Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classtreated
GeneSetGO|GO:0005635
Enrichment Score (ES)0.6804419
Normalized Enrichment Score (NES)1.6087886
Nominal p-value0.0
FDR q-value0.049611915
FWER p-Value0.981
Table: GSEA Results Summary



Fig 1: Enrichment plot: GO|GO:0005635   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
15901"RAN (RAN, member RAS oncogene family)"27250.1270.0564Yes
210202DHRS2 (dehydrogenase/reductase (SDR family) member 2)31238.8430.1113Yes
326509"FER1L3 (fer-1-like 3, myoferlin (C. elegans))"45196.1110.1559Yes
41984EIF5A (eukaryotic translation initiation factor 5A)68172.1200.1945Yes
551649MRPS23 (mitochondrial ribosomal protein S23)71168.4920.2333Yes
610204NUTF2 (nuclear transport factor 2)111139.4500.2636Yes
75902RANBP1 (RAN binding protein 1)172109.9520.2859Yes
83837KPNB1 (karyopherin (importin) beta 1)180107.7010.3104Yes
9664BNIP3 (BCL2/adenovirus E1B 19kDa interacting protein 3)22897.4040.3306Yes
108407TAGLN2 (transgelin 2)24194.4400.3518Yes
1111335"CBX3 (chromobox homolog 3 (HP1 gamma homolog, Drosophila))"26790.7580.3715Yes
1257122NUP107 (nucleoporin 107kDa)27689.5880.3918Yes
138480RAE1 (RAE1 RNA export 1 homolog (S. pombe))32283.3120.4087Yes
144085MAD2L1 (MAD2 mitotic arrest deficient-like 1 (yeast))36077.8680.4249Yes
1511260"XPOT (exportin, tRNA (nuclear export receptor for tRNAs))"36776.8440.4423Yes
161717DHCR7 (7-dehydrocholesterol reductase)38275.0840.4589Yes
177112TMPO (thymopoietin)39273.4000.4754Yes
184001LMNB1 (lamin B1)41071.2660.4910Yes
1927346TMEM97 (transmembrane protein 97)42069.8950.5067Yes
2051154MRTO4 (mRNA turnover 4 homolog (S. cerevisiae))43468.3770.5218Yes
212643GCH1 (GTP cyclohydrolase 1)45665.5240.5359Yes
2281929SEH1L (SEH1-like (S. cerevisiae))49162.7650.5487Yes
23129401NUP35 (nucleoporin 35kDa)50261.8730.5625Yes
247514"XPO1 (exportin 1 (CRM1 homolog, yeast))"53959.4620.5744Yes
2510885WDR3 (WD repeat domain 3)69849.5080.5780Yes
2627000"DNAJC2 (DnaJ (Hsp40) homolog, subfamily C, member 2)"72448.0370.5878Yes
2779023NUP37 (nucleoporin 37kDa)77046.1890.5963Yes
2855706TMEM48 (transmembrane protein 48)80644.5410.6048Yes
2910527IPO7 (importin 7)88641.0820.6104Yes
309972NUP153 (nucleoporin 153kDa)92439.6720.6177Yes
3123636NUP62 (nucleoporin 62kDa)98037.6920.6237Yes
329589WTAP (Wilms tumor 1 associated protein)99437.2010.6316Yes
3379711IPO4 (importin 4)103035.8110.6381Yes
3455151TMEM38B (transmembrane protein 38B)112433.1610.6412Yes
3523165NUP205 (nucleoporin 205kDa)114332.6050.6478Yes
361019CDK4 (cyclin-dependent kinase 4)151125.2100.6354Yes
3723"ABCF1 (ATP-binding cassette, sub-family F (GCN20), member 1)"152724.9430.6404Yes
3853371NUP54 (nucleoporin 54kDa)160423.8590.6422Yes
395987TRIM27 (tripartite motif-containing 27)161523.6910.6471Yes
4029057"FAM156A (family with sequence similarity 156, member A)"164023.3710.6513Yes
419631NUP155 (nucleoporin 155kDa)164123.3600.6567Yes
429818NUPL1 (nucleoporin like 1)167022.9440.6606Yes
4357142RTN4 (reticulon 4)173521.9610.6625Yes
44596BCL2 (B-cell CLL/lymphoma 2)176021.5050.6663Yes
451615DARS (aspartyl-tRNA synthetase)178421.3110.6701Yes
4623468"CBX5 (chromobox homolog 5 (HP1 alpha homolog, Drosophila))"180021.0600.6742Yes
4723279NUP160 (nucleoporin 160kDa)180420.9880.6789Yes
4823224"SYNE2 (spectrin repeat containing, nuclear envelope 2)"186820.2870.6804Yes
495903RANBP2 (RAN binding protein 2)216417.3990.6698No
5080314EPC1 (enhancer of polycomb homolog 1 (Drosophila))217117.3620.6735No
513843IPO5 (importin 5)232915.8040.6694No
529801MRPL19 (mitochondrial ribosomal protein L19)236515.4360.6712No
531192CLIC1 (chloride intracellular channel 1)237315.3490.6744No
54663BNIP2 (BCL2/adenovirus E1B 19kDa interacting protein 2)244614.7500.6743No
5522926ATF6 (activating transcription factor 6)252814.0540.6735No
565422"POLA1 (polymerase (DNA directed), alpha 1, catalytic subunit)"254313.9450.6760No
575108PCM1 (pericentriolar material 1)255113.8780.6789No
5823511NUP188 (nucleoporin 188kDa)262313.2560.6784No
591104RCC1 (regulator of chromosome condensation 1)270012.8700.6776No
609688NUP93 (nucleoporin 93kDa)270912.8140.6802No
6155746NUP133 (nucleoporin 133kDa)278712.2810.6792No
6281488"GRINL1A (glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A)"288611.7470.6770No
6323411SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae))293311.4200.6774No
645905RANGAP1 (Ran GTPase activating protein 1)299711.0600.6768No
6510456HAX1 (HCLS1 associated protein X-1)32519.7090.6665No
6679902NUP85 (nucleoporin 85kDa)32899.5860.6669No
67348995NUP43 (nucleoporin 43kDa)33559.3500.6658No
6823225NUP210 (nucleoporin 210kDa)33969.1690.6660No
699782MATR3 (matrin 3)34918.7700.6633No
708481OFD1 (oral-facial-digital syndrome 1)34988.7510.6650No
712010EMD (emerin)35498.5980.6645No
723930LBR (lamin B receptor)35898.4040.6645No
737341SUMO1 (SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae))36578.1570.6631No
7479073TMEM109 (transmembrane protein 109)39336.9930.6511No
755048"PAFAH1B1 (platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa)"39506.9560.6519No
7623353UNC84A (unc-84 homolog A (C. elegans))40576.5980.6482No
77142PARP1 (poly (ADP-ribose) polymerase 1)40896.4790.6481No
7825909AHCTF1 (AT hook containing transcription factor 1)44645.3350.6308No
7923592LEMD3 (LEM domain containing 3)44955.2620.6305No
808379MAD1L1 (MAD1 mitotic arrest deficient-like 1 (yeast))47534.5810.6189No
8123039XPO7 (exportin 7)47834.5270.6185No
8223200"ATP11B (ATPase, class VI, type 11B)"48124.4470.6181No
839883POM121 (POM121 membrane glycoprotein (rat))50273.9780.6084No
8410553"HTATIP2 (HIV-1 Tat interactive protein 2, 30kDa)"55842.9430.5815No
8510280"OPRS1 (opioid receptor, sigma 1)"55872.9400.5821No
862623GATA1 (GATA binding protein 1 (globin transcription factor 1))56482.8500.5798No
874928NUP98 (nucleoporin 98kDa)57212.7160.5768No
8811270NRM (nurim (nuclear envelope membrane protein))57302.7090.5771No
89662BNIP1 (BCL2/adenovirus E1B 19kDa interacting protein 1)59012.4950.5692No
90241ALOX5AP (arachidonate 5-lipoxygenase-activating protein)61622.1590.5568No
916720SREBF1 (sterol regulatory element binding transcription factor 1)61742.1480.5568No
92822"CAPG (capping protein (actin filament), gelsolin-like)"71201.2540.5102No
9323399DULLARD (dullard homolog (Xenopus laevis))71241.2520.5104No
9457534MIB1 (mindbomb homolog 1 (Drosophila))77860.8440.4778No
953710"ITPR3 (inositol 1,4,5-triphosphate receptor, type 3)"80250.7230.4661No
96161176C14orf49 (chromosome 14 open reading frame 49)83080.6110.4523No
974086SMAD1 (SMAD family member 1)87060.4790.4327No
9879041TMEM38A (transmembrane protein 38A)92260.3240.4071No
996783"SULT1E1 (sulfotransferase family 1E, estrogen-preferring, member 1)"94150.2750.3978No
1003000"GUCY2D (guanylate cyclase 2D, membrane (retina-specific))"94760.2600.3949No
1012986"GUCY2F (guanylate cyclase 2F, retinal)"96700.2160.3854No
1022692GHRHR (growth hormone releasing hormone receptor)99520.1460.3715No
103144165PRICKLE1 (prickle homolog 1 (Drosophila))101100.1080.3637No
104358AQP1 (aquaporin 1 (Colton blood group))102260.0780.3581No
1059472AKAP6 (A kinase (PRKA) anchor protein 6)103760.0440.3507No
10611262SP140 (SP140 nuclear body protein)105070.0130.3442No
10723439"ATP1B4 (ATPase, (Na+)/K+ transporting, beta 4 polypeptide)"10727-0.0310.3334No
10859343SENP2 (SUMO1/sentrin/SMT3 specific peptidase 2)11845-0.2900.2781No
10990523C6orf142 (chromosome 6 open reading frame 142)13012-0.6110.2204No
1105733PTGER3 (prostaglandin E receptor 3 (subtype EP3))13411-0.7450.2009No
1117468WHSC1 (Wolf-Hirschhorn syndrome candidate 1)14027-1.0080.1706No
112129787TMEM18 (transmembrane protein 18)14600-1.2960.1425No
113894CCND2 (cyclin D2)14670-1.3390.1394No
1144864"NPC1 (Niemann-Pick disease, type C1)"14730-1.3830.1368No
11511277TREX1 (three prime repair exonuclease 1)14986-1.5540.1245No
1167189TRAF6 (TNF receptor-associated factor 6)15046-1.5950.1220No
117240ALOX5 (arachidonate 5-lipoxygenase)15060-1.6080.1217No
11823345"SYNE1 (spectrin repeat containing, nuclear envelope 1)"15075-1.6200.1214No
1194258MGST2 (microsomal glutathione S-transferase 2)15356-1.8350.1079No
1203267HRB (HIV-1 Rev binding protein)15546-2.0070.0990No
121221496LEMD2 (LEM domain containing 2)15923-2.3950.0809No
12210901DHRS4 (dehydrogenase/reductase (SDR family) member 4)16015-2.5130.0770No
12364901RANBP17 (RAN binding protein 17)16198-2.7540.0686No
1244056LTC4S (leukotriene C4 synthase)16400-3.0620.0594No
125327APEH (N-acylaminoacyl-peptide hydrolase)16847-3.8610.0381No
1262781"GNAZ (guanine nucleotide binding protein (G protein), alpha z polypeptide)"16899-3.9900.0365No
12764960MRPS15 (mitochondrial ribosomal protein S15)16917-4.0260.0366No
1288658"TNKS (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase)"16951-4.1200.0359No
1299123"SLC16A3 (solute carrier family 16, member 3 (monocarboxylic acid transporter 4))"16969-4.1700.0360No
1308086"AAAS (achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A))"16985-4.2110.0363No
13157540PTCHD2 (patched domain containing 2)17039-4.3690.0347No
1324000LMNA (lamin A/C)17307-5.0120.0226No
1335002"SLC22A18 (solute carrier family 22, member 18)"17319-5.0430.0232No
1349400RECQL5 (RecQ protein-like 5)17367-5.1840.0221No
13554884"RETSAT (retinol saturase (all-trans-retinol 13,14-reductase))"17413-5.3300.0211No
1367175TPR (translocated promoter region (to activated MET oncogene))17416-5.3360.0222No
13755219TMEM57 (transmembrane protein 57)17459-5.4880.0214No
138163183C19orf46 (chromosome 19 open reading frame 46)17491-5.5970.0211No
1395664PSEN2 (presenilin 2 (Alzheimer disease 4))18005-7.937-0.0025No
140665BNIP3L (BCL2/adenovirus E1B 19kDa interacting protein 3-like)18121-8.583-0.0062No
1411063"CENPF (centromere protein F, 350/400ka (mitosin))"18214-9.131-0.0087No
14223001WDFY3 (WD repeat and FYVE domain containing 3)18326-9.779-0.0119No
1432644GCHFR (GTP cyclohydrolase I feedback regulator)18349-9.921-0.0107No
1445371PML (promyelocytic leukemia)18450-10.797-0.0132No
1454088SMAD3 (SMAD family member 3)18573-11.772-0.0165No
14680351"TNKS2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2)"18583-11.868-0.0142No
1476396SEC13 (SEC13 homolog (S. cerevisiae))18834-14.381-0.0233No
14825777UNC84B (unc-84 homolog B (C. elegans))19082-18.544-0.0312No
149311ANXA11 (annexin A11)19313-23.233-0.0373No
1505663PSEN1 (presenilin 1)19728-38.379-0.0490No
1519805SCRN1 (secernin 1)19942-56.468-0.0465No
1526277S100A6 (S100 calcium binding protein A6)20039-67.107-0.0358No
15328996HIPK2 (homeodomain interacting protein kinase 2)20050-69.317-0.0203No
15429956"LASS2 (LAG1 homolog, ceramide synthase 2)"20072-72.378-0.0046No
1554646MYO6 (myosin VI)20081-74.1650.0121No
Table: GSEA details [plain text format]



Fig 2: GO|GO:0005635   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: GO|GO:0005635: Random ES distribution   
Gene set null distribution of ES for GO|GO:0005635