Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classcont
GeneSetREACTOME|REACT_75790.1
Enrichment Score (ES)-0.6313408
Normalized Enrichment Score (NES)-1.744663
Nominal p-value0.0
FDR q-value0.08425046
FWER p-Value0.594
Table: GSEA Results Summary



Fig 1: Enrichment plot: REACTOME|REACT_75790.1   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
17529"YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide)"125128.5400.0252No
2818CAMK2G (calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma)32882.5410.0354No
36500SKP1 (S-phase kinase-associated protein 1)41570.8440.0485No
47334"UBE2N (ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast))"44167.2260.0637No
53716JAK1 (Janus kinase 1 (a protein tyrosine kinase))60654.8420.0690No
65781"PTPN11 (protein tyrosine phosphatase, non-receptor type 11)"66851.1180.0784No
75604MAP2K1 (mitogen-activated protein kinase kinase 1)92139.9750.0757No
8960CD44 (CD44 molecule (Indian blood group))112233.1750.0739No
91147CHUK (conserved helix-loop-helix ubiquitous kinase)128729.3160.0729No
108454CUL1 (cullin 1)141326.7660.0733No
113669ISG20 (interferon stimulated exonuclease gene 20kDa)148625.6750.0760No
123717JAK2 (Janus kinase 2 (a protein tyrosine kinase))152624.9470.0801No
131399CRKL (v-crk sarcoma virus CT10 oncogene homolog (avian)-like)166523.0130.0789No
143265HRAS (v-Ha-ras Harvey rat sarcoma viral oncogene homolog)172322.0730.0815No
153654IRAK1 (interleukin-1 receptor-associated kinase 1)182920.7760.0814No
165605MAP2K2 (mitogen-activated protein kinase kinase 2)188720.0840.0834No
176464SHC1 (SHC (Src homology 2 domain containing) transforming protein 1)189320.0450.0881No
187525YES1 (v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1)198718.9100.0881No
194893NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog)256913.7040.0626No
203123"HLA-DRB1 (major histocompatibility complex, class II, DR beta 1)"257913.6550.0655No
215770"PTPN1 (protein tyrosine phosphatase, non-receptor type 1)"264613.0990.0654No
223661IRF3 (interferon regulatory factor 3)265513.0860.0682No
239846GAB2 (GRB2-associated binding protein 2)273112.6380.0676No
244791NFKB2 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100))32009.9720.0468No
2554472TOLLIP (toll interacting protein)33439.3800.0420No
2679155TNIP2 (TNFAIP3 interacting protein 2)33689.2970.0431No
276885MAP3K7 (mitogen-activated protein kinase kinase kinase 7)34089.1330.0434No
2864127NOD2 (nucleotide-binding oligomerization domain containing 2)35948.3890.0363No
297341SUMO1 (SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae))36578.1570.0352No
30246330PELI3 (pellino homolog 3 (Drosophila))41106.4140.0143No
312534"FYN (FYN oncogene related to SRC, FGR, YES)"42445.9920.0092No
323126"HLA-DRB4 (major histocompatibility complex, class II, DR beta 4)"43715.5600.0043No
338517"IKBKG (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma)"45605.094-0.0038No
346777STAT5B (signal transducer and activator of transcription 5B)49854.066-0.0239No
351326MAP3K8 (mitogen-activated protein kinase kinase kinase 8)50723.886-0.0272No
365291"PIK3CB (phosphoinositide-3-kinase, catalytic, beta polypeptide)"51933.637-0.0323No
3757162PELI1 (pellino homolog 1 (Drosophila))52973.395-0.0366No
383663IRF5 (interferon regulatory factor 5)53333.348-0.0375No
39867CBL (Cas-Br-M (murine) ecotropic retroviral transforming sequence)55632.971-0.0481No
403127"HLA-DRB5 (major histocompatibility complex, class II, DR beta 5)"60782.255-0.0731No
413551"IKBKB (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta)"63591.926-0.0865No
423113"HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)"64331.847-0.0897No
43163351"GBP6 (guanylate binding protein family, member 6)"64541.813-0.0903No
445293"PIK3CD (phosphoinositide-3-kinase, catalytic, delta polypeptide)"65541.725-0.0948No
455777"PTPN6 (protein tyrosine phosphatase, non-receptor type 6)"69581.373-0.1144No
463606IL18 (interleukin 18 (interferon-gamma-inducing factor))71461.235-0.1234No
473568"IL5RA (interleukin 5 receptor, alpha)"71601.221-0.1238No
485696"PSMB8 (proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7))"72191.180-0.1264No
491437CSF2 (colony stimulating factor 2 (granulocyte-macrophage))73781.080-0.1339No
506776STAT5A (signal transducer and activator of transcription 5A)75860.951-0.1440No
513443"IFNA6 (interferon, alpha 6)"77570.861-0.1522No
528651SOCS1 (suppressor of cytokine signaling 1)78250.822-0.1554No
537006TEC (tec protein tyrosine kinase)78470.811-0.1562No
543440"IFNA2 (interferon, alpha 2)"81440.676-0.1707No
553460IFNGR2 (interferon gamma receptor 2 (interferon gamma transducer 1))82640.626-0.1765No
563562"IL3 (interleukin 3 (colony-stimulating factor, multiple))"83050.613-0.1783No
574684NCAM1 (neural cell adhesion molecule 1)83220.605-0.1790No
583558IL2 (interleukin 2)83650.590-0.1809No
593635"INPP5D (inositol polyphosphate-5-phosphatase, 145kDa)"84880.547-0.1868No
603932LCK (lymphocyte-specific protein tyrosine kinase)86020.511-0.1923No
613557IL1RN (interleukin 1 receptor antagonist)86500.496-0.1945No
623662IRF4 (interferon regulatory factor 4)88960.417-0.2066No
633115"HLA-DPB1 (major histocompatibility complex, class II, DP beta 1)"89030.414-0.2068No
646654SOS1 (son of sevenless homolog 1 (Drosophila))94960.254-0.2362No
654502MT2A (metallothionein 2A)95880.231-0.2406No
663569"IL6 (interleukin 6 (interferon, beta 2))"97700.188-0.2496No
677412VCAM1 (vascular cell adhesion molecule 1)97950.183-0.2507No
683458"IFNG (interferon, gamma)"98350.174-0.2526No
693442"IFNA5 (interferon, alpha 5)"99680.144-0.2591No
705724PTAFR (platelet-activating factor receptor)100870.113-0.2650No
71115361GBP4 (guanylate binding protein 4)103980.039-0.2803No
721439"CSF2RB (colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage))"10629-0.011-0.2918No
733446"IFNA10 (interferon, alpha 10)"10839-0.055-0.3021No
743559"IL2RA (interleukin 2 receptor, alpha)"10998-0.092-0.3100No
753439"IFNA1 (interferon, alpha 1)"11441-0.201-0.3319No
763445"IFNA8 (interferon, alpha 8)"11458-0.205-0.3326No
7757161PELI2 (pellino homolog 2 (Drosophila))11695-0.258-0.3443No
783567"IL5 (interleukin 5 (colony-stimulating factor, eosinophil))"11758-0.272-0.3473No
793553"IL1B (interleukin 1, beta)"11912-0.304-0.3548No
807850"IL1R2 (interleukin 1 receptor, type II)"11964-0.314-0.3573No
819021SOCS3 (suppressor of cytokine signaling 3)12244-0.385-0.3710No
82834"CASP1 (caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase))"12329-0.408-0.3751No
833441"IFNA4 (interferon, alpha 4)"12451-0.445-0.3810No
843449"IFNA16 (interferon, alpha 16)"12618-0.489-0.3891No
853451"IFNA17 (interferon, alpha 17)"12711-0.517-0.3936No
86115362GBP5 (guanylate binding protein 5)12797-0.543-0.3977No
872210"FCGR1B (Fc fragment of IgG, high affinity Ib, receptor (CD64))"12991-0.602-0.4071No
884600MX2 (myxovirus (influenza virus) resistance 2 (mouse))13084-0.634-0.4115No
894599"MX1 (myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse))"13262-0.687-0.4201No
903552"IL1A (interleukin 1, alpha)"13376-0.731-0.4256No
913112"HLA-DOB (major histocompatibility complex, class II, DO beta)"13515-0.781-0.4322No
923108"HLA-DMA (major histocompatibility complex, class II, DM alpha)"13572-0.805-0.4348No
933444"IFNA7 (interferon, alpha 7)"13599-0.815-0.4359No
941958EGR1 (early growth response 1)13634-0.827-0.4374No
9511213IRAK3 (interleukin-1 receptor-associated kinase 3)13644-0.831-0.4376No
966041"RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent))"13797-0.896-0.4450No
977409VAV1 (vav 1 guanine nucleotide exchange factor)14093-1.044-0.4594No
985580"PRKCD (protein kinase C, delta)"14205-1.089-0.4646No
9954739XAF1 (XIAP associated factor 1)14206-1.089-0.4643No
1003448"IFNA14 (interferon, alpha 14)"14278-1.122-0.4676No
1013452"IFNA21 (interferon, alpha 21)"14303-1.135-0.4685No
1023109"HLA-DMB (major histocompatibility complex, class II, DM beta)"14469-1.219-0.4764No
1033456"IFNB1 (interferon, beta 1, fibroblast)"14732-1.384-0.4891No
10410454MAP3K7IP1 (mitogen-activated protein kinase kinase kinase 7 interacting protein 1)14980-1.550-0.5010No
1057189TRAF6 (TNF receptor-associated factor 6)15046-1.595-0.5038No
1062209"FCGR1A (Fc fragment of IgG, high affinity Ia, receptor (CD64))"15096-1.635-0.5058No
107816CAMK2B (calcium/calmodulin-dependent protein kinase (CaM kinase) II beta)15145-1.669-0.5078No
1083394IRF8 (interferon regulatory factor 8)15221-1.737-0.5111No
1092889RAPGEF1 (Rap guanine nucleotide exchange factor (GEF) 1)15375-1.851-0.5183No
1103454"IFNAR1 (interferon (alpha, beta and omega) receptor 1)"15684-2.132-0.5330No
1118945BTRC (beta-transducin repeat containing)15878-2.336-0.5421No
1123055HCK (hemopoietic cell kinase)16018-2.517-0.5483No
113815CAMK2A (calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha)16092-2.630-0.5513No
1141438"CSF2RA (colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage))"16220-2.782-0.5570No
1155608MAP2K6 (mitogen-activated protein kinase kinase 6)16252-2.828-0.5578No
1163563"IL3RA (interleukin 3 receptor, alpha (low affinity))"16395-3.049-0.5641No
1173561"IL2RG (interleukin 2 receptor, gamma (severe combined immunodeficiency))"16409-3.071-0.5640No
1184261"CIITA (class II, major histocompatibility complex, transactivator)"16562-3.334-0.5707No
1194215MAP3K3 (mitogen-activated protein kinase kinase kinase 3)16638-3.478-0.5736No
1208638OASL (2'-5'-oligoadenylate synthetase-like)16666-3.527-0.5741No
1217297TYK2 (tyrosine kinase 2)16697-3.598-0.5747No
12251135IRAK4 (interleukin-1 receptor-associated kinase 4)16710-3.620-0.5744No
1236672SP100 (SP100 nuclear antigen)16717-3.632-0.5738No
12410392NOD1 (nucleotide-binding oligomerization domain containing 1)16883-3.962-0.5810No
12523118MAP3K7IP2 (mitogen-activated protein kinase kinase kinase 7 interacting protein 2)16913-4.022-0.5815No
1263560"IL2RB (interleukin 2 receptor, beta)"16974-4.182-0.5835No
1273718"JAK3 (Janus kinase 3 (a protein tyrosine kinase, leukocyte))"17148-4.623-0.5909No
1283433IFIT2 (interferon-induced protein with tetratricopeptide repeats 2)17164-4.656-0.5905No
1293660IRF2 (interferon regulatory factor 2)17207-4.758-0.5914No
1309978RBX1 (ring-box 1)17251-4.857-0.5924No
1312185PTK2B (PTK2B protein tyrosine kinase 2 beta)17444-5.452-0.6006No
1326416MAP2K4 (mitogen-activated protein kinase kinase 4)17489-5.590-0.6014No
1334790NFKB1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 1)17493-5.614-0.6002No
1343111"HLA-DOA (major histocompatibility complex, class II, DO alpha)"17650-6.220-0.6064No
1353383ICAM1 (intercellular adhesion molecule 1)17688-6.391-0.6067No
1363656IRAK2 (interleukin-1 receptor-associated kinase 2)17746-6.667-0.6079No
1375290"PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide)"17764-6.773-0.6071No
1386850SYK (spleen tyrosine kinase)17777-6.807-0.6060No
1393664IRF6 (interferon regulatory factor 6)17986-7.831-0.6144No
1403122"HLA-DRA (major histocompatibility complex, class II, DR alpha)"17997-7.888-0.6130No
1413659IRF1 (interferon regulatory factor 1)18007-7.943-0.6115No
1425970RELA (v-rel reticuloendotheliosis viral oncogene homolog A (avian))18184-8.954-0.6180No
1438554"PIAS1 (protein inhibitor of activated STAT, 1)"18340-9.843-0.6233No
1448767RIPK2 (receptor-interacting serine-threonine kinase 2)18377-10.118-0.6226No
1454067LYN (v-yes-1 Yamaguchi sarcoma viral related oncogene homolog)18419-10.518-0.6221No
1465371PML (promyelocytic leukemia)18450-10.797-0.6210No
1472635GBP3 (guanylate binding protein 3)18501-11.136-0.6207No
1485894RAF1 (v-raf-1 murine leukemia viral oncogene homolog 1)18716-13.248-0.6281Yes
149257397MAP3K7IP3 (mitogen-activated protein kinase kinase kinase 7 interacting protein 3)18743-13.542-0.6261Yes
1503665IRF7 (interferon regulatory factor 7)18746-13.575-0.6229Yes
1513636INPPL1 (inositol polyphosphate phosphatase-like 1)18769-13.776-0.6206Yes
1522633"GBP1 (guanylate binding protein 1, interferon-inducible, 67kDa)"18816-14.186-0.6194Yes
15311274USP18 (ubiquitin specific peptidase 18)18861-14.702-0.6180Yes
1542634"GBP2 (guanylate binding protein 2, interferon-inducible)"18868-14.825-0.6146Yes
1553430IFI35 (interferon-induced protein 35)19007-16.958-0.6174Yes
1565567"PRKACB (protein kinase, cAMP-dependent, catalytic, beta)"19040-17.599-0.6146Yes
1573437IFIT3 (interferon-induced protein with tetratricopeptide repeats 3)19104-18.975-0.6131Yes
158387522TMEM189-UBE2V1 (TMEM189-UBE2V1)19179-20.169-0.6119Yes
1593134"HLA-F (major histocompatibility complex, class I, F)"19233-21.099-0.6093Yes
1604615MYD88 (myeloid differentiation primary response gene (88))19292-22.872-0.6066Yes
1614939"OAS2 (2'-5'-oligoadenylate synthetase 2, 69/71kDa)"19395-25.501-0.6054Yes
1626773"STAT2 (signal transducer and activator of transcription 2, 113kDa)"19399-25.624-0.5993Yes
1635295"PIK3R1 (phosphoinositide-3-kinase, regulatory subunit 1 (alpha))"19422-26.295-0.5940Yes
1643429"IFI27 (interferon, alpha-inducible protein 27)"19448-26.932-0.5886Yes
1656774STAT3 (signal transducer and activator of transcription 3 (acute-phase response factor))19451-27.002-0.5821Yes
1663133"HLA-E (major histocompatibility complex, class I, E)"19478-27.797-0.5766Yes
16751447IHPK2 (inositol hexaphosphate kinase 2)19516-28.829-0.5714Yes
168817CAMK2D (calcium/calmodulin-dependent protein kinase (CaM kinase) II delta)19600-31.852-0.5677Yes
16929760BLNK (B-cell linker)19609-32.051-0.5603Yes
1707534"YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide)"19611-32.169-0.5524Yes
1713845KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog)19615-32.381-0.5447Yes
1722537"IFI6 (interferon, alpha-inducible protein 6)"19662-35.028-0.5384Yes
1733554"IL1R1 (interleukin 1 receptor, type I)"19759-39.637-0.5335Yes
17410437"IFI30 (interferon, gamma-inducible protein 30)"19766-40.310-0.5239Yes
1753135"HLA-G (major histocompatibility complex, class I, G)"19863-47.478-0.5170Yes
1764938"OAS1 (2',5'-oligoadenylate synthetase 1, 40/46kDa)"19903-51.434-0.5064Yes
1775296"PIK3R2 (phosphoinositide-3-kinase, regulatory subunit 2 (beta))"19918-53.218-0.4941Yes
1783459IFNGR1 (interferon gamma receptor 1)19965-58.421-0.4820Yes
17910581IFITM2 (interferon induced transmembrane protein 2 (1-8D))19970-58.782-0.4679Yes
1808878SQSTM1 (sequestosome 1)19982-61.077-0.4535Yes
1813105"HLA-A (major histocompatibility complex, class I, A)"20027-65.132-0.4397Yes
1827335UBE2V1 (ubiquitin-conjugating enzyme E2 variant 1)20096-76.767-0.4243Yes
1833106"HLA-B (major histocompatibility complex, class I, B)"20100-78.491-0.4052Yes
1844940"OAS3 (2'-5'-oligoadenylate synthetase 3, 100kDa)"20125-86.843-0.3852Yes
1858519IFITM1 (interferon induced transmembrane protein 1 (9-27))20204-117.578-0.3603Yes
186103"ADAR (adenosine deaminase, RNA-specific)"20231-134.677-0.3286Yes
1873107"HLA-C (major histocompatibility complex, class I, C)"20243-142.867-0.2942Yes
18810379IRF9 (interferon regulatory factor 9)20262-164.279-0.2549Yes
18910410IFITM3 (interferon induced transmembrane protein 3 (1-8U))20271-173.958-0.2127Yes
1908503"PIK3R3 (phosphoinositide-3-kinase, regulatory subunit 3 (gamma))"20275-179.372-0.1690Yes
191567B2M (beta-2-microglobulin)20305-220.982-0.1163Yes
1923434IFIT1 (interferon-induced protein with tetratricopeptide repeats 1)20306-233.172-0.0593Yes
1939636ISG15 (ISG15 ubiquitin-like modifier)20309-245.8520.0008Yes
Table: GSEA details [plain text format]



Fig 2: REACTOME|REACT_75790.1   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: REACTOME|REACT_75790.1: Random ES distribution   
Gene set null distribution of ES for REACTOME|REACT_75790.1