Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | treated |
GeneSet | REACTOME|REACT_1675.1 |
Enrichment Score (ES) | 0.7272599 |
Normalized Enrichment Score (NES) | 1.7164828 |
Nominal p-value | 0.0 |
FDR q-value | 0.009526097 |
FWER p-Value | 0.104 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 6432 | "SFRS7 (splicing factor, arginine/serine-rich 7, 35kDa)" | 38 | 213.976 | 0.0355 | Yes | ||
2 | 6635 | SNRPE (small nuclear ribonucleoprotein polypeptide E) | 43 | 207.433 | 0.0716 | Yes | ||
3 | 4904 | YBX1 (Y box binding protein 1) | 52 | 184.177 | 0.1034 | Yes | ||
4 | 6627 | SNRPA1 (small nuclear ribonucleoprotein polypeptide A') | 87 | 156.383 | 0.1290 | Yes | ||
5 | 3187 | HNRNPH1 (heterogeneous nuclear ribonucleoprotein H1 (H)) | 89 | 155.603 | 0.1562 | Yes | ||
6 | 6636 | SNRPF (small nuclear ribonucleoprotein polypeptide F) | 93 | 154.388 | 0.1830 | Yes | ||
7 | 3184 | "HNRNPD (heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa))" | 114 | 136.858 | 0.2060 | Yes | ||
8 | 6426 | "SFRS1 (splicing factor, arginine/serine-rich 1)" | 119 | 133.017 | 0.2290 | Yes | ||
9 | 10189 | THOC4 (THO complex 4) | 158 | 117.078 | 0.2476 | Yes | ||
10 | 4809 | NHP2L1 (NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)) | 162 | 113.700 | 0.2673 | Yes | ||
11 | 2521 | FUS (fusion (involved in t(12;16) in malignant liposarcoma)) | 182 | 107.302 | 0.2852 | Yes | ||
12 | 6634 | SNRPD3 (small nuclear ribonucleoprotein D3 polypeptide 18kDa) | 196 | 103.434 | 0.3026 | Yes | ||
13 | 9939 | RBM8A (RNA binding motif protein 8A) | 201 | 102.613 | 0.3203 | Yes | ||
14 | 51639 | "SF3B14 (splicing factor 3B, 14 kDa subunit)" | 232 | 96.686 | 0.3358 | Yes | ||
15 | 5431 | "POLR2B (polymerase (RNA) II (DNA directed) polypeptide B, 140kDa)" | 248 | 93.705 | 0.3514 | Yes | ||
16 | 6427 | "SFRS2 (splicing factor, arginine/serine-rich 2)" | 273 | 90.107 | 0.3660 | Yes | ||
17 | 57122 | NUP107 (nucleoporin 107kDa) | 276 | 89.588 | 0.3815 | Yes | ||
18 | 10907 | TXNL4A (thioredoxin-like 4A) | 283 | 88.484 | 0.3967 | Yes | ||
19 | 6428 | "SFRS3 (splicing factor, arginine/serine-rich 3)" | 302 | 85.664 | 0.4108 | Yes | ||
20 | 1977 | EIF4E (eukaryotic translation initiation factor 4E) | 306 | 84.641 | 0.4254 | Yes | ||
21 | 8480 | RAE1 (RAE1 RNA export 1 homolog (S. pombe)) | 322 | 83.312 | 0.4392 | Yes | ||
22 | 2966 | "GTF2H2 (general transcription factor IIH, polypeptide 2, 44kDa)" | 337 | 80.980 | 0.4527 | Yes | ||
23 | 6632 | SNRPD1 (small nuclear ribonucleoprotein D1 polypeptide 16kDa) | 352 | 78.903 | 0.4658 | Yes | ||
24 | 6629 | SNRPB2 (small nuclear ribonucleoprotein polypeptide B'') | 421 | 69.844 | 0.4746 | Yes | ||
25 | 5436 | POLR2G (polymerase (RNA) II (DNA directed) polypeptide G) | 439 | 67.768 | 0.4856 | Yes | ||
26 | 3192 | HNRNPU (heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)) | 450 | 66.400 | 0.4968 | Yes | ||
27 | 129401 | NUP35 (nucleoporin 35kDa) | 502 | 61.873 | 0.5051 | Yes | ||
28 | 7307 | U2AF1 (U2 small nuclear RNA auxiliary factor 1) | 509 | 61.555 | 0.5155 | Yes | ||
29 | 6633 | SNRPD2 (small nuclear ribonucleoprotein D2 polypeptide 16.5kDa) | 528 | 60.471 | 0.5252 | Yes | ||
30 | 5435 | POLR2F (polymerase (RNA) II (DNA directed) polypeptide F) | 531 | 60.346 | 0.5356 | Yes | ||
31 | 902 | CCNH (cyclin H) | 536 | 59.543 | 0.5459 | Yes | ||
32 | 9128 | PRPF4 (PRP4 pre-mRNA processing factor 4 homolog (yeast)) | 558 | 58.180 | 0.5550 | Yes | ||
33 | 83443 | "SF3B5 (splicing factor 3b, subunit 5, 10kDa)" | 605 | 54.853 | 0.5623 | Yes | ||
34 | 84844 | PHF5A (PHD finger protein 5A) | 616 | 54.060 | 0.5712 | Yes | ||
35 | 5441 | "POLR2L (polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa)" | 655 | 51.833 | 0.5784 | Yes | ||
36 | 6628 | SNRPB (small nuclear ribonucleoprotein polypeptides B and B1) | 697 | 49.717 | 0.5851 | Yes | ||
37 | 23450 | "SF3B3 (splicing factor 3b, subunit 3, 130kDa)" | 711 | 48.605 | 0.5929 | Yes | ||
38 | 1479 | "CSTF3 (cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa)" | 767 | 46.272 | 0.5983 | Yes | ||
39 | 79023 | NUP37 (nucleoporin 37kDa) | 770 | 46.189 | 0.6063 | Yes | ||
40 | 10236 | HNRNPR (heterogeneous nuclear ribonucleoprotein R) | 803 | 44.712 | 0.6125 | Yes | ||
41 | 4686 | "NCBP1 (nuclear cap binding protein subunit 1, 80kDa)" | 860 | 42.266 | 0.6171 | Yes | ||
42 | 10262 | "SF3B4 (splicing factor 3b, subunit 4, 49kDa)" | 882 | 41.258 | 0.6233 | Yes | ||
43 | 6626 | SNRPA (small nuclear ribonucleoprotein polypeptide A) | 920 | 40.041 | 0.6285 | Yes | ||
44 | 9972 | NUP153 (nucleoporin 153kDa) | 924 | 39.672 | 0.6352 | Yes | ||
45 | 7884 | SLBP (stem-loop binding protein) | 966 | 37.985 | 0.6399 | Yes | ||
46 | 23636 | NUP62 (nucleoporin 62kDa) | 980 | 37.692 | 0.6458 | Yes | ||
47 | 22916 | "NCBP2 (nuclear cap binding protein subunit 2, 20kDa)" | 986 | 37.528 | 0.6521 | Yes | ||
48 | 4116 | "MAGOH (mago-nashi homolog, proliferation-associated (Drosophila))" | 1009 | 36.619 | 0.6574 | Yes | ||
49 | 56339 | METTL3 (methyltransferase like 3) | 1012 | 36.545 | 0.6637 | Yes | ||
50 | 9295 | "SFRS11 (splicing factor, arginine/serine-rich 11)" | 1042 | 35.388 | 0.6685 | Yes | ||
51 | 84967 | "LSM10 (LSM10, U7 small nuclear RNA associated)" | 1065 | 34.719 | 0.6734 | Yes | ||
52 | 10921 | "RNPS1 (RNA binding protein S1, serine-rich domain)" | 1107 | 33.536 | 0.6773 | Yes | ||
53 | 11338 | U2AF2 (U2 small nuclear RNA auxiliary factor 2) | 1112 | 33.372 | 0.6829 | Yes | ||
54 | 10762 | NUP50 (nucleoporin 50kDa) | 1132 | 32.860 | 0.6877 | Yes | ||
55 | 27316 | "RBMX (RNA binding motif protein, X-linked)" | 1142 | 32.605 | 0.6930 | Yes | ||
56 | 23165 | NUP205 (nucleoporin 205kDa) | 1143 | 32.605 | 0.6987 | Yes | ||
57 | 4927 | NUP88 (nucleoporin 88kDa) | 1149 | 32.455 | 0.7041 | Yes | ||
58 | 5438 | "POLR2I (polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa)" | 1157 | 32.249 | 0.7094 | Yes | ||
59 | 3185 | HNRNPF (heterogeneous nuclear ribonucleoprotein F) | 1217 | 30.732 | 0.7118 | Yes | ||
60 | 3188 | HNRNPH2 (heterogeneous nuclear ribonucleoprotein H2 (H')) | 1265 | 29.760 | 0.7147 | Yes | ||
61 | 2967 | "GTF2H3 (general transcription factor IIH, polypeptide 3, 34kDa)" | 1273 | 29.625 | 0.7195 | Yes | ||
62 | 5434 | "POLR2E (polymerase (RNA) II (DNA directed) polypeptide E, 25kDa)" | 1328 | 28.268 | 0.7218 | Yes | ||
63 | 8243 | SMC1A (structural maintenance of chromosomes 1A) | 1597 | 23.987 | 0.7127 | Yes | ||
64 | 53371 | NUP54 (nucleoporin 54kDa) | 1604 | 23.859 | 0.7166 | Yes | ||
65 | 9631 | NUP155 (nucleoporin 155kDa) | 1641 | 23.360 | 0.7189 | Yes | ||
66 | 5433 | POLR2D (polymerase (RNA) II (DNA directed) polypeptide D) | 1747 | 21.711 | 0.7175 | Yes | ||
67 | 5432 | "POLR2C (polymerase (RNA) II (DNA directed) polypeptide C, 33kDa)" | 1772 | 21.389 | 0.7200 | Yes | ||
68 | 65109 | UPF3B (UPF3 regulator of nonsense transcripts homolog B (yeast)) | 1778 | 21.341 | 0.7235 | Yes | ||
69 | 23279 | NUP160 (nucleoporin 160kDa) | 1804 | 20.988 | 0.7259 | Yes | ||
70 | 6429 | "SFRS4 (splicing factor, arginine/serine-rich 4)" | 1970 | 19.104 | 0.7211 | Yes | ||
71 | 2963 | "GTF2F2 (general transcription factor IIF, polypeptide 2, 30kDa)" | 2056 | 18.264 | 0.7201 | Yes | ||
72 | 51362 | CDC40 (cell division cycle 40 homolog (S. cerevisiae)) | 2098 | 17.942 | 0.7212 | Yes | ||
73 | 6431 | "SFRS6 (splicing factor, arginine/serine-rich 6)" | 2113 | 17.800 | 0.7236 | Yes | ||
74 | 6625 | SNRP70 (small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen)) | 2159 | 17.443 | 0.7244 | Yes | ||
75 | 5903 | RANBP2 (RAN binding protein 2) | 2164 | 17.399 | 0.7273 | Yes | ||
76 | 1660 | DHX9 (DEAH (Asp-Glu-Ala-His) box polypeptide 9) | 2258 | 16.521 | 0.7255 | No | ||
77 | 9410 | WDR57 (WD repeat domain 57 (U5 snRNP specific)) | 2434 | 14.849 | 0.7195 | No | ||
78 | 5093 | PCBP1 (poly(rC) binding protein 1) | 2606 | 13.429 | 0.7133 | No | ||
79 | 23511 | NUP188 (nucleoporin 188kDa) | 2623 | 13.256 | 0.7149 | No | ||
80 | 9416 | DDX23 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 23) | 2653 | 13.087 | 0.7157 | No | ||
81 | 55749 | CCAR1 (cell division cycle and apoptosis regulator 1) | 2684 | 12.953 | 0.7165 | No | ||
82 | 9688 | NUP93 (nucleoporin 93kDa) | 2709 | 12.814 | 0.7175 | No | ||
83 | 29894 | "CPSF1 (cleavage and polyadenylation specific factor 1, 160kDa)" | 2720 | 12.711 | 0.7193 | No | ||
84 | 55746 | NUP133 (nucleoporin 133kDa) | 2787 | 12.281 | 0.7181 | No | ||
85 | 10482 | NXF1 (nuclear RNA export factor 1) | 2811 | 12.145 | 0.7191 | No | ||
86 | 10946 | "SF3A3 (splicing factor 3a, subunit 3, 60kDa)" | 2906 | 11.623 | 0.7165 | No | ||
87 | 57819 | "LSM2 (LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae))" | 3136 | 10.251 | 0.7069 | No | ||
88 | 11051 | NUDT21 (nudix (nucleoside diphosphate linked moiety X)-type motif 21) | 3139 | 10.233 | 0.7086 | No | ||
89 | 79902 | NUP85 (nucleoporin 85kDa) | 3289 | 9.586 | 0.7029 | No | ||
90 | 51692 | "CPSF3 (cleavage and polyadenylation specific factor 3, 73kDa)" | 3299 | 9.533 | 0.7041 | No | ||
91 | 348995 | NUP43 (nucleoporin 43kDa) | 3355 | 9.350 | 0.7030 | No | ||
92 | 23225 | NUP210 (nucleoporin 210kDa) | 3396 | 9.169 | 0.7027 | No | ||
93 | 2968 | "GTF2H4 (general transcription factor IIH, polypeptide 4, 52kDa)" | 3416 | 9.103 | 0.7033 | No | ||
94 | 79869 | "FLJ12529 (pre-mRNA cleavage factor I, 59 kDa subunit)" | 3482 | 8.799 | 0.7016 | No | ||
95 | 10250 | SRRM1 (serine/arginine repetitive matrix 1) | 3484 | 8.795 | 0.7031 | No | ||
96 | 4331 | "MNAT1 (menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis))" | 3583 | 8.417 | 0.6997 | No | ||
97 | 10291 | "SF3A1 (splicing factor 3a, subunit 1, 120kDa)" | 3597 | 8.360 | 0.7005 | No | ||
98 | 9343 | EFTUD2 (elongation factor Tu GTP binding domain containing 2) | 3617 | 8.280 | 0.7011 | No | ||
99 | 5430 | "POLR2A (polymerase (RNA) II (DNA directed) polypeptide A, 220kDa)" | 3626 | 8.231 | 0.7021 | No | ||
100 | 10914 | PAPOLA (poly(A) polymerase alpha) | 3875 | 7.187 | 0.6911 | No | ||
101 | 3191 | HNRNPL (heterogeneous nuclear ribonucleoprotein L) | 4006 | 6.766 | 0.6858 | No | ||
102 | 25888 | ZNF473 (zinc finger protein 473) | 4409 | 5.467 | 0.6668 | No | ||
103 | 5437 | POLR2H (polymerase (RNA) II (DNA directed) polypeptide H) | 4596 | 5.000 | 0.6585 | No | ||
104 | 9883 | POM121 (POM121 membrane glycoprotein (rat)) | 5027 | 3.978 | 0.6379 | No | ||
105 | 2068 | "ERCC2 (excision repair cross-complementing rodent repair deficiency, complementation group 2)" | 5159 | 3.702 | 0.6320 | No | ||
106 | 10421 | CD2BP2 (CD2 (cytoplasmic tail) binding protein 2) | 5357 | 3.307 | 0.6228 | No | ||
107 | 1478 | "CSTF2 (cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa)" | 5494 | 3.074 | 0.6166 | No | ||
108 | 10978 | "CLP1 (CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae))" | 5783 | 2.637 | 0.6028 | No | ||
109 | 2071 | "ERCC3 (excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing))" | 5944 | 2.439 | 0.5953 | No | ||
110 | 134353 | "LSM11 (LSM11, U7 small nuclear RNA associated)" | 6024 | 2.346 | 0.5918 | No | ||
111 | 2965 | "GTF2H1 (general transcription factor IIH, polypeptide 1, 62kDa)" | 6155 | 2.163 | 0.5857 | No | ||
112 | 5440 | "POLR2K (polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa)" | 6321 | 1.970 | 0.5779 | No | ||
113 | 2962 | "GTF2F1 (general transcription factor IIF, polypeptide 1, 74kDa)" | 6388 | 1.894 | 0.5750 | No | ||
114 | 652147 | "LOC652147 (similar to U5 snRNP-specific protein, 200 kDa)" | 6532 | 1.750 | 0.5682 | No | ||
115 | 57794 | SF4 (splicing factor 4) | 6691 | 1.597 | 0.5606 | No | ||
116 | 10949 | HNRNPA0 (heterogeneous nuclear ribonucleoprotein A0) | 7990 | 0.741 | 0.4964 | No | ||
117 | 8106 | "PABPN1 (poly(A) binding protein, nuclear 1)" | 9866 | 0.167 | 0.4035 | No | ||
118 | 339 | "APOBEC1 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1)" | 10946 | -0.082 | 0.3500 | No | ||
119 | 3181 | HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1) | 13361 | -0.727 | 0.2305 | No | ||
120 | 9785 | DHX38 (DEAH (Asp-Glu-Ala-His) box polypeptide 38) | 14908 | -1.491 | 0.1541 | No | ||
121 | 53981 | "CPSF2 (cleavage and polyadenylation specific factor 2, 100kDa)" | 15120 | -1.654 | 0.1440 | No | ||
122 | 8175 | "SF3A2 (splicing factor 3a, subunit 2, 66kDa)" | 15425 | -1.893 | 0.1292 | No | ||
123 | 23451 | "SF3B1 (splicing factor 3b, subunit 1, 155kDa)" | 15886 | -2.348 | 0.1068 | No | ||
124 | 8021 | NUP214 (nucleoporin 214kDa) | 16014 | -2.513 | 0.1010 | No | ||
125 | 8732 | RNGTT (RNA guanylyltransferase and 5'-phosphatase) | 16653 | -3.499 | 0.0700 | No | ||
126 | 8731 | RNMT (RNA (guanine-7-) methyltransferase) | 16887 | -3.967 | 0.0591 | No | ||
127 | 8086 | "AAAS (achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A))" | 16985 | -4.211 | 0.0550 | No | ||
128 | 11100 | HNRNPUL1 (heterogeneous nuclear ribonucleoprotein U-like 1) | 17403 | -5.300 | 0.0353 | No | ||
129 | 7175 | TPR (translocated promoter region (to activated MET oncogene)) | 17416 | -5.336 | 0.0356 | No | ||
130 | 104 | "ADARB1 (adenosine deaminase, RNA-specific, B1 (RED1 homolog rat))" | 17599 | -6.004 | 0.0277 | No | ||
131 | 10181 | RBM5 (RNA binding motif protein 5) | 17795 | -6.897 | 0.0192 | No | ||
132 | 10594 | PRPF8 (PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)) | 17881 | -7.246 | 0.0162 | No | ||
133 | 4670 | HNRNPM (heterogeneous nuclear ribonucleoprotein M) | 17936 | -7.587 | 0.0149 | No | ||
134 | 1477 | "CSTF1 (cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa)" | 18059 | -8.190 | 0.0103 | No | ||
135 | 5439 | "POLR2J (polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa)" | 18134 | -8.661 | 0.0081 | No | ||
136 | 3178 | HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) | 18139 | -8.691 | 0.0094 | No | ||
137 | 11097 | NUPL2 (nucleoporin like 2) | 18164 | -8.850 | 0.0098 | No | ||
138 | 3190 | HNRNPK (heterogeneous nuclear ribonucleoprotein K) | 18557 | -11.620 | -0.0076 | No | ||
139 | 24148 | PRPF6 (PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)) | 18644 | -12.510 | -0.0097 | No | ||
140 | 22826 | "DNAJC8 (DnaJ (Hsp40) homolog, subfamily C, member 8)" | 18654 | -12.595 | -0.0079 | No | ||
141 | 8683 | "SFRS9 (splicing factor, arginine/serine-rich 9)" | 18964 | -16.250 | -0.0204 | No | ||
142 | 10992 | "SF3B2 (splicing factor 3b, subunit 2, 145kDa)" | 19037 | -17.576 | -0.0209 | No | ||
143 | 6637 | SNRPG (small nuclear ribonucleoprotein polypeptide G) | 19107 | -18.986 | -0.0210 | No | ||
144 | 5725 | PTBP1 (polypyrimidine tract binding protein 1) | 19275 | -22.290 | -0.0254 | No | ||
145 | 51585 | "PCF11 (PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae))" | 19324 | -23.584 | -0.0236 | No | ||
146 | 23020 | ASCC3L1 (activating signal cointegrator 1 complex subunit 3-like 1) | 19614 | -32.261 | -0.0323 | No | ||
147 | 1022 | CDK7 (cyclin-dependent kinase 7) | 19757 | -39.600 | -0.0324 | No | ||
148 | 220988 | HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3) | 19789 | -41.609 | -0.0267 | No | ||
149 | 3183 | HNRNPC (heterogeneous nuclear ribonucleoprotein C (C1/C2)) | 19797 | -42.022 | -0.0197 | No | ||
150 | 6430 | "SFRS5 (splicing factor, arginine/serine-rich 5)" | 19923 | -53.636 | -0.0165 | No | ||
151 | 5094 | PCBP2 (poly(rC) binding protein 2) | 20076 | -73.183 | -0.0113 | No | ||
152 | 103 | "ADAR (adenosine deaminase, RNA-specific)" | 20231 | -134.677 | 0.0047 | No |