Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classtreated
GeneSetREACTOME|REACT_6361.3
Enrichment Score (ES)0.74765337
Normalized Enrichment Score (NES)1.6590652
Nominal p-value0.0014265336
FDR q-value0.02656285
FWER p-Value0.634
Table: GSEA Results Summary



Fig 1: Enrichment plot: REACTOME|REACT_6361.3   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
15901"RAN (RAN, member RAS oncogene family)"27250.1270.1038Yes
25902RANBP1 (RAN binding protein 1)172109.9520.1430Yes
35431"POLR2B (polymerase (RNA) II (DNA directed) polypeptide B, 140kDa)"24893.7050.1786Yes
457122NUP107 (nucleoporin 107kDa)27689.5880.2150Yes
58480RAE1 (RAE1 RNA export 1 homolog (S. pombe))32283.3120.2478Yes
62966"GTF2H2 (general transcription factor IIH, polypeptide 2, 44kDa)"33780.9800.2811Yes
76921"TCEB1 (transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C))"37775.3770.3109Yes
85436POLR2G (polymerase (RNA) II (DNA directed) polypeptide G)43967.7680.3364Yes
911198SUPT16H (suppressor of Ty 16 homolog (S. cerevisiae))48463.4690.3609Yes
10129401NUP35 (nucleoporin 35kDa)50261.8730.3861Yes
115435POLR2F (polymerase (RNA) II (DNA directed) polypeptide F)53160.3460.4101Yes
12902CCNH (cyclin H)53659.5430.4349Yes
137514"XPO1 (exportin 1 (CRM1 homolog, yeast))"53959.4620.4598Yes
145441"POLR2L (polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa)"65551.8330.4759Yes
156923"TCEB2 (transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B))"70748.6990.4939Yes
1679023NUP37 (nucleoporin 37kDa)77046.1890.5102Yes
176882"TAF11 (TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa)"85442.4290.5240Yes
184686"NCBP1 (nuclear cap binding protein subunit 1, 80kDa)"86042.2660.5415Yes
199972NUP153 (nucleoporin 153kDa)92439.6720.5551Yes
2023636NUP62 (nucleoporin 62kDa)98037.6920.5682Yes
2122916"NCBP2 (nuclear cap binding protein subunit 2, 20kDa)"98637.5280.5837Yes
2210762NUP50 (nucleoporin 50kDa)113232.8600.5904Yes
2323165NUP205 (nucleoporin 205kDa)114332.6050.6036Yes
244927NUP88 (nucleoporin 88kDa)114932.4550.6170Yes
255438"POLR2I (polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa)"115732.2490.6302Yes
266878"TAF6 (TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa)"122330.5550.6398Yes
272967"GTF2H3 (general transcription factor IIH, polypeptide 3, 34kDa)"127329.6250.6499Yes
285434"POLR2E (polymerase (RNA) II (DNA directed) polypeptide E, 25kDa)"132828.2680.6591Yes
296880"TAF9 (TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa)"150125.3500.6613Yes
3053371NUP54 (nucleoporin 54kDa)160423.8590.6662Yes
316917"TCEA1 (transcription elongation factor A (SII), 1)"163523.4060.6746Yes
329631NUP155 (nucleoporin 155kDa)164123.3600.6842Yes
332957"GTF2A1 (general transcription factor IIA, 1, 19/37kDa)"167922.7080.6919Yes
345433POLR2D (polymerase (RNA) II (DNA directed) polypeptide D)174721.7110.6977Yes
356874"TAF4 (TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa)"175921.5090.7062Yes
365432"POLR2C (polymerase (RNA) II (DNA directed) polypeptide C, 33kDa)"177221.3890.7146Yes
3723279NUP160 (nucleoporin 160kDa)180420.9880.7219Yes
386749SSRP1 (structure specific recognition protein 1)194319.5770.7233Yes
392963"GTF2F2 (general transcription factor IIF, polypeptide 2, 30kDa)"205618.2640.7255Yes
405903RANBP2 (RAN binding protein 2)216417.3990.7275Yes
41905CCNT2 (cyclin T2)242914.8800.7207Yes
4223511NUP188 (nucleoporin 188kDa)262313.2560.7167Yes
436881"TAF10 (TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa)"268112.9630.7194Yes
441104RCC1 (regulator of chromosome condensation 1)270012.8700.7239Yes
459688NUP93 (nucleoporin 93kDa)270912.8140.7289Yes
462961"GTF2E2 (general transcription factor IIE, polypeptide 2, beta 34kDa)"273012.6400.7332Yes
4755746NUP133 (nucleoporin 133kDa)278712.2810.7356Yes
486877"TAF5 (TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa)"292111.5050.7339Yes
495905RANGAP1 (Ran GTPase activating protein 1)299711.0600.7348Yes
506827SUPT4H1 (suppressor of Ty 4 homolog 1 (S. cerevisiae))305810.6690.7363Yes
517936RDBP (RD RNA binding protein)308610.5150.7394Yes
526875"TAF4B (TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa)"32169.8710.7372Yes
5379902NUP85 (nucleoporin 85kDa)32899.5860.7377Yes
549150"CTDP1 (CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1)"33039.5180.7410Yes
55348995NUP43 (nucleoporin 43kDa)33559.3500.7425Yes
5623225NUP210 (nucleoporin 210kDa)33969.1690.7443Yes
572968"GTF2H4 (general transcription factor IIH, polypeptide 4, 52kDa)"34169.1030.7472Yes
586872"TAF1 (TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa)"35108.7050.7463Yes
594331"MNAT1 (menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis))"35838.4170.7463Yes
605430"POLR2A (polymerase (RNA) II (DNA directed) polypeptide A, 220kDa)"36268.2310.7477Yes
61904CCNT1 (cyclin T1)40466.6530.7297No
625437POLR2H (polymerase (RNA) II (DNA directed) polypeptide H)45965.0000.7047No
636908TBP (TATA box binding protein)46904.7390.7021No
649883POM121 (POM121 membrane glycoprotein (rat))50273.9780.6872No
652068"ERCC2 (excision repair cross-complementing rodent repair deficiency, complementation group 2)"51593.7020.6823No
662071"ERCC3 (excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing))"59442.4390.6446No
672965"GTF2H1 (general transcription factor IIH, polypeptide 1, 62kDa)"61552.1630.6351No
687469WHSC2 (Wolf-Hirschhorn syndrome candidate 2)62782.0210.6299No
695440"POLR2K (polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa)"63211.9700.6287No
702962"GTF2F1 (general transcription factor IIF, polypeptide 1, 74kDa)"63881.8940.6262No
716924"TCEB3 (transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A))"103190.0590.4320No
721025CDK9 (cyclin-dependent kinase 9)104180.0340.4272No
736884"TAF13 (TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa)"13077-0.6300.2961No
748178ELL (elongation factor RNA polymerase II)14520-1.2540.2254No
752958"GTF2A2 (general transcription factor IIA, 2, 12kDa)"14627-1.3110.2207No
762960"GTF2E1 (general transcription factor IIE, polypeptide 1, alpha 56kDa)"16002-2.5030.1539No
778021NUP214 (nucleoporin 214kDa)16014-2.5130.1544No
788732RNGTT (RNA guanylyltransferase and 5'-phosphatase)16653-3.4990.1243No
798731RNMT (RNA (guanine-7-) methyltransferase)16887-3.9670.1145No
808086"AAAS (achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A))"16985-4.2110.1115No
816883"TAF12 (TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa)"17252-4.8580.1004No
827175TPR (translocated promoter region (to activated MET oncogene))17416-5.3360.0946No
835439"POLR2J (polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa)"18134-8.6610.0628No
8411097NUPL2 (nucleoporin like 2)18164-8.8500.0651No
852959GTF2B (general transcription factor IIB)18273-9.4290.0637No
8625920COBRA1 (cofactor of BRCA1)19016-17.1340.0342No
8751497TH1L (TH1-like (Drosophila))19618-32.5680.0182No
881022CDK7 (cyclin-dependent kinase 7)19757-39.6000.0281No
Table: GSEA details [plain text format]



Fig 2: REACTOME|REACT_6361.3   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: REACTOME|REACT_6361.3: Random ES distribution   
Gene set null distribution of ES for REACTOME|REACT_6361.3