Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | cont |
GeneSet | REACTOME|REACT_19183.1 |
Enrichment Score (ES) | -0.8218738 |
Normalized Enrichment Score (NES) | -1.6666436 |
Nominal p-value | 0.0051020407 |
FDR q-value | 0.17908883 |
FWER p-Value | 0.994 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 7525 | YES1 (v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1) | 1987 | 18.910 | -0.0647 | No | ||
2 | 2534 | "FYN (FYN oncogene related to SRC, FGR, YES)" | 4244 | 5.992 | -0.1653 | No | ||
3 | 208 | AKT2 (v-akt murine thymoma viral oncogene homolog 2) | 4879 | 4.290 | -0.1890 | No | ||
4 | 1326 | MAP3K8 (mitogen-activated protein kinase kinase kinase 8) | 5072 | 3.886 | -0.1917 | No | ||
5 | 2475 | FRAP1 (FK506 binding protein 12-rapamycin associated protein 1) | 5135 | 3.745 | -0.1882 | No | ||
6 | 117145 | THEM4 (thioesterase superfamily member 4) | 5163 | 3.689 | -0.1830 | No | ||
7 | 5058 | PAK1 (p21 protein (Cdc42/Rac)-activated kinase 1) | 7646 | 0.920 | -0.3037 | No | ||
8 | 3932 | LCK (lymphocyte-specific protein tyrosine kinase) | 8602 | 0.511 | -0.3498 | No | ||
9 | 942 | CD86 (CD86 molecule) | 10585 | -0.000 | -0.4475 | No | ||
10 | 940 | CD28 (CD28 molecule) | 12034 | -0.333 | -0.5182 | No | ||
11 | 941 | CD80 (CD80 molecule) | 13279 | -0.692 | -0.5783 | No | ||
12 | 9020 | MAP3K14 (mitogen-activated protein kinase kinase kinase 14) | 14010 | -1.000 | -0.6125 | No | ||
13 | 7409 | VAV1 (vav 1 guanine nucleotide exchange factor) | 14093 | -1.044 | -0.6147 | No | ||
14 | 57761 | TRIB3 (tribbles homolog 3 (Drosophila)) | 15347 | -1.824 | -0.6732 | No | ||
15 | 253260 | RICTOR (rapamycin-insensitive companion of mTOR) | 16150 | -2.699 | -0.7080 | No | ||
16 | 9402 | GRAP2 (GRB2-related adaptor protein 2) | 16323 | -2.949 | -0.7113 | No | ||
17 | 64223 | GBL (G protein beta subunit-like) | 17731 | -6.592 | -0.7691 | No | ||
18 | 5290 | "PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide)" | 17764 | -6.773 | -0.7587 | No | ||
19 | 4067 | LYN (v-yes-1 Yamaguchi sarcoma viral related oncogene homolog) | 18419 | -10.518 | -0.7725 | No | ||
20 | 5295 | "PIK3R1 (phosphoinositide-3-kinase, regulatory subunit 1 (alpha))" | 19422 | -26.295 | -0.7757 | Yes | ||
21 | 207 | AKT1 (v-akt murine thymoma viral oncogene homolog 1) | 19588 | -31.123 | -0.7293 | Yes | ||
22 | 5879 | "RAC1 (ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1))" | 19612 | -32.214 | -0.6739 | Yes | ||
23 | 5062 | PAK2 (p21 protein (Cdc42/Rac)-activated kinase 2) | 19777 | -40.918 | -0.6102 | Yes | ||
24 | 5170 | PDPK1 (3-phosphoinositide dependent protein kinase-1) | 19867 | -47.955 | -0.5304 | Yes | ||
25 | 5296 | "PIK3R2 (phosphoinositide-3-kinase, regulatory subunit 2 (beta))" | 19918 | -53.218 | -0.4395 | Yes | ||
26 | 998 | "CDC42 (cell division cycle 42 (GTP binding protein, 25kDa))" | 20112 | -82.496 | -0.3043 | Yes | ||
27 | 8503 | "PIK3R3 (phosphoinositide-3-kinase, regulatory subunit 3 (gamma))" | 20275 | -179.372 | 0.0025 | Yes |