Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos
Phenotype | Phenotype.cls#treated_versus_cont_repos
Upregulated in class | treated
GeneSet | REACTOME|REACT_23947.1
Enrichment Score (ES) | 0.9350596
Normalized Enrichment Score (NES) | 1.6656836
Nominal p-value | 0.0
FDR q-value | 0.023182375
FWER p-Value | 0.552
Table: GSEA Results Summary

Fig 1: Enrichment plot: REACTOME|REACT_23947.1
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT
1 | 3312 | HSPA8 (heat shock 70kDa protein 8) |  |  | 2 | 503.357 | 0.6289 | Yes
2 | 18 | ABAT (4-aminobutyrate aminotransferase) |  |  | 30 | 246.128 | 0.9351 | Yes
3 | 2571 | "GAD1 (glutamate decarboxylase 1 (brain, 67kDa))" |  |  | 3013 | 10.953 | 0.8019 | No
4 | 7915 | "ALDH5A1 (aldehyde dehydrogenase 5 family, member A1)" |  |  | 3874 | 7.198 | 0.7686 | No
5 | 6857 | SYT1 (synaptotagmin I) |  |  | 3926 | 7.010 | 0.7748 | No
6 | 5864 | "RAB3A (RAB3A, member RAS oncogene family)" |  |  | 5286 | 3.419 | 0.7122 | No
7 | 10815 | CPLX1 (complexin 1) |  |  | 7915 | 0.777 | 0.5838 | No
8 | 6538 | "SLC6A11 (solute carrier family 6 (neurotransmitter transporter, GABA), member 11)" |  |  | 8443 | 0.562 | 0.5585 | No
9 | 140679 | "SLC32A1 (solute carrier family 32 (GABA vesicular transporter), member 1)" |  |  | 8701 | 0.480 | 0.5465 | No
10 | 22999 | RIMS1 (regulating synaptic membrane exocytosis 1) |  |  | 9653 | 0.219 | 0.4999 | No
11 | 6539 | "SLC6A12 (solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12)" |  |  | 11408 | -0.194 | 0.4138 | No
12 | 6529 | "SLC6A1 (solute carrier family 6 (neurotransmitter transporter, GABA), member 1)" |  |  | 13123 | -0.644 | 0.3302 | No
13 | 6540 | "SLC6A13 (solute carrier family 6 (neurotransmitter transporter, GABA), member 13)" |  |  | 13931 | -0.964 | 0.2917 | No
14 | 2572 | "GAD2 (glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa))" |  |  | 15306 | -1.796 | 0.2263 | No
15 | 6844 | VAMP2 (vesicle-associated membrane protein 2 (synaptobrevin 2)) |  |  | 17160 | -4.647 | 0.1408 | No
16 | 80331 | "DNAJC5 (DnaJ (Hsp40) homolog, subfamily C, member 5)" |  |  | 18592 | -11.966 | 0.0853 | No
Table: GSEA details [plain text format]

Fig 2: REACTOME|REACT_23947.1
Blue-Pink O' Gram in the Space of the Analyzed GeneSet
Fig 3: REACTOME|REACT_23947.1: Random ES distribution
Gene set null distribution of ES for REACTOME|REACT_23947.1