Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | cont |
GeneSet | GO|GO:0030133 |
Enrichment Score (ES) | -0.7995264 |
Normalized Enrichment Score (NES) | -1.9036759 |
Nominal p-value | 0.0 |
FDR q-value | 0.002433711 |
FWER p-Value | 0.0060 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 203547 | LOC203547 (hypothetical protein LOC203547) | 1126 | 33.003 | -0.0375 | No | ||
2 | 90411 | MCFD2 (multiple coagulation factor deficiency 2) | 1169 | 31.966 | -0.0220 | No | ||
3 | 858 | CAV2 (caveolin 2) | 2971 | 11.142 | -0.1048 | No | ||
4 | 80023 | NRSN2 (neurensin 2) | 3183 | 10.037 | -0.1097 | No | ||
5 | 11161 | C14orf1 (chromosome 14 open reading frame 1) | 3298 | 9.540 | -0.1101 | No | ||
6 | 8269 | TMEM187 (transmembrane protein 187) | 3603 | 8.333 | -0.1205 | No | ||
7 | 55435 | C4orf16 (chromosome 4 open reading frame 16) | 3604 | 8.332 | -0.1159 | No | ||
8 | 6857 | SYT1 (synaptotagmin I) | 3926 | 7.010 | -0.1279 | No | ||
9 | 1174 | "AP1S1 (adaptor-related protein complex 1, sigma 1 subunit)" | 4682 | 4.756 | -0.1626 | No | ||
10 | 160 | "AP2A1 (adaptor-related protein complex 2, alpha 1 subunit)" | 4698 | 4.725 | -0.1607 | No | ||
11 | 51324 | "SPG21 (spastic paraplegia 21 (autosomal recessive, Mast syndrome))" | 4918 | 4.193 | -0.1692 | No | ||
12 | 10427 | "SEC24B (SEC24 related gene family, member B (S. cerevisiae))" | 5222 | 3.561 | -0.1822 | No | ||
13 | 5864 | "RAB3A (RAB3A, member RAS oncogene family)" | 5286 | 3.419 | -0.1835 | No | ||
14 | 762 | CA4 (carbonic anhydrase IV) | 5794 | 2.623 | -0.2071 | No | ||
15 | 1176 | "AP3S1 (adaptor-related protein complex 3, sigma 1 subunit)" | 5822 | 2.587 | -0.2070 | No | ||
16 | 359 | AQP2 (aquaporin 2 (collecting duct)) | 6496 | 1.785 | -0.2392 | No | ||
17 | 81562 | "LMAN2L (lectin, mannose-binding 2-like)" | 6879 | 1.430 | -0.2573 | No | ||
18 | 23392 | KIAA0368 (KIAA0368) | 6922 | 1.396 | -0.2586 | No | ||
19 | 78992 | "YIPF2 (Yip1 domain family, member 2)" | 7390 | 1.071 | -0.2811 | No | ||
20 | 163882 | C1orf71 (chromosome 1 open reading frame 71) | 8114 | 0.686 | -0.3164 | No | ||
21 | 117248 | GALNTL2 (UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2) | 8630 | 0.503 | -0.3415 | No | ||
22 | 8906 | "AP1G2 (adaptor-related protein complex 1, gamma 2 subunit)" | 8858 | 0.428 | -0.3525 | No | ||
23 | 57120 | GOPC (golgi associated PDZ and coiled-coil motif containing) | 8885 | 0.421 | -0.3535 | No | ||
24 | 6572 | "SLC18A3 (solute carrier family 18 (vesicular acetylcholine), member 3)" | 9024 | 0.377 | -0.3601 | No | ||
25 | 140767 | NRSN1 (neurensin 1) | 9551 | 0.241 | -0.3860 | No | ||
26 | 6570 | "SLC18A1 (solute carrier family 18 (vesicular monoamine), member 1)" | 9563 | 0.238 | -0.3864 | No | ||
27 | 83988 | NCALD (neurocalcin delta) | 9741 | 0.197 | -0.3950 | No | ||
28 | 261729 | STEAP2 (six transmembrane epithelial antigen of the prostate 2) | 12567 | -0.474 | -0.5342 | No | ||
29 | 57586 | SYT13 (synaptotagmin XIII) | 12788 | -0.541 | -0.5448 | No | ||
30 | 9182 | RASSF9 (Ras association (RalGDS/AF-6) domain family (N-terminal) member 9) | 13400 | -0.741 | -0.5746 | No | ||
31 | 5873 | "RAB27A (RAB27A, member RAS oncogene family)" | 13611 | -0.820 | -0.5845 | No | ||
32 | 8082 | SSPN (sarcospan (Kras oncogene-associated gene)) | 13751 | -0.877 | -0.5908 | No | ||
33 | 6571 | "SLC18A2 (solute carrier family 18 (vesicular monoamine), member 2)" | 13806 | -0.903 | -0.5930 | No | ||
34 | 11276 | AP1GBP1 (AP1 gamma subunit binding protein 1) | 14922 | -1.502 | -0.6472 | No | ||
35 | 633 | BGN (biglycan) | 15128 | -1.662 | -0.6564 | No | ||
36 | 201294 | UNC13D (unc-13 homolog D (C. elegans)) | 15171 | -1.699 | -0.6576 | No | ||
37 | 64418 | TMEM168 (transmembrane protein 168) | 15273 | -1.775 | -0.6616 | No | ||
38 | 9871 | "SEC24D (SEC24 related gene family, member D (S. cerevisiae))" | 15378 | -1.853 | -0.6657 | No | ||
39 | 363 | "AQP6 (aquaporin 6, kidney specific)" | 15778 | -2.238 | -0.6842 | No | ||
40 | 57030 | "SLC17A7 (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7)" | 16056 | -2.581 | -0.6964 | No | ||
41 | 51128 | SAR1B (SAR1 gene homolog B (S. cerevisiae)) | 16892 | -3.976 | -0.7355 | No | ||
42 | 26119 | LDLRAP1 (low density lipoprotein receptor adaptor protein 1) | 16987 | -4.212 | -0.7378 | No | ||
43 | 6844 | VAMP2 (vesicle-associated membrane protein 2 (synaptobrevin 2)) | 17160 | -4.647 | -0.7437 | No | ||
44 | 5045 | FURIN (furin (paired basic amino acid cleaving enzyme)) | 17734 | -6.604 | -0.7684 | No | ||
45 | 83716 | CRISPLD2 (cysteine-rich secretory protein LCCL domain containing 2) | 17766 | -6.775 | -0.7662 | No | ||
46 | 9632 | "SEC24C (SEC24 related gene family, member C (S. cerevisiae))" | 18266 | -9.369 | -0.7857 | No | ||
47 | 538 | "ATP7A (ATPase, Cu++ transporting, alpha polypeptide)" | 18547 | -11.483 | -0.7932 | Yes | ||
48 | 10802 | "SEC24A (SEC24 related gene family, member A (S. cerevisiae))" | 18548 | -11.495 | -0.7869 | Yes | ||
49 | 3482 | IGF2R (insulin-like growth factor 2 receptor) | 18791 | -13.902 | -0.7912 | Yes | ||
50 | 6396 | SEC13 (SEC13 homolog (S. cerevisiae)) | 18834 | -14.381 | -0.7854 | Yes | ||
51 | 54432 | "YIPF1 (Yip1 domain family, member 1)" | 18928 | -15.605 | -0.7814 | Yes | ||
52 | 83464 | APH1B (anterior pharynx defective 1 homolog B (C. elegans)) | 18937 | -15.812 | -0.7731 | Yes | ||
53 | 25844 | "YIPF3 (Yip1 domain family, member 3)" | 19174 | -20.092 | -0.7737 | Yes | ||
54 | 10484 | SEC23A (Sec23 homolog A (S. cerevisiae)) | 19218 | -20.816 | -0.7644 | Yes | ||
55 | 3134 | "HLA-F (major histocompatibility complex, class I, F)" | 19233 | -21.099 | -0.7535 | Yes | ||
56 | 9114 | "ATP6V0D1 (ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1)" | 19347 | -24.177 | -0.7458 | Yes | ||
57 | 3133 | "HLA-E (major histocompatibility complex, class I, E)" | 19478 | -27.797 | -0.7370 | Yes | ||
58 | 51552 | "RAB14 (RAB14, member RAS oncogene family)" | 19535 | -29.482 | -0.7236 | Yes | ||
59 | 22872 | SEC31A (SEC31 homolog A (S. cerevisiae)) | 19760 | -39.650 | -0.7128 | Yes | ||
60 | 10618 | TGOLN2 (trans-golgi network protein 2) | 19850 | -46.283 | -0.6918 | Yes | ||
61 | 3135 | "HLA-G (major histocompatibility complex, class I, G)" | 19863 | -47.478 | -0.6663 | Yes | ||
62 | 3998 | "LMAN1 (lectin, mannose-binding, 1)" | 19954 | -57.564 | -0.6391 | Yes | ||
63 | 54812 | AFTPH (aftiphilin) | 19968 | -58.680 | -0.6076 | Yes | ||
64 | 3105 | "HLA-A (major histocompatibility complex, class I, A)" | 20027 | -65.132 | -0.5746 | Yes | ||
65 | 3106 | "HLA-B (major histocompatibility complex, class I, B)" | 20100 | -78.491 | -0.5351 | Yes | ||
66 | 54843 | SYTL2 (synaptotagmin-like 2) | 20210 | -119.018 | -0.4751 | Yes | ||
67 | 3107 | "HLA-C (major histocompatibility complex, class I, C)" | 20243 | -142.867 | -0.3982 | Yes | ||
68 | 5874 | "RAB27B (RAB27B, member RAS oncogene family)" | 20248 | -150.223 | -0.3159 | Yes | ||
69 | 567 | B2M (beta-2-microglobulin) | 20305 | -220.982 | -0.1973 | Yes | ||
70 | 79666 | "PLEKHF2 (pleckstrin homology domain containing, family F (with FYVE domain) member 2)" | 20321 | -360.895 | 0.0002 | Yes |