Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classtreated
GeneSetGO|GO:0006261
Enrichment Score (ES)0.7545145
Normalized Enrichment Score (NES)1.6576405
Nominal p-value0.0
FDR q-value0.026844855
FWER p-Value0.646
Table: GSEA Results Summary



Fig 1: Enrichment plot: GO|GO:0006261   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
14175MCM6 (minichromosome maintenance complex component 6)78163.8120.0744Yes
25111PCNA (proliferating cell nuclear antigen)102146.2210.1431Yes
34176MCM7 (minichromosome maintenance complex component 7)145121.4390.1990Yes
45983"RFC3 (replication factor C (activator 1) 3, 38kDa)"215100.3380.2436Yes
58099CDK2AP1 (CDK2-associated protein 1)23197.1750.2892Yes
64171MCM2 (minichromosome maintenance complex component 2)25991.9010.3318Yes
72237FEN1 (flap structure-specific endonuclease 1)34879.3160.3653Yes
851659GINS2 (GINS complex subunit 2 (Psf2 homolog))42469.2840.3947Yes
979892C10orf119 (chromosome 10 open reading frame 119)66151.4060.4076Yes
109837GINS1 (GINS complex subunit 1 (Psf1 homolog))73147.8330.4271Yes
115557"PRIM1 (primase, DNA, polypeptide 1 (49kDa))"75647.0790.4484Yes
124172MCM3 (minichromosome maintenance complex component 3)81643.8920.4664Yes
135425"POLD2 (polymerase (DNA directed), delta 2, regulatory subunit 50kDa)"91240.2180.4809Yes
1454962TIPIN (TIMELESS interacting protein)92739.5320.4991Yes
154174MCM5 (minichromosome maintenance complex component 5)95438.3410.5162Yes
167884SLBP (stem-loop binding protein)96637.9850.5338Yes
179126SMC3 (structural maintenance of chromosomes 3)99837.0970.5499Yes
1811177"BAZ1A (bromodomain adjacent to zinc finger domain, 1A)"110033.7300.5611Yes
197019"TFAM (transcription factor A, mitochondrial)"126729.7270.5671Yes
205982"RFC2 (replication factor C (activator 1) 2, 40kDa)"128829.3030.5801Yes
216119"RPA3 (replication protein A3, 14kDa)"128929.2970.5941Yes
228243SMC1A (structural maintenance of chromosomes 1A)159723.9870.5904Yes
2323649"POLA2 (polymerase (DNA directed), alpha 2 (70kD subunit))"159823.9760.6018Yes
245985"RFC5 (replication factor C (activator 1) 5, 36.5kDa)"161723.6760.6122Yes
254998"ORC1L (origin recognition complex, subunit 1-like (yeast))"165823.1330.6213Yes
264683NBN (nibrin)170622.3160.6297Yes
2781620CDT1 (chromatin licensing and DNA replication factor 1)179021.2050.6357Yes
285888"RAD51 (RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae))"182220.7980.6441Yes
294999"ORC2L (origin recognition complex, subunit 2-like (yeast))"183020.7700.6537Yes
305424"POLD1 (polymerase (DNA directed), delta 1, catalytic subunit 125kDa)"186620.3340.6617Yes
314173MCM4 (minichromosome maintenance complex component 4)193819.6300.6675Yes
3284515MCM8 (minichromosome maintenance complex component 8)194919.4440.6763Yes
3356897WRNIP1 (Werner helicase interacting protein 1)202818.5010.6813Yes
345001"ORC5L (origin recognition complex, subunit 5-like (yeast))"203018.4860.6901Yes
355558"PRIM2 (primase, DNA, polypeptide 2 (58kDa))"203118.4850.6989Yes
366118"RPA2 (replication protein A2, 32kDa)"204818.3550.7069Yes
378318CDC45L (CDC45 cell division cycle 45-like (S. cerevisiae))215117.4750.7102Yes
387486WRN (Werner syndrome)216617.3860.7178Yes
395427"POLE2 (polymerase (DNA directed), epsilon 2 (p59 subunit))"217617.3320.7256Yes
405984"RFC4 (replication factor C (activator 1) 4, 37kDa)"233515.7350.7254Yes
414361MRE11A (MRE11 meiotic recombination 11 homolog A (S. cerevisiae))245714.7160.7264Yes
4256652C10orf2 (chromosome 10 open reading frame 2)246614.6760.7330Yes
435981"RFC1 (replication factor C (activator 1) 1, 145kDa)"251914.0980.7372Yes
445422"POLA1 (polymerase (DNA directed), alpha 1, catalytic subunit)"254313.9450.7427Yes
456117"RPA1 (replication protein A1, 70kDa)"254913.8880.7491Yes
46222229LRWD1 (leucine-rich repeats and WD repeat domain containing 1)257313.6950.7545Yes
4790381C15orf42 (chromosome 15 open reading frame 42)276912.3700.7508No
4810714"POLD3 (polymerase (DNA-directed), delta 3, accessory subunit)"309710.4490.7396No
4979736C17orf42 (chromosome 17 open reading frame 42)33319.4270.7326No
505813PURA (purine-rich element binding protein A)33729.2740.7351No
5111232"POLG2 (polymerase (DNA directed), gamma 2, accessory subunit)"34279.0640.7368No
52641BLM (Bloom syndrome)35528.5830.7347No
5355294FBXW7 (F-box and WD repeat domain containing 7)37507.6970.7287No
5484268RPAIN (RPA interacting protein)42126.0530.7088No
5584296GINS4 (GINS complex subunit 4 (Sld5 homolog))44135.4610.7015No
564796NFKBIL2 (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2)48444.3710.6824No
575980"REV3L (REV3-like, catalytic subunit of DNA polymerase zeta (yeast))"51453.7210.6693No
585426"POLE (polymerase (DNA directed), epsilon)"58782.5200.6344No
591763DNA2 (DNA replication helicase 2 homolog (yeast))60492.3100.6271No
6092797HELB (helicase (DNA) B)63861.8950.6114No
6154617INO80 (INO80 homolog (S. cerevisiae))68341.4760.5901No
627013TERF1 (telomeric repeat binding factor (NIMA-interacting) 1)74121.0590.5621No
6329935"RPA4 (replication protein A4, 34kDa)"81200.6840.5275No
643978"LIG1 (ligase I, DNA, ATP-dependent)"10691-0.0240.4006No
655428"POLG (polymerase (DNA directed), gamma)"10805-0.0480.3950No
66340533KIAA2022 (KIAA2022)13859-0.9270.2447No
675423"POLB (polymerase (DNA directed), beta)"15243-1.7500.1772No
683159HMGA1 (high mobility group AT-hook 1)16865-3.9170.0991No
6957804"POLD4 (polymerase (DNA-directed), delta 4)"17078-4.4470.0907No
7011284PNKP (polynucleotide kinase 3'-phosphatase)17615-6.0770.0671No
71997CDC34 (cell division cycle 34 homolog (S. cerevisiae))17810-6.9600.0609No
727014TERF2 (telomeric repeat binding factor 2)18350-9.9210.0390No
735000"ORC4L (origin recognition complex, subunit 4-like (yeast))"18666-12.7060.0295No
747153TOP2A (topoisomerase (DNA) II alpha 170kDa)19279-22.3860.0100No
757155TOP2B (topoisomerase (DNA) II beta 180kDa)19771-40.6210.0052No
7610735STAG2 (stromal antigen 2)19852-46.3800.0234No
Table: GSEA details [plain text format]



Fig 2: GO|GO:0006261   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: GO|GO:0006261: Random ES distribution   
Gene set null distribution of ES for GO|GO:0006261