Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classcont
GeneSetKEGG|HSA05410
Enrichment Score (ES)-0.63559335
Normalized Enrichment Score (NES)-1.5729328
Nominal p-value0.0063897762
FDR q-value0.30293214
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: KEGG|HSA05410   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
13673"ITGA2 (integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor))"127129.671-0.0265No
26443"SGCB (sarcoglycan, beta (43kDa dystrophin-associated glycoprotein))"195319.400-0.0364No
37168TPM1 (tropomyosin 1 (alpha))251514.150-0.0467No
4488"ATP2A2 (ATPase, Ca++ transporting, cardiac muscle, slow twitch 2)"278512.295-0.0450No
55571"PRKAG1 (protein kinase, AMP-activated, gamma 1 non-catalytic subunit)"33769.250-0.0628No
62010EMD (emerin)35498.598-0.0608No
77040"TGFB1 (transforming growth factor, beta 1)"36658.104-0.0565No
83675"ITGA3 (integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor))"43985.483-0.0860No
97169TPM2 (tropomyosin 2 (beta))48754.296-0.1042No
1051422"PRKAG2 (protein kinase, AMP-activated, gamma 2 non-catalytic subunit)"50873.865-0.1099No
1170"ACTC1 (actin, alpha, cardiac muscle 1)"51493.714-0.1084No
12786"CACNG1 (calcium channel, voltage-dependent, gamma subunit 1)"52943.402-0.1113No
133688"ITGB1 (integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12))"54403.175-0.1146No
145564"PRKAB1 (protein kinase, AMP-activated, beta 1 non-catalytic subunit)"55812.946-0.1179No
153908"LAMA2 (laminin, alpha 2)"57122.730-0.1210No
167273TTN (titin)58442.557-0.1244No
176546"SLC8A1 (solute carrier family 8 (sodium/calcium exchanger), member 1)"62632.049-0.1425No
1810369"CACNG2 (calcium channel, voltage-dependent, gamma subunit 2)"63941.890-0.1466No
1910368"CACNG3 (calcium channel, voltage-dependent, gamma subunit 3)"65651.711-0.1529No
203679"ITGA7 (integrin, alpha 7)"67241.575-0.1588No
211674DES (desmin)67271.572-0.1570No
223479IGF1 (insulin-like growth factor 1 (somatomedin C))70981.270-0.1737No
233695"ITGB7 (integrin, beta 7)"72001.196-0.1772No
246262RYR2 (ryanodine receptor 2 (cardiac))72331.172-0.1773No
25775"CACNA1C (calcium channel, voltage-dependent, L type, alpha 1C subunit)"72391.168-0.1762No
266444"SGCD (sarcoglycan, delta (35kDa dystrophin-associated glycoprotein))"72891.143-0.1772No
271636ACE (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1)73681.086-0.1797No
289254"CACNA2D2 (calcium channel, voltage-dependent, alpha 2/delta subunit 2)"76710.900-0.1935No
29124989C17orf57 (chromosome 17 open reading frame 57)78810.793-0.2029No
304624"MYH6 (myosin, heavy chain 6, cardiac muscle, alpha)"79040.782-0.2030No
31783"CACNB2 (calcium channel, voltage-dependent, beta 2 subunit)"81410.678-0.2138No
323680"ITGA9 (integrin, alpha 9)"95360.246-0.2824No
333569"IL6 (interleukin 6 (interferon, beta 2))"97700.188-0.2937No
344633"MYL2 (myosin, light chain 2, regulatory, cardiac, slow)"97760.187-0.2937No
353672"ITGA1 (integrin, alpha 1)"103100.061-0.3200No
36778"CACNA1F (calcium channel, voltage-dependent, L type, alpha 1F subunit)"104700.020-0.3278No
373696"ITGB8 (integrin, beta 8)"10596-0.003-0.3340No
383674"ITGA2B (integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41))"10821-0.051-0.3450No
3955799"CACNA2D3 (calcium channel, voltage-dependent, alpha 2/delta subunit 3)"10930-0.078-0.3502No
407137TNNI3 (troponin I type 3 (cardiac))11047-0.103-0.3558No
4193589"CACNA2D4 (calcium channel, voltage-dependent, alpha 2/delta subunit 4)"11422-0.196-0.3740No
423676"ITGA4 (integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor))"11477-0.208-0.3765No
437042"TGFB2 (transforming growth factor, beta 2)"11675-0.254-0.3859No
4459283"CACNG8 (calcium channel, voltage-dependent, gamma subunit 8)"11764-0.273-0.3899No
457139TNNT2 (troponin T type 2 (cardiac))11924-0.306-0.3974No
4622801"ITGA11 (integrin, alpha 11)"11965-0.314-0.3990No
477134TNNC1 (troponin C type 1 (slow))12041-0.334-0.4023No
4827091"CACNG5 (calcium channel, voltage-dependent, gamma subunit 5)"12129-0.354-0.4061No
4953632"PRKAG3 (protein kinase, AMP-activated, gamma 3 non-catalytic subunit)"12210-0.374-0.4096No
507124"TNF (tumor necrosis factor (TNF superfamily, member 2))"12777-0.537-0.4369No
5159284"CACNG7 (calcium channel, voltage-dependent, gamma subunit 7)"13119-0.643-0.4530No
524625"MYH7 (myosin, heavy chain 7, cardiac muscle, beta)"13395-0.740-0.4656No
538515"ITGA10 (integrin, alpha 10)"13455-0.762-0.4676No
545563"PRKAA2 (protein kinase, AMP-activated, alpha 2 catalytic subunit)"13762-0.881-0.4817No
55781"CACNA2D1 (calcium channel, voltage-dependent, alpha 2/delta subunit 1)"14094-1.044-0.4967No
566442"SGCA (sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein))"14500-1.239-0.5152No
57782"CACNB1 (calcium channel, voltage-dependent, beta 1 subunit)"14788-1.415-0.5277No
584634"MYL3 (myosin, light chain 3, alkali; ventricular, skeletal, slow)"14883-1.476-0.5305No
59779"CACNA1S (calcium channel, voltage-dependent, L type, alpha 1S subunit)"14936-1.512-0.5312No
608516"ITGA8 (integrin, alpha 8)"15186-1.713-0.5414No
61784"CACNB3 (calcium channel, voltage-dependent, beta 3 subunit)"15437-1.904-0.5515No
621756DMD (dystrophin)15542-2.006-0.5541No
633690"ITGB3 (integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61))"15709-2.159-0.5597No
64785"CACNB4 (calcium channel, voltage-dependent, beta 4 subunit)"15727-2.181-0.5579No
65776"CACNA1D (calcium channel, voltage-dependent, L type, alpha 1D subunit)"16107-2.645-0.5733No
663655"ITGA6 (integrin, alpha 6)"16228-2.794-0.5759No
677171TPM4 (tropomyosin 4)16633-3.467-0.5916No
683678"ITGA5 (integrin, alpha 5 (fibronectin receptor, alpha polypeptide))"16955-4.130-0.6024No
694000LMNA (lamin A/C)17307-5.012-0.6136No
705565"PRKAB2 (protein kinase, AMP-activated, beta 2 non-catalytic subunit)"17504-5.657-0.6163No
7127092"CACNG4 (calcium channel, voltage-dependent, gamma subunit 4)"17895-7.344-0.6266Yes
724607"MYBPC3 (myosin binding protein C, cardiac)"17937-7.595-0.6193Yes
737043"TGFB3 (transforming growth factor, beta 3)"18102-8.466-0.6171Yes
743691"ITGB4 (integrin, beta 4)"18322-9.752-0.6159Yes
757170TPM3 (tropomyosin 3)18580-11.843-0.6141Yes
7659285"CACNG6 (calcium channel, voltage-dependent, gamma subunit 6)"18669-12.766-0.6029Yes
773694"ITGB6 (integrin, beta 6)"18774-13.800-0.5911Yes
783685"ITGAV (integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51))"19403-25.664-0.5907Yes
793693"ITGB5 (integrin, beta 5)"19543-29.664-0.5613Yes
801605DAG1 (dystroglycan 1 (dystrophin-associated glycoprotein 1))19828-44.564-0.5207Yes
816445"SGCG (sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein))"20063-70.736-0.4457Yes
8271"ACTG1 (actin, gamma 1)"20270-173.229-0.2438Yes
8360"ACTB (actin, beta)"20292-201.3250.0016Yes
Table: GSEA details [plain text format]



Fig 2: KEGG|HSA05410   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: KEGG|HSA05410: Random ES distribution   
Gene set null distribution of ES for KEGG|HSA05410