.1469No
7125"ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide)"63841.897-0.1530No
827294DHDH (dihydrodiol dehydrogenase (dimeric))66741.615-0.1652No
9131"ADH7 (alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide)"73931.070-0.1992No
1010941"UGT2A1 (UDP glucuronosyltransferase 2 family, polypeptide A1)"74351.045-0.1999No
117367"UGT2B17 (UDP glucuronosyltransferase 2 family, polypeptide B17)"75070.992-0.2021No
1254576"UGT1A8 (UDP glucuronosyltransferase 1 family, polypeptide A8)"77900.840-0.2150No
131562"CYP2C18 (cytochrome P450, family 2, subfamily C, polypeptide 18)"82090.651-0.2348No
142939GSTA2 (glutathione S-transferase A2)86720.488-0.2569No
152940GSTA3 (glutathione S-transferase A3)88100.441-0.2631No
1629785"CYP2S1 (cytochrome P450, family 2, subfamily S, polypeptide 1)"94440.268-0.2940No
179446GSTO1 (glutathione S-transferase omega 1)95330.247-0.2980No
181559"CYP2C9 (cytochrome P450, family 2, subfamily C, polypeptide 9)"96590.218-0.3039No
197363"UGT2B4 (UDP glucuronosyltransferase 2 family, polypeptide B4)"99830.140-0.3197No
201557"CYP2C19 (cytochrome P450, family 2, subfamily C, polypeptide 19)"100310.126-0.3218No
211572"CYP2F1 (cytochrome P450, family 2, subfamily F, polypeptide 1)"103430.050-0.3371No
2279799"UGT2A3 (UDP glucuronosyltransferase 2 family, polypeptide A3)"104730.020-0.3434No
231577"CYP3A5 (cytochrome P450, family 3, subfamily A, polypeptide 5)"11368-0.182-0.3873No
241109"AKR1C4 (aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4))"11624-0.241-0.3996No
251571"CYP2E1 (cytochrome P450, family 2, subfamily E, polypeptide 1)"11643-0.247-0.4002No
26126"ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide)"11861-0.295-0.4105No
271551"CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7)"12122-0.351-0.4229No
28130ADH6 (alcohol dehydrogenase 6 (class V))12133-0.354-0.4229No
2964816"CYP3A43 (cytochrome P450, family 3, subfamily A, polypeptide 43)"12392-0.426-0.4351No
301558"CYP2C8 (cytochrome P450, family 2, subfamily C, polypeptide 8)"12546-0.467-0.4420No
31127"ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide)"13289-0.696-0.4777No
32124"ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide)"13305-0.704-0.4776No
331543"CYP1A1 (cytochrome P450, family 1, subfamily A, polypeptide 1)"13757-0.879-0.4987No
342949GSTM5 (glutathione S-transferase M5)13932-0.964-0.5060No
352952GSTT1 (glutathione S-transferase theta 1)14395-1.180-0.5273No
361576"CYP3A4 (cytochrome P450, family 3, subfamily A, polypeptide 4)"14478-1.225-0.5298No
374258MGST2 (microsomal glutathione S-transferase 2)15356-1.835-0.5707No
38218"ALDH3A1 (aldehyde dehydrogenase 3 family, memberA1)"15430-1.895-0.5718No
392938GSTA1 (glutathione S-transferase A1)15485-1.949-0.5720No
401544"CYP1A2 (cytochrome P450, family 1, subfamily A, polypeptide 2)"15705-2.154-0.5800No
412944GSTM1 (glutathione S-transferase M1)16406-3.068-0.6106No
422950GSTP1 (glutathione S-transferase pi 1)16706-3.615-0.6206No
432052"EPHX1 (epoxide hydrolase 1, microsomal (xenobiotic))"16777-3.740-0.6193No
44220"ALDH1A3 (aldehyde dehydrogenase 1 family, member A3)"17151-4.631-0.6317No
451555"CYP2B6 (cytochrome P450, family 2, subfamily B, polypeptide 6)"17332-5.087-0.6340No
468644"AKR1C3 (aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II))"17878-7.217-0.6516No
474259MGST3 (microsomal glutathione S-transferase 3)17911-7.426-0.6435No
4854658"UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1)"18870-14.863-0.6716Yes
492948GSTM4 (glutathione S-transferase M4)18947-16.012-0.6547Yes
502946GSTM2 (glutathione S-transferase M2 (muscle))19009-16.975-0.6357Yes
51222"ALDH3B2 (aldehyde dehydrogenase 3 family, member B2)"19129-19.442-0.6165Yes
5254578"UGT1A6 (UDP glucuronosyltransferase 1 family, polypeptide A6)"19172-20.072-0.5926Yes
5354600"UGT1A9 (UDP glucuronosyltransferase 1 family, polypeptide A9)"19200-20.548-0.5674Yes
5454659"UGT1A3 (UDP glucuronosyltransferase 1 family, polypeptide A3)"19288-22.707-0.5424Yes
551646"AKR1C2 (aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III))"19320-23.455-0.5136Yes
562954GSTZ1 (glutathione transferase zeta 1)19335-23.767-0.4836Yes
57128"ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide)"19739-38.871-0.4532Yes
584257MGST1 (microsomal glutathione S-transferase 1)20142-90.749-0.3558Yes
591645"AKR1C1 (aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase))"20157-96.337-0.2320Yes
602947GSTM3 (glutathione S-transferase M3 (brain))20280-185.9160.0022Yes
Table: GSEA details [plain text format]



Fig 2: KEGG|HSA00980   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: KEGG|HSA00980: Random ES distribution   
Gene set null distribution of ES for KEGG|HSA00980