Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classcont
GeneSetKEGG|HSA05414
Enrichment Score (ES)-0.68894637
Normalized Enrichment Score (NES)-1.7643789
Nominal p-value0.0
FDR q-value0.05604506
FWER p-Value0.431
Table: GSEA Results Summary



Fig 1: Enrichment plot: KEGG|HSA05414   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
13673"ITGA2 (integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor))"127129.671-0.0375No
2115ADCY9 (adenylate cyclase 9)183120.759-0.0474No
36443"SGCB (sarcoglycan, beta (43kDa dystrophin-associated glycoprotein))"195319.400-0.0368No
47168TPM1 (tropomyosin 1 (alpha))251514.150-0.0525No
5109ADCY3 (adenylate cyclase 3)270812.819-0.0510No
6488"ATP2A2 (ATPase, Ca++ transporting, cardiac muscle, slow twitch 2)"278512.295-0.0443No
72010EMD (emerin)35498.598-0.0746No
87040"TGFB1 (transforming growth factor, beta 1)"36658.104-0.0734No
93675"ITGA3 (integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor))"43985.483-0.1049No
105613"PRKX (protein kinase, X-linked)"46224.924-0.1117No
117169TPM2 (tropomyosin 2 (beta))48754.296-0.1205No
12153"ADRB1 (adrenergic, beta-1-, receptor)"49504.122-0.1206No
1370"ACTC1 (actin, alpha, cardiac muscle 1)"51493.714-0.1272No
14786"CACNG1 (calcium channel, voltage-dependent, gamma subunit 1)"52943.402-0.1315No
153688"ITGB1 (integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12))"54403.175-0.1359No
163908"LAMA2 (laminin, alpha 2)"57122.730-0.1470No
177273TTN (titin)58442.557-0.1513No
186546"SLC8A1 (solute carrier family 8 (sodium/calcium exchanger), member 1)"62632.049-0.1702No
1910369"CACNG2 (calcium channel, voltage-dependent, gamma subunit 2)"63941.890-0.1750No
2010368"CACNG3 (calcium channel, voltage-dependent, gamma subunit 3)"65651.711-0.1819No
213679"ITGA7 (integrin, alpha 7)"67241.575-0.1884No
221674DES (desmin)67271.572-0.1872No
233479IGF1 (insulin-like growth factor 1 (somatomedin C))70981.270-0.2044No
243695"ITGB7 (integrin, beta 7)"72001.196-0.2083No
256262RYR2 (ryanodine receptor 2 (cardiac))72331.172-0.2089No
26775"CACNA1C (calcium channel, voltage-dependent, L type, alpha 1C subunit)"72391.168-0.2082No
276444"SGCD (sarcoglycan, delta (35kDa dystrophin-associated glycoprotein))"72891.143-0.2096No
28108ADCY2 (adenylate cyclase 2 (brain))74940.999-0.2188No
299254"CACNA2D2 (calcium channel, voltage-dependent, alpha 2/delta subunit 2)"76710.900-0.2268No
30114ADCY8 (adenylate cyclase 8 (brain))77540.864-0.2301No
31124989C17orf57 (chromosome 17 open reading frame 57)78810.793-0.2356No
324624"MYH6 (myosin, heavy chain 6, cardiac muscle, alpha)"79040.782-0.2360No
33783"CACNB2 (calcium channel, voltage-dependent, beta 2 subunit)"81410.678-0.2471No
345568"PRKACG (protein kinase, cAMP-dependent, catalytic, gamma)"85650.525-0.2676No
353680"ITGA9 (integrin, alpha 9)"95360.246-0.3153No
364633"MYL2 (myosin, light chain 2, regulatory, cardiac, slow)"97760.187-0.3270No
37196883ADCY4 (adenylate cyclase 4)98490.170-0.3304No
383672"ITGA1 (integrin, alpha 1)"103100.061-0.3531No
39778"CACNA1F (calcium channel, voltage-dependent, L type, alpha 1F subunit)"104700.020-0.3609No
403696"ITGB8 (integrin, beta 8)"10596-0.003-0.3671No
413674"ITGA2B (integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41))"10821-0.051-0.3781No
4255799"CACNA2D3 (calcium channel, voltage-dependent, alpha 2/delta subunit 3)"10930-0.078-0.3834No
437137TNNI3 (troponin I type 3 (cardiac))11047-0.103-0.3890No
445350PLN (phospholamban)11125-0.127-0.3927No
4593589"CACNA2D4 (calcium channel, voltage-dependent, alpha 2/delta subunit 4)"11422-0.196-0.4072No
46113ADCY7 (adenylate cyclase 7)11465-0.206-0.4091No
473676"ITGA4 (integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor))"11477-0.208-0.4094No
487042"TGFB2 (transforming growth factor, beta 2)"11675-0.254-0.4190No
4959283"CACNG8 (calcium channel, voltage-dependent, gamma subunit 8)"11764-0.273-0.4231No
507139TNNT2 (troponin T type 2 (cardiac))11924-0.306-0.4307No
5122801"ITGA11 (integrin, alpha 11)"11965-0.314-0.4324No
527134TNNC1 (troponin C type 1 (slow))12041-0.334-0.4358No
5327091"CACNG5 (calcium channel, voltage-dependent, gamma subunit 5)"12129-0.354-0.4398No
547124"TNF (tumor necrosis factor (TNF superfamily, member 2))"12777-0.537-0.4713No
5559284"CACNG7 (calcium channel, voltage-dependent, gamma subunit 7)"13119-0.643-0.4876No
564625"MYH7 (myosin, heavy chain 7, cardiac muscle, beta)"13395-0.740-0.5006No
578515"ITGA10 (integrin, alpha 10)"13455-0.762-0.5028No
58107ADCY1 (adenylate cyclase 1 (brain))13734-0.870-0.5158No
59781"CACNA2D1 (calcium channel, voltage-dependent, alpha 2/delta subunit 1)"14094-1.044-0.5327No
606442"SGCA (sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein))"14500-1.239-0.5516No
61782"CACNB1 (calcium channel, voltage-dependent, beta 1 subunit)"14788-1.415-0.5646No
624634"MYL3 (myosin, light chain 3, alkali; ventricular, skeletal, slow)"14883-1.476-0.5680No
63779"CACNA1S (calcium channel, voltage-dependent, L type, alpha 1S subunit)"14936-1.512-0.5693No
648516"ITGA8 (integrin, alpha 8)"15186-1.713-0.5801No
65784"CACNB3 (calcium channel, voltage-dependent, beta 3 subunit)"15437-1.904-0.5909No
661756DMD (dystrophin)15542-2.006-0.5943No
673690"ITGB3 (integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61))"15709-2.159-0.6006No
68785"CACNB4 (calcium channel, voltage-dependent, beta 4 subunit)"15727-2.181-0.5996No
69111ADCY5 (adenylate cyclase 5)15933-2.417-0.6077No
70776"CACNA1D (calcium channel, voltage-dependent, L type, alpha 1D subunit)"16107-2.645-0.6140No
713655"ITGA6 (integrin, alpha 6)"16228-2.794-0.6175No
727171TPM4 (tropomyosin 4)16633-3.467-0.6345No
733678"ITGA5 (integrin, alpha 5 (fibronectin receptor, alpha polypeptide))"16955-4.130-0.6469No
744000LMNA (lamin A/C)17307-5.012-0.6599No
7527092"CACNG4 (calcium channel, voltage-dependent, gamma subunit 4)"17895-7.344-0.6827Yes
764607"MYBPC3 (myosin binding protein C, cardiac)"17937-7.595-0.6782Yes
777043"TGFB3 (transforming growth factor, beta 3)"18102-8.466-0.6791Yes
785566"PRKACA (protein kinase, cAMP-dependent, catalytic, alpha)"18280-9.482-0.6798Yes
793691"ITGB4 (integrin, beta 4)"18322-9.752-0.6735Yes
807170TPM3 (tropomyosin 3)18580-11.843-0.6760Yes
8159285"CACNG6 (calcium channel, voltage-dependent, gamma subunit 6)"18669-12.766-0.6695Yes
823694"ITGB6 (integrin, beta 6)"18774-13.800-0.6629Yes
83112ADCY6 (adenylate cyclase 6)18936-15.810-0.6573Yes
845567"PRKACB (protein kinase, cAMP-dependent, catalytic, beta)"19040-17.599-0.6474Yes
853685"ITGAV (integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51))"19403-25.664-0.6434Yes
863693"ITGB5 (integrin, beta 5)"19543-29.664-0.6249Yes
871605DAG1 (dystroglycan 1 (dystrophin-associated glycoprotein 1))19828-44.564-0.6009Yes
886445"SGCG (sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein))"20063-70.736-0.5521Yes
8971"ACTG1 (actin, gamma 1)"20270-173.229-0.4144Yes
9060"ACTB (actin, beta)"20292-201.325-0.2436Yes
912778GNAS (GNAS complex locus)20315-287.2330.0005Yes
Table: GSEA details [plain text format]



Fig 2: KEGG|HSA05414   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: KEGG|HSA05414: Random ES distribution   
Gene set null distribution of ES for KEGG|HSA05414