Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classtreated
GeneSetGO|GO:0034660
Enrichment Score (ES)0.705282
Normalized Enrichment Score (NES)1.694809
Nominal p-value0.0
FDR q-value0.01517902
FWER p-Value0.246
Table: GSEA Results Summary



Fig 1: Enrichment plot: GO|GO:0034660   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
155651"NOLA2 (nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs))"16288.7670.0436Yes
23735KARS (lysyl-tRNA synthetase)40210.7150.0748Yes
36635SNRPE (small nuclear ribonucleoprotein polypeptide E)43207.4330.1066Yes
46636SNRPF (small nuclear ribonucleoprotein polypeptide F)93154.3880.1279Yes
551602NOP5/NOP58 (nucleolar protein NOP5/NOP58)106143.5740.1494Yes
610436EMG1 (EMG1 nucleolar protein homolog (S. cerevisiae))107143.2520.1714Yes
79221NOLC1 (nucleolar and coiled-body phosphoprotein 1)110140.4150.1929Yes
86209RPS15 (ribosomal protein S15)122130.5170.2124Yes
93376IARS (isoleucyl-tRNA synthetase)127127.8060.2319Yes
1025929GEMIN5 (gem (nuclear organelle) associated protein 5)175109.0630.2463Yes
114677NARS (asparaginyl-tRNA synthetase)181107.3440.2625Yes
126634SNRPD3 (small nuclear ribonucleoprotein D3 polypeptide 18kDa)196103.4340.2777Yes
132617GARS (glycyl-tRNA synthetase)210101.5320.2927Yes
1487178PNPT1 (polyribonucleotide nucleotidyltransferase 1)22598.2510.3071Yes
156135RPL11 (ribosomal protein L11)24793.7090.3205Yes
1692856"IMP4 (IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast))"25592.3090.3343Yes
176301SARS (seryl-tRNA synthetase)29486.3830.3457Yes
185464PPA1 (pyrophosphatase (inorganic) 1)30584.8010.3582Yes
196201RPS7 (ribosomal protein S7)32183.3590.3703Yes
206632SNRPD1 (small nuclear ribonucleoprotein D1 polypeptide 16kDa)35278.9030.3810Yes
2110528NOL5A (nucleolar protein 5A (56kDa with KKE/D repeat))35378.8900.3931Yes
2284365MKI67IP (MKI67 (FHA domain) interacting nucleolar phosphoprotein)37875.3700.4035Yes
239255"SCYE1 (small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating))"38474.8060.4147Yes
246741SSB (Sjogren syndrome antigen B (autoantigen La))39073.8580.4258Yes
2555759WDR12 (WD repeat domain 12)39572.8650.4368Yes
2610419PRMT5 (protein arginine methyltransferase 5)41371.0430.4469Yes
272193"FARSA (phenylalanyl-tRNA synthetase, alpha subunit)"41770.5670.4576Yes
2855699"IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial)"45366.1120.4660Yes
2923246BOP1 (block of proliferation 1)46265.0150.4756Yes
306217RPS16 (ribosomal protein S16)46664.9090.4855Yes
3179731"NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial (putative))"46764.8590.4954Yes
327965JTV1 (JTV1 gene)48563.4500.5043Yes
3310056"FARSB (phenylalanyl-tRNA synthetase, beta subunit)"49362.3880.5136Yes
346633SNRPD2 (small nuclear ribonucleoprotein D2 polypeptide 16.5kDa)52860.4710.5212Yes
356129RPL7 (ribosomal protein L7)54359.1900.5296Yes
369045RPL14 (ribosomal protein L14)55758.2010.5379Yes
376897TARS (threonyl-tRNA synthetase)56857.5050.5462Yes
386229RPS24 (ribosomal protein S24)63253.3400.5513Yes
399521EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1)66251.3930.5578Yes
4051095"TRNT1 (tRNA nucleotidyl transferase, CCA-adding, 1)"66451.2050.5656Yes
416628SNRPB (small nuclear ribonucleoprotein polypeptides B and B1)69749.7170.5716Yes
423035HARS (histidyl-tRNA synthetase)72048.2410.5780Yes
43113802C1orf59 (chromosome 1 open reading frame 59)80744.5130.5805Yes
444686"NCBP1 (nuclear cap binding protein subunit 1, 80kDa)"86042.2660.5845Yes
45283989TSEN54 (tRNA splicing endonuclease 54 homolog (S. cerevisiae))89040.9180.5893Yes
464234METTL1 (methyltransferase like 1)91340.2020.5944Yes
4779084WDR77 (WD repeat domain 77)95038.4490.5985Yes
4879833GEMIN6 (gem (nuclear organelle) associated protein 6)96737.9740.6036Yes
4922916"NCBP2 (nuclear cap binding protein subunit 2, 20kDa)"98637.5280.6084Yes
5023405"DICER1 (dicer 1, ribonuclease type III)"99537.1810.6138Yes
5123481"PES1 (pescadillo homolog 1, containing BRCT domain (zebrafish))"102536.0270.6179Yes
528565YARS (tyrosyl-tRNA synthetase)105735.0650.6217Yes
5380324PUS1 (pseudouridylate synthase 1)106634.6890.6266Yes
547453WARS (tryptophanyl-tRNA synthetase)106934.5810.6319Yes
5588745C6orf153 (chromosome 6 open reading frame 153)110333.6190.6354Yes
5651119SBDS (Shwachman-Bodian-Diamond syndrome)112033.2040.6397Yes
5754888"NSUN2 (NOL1/NOP2/Sun domain family, member 2)"116132.0540.6426Yes
581207"CLNS1A (chloride channel, nucleotide-sensitive, 1A)"118631.4530.6463Yes
5954512EXOSC4 (exosome component 4)118931.2930.6510Yes
6051520LARS (leucyl-tRNA synthetase)119431.2420.6556Yes
616606"SMN1 (survival of motor neuron 1, telomeric)"123330.3500.6584Yes
6256915EXOSC5 (exosome component 5)135327.7710.6567Yes
636165RPL35A (ribosomal protein L35a)135727.7020.6608Yes
6429960FTSJ2 (FtsJ homolog 2 (E. coli))138527.2900.6637Yes
6551493C22orf28 (chromosome 22 open reading frame 28)139027.1850.6677Yes
665393EXOSC9 (exosome component 9)139127.1610.6719Yes
6711218DDX20 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 20)142026.7190.6746Yes
685917RARS (arginyl-tRNA synthetase)144026.3950.6777Yes
6957508INTS2 (integrator complex subunit 2)144926.2160.6813Yes
7023517SKIV2L2 (superkiller viralicidic activity 2-like 2 (S. cerevisiae))152924.8940.6812Yes
71283459"GATC (glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial))"155124.6610.6840Yes
72124454"EARS2 (glutamyl-tRNA synthetase 2, mitochondrial (putative))"155624.5570.6876Yes
7350628GEMIN4 (gem (nuclear organelle) associated protein 4)158924.0860.6897Yes
7481605URM1 (ubiquitin related modifier 1 homolog (S. cerevisiae))165723.1360.6899Yes
7551808"RNUXA (RNA U, small nuclear RNA export adaptor (phosphorylation regulated))"166023.1000.6934Yes
768602NOL14 (nucleolar protein 14)168622.5950.6956Yes
7710785WDR4 (WD repeat domain 4)173221.9740.6967Yes
781615DARS (aspartyl-tRNA synthetase)178421.3110.6975Yes
79201164"PLD6 (phospholipase D family, member 6)"182720.7830.6986Yes
8023536"ADAT1 (adenosine deaminase, tRNA-specific 1)"187420.1960.6994Yes
8155656INTS8 (integrator complex subunit 8)188520.1240.7020Yes
8280746TSEN2 (tRNA splicing endonuclease 2 homolog (S. cerevisiae))191319.8420.7037Yes
8316AARS (alanyl-tRNA synthetase)202718.5290.7010Yes
8479760GEMIN7 (gem (nuclear organelle) associated protein 7)205718.2560.7023Yes
8551010EXOSC3 (exosome component 3)207318.0990.7044Yes
8610667"FARS2 (phenylalanyl-tRNA synthetase 2, mitochondrial)"215817.4460.7029Yes
876895TARBP2 (TAR (HIV-1) RNA binding protein 2)225116.6370.7009Yes
8827340"UTP20 (UTP20, small subunit (SSU) processome component, homolog (yeast))"225716.5250.7032Yes
8954974THG1L (tRNA-histidine guanylyltransferase 1-like (S. cerevisiae))226616.4100.7053Yes
9051067"YARS2 (tyrosyl-tRNA synthetase 2, mitochondrial)"238115.2820.7020No
912058EPRS (glutamyl-prolyl-tRNA synthetase)242214.9580.7023No
924141MARS (methionyl-tRNA synthetase)249514.3130.7009No
9365123INTS3 (integrator complex subunit 3)255013.8830.7004No
9410200MPHOSPH6 (M-phase phosphoprotein 6)262813.2310.6986No
95348180C16orf84 (chromosome 16 open reading frame 84)264313.1270.6999No
9680789INTS5 (integrator complex subunit 5)264513.1140.7019No
9755174INTS10 (integrator complex subunit 10)267312.9980.7025No
9879050NOC4L (nucleolar complex associated 4 homolog (S. cerevisiae))284811.9620.6957No
9957038"RARS2 (arginyl-tRNA synthetase 2, mitochondrial)"294811.3400.6926No
10079691QTRTD1 (queuine tRNA-ribosyltransferase domain containing 1)298311.1000.6926No
101162989DEDD2 (death effector domain containing 2)313210.2760.6868No
10227304MOCS3 (molybdenum cofactor synthesis 3)313510.2570.6883No
10365083NOL6 (nucleolar protein family 6 (RNA-associated))31929.9990.6871No
1044087SMAD2 (SMAD family member 2)32089.9120.6878No
10579587"CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial (putative))"32159.8800.6891No
10610352"WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial)"32269.8230.6901No
10754464XRN1 (5'-3' exoribonuclease 1)32639.6670.6898No
1087407VARS (valyl-tRNA synthetase)32669.6600.6912No
10979707NOL9 (nucleolar protein 9)32849.6050.6918No
11057176"VARS2 (valyl-tRNA synthetase 2, mitochondrial (putative))"33429.3810.6904No
11196764TGS1 (trimethylguanosine synthase homolog (S. cerevisiae))33889.2000.6896No
11290459THEX1 (three prime histone mRNA exonuclease 1)34818.8030.6864No
11310940"POP1 (processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae))"35708.4680.6833No
11422894DIS3 (DIS3 mitotic control homolog (S. cerevisiae))37837.5770.6740No
11527068PPA2 (pyrophosphatase (inorganic) 2)39486.9640.6669No
11655157"DARS2 (aspartyl-tRNA synthetase 2, mitochondrial)"39736.8770.6668No
11755756INTS9 (integrator complex subunit 9)41626.2160.6584No
1188487SIP1 (survival of motor neuron protein interacting protein 1)42336.0090.6558No
11910438C1D (nuclear DNA-binding protein)43265.7000.6521No
120115752DIS3L (DIS3 mitotic control homolog (S. cerevisiae)-like)44305.4300.6479No
12126512INTS6 (integrator complex subunit 6)44395.4040.6483No
12257117INTS12 (integrator complex subunit 12)45715.0630.6426No
12323395"LARS2 (leucyl-tRNA synthetase 2, mitochondrial)"46094.9480.6415No
12454487DGCR8 (DiGeorge syndrome critical region gene 8)49314.1660.6262No
12581890QTRT1 (queuine tRNA-ribosyltransferase 1)54383.1760.6016No
12625896INTS7 (integrator complex subunit 7)54523.1620.6014No
12780222"TARS2 (threonyl-tRNA synthetase 2, mitochondrial (putative))"55093.0500.5991No
12827161"EIF2C2 (eukaryotic translation initiation factor 2C, 2)"55393.0050.5982No
12910978"CLP1 (CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae))"57832.6370.5865No
13057505"AARS2 (alanyl-tRNA synthetase 2, mitochondrial (putative))"58492.5520.5837No
13155278QRSL1 (glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1)61542.1650.5689No
1325394EXOSC10 (exosome component 10)62762.0230.5632No
13392935"MARS2 (methionyl-tRNA synthetase 2, mitochondrial)"63321.9570.5608No
13455687TRMU (tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase)66831.6070.5437No
13554802TRIT1 (tRNA isopentenyltransferase 1)70321.3240.5266No
1364086SMAD1 (SMAD family member 1)87060.4790.4437No
1376125RPL5 (ribosomal protein L5)87410.4650.4421No
13856165TDRD1 (tudor domain containing 1)91790.3390.4204No
139389421LIN28B (lin-28 homolog B (C. elegans))99430.1480.3826No
140143689PIWIL4 (piwi-like 4 (Drosophila))105000.0140.3550No
14179727LIN28 (lin-28 homolog (C. elegans))11232-0.1500.3188No
142122402TDRD9 (tudor domain containing 9)12182-0.3680.2717No
143129450C2orf60 (chromosome 2 open reading frame 60)12356-0.4160.2632No
144136991"ASZ1 (ankyrin repeat, SAM and basic leucine zipper domain containing 1)"12989-0.6020.2319No
14584944MAEL (maelstrom homolog (Drosophila))13360-0.7260.2137No
14691801"ALKBH8 (alkB, alkylation repair homolog 8 (E. coli))"15416-1.8850.1120No
14755124PIWIL2 (piwi-like 2 (Drosophila))15626-2.0710.1020No
14825973"PARS2 (prolyl-tRNA synthetase 2, mitochondrial (putative))"15762-2.2230.0956No
14910595ERN2 (endoplasmic reticulum to nucleus signaling 2)16031-2.5380.0827No
15054938"SARS2 (seryl-tRNA synthetase 2, mitochondrial)"16128-2.6720.0784No
1515303"PIN4 (protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin))"16171-2.7210.0767No
1526202RPS8 (ribosomal protein S8)16179-2.7280.0768No
1535188PET112L (PET112-like (yeast))16674-3.5490.0528No
15423318"ZCCHC11 (zinc finger, CCHC domain containing 11)"16916-4.0260.0415No
15592105INTS4 (integrator complex subunit 4)16949-4.1180.0405No
15664852"TUT1 (terminal uridylyl transferase 1, U6 snRNA-specific)"16954-4.1290.0409No
15710073SNUPN (snurportin 1)16960-4.1450.0413No
15826173INTS1 (integrator complex subunit 1)17371-5.1970.0218No
15923438"HARS2 (histidyl-tRNA synthetase 2, mitochondrial (putative))"17469-5.5230.0178No
16054853WDR55 (WD repeat domain 55)18030-8.043-0.0087No
1614088SMAD3 (SMAD family member 3)18573-11.772-0.0338No
1626637SNRPG (small nuclear ribonucleoprotein polypeptide G)19107-18.986-0.0573No
1636227RPS21 (ribosomal protein S21)19135-19.508-0.0557No
164833CARS (cysteinyl-tRNA synthetase)19280-22.411-0.0594No
1655859QARS (glutaminyl-tRNA synthetase)19303-22.978-0.0569No
1663921RPSA (ribosomal protein SA)19315-23.344-0.0539No
16751593ARS2 (arsenate resistance protein 2)19417-26.154-0.0549No
1686194RPS6 (ribosomal protein S6)20091-76.100-0.0766No
1696208RPS14 (ribosomal protein S14)20109-82.199-0.0648No
1706234RPS28 (ribosomal protein S28)20178-103.480-0.0523No
1716218RPS17 (ribosomal protein S17)20283-190.183-0.0282No
1726223RPS19 (ribosomal protein S19)20288-196.6800.0018No
Table: GSEA details [plain text format]



Fig 2: GO|GO:0034660   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: GO|GO:0034660: Random ES distribution   
Gene set null distribution of ES for GO|GO:0034660