Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classcont
GeneSetPATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA|IL12-MEDIATED SIGNALING EVENTS
Enrichment Score (ES)-0.71140575
Normalized Enrichment Score (NES)-1.7184052
Nominal p-value0.0029850747
FDR q-value0.104168065
FWER p-Value0.815
Table: GSEA Results Summary



Fig 1: Enrichment plot: PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA|IL12-MEDIATED SIGNALING EVENTS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
14616"GADD45B (growth arrest and DNA-damage-inducible, beta)"88841.0660.0077No
23717JAK2 (Janus kinase 2 (a protein tyrosine kinase))152624.9470.0076No
33123"HLA-DRB1 (major histocompatibility complex, class II, DR beta 1)"257913.655-0.0272No
44791NFKB2 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100))32009.972-0.0452No
55606MAP2K3 (mitogen-activated protein kinase kinase 3)35818.419-0.0534No
62353FOS (v-fos FBJ murine osteosarcoma viral oncogene homolog)39386.979-0.0622No
72475FRAP1 (FK506 binding protein 12-rapamycin associated protein 1)51353.745-0.1165No
84843"NOS2A (nitric oxide synthase 2A (inducible, hepatocytes))"55023.060-0.1308No
98320EOMES (eomesodermin homolog (Xenopus laevis))61512.165-0.1600No
106778"STAT6 (signal transducer and activator of transcription 6, interleukin-4 induced)"67371.560-0.1869No
111386ATF2 (activating transcription factor 2)67841.528-0.1873No
128807IL18RAP (interleukin 18 receptor accessory protein)68021.511-0.1862No
1310912"GADD45G (growth arrest and DNA-damage-inducible, gamma)"69711.361-0.1928No
143606IL18 (interleukin 18 (interferon-gamma-inducing factor))71461.235-0.1998No
153142HLX (H2.0-like homeobox)75320.976-0.2176No
166776STAT5A (signal transducer and activator of transcription 5A)75860.951-0.2190No
178651SOCS1 (suppressor of cytokine signaling 1)78250.822-0.2297No
18915"CD3D (CD3d molecule, delta (CD3-TCR complex))"80760.700-0.2412No
198809IL18R1 (interleukin 18 receptor 1)81580.671-0.2443No
206348CCL3 (chemokine (C-C motif) ligand 3)82940.617-0.2502No
213558IL2 (interleukin 2)83650.590-0.2529No
223932LCK (lymphocyte-specific protein tyrosine kinase)86020.511-0.2639No
231234CCR5 (chemokine (C-C motif) receptor 5)87600.457-0.2711No
24356"FASLG (Fas ligand (TNF superfamily, member 6))"91550.344-0.2901No
2530009TBX21 (T-box 21)94260.272-0.3031No
263595"IL12RB2 (interleukin 12 receptor, beta 2)"96860.211-0.3156No
273458"IFNG (interferon, gamma)"98350.174-0.3227No
283001"GZMA (granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3))"98480.171-0.3231No
29919CD247 (CD247 molecule)98650.167-0.3237No
303002"GZMB (granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1))"104540.024-0.3527No
313559"IL2RA (interleukin 2 receptor, alpha)"10998-0.092-0.3793No
326351CCL4 (chemokine (C-C motif) ligand 4)11194-0.143-0.3888No
333593"IL12B (interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40))"11374-0.185-0.3974No
343553"IL1B (interleukin 1, beta)"11912-0.304-0.4235No
353592"IL12A (interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35))"12016-0.327-0.4282No
36920CD4 (CD4 molecule)12457-0.446-0.4493No
3756848SPHK2 (sphingosine kinase 2)12748-0.527-0.4630No
38925CD8A (CD8a molecule)13489-0.771-0.4985No
39926CD8B (CD8b molecule)14383-1.176-0.5411No
40917"CD3G (CD3g molecule, gamma (CD3-TCR complex))"14522-1.255-0.5463No
413565IL4 (interleukin 4)14888-1.480-0.5625No
425971RELB (v-rel reticuloendotheliosis viral oncogene homolog B)15250-1.754-0.5781No
433594"IL12RB1 (interleukin 12 receptor, beta 1)"15945-2.429-0.6093No
446775STAT4 (signal transducer and activator of transcription 4)16188-2.744-0.6178No
455608MAP2K6 (mitogen-activated protein kinase kinase 6)16252-2.828-0.6173No
463561"IL2RG (interleukin 2 receptor, gamma (severe combined immunodeficiency))"16409-3.071-0.6212No
471432MAPK14 (mitogen-activated protein kinase 14)16465-3.158-0.6199No
487297TYK2 (tyrosine kinase 2)16697-3.598-0.6268No
49916"CD3E (CD3e molecule, epsilon (CD3-TCR complex))"16842-3.845-0.6291No
503560"IL2RB (interleukin 2 receptor, beta)"16974-4.182-0.6303No
514790NFKB1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 1)17493-5.614-0.6488No
523122"HLA-DRA (major histocompatibility complex, class II, DR alpha)"17997-7.888-0.6637No
535970RELA (v-rel reticuloendotheliosis viral oncogene homolog A (avian))18184-8.954-0.6617No
548767RIPK2 (receptor-interacting serine-threonine kinase 2)18377-10.118-0.6585No
556774STAT3 (signal transducer and activator of transcription 3 (acute-phase response factor))19451-27.002-0.6775Yes
567879"RAB7A (RAB7A, member RAS oncogene family)"19623-32.714-0.6449Yes
573554"IL1R1 (interleukin 1 receptor, type I)"19759-39.637-0.6018Yes
583105"HLA-A (major histocompatibility complex, class I, A)"20027-65.132-0.5332Yes
596772"STAT1 (signal transducer and activator of transcription 1, 91kDa)"20302-215.432-0.2763Yes
60567B2M (beta-2-microglobulin)20305-220.9820.0010Yes
Table: GSEA details [plain text format]



Fig 2: PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA|IL12-MEDIATED SIGNALING EVENTS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA|IL12-MEDIATED SIGNALING EVENTS: Random ES distribution   
Gene set null distribution of ES for PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA|IL12-MEDIATED SIGNALING EVENTS