Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classcont
GeneSetIOB|IFN-ALPHA
Enrichment Score (ES)-0.72014433
Normalized Enrichment Score (NES)-1.5900075
Nominal p-value0.024464833
FDR q-value0.28798974
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: IOB|IFN-ALPHA   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
16198"RPS6KB1 (ribosomal protein S6 kinase, 70kDa, polypeptide 1)"35678.6970.0631No
23716JAK1 (Janus kinase 1 (a protein tyrosine kinase))60654.8420.1070No
31399CRKL (v-crk sarcoma virus CT10 oncogene homolog (avian)-like)166523.0130.0784No
45606MAP2K3 (mitogen-activated protein kinase kinase 3)35818.419-0.0073No
51978EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1)36198.271-0.0007No
61398CRK (v-crk sarcoma virus CT10 oncogene homolog (avian))40476.649-0.0149No
76777STAT5B (signal transducer and activator of transcription 5B)49854.066-0.0569No
82475FRAP1 (FK506 binding protein 12-rapamycin associated protein 1)51353.745-0.0604No
9867CBL (Cas-Br-M (murine) ecotropic retroviral transforming sequence)55632.971-0.0784No
106778"STAT6 (signal transducer and activator of transcription 6, interleukin-4 induced)"67371.560-0.1346No
118660IRS2 (insulin receptor substrate 2)69361.386-0.1430No
126776STAT5A (signal transducer and activator of transcription 5A)75860.951-0.1740No
138793"TNFRSF10D (tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain)"83170.607-0.2094No
14257106ARHGAP30 (Rho GTPase activating protein 30)86740.488-0.2264No
155321"PLA2G4A (phospholipase A2, group IVA (cytosolic, calcium-dependent))"10614-0.006-0.3220No
162308FOXO1 (forkhead box O1)11939-0.309-0.3869No
173455"IFNAR2 (interferon (alpha, beta and omega) receptor 2)"12067-0.341-0.3928No
185588"PRKCQ (protein kinase C, theta)"12889-0.572-0.4327No
197409VAV1 (vav 1 guanine nucleotide exchange factor)14093-1.044-0.4909No
205580"PRKCD (protein kinase C, delta)"14205-1.089-0.4953No
213454"IFNAR1 (interferon (alpha, beta and omega) receptor 1)"15684-2.132-0.5659No
227535ZAP70 (zeta-chain (TCR) associated protein kinase 70kDa)15903-2.365-0.5743No
236775STAT4 (signal transducer and activator of transcription 4)16188-2.744-0.5854No
245608MAP2K6 (mitogen-activated protein kinase kinase 6)16252-2.828-0.5856No
251432MAPK14 (mitogen-activated protein kinase 14)16465-3.158-0.5929No
267297TYK2 (tyrosine kinase 2)16697-3.598-0.6006No
276416MAP2K4 (mitogen-activated protein kinase kinase 4)17489-5.590-0.6338No
283667IRS1 (insulin receptor substrate 1)17930-7.532-0.6478No
296773"STAT2 (signal transducer and activator of transcription 2, 113kDa)"19399-25.624-0.6939Yes
306774STAT3 (signal transducer and activator of transcription 3 (acute-phase response factor))19451-27.002-0.6687Yes
319252"RPS6KA5 (ribosomal protein S6 kinase, 90kDa, polypeptide 5)"19571-30.619-0.6432Yes
32207AKT1 (v-akt murine thymoma viral oncogene homolog 1)19588-31.123-0.6121Yes
331975EIF4B (eukaryotic translation initiation factor 4B)19927-54.393-0.5731Yes
346194RPS6 (ribosomal protein S6)20091-76.100-0.5031Yes
354792"NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha)"20116-83.052-0.4192Yes
362065ERBB3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian))20296-203.653-0.2194Yes
376772"STAT1 (signal transducer and activator of transcription 1, 91kDa)"20302-215.4320.0011Yes
Table: GSEA details [plain text format]



Fig 2: IOB|IFN-ALPHA   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: IOB|IFN-ALPHA: Random ES distribution   
Gene set null distribution of ES for IOB|IFN-ALPHA