Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | treated |
GeneSet | REACTOME|REACT_1366.1 |
Enrichment Score (ES) | 0.7460373 |
Normalized Enrichment Score (NES) | 1.686816 |
Nominal p-value | 0.0 |
FDR q-value | 0.01608514 |
FWER p-Value | 0.327 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 6432 | "SFRS7 (splicing factor, arginine/serine-rich 7, 35kDa)" | 38 | 213.976 | 0.0661 | Yes | ||
2 | 6635 | SNRPE (small nuclear ribonucleoprotein polypeptide E) | 43 | 207.433 | 0.1317 | Yes | ||
3 | 6636 | SNRPF (small nuclear ribonucleoprotein polypeptide F) | 93 | 154.388 | 0.1783 | Yes | ||
4 | 6426 | "SFRS1 (splicing factor, arginine/serine-rich 1)" | 119 | 133.017 | 0.2193 | Yes | ||
5 | 10189 | THOC4 (THO complex 4) | 158 | 117.078 | 0.2546 | Yes | ||
6 | 6634 | SNRPD3 (small nuclear ribonucleoprotein D3 polypeptide 18kDa) | 196 | 103.434 | 0.2856 | Yes | ||
7 | 9939 | RBM8A (RNA binding motif protein 8A) | 201 | 102.613 | 0.3180 | Yes | ||
8 | 5431 | "POLR2B (polymerase (RNA) II (DNA directed) polypeptide B, 140kDa)" | 248 | 93.705 | 0.3455 | Yes | ||
9 | 6427 | "SFRS2 (splicing factor, arginine/serine-rich 2)" | 273 | 90.107 | 0.3729 | Yes | ||
10 | 6428 | "SFRS3 (splicing factor, arginine/serine-rich 3)" | 302 | 85.664 | 0.3987 | Yes | ||
11 | 2966 | "GTF2H2 (general transcription factor IIH, polypeptide 2, 44kDa)" | 337 | 80.980 | 0.4228 | Yes | ||
12 | 6921 | "TCEB1 (transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C))" | 377 | 75.377 | 0.4448 | Yes | ||
13 | 5436 | POLR2G (polymerase (RNA) II (DNA directed) polypeptide G) | 439 | 67.768 | 0.4633 | Yes | ||
14 | 11198 | SUPT16H (suppressor of Ty 16 homolog (S. cerevisiae)) | 484 | 63.469 | 0.4812 | Yes | ||
15 | 7307 | U2AF1 (U2 small nuclear RNA auxiliary factor 1) | 509 | 61.555 | 0.4996 | Yes | ||
16 | 5435 | POLR2F (polymerase (RNA) II (DNA directed) polypeptide F) | 531 | 60.346 | 0.5177 | Yes | ||
17 | 902 | CCNH (cyclin H) | 536 | 59.543 | 0.5364 | Yes | ||
18 | 5441 | "POLR2L (polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa)" | 655 | 51.833 | 0.5471 | Yes | ||
19 | 6628 | SNRPB (small nuclear ribonucleoprotein polypeptides B and B1) | 697 | 49.717 | 0.5608 | Yes | ||
20 | 6923 | "TCEB2 (transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B))" | 707 | 48.699 | 0.5758 | Yes | ||
21 | 1479 | "CSTF3 (cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa)" | 767 | 46.272 | 0.5876 | Yes | ||
22 | 6882 | "TAF11 (TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa)" | 854 | 42.429 | 0.5968 | Yes | ||
23 | 4686 | "NCBP1 (nuclear cap binding protein subunit 1, 80kDa)" | 860 | 42.266 | 0.6100 | Yes | ||
24 | 7884 | SLBP (stem-loop binding protein) | 966 | 37.985 | 0.6169 | Yes | ||
25 | 22916 | "NCBP2 (nuclear cap binding protein subunit 2, 20kDa)" | 986 | 37.528 | 0.6279 | Yes | ||
26 | 4116 | "MAGOH (mago-nashi homolog, proliferation-associated (Drosophila))" | 1009 | 36.619 | 0.6384 | Yes | ||
27 | 9295 | "SFRS11 (splicing factor, arginine/serine-rich 11)" | 1042 | 35.388 | 0.6480 | Yes | ||
28 | 84967 | "LSM10 (LSM10, U7 small nuclear RNA associated)" | 1065 | 34.719 | 0.6580 | Yes | ||
29 | 10921 | "RNPS1 (RNA binding protein S1, serine-rich domain)" | 1107 | 33.536 | 0.6666 | Yes | ||
30 | 11338 | U2AF2 (U2 small nuclear RNA auxiliary factor 2) | 1112 | 33.372 | 0.6770 | Yes | ||
31 | 5438 | "POLR2I (polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa)" | 1157 | 32.249 | 0.6851 | Yes | ||
32 | 6878 | "TAF6 (TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa)" | 1223 | 30.555 | 0.6916 | Yes | ||
33 | 2967 | "GTF2H3 (general transcription factor IIH, polypeptide 3, 34kDa)" | 1273 | 29.625 | 0.6985 | Yes | ||
34 | 5434 | "POLR2E (polymerase (RNA) II (DNA directed) polypeptide E, 25kDa)" | 1328 | 28.268 | 0.7048 | Yes | ||
35 | 6880 | "TAF9 (TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa)" | 1501 | 25.350 | 0.7044 | Yes | ||
36 | 6917 | "TCEA1 (transcription elongation factor A (SII), 1)" | 1635 | 23.406 | 0.7052 | Yes | ||
37 | 2957 | "GTF2A1 (general transcription factor IIA, 1, 19/37kDa)" | 1679 | 22.708 | 0.7103 | Yes | ||
38 | 5433 | POLR2D (polymerase (RNA) II (DNA directed) polypeptide D) | 1747 | 21.711 | 0.7139 | Yes | ||
39 | 6874 | "TAF4 (TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa)" | 1759 | 21.509 | 0.7202 | Yes | ||
40 | 5432 | "POLR2C (polymerase (RNA) II (DNA directed) polypeptide C, 33kDa)" | 1772 | 21.389 | 0.7264 | Yes | ||
41 | 65109 | UPF3B (UPF3 regulator of nonsense transcripts homolog B (yeast)) | 1778 | 21.341 | 0.7329 | Yes | ||
42 | 6749 | SSRP1 (structure specific recognition protein 1) | 1943 | 19.577 | 0.7310 | Yes | ||
43 | 6429 | "SFRS4 (splicing factor, arginine/serine-rich 4)" | 1970 | 19.104 | 0.7358 | Yes | ||
44 | 2963 | "GTF2F2 (general transcription factor IIF, polypeptide 2, 30kDa)" | 2056 | 18.264 | 0.7374 | Yes | ||
45 | 51362 | CDC40 (cell division cycle 40 homolog (S. cerevisiae)) | 2098 | 17.942 | 0.7411 | Yes | ||
46 | 6431 | "SFRS6 (splicing factor, arginine/serine-rich 6)" | 2113 | 17.800 | 0.7460 | Yes | ||
47 | 905 | CCNT2 (cyclin T2) | 2429 | 14.880 | 0.7352 | No | ||
48 | 6881 | "TAF10 (TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa)" | 2681 | 12.963 | 0.7269 | No | ||
49 | 29894 | "CPSF1 (cleavage and polyadenylation specific factor 1, 160kDa)" | 2720 | 12.711 | 0.7291 | No | ||
50 | 2961 | "GTF2E2 (general transcription factor IIE, polypeptide 2, beta 34kDa)" | 2730 | 12.640 | 0.7326 | No | ||
51 | 6877 | "TAF5 (TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa)" | 2921 | 11.505 | 0.7269 | No | ||
52 | 6827 | SUPT4H1 (suppressor of Ty 4 homolog 1 (S. cerevisiae)) | 3058 | 10.669 | 0.7235 | No | ||
53 | 7936 | RDBP (RD RNA binding protein) | 3086 | 10.515 | 0.7255 | No | ||
54 | 11051 | NUDT21 (nudix (nucleoside diphosphate linked moiety X)-type motif 21) | 3139 | 10.233 | 0.7262 | No | ||
55 | 6875 | "TAF4B (TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa)" | 3216 | 9.871 | 0.7256 | No | ||
56 | 51692 | "CPSF3 (cleavage and polyadenylation specific factor 3, 73kDa)" | 3299 | 9.533 | 0.7246 | No | ||
57 | 9150 | "CTDP1 (CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1)" | 3303 | 9.518 | 0.7275 | No | ||
58 | 2968 | "GTF2H4 (general transcription factor IIH, polypeptide 4, 52kDa)" | 3416 | 9.103 | 0.7248 | No | ||
59 | 79869 | "FLJ12529 (pre-mRNA cleavage factor I, 59 kDa subunit)" | 3482 | 8.799 | 0.7244 | No | ||
60 | 10250 | SRRM1 (serine/arginine repetitive matrix 1) | 3484 | 8.795 | 0.7271 | No | ||
61 | 6872 | "TAF1 (TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa)" | 3510 | 8.705 | 0.7287 | No | ||
62 | 4331 | "MNAT1 (menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis))" | 3583 | 8.417 | 0.7278 | No | ||
63 | 5430 | "POLR2A (polymerase (RNA) II (DNA directed) polypeptide A, 220kDa)" | 3626 | 8.231 | 0.7283 | No | ||
64 | 10914 | PAPOLA (poly(A) polymerase alpha) | 3875 | 7.187 | 0.7183 | No | ||
65 | 904 | CCNT1 (cyclin T1) | 4046 | 6.653 | 0.7120 | No | ||
66 | 25888 | ZNF473 (zinc finger protein 473) | 4409 | 5.467 | 0.6959 | No | ||
67 | 5437 | POLR2H (polymerase (RNA) II (DNA directed) polypeptide H) | 4596 | 5.000 | 0.6883 | No | ||
68 | 6908 | TBP (TATA box binding protein) | 4690 | 4.739 | 0.6852 | No | ||
69 | 2068 | "ERCC2 (excision repair cross-complementing rodent repair deficiency, complementation group 2)" | 5159 | 3.702 | 0.6632 | No | ||
70 | 1478 | "CSTF2 (cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa)" | 5494 | 3.074 | 0.6477 | No | ||
71 | 10978 | "CLP1 (CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae))" | 5783 | 2.637 | 0.6343 | No | ||
72 | 2071 | "ERCC3 (excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing))" | 5944 | 2.439 | 0.6271 | No | ||
73 | 134353 | "LSM11 (LSM11, U7 small nuclear RNA associated)" | 6024 | 2.346 | 0.6240 | No | ||
74 | 2965 | "GTF2H1 (general transcription factor IIH, polypeptide 1, 62kDa)" | 6155 | 2.163 | 0.6182 | No | ||
75 | 7469 | WHSC2 (Wolf-Hirschhorn syndrome candidate 2) | 6278 | 2.021 | 0.6128 | No | ||
76 | 5440 | "POLR2K (polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa)" | 6321 | 1.970 | 0.6114 | No | ||
77 | 2962 | "GTF2F1 (general transcription factor IIF, polypeptide 1, 74kDa)" | 6388 | 1.894 | 0.6087 | No | ||
78 | 8106 | "PABPN1 (poly(A) binding protein, nuclear 1)" | 9866 | 0.167 | 0.4369 | No | ||
79 | 6924 | "TCEB3 (transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A))" | 10319 | 0.059 | 0.4146 | No | ||
80 | 1025 | CDK9 (cyclin-dependent kinase 9) | 10418 | 0.034 | 0.4097 | No | ||
81 | 6884 | "TAF13 (TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa)" | 13077 | -0.630 | 0.2785 | No | ||
82 | 8178 | ELL (elongation factor RNA polymerase II) | 14520 | -1.254 | 0.2076 | No | ||
83 | 2958 | "GTF2A2 (general transcription factor IIA, 2, 12kDa)" | 14627 | -1.311 | 0.2028 | No | ||
84 | 9785 | DHX38 (DEAH (Asp-Glu-Ala-His) box polypeptide 38) | 14908 | -1.491 | 0.1894 | No | ||
85 | 53981 | "CPSF2 (cleavage and polyadenylation specific factor 2, 100kDa)" | 15120 | -1.654 | 0.1795 | No | ||
86 | 2960 | "GTF2E1 (general transcription factor IIE, polypeptide 1, alpha 56kDa)" | 16002 | -2.503 | 0.1368 | No | ||
87 | 8732 | RNGTT (RNA guanylyltransferase and 5'-phosphatase) | 16653 | -3.499 | 0.1057 | No | ||
88 | 8731 | RNMT (RNA (guanine-7-) methyltransferase) | 16887 | -3.967 | 0.0955 | No | ||
89 | 6883 | "TAF12 (TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa)" | 17252 | -4.858 | 0.0790 | No | ||
90 | 1477 | "CSTF1 (cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa)" | 18059 | -8.190 | 0.0418 | No | ||
91 | 5439 | "POLR2J (polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa)" | 18134 | -8.661 | 0.0409 | No | ||
92 | 2959 | GTF2B (general transcription factor IIB) | 18273 | -9.429 | 0.0370 | No | ||
93 | 8683 | "SFRS9 (splicing factor, arginine/serine-rich 9)" | 18964 | -16.250 | 0.0081 | No | ||
94 | 25920 | COBRA1 (cofactor of BRCA1) | 19016 | -17.134 | 0.0110 | No | ||
95 | 6637 | SNRPG (small nuclear ribonucleoprotein polypeptide G) | 19107 | -18.986 | 0.0126 | No | ||
96 | 51585 | "PCF11 (PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae))" | 19324 | -23.584 | 0.0094 | No | ||
97 | 51497 | TH1L (TH1-like (Drosophila)) | 19618 | -32.568 | 0.0053 | No | ||
98 | 1022 | CDK7 (cyclin-dependent kinase 7) | 19757 | -39.600 | 0.0110 | No | ||
99 | 6430 | "SFRS5 (splicing factor, arginine/serine-rich 5)" | 19923 | -53.636 | 0.0199 | No |