Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | cont |
GeneSet | PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA|IL12-MEDIATED SIGNALING EVENTS |
Enrichment Score (ES) | -0.71140575 |
Normalized Enrichment Score (NES) | -1.7184052 |
Nominal p-value | 0.0029850747 |
FDR q-value | 0.104168065 |
FWER p-Value | 0.815 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 4616 | "GADD45B (growth arrest and DNA-damage-inducible, beta)" | 888 | 41.066 | 0.0077 | No | ||
2 | 3717 | JAK2 (Janus kinase 2 (a protein tyrosine kinase)) | 1526 | 24.947 | 0.0076 | No | ||
3 | 3123 | "HLA-DRB1 (major histocompatibility complex, class II, DR beta 1)" | 2579 | 13.655 | -0.0272 | No | ||
4 | 4791 | NFKB2 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)) | 3200 | 9.972 | -0.0452 | No | ||
5 | 5606 | MAP2K3 (mitogen-activated protein kinase kinase 3) | 3581 | 8.419 | -0.0534 | No | ||
6 | 2353 | FOS (v-fos FBJ murine osteosarcoma viral oncogene homolog) | 3938 | 6.979 | -0.0622 | No | ||
7 | 2475 | FRAP1 (FK506 binding protein 12-rapamycin associated protein 1) | 5135 | 3.745 | -0.1165 | No | ||
8 | 4843 | "NOS2A (nitric oxide synthase 2A (inducible, hepatocytes))" | 5502 | 3.060 | -0.1308 | No | ||
9 | 8320 | EOMES (eomesodermin homolog (Xenopus laevis)) | 6151 | 2.165 | -0.1600 | No | ||
10 | 6778 | "STAT6 (signal transducer and activator of transcription 6, interleukin-4 induced)" | 6737 | 1.560 | -0.1869 | No | ||
11 | 1386 | ATF2 (activating transcription factor 2) | 6784 | 1.528 | -0.1873 | No | ||
12 | 8807 | IL18RAP (interleukin 18 receptor accessory protein) | 6802 | 1.511 | -0.1862 | No | ||
13 | 10912 | "GADD45G (growth arrest and DNA-damage-inducible, gamma)" | 6971 | 1.361 | -0.1928 | No | ||
14 | 3606 | IL18 (interleukin 18 (interferon-gamma-inducing factor)) | 7146 | 1.235 | -0.1998 | No | ||
15 | 3142 | HLX (H2.0-like homeobox) | 7532 | 0.976 | -0.2176 | No | ||
16 | 6776 | STAT5A (signal transducer and activator of transcription 5A) | 7586 | 0.951 | -0.2190 | No | ||
17 | 8651 | SOCS1 (suppressor of cytokine signaling 1) | 7825 | 0.822 | -0.2297 | No | ||
18 | 915 | "CD3D (CD3d molecule, delta (CD3-TCR complex))" | 8076 | 0.700 | -0.2412 | No | ||
19 | 8809 | IL18R1 (interleukin 18 receptor 1) | 8158 | 0.671 | -0.2443 | No | ||
20 | 6348 | CCL3 (chemokine (C-C motif) ligand 3) | 8294 | 0.617 | -0.2502 | No | ||
21 | 3558 | IL2 (interleukin 2) | 8365 | 0.590 | -0.2529 | No | ||
22 | 3932 | LCK (lymphocyte-specific protein tyrosine kinase) | 8602 | 0.511 | -0.2639 | No | ||
23 | 1234 | CCR5 (chemokine (C-C motif) receptor 5) | 8760 | 0.457 | -0.2711 | No | ||
24 | 356 | "FASLG (Fas ligand (TNF superfamily, member 6))" | 9155 | 0.344 | -0.2901 | No | ||
25 | 30009 | TBX21 (T-box 21) | 9426 | 0.272 | -0.3031 | No | ||
26 | 3595 | "IL12RB2 (interleukin 12 receptor, beta 2)" | 9686 | 0.211 | -0.3156 | No | ||
27 | 3458 | "IFNG (interferon, gamma)" | 9835 | 0.174 | -0.3227 | No | ||
28 | 3001 | "GZMA (granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3))" | 9848 | 0.171 | -0.3231 | No | ||
29 | 919 | CD247 (CD247 molecule) | 9865 | 0.167 | -0.3237 | No | ||
30 | 3002 | "GZMB (granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1))" | 10454 | 0.024 | -0.3527 | No | ||
31 | 3559 | "IL2RA (interleukin 2 receptor, alpha)" | 10998 | -0.092 | -0.3793 | No | ||
32 | 6351 | CCL4 (chemokine (C-C motif) ligand 4) | 11194 | -0.143 | -0.3888 | No | ||
33 | 3593 | "IL12B (interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40))" | 11374 | -0.185 | -0.3974 | No | ||
34 | 3553 | "IL1B (interleukin 1, beta)" | 11912 | -0.304 | -0.4235 | No | ||
35 | 3592 | "IL12A (interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35))" | 12016 | -0.327 | -0.4282 | No | ||
36 | 920 | CD4 (CD4 molecule) | 12457 | -0.446 | -0.4493 | No | ||
37 | 56848 | SPHK2 (sphingosine kinase 2) | 12748 | -0.527 | -0.4630 | No | ||
38 | 925 | CD8A (CD8a molecule) | 13489 | -0.771 | -0.4985 | No | ||
39 | 926 | CD8B (CD8b molecule) | 14383 | -1.176 | -0.5411 | No | ||
40 | 917 | "CD3G (CD3g molecule, gamma (CD3-TCR complex))" | 14522 | -1.255 | -0.5463 | No | ||
41 | 3565 | IL4 (interleukin 4) | 14888 | -1.480 | -0.5625 | No | ||
42 | 5971 | RELB (v-rel reticuloendotheliosis viral oncogene homolog B) | 15250 | -1.754 | -0.5781 | No | ||
43 | 3594 | "IL12RB1 (interleukin 12 receptor, beta 1)" | 15945 | -2.429 | -0.6093 | No | ||
44 | 6775 | STAT4 (signal transducer and activator of transcription 4) | 16188 | -2.744 | -0.6178 | No | ||
45 | 5608 | MAP2K6 (mitogen-activated protein kinase kinase 6) | 16252 | -2.828 | -0.6173 | No | ||
46 | 3561 | "IL2RG (interleukin 2 receptor, gamma (severe combined immunodeficiency))" | 16409 | -3.071 | -0.6212 | No | ||
47 | 1432 | MAPK14 (mitogen-activated protein kinase 14) | 16465 | -3.158 | -0.6199 | No | ||
48 | 7297 | TYK2 (tyrosine kinase 2) | 16697 | -3.598 | -0.6268 | No | ||
49 | 916 | "CD3E (CD3e molecule, epsilon (CD3-TCR complex))" | 16842 | -3.845 | -0.6291 | No | ||
50 | 3560 | "IL2RB (interleukin 2 receptor, beta)" | 16974 | -4.182 | -0.6303 | No | ||
51 | 4790 | NFKB1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) | 17493 | -5.614 | -0.6488 | No | ||
52 | 3122 | "HLA-DRA (major histocompatibility complex, class II, DR alpha)" | 17997 | -7.888 | -0.6637 | No | ||
53 | 5970 | RELA (v-rel reticuloendotheliosis viral oncogene homolog A (avian)) | 18184 | -8.954 | -0.6617 | No | ||
54 | 8767 | RIPK2 (receptor-interacting serine-threonine kinase 2) | 18377 | -10.118 | -0.6585 | No | ||
55 | 6774 | STAT3 (signal transducer and activator of transcription 3 (acute-phase response factor)) | 19451 | -27.002 | -0.6775 | Yes | ||
56 | 7879 | "RAB7A (RAB7A, member RAS oncogene family)" | 19623 | -32.714 | -0.6449 | Yes | ||
57 | 3554 | "IL1R1 (interleukin 1 receptor, type I)" | 19759 | -39.637 | -0.6018 | Yes | ||
58 | 3105 | "HLA-A (major histocompatibility complex, class I, A)" | 20027 | -65.132 | -0.5332 | Yes | ||
59 | 6772 | "STAT1 (signal transducer and activator of transcription 1, 91kDa)" | 20302 | -215.432 | -0.2763 | Yes | ||
60 | 567 | B2M (beta-2-microglobulin) | 20305 | -220.982 | 0.0010 | Yes |