Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classcont
GeneSetPATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA|IL23-MEDIATED SIGNALING EVENTS
Enrichment Score (ES)-0.75125384
Normalized Enrichment Score (NES)-1.627747
Nominal p-value0.005899705
FDR q-value0.2668648
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA|IL23-MEDIATED SIGNALING EVENTS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
13717JAK2 (Janus kinase 2 (a protein tyrosine kinase))152624.947-0.0201No
23675"ITGA3 (integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor))"43985.483-0.1495No
34843"NOS2A (nitric oxide synthase 2A (inducible, hepatocytes))"55023.060-0.1971No
429949IL19 (interleukin 19)67801.530-0.2567No
58807IL18RAP (interleukin 18 receptor accessory protein)68021.511-0.2544No
63606IL18 (interleukin 18 (interferon-gamma-inducing factor))71461.235-0.2686No
7149233IL23R (interleukin 23 receptor)72281.174-0.2700No
84353MPO (myeloperoxidase)72491.163-0.2684No
911009IL24 (interleukin 24)72701.157-0.2668No
106776STAT5A (signal transducer and activator of transcription 5A)75860.951-0.2803No
11112744IL17F (interleukin 17F)77460.868-0.2862No
128809IL18R1 (interleukin 18 receptor 1)81580.671-0.3050No
133558IL2 (interleukin 2)83650.590-0.3138No
14242"ALOX12B (arachidonate 12-lipoxygenase, 12R type)"97500.195-0.3816No
153569"IL6 (interleukin 6 (interferon, beta 2))"97700.188-0.3821No
163458"IFNG (interferon, gamma)"98350.174-0.3849No
172919"CXCL1 (chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha))"98750.163-0.3865No
183605IL17A (interleukin 17A)102380.077-0.4041No
193593"IL12B (interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40))"11374-0.185-0.4597No
203553"IL1B (interleukin 1, beta)"11912-0.304-0.4855No
219021SOCS3 (suppressor of cytokine signaling 3)12244-0.385-0.5009No
22920CD4 (CD4 molecule)12457-0.446-0.5104No
237124"TNF (tumor necrosis factor (TNF superfamily, member 2))"12777-0.537-0.5249No
246347CCL2 (chemokine (C-C motif) ligand 2)14056-1.027-0.5856No
254283CXCL9 (chemokine (C-X-C motif) ligand 9)15376-1.852-0.6466No
263594"IL12RB1 (interleukin 12 receptor, beta 1)"15945-2.429-0.6692No
276775STAT4 (signal transducer and activator of transcription 4)16188-2.744-0.6751No
287297TYK2 (tyrosine kinase 2)16697-3.598-0.6922No
29916"CD3E (CD3e molecule, epsilon (CD3-TCR complex))"16842-3.845-0.6908No
304790NFKB1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 1)17493-5.614-0.7104No
315290"PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide)"17764-6.773-0.7088No
325970RELA (v-rel reticuloendotheliosis viral oncogene homolog A (avian))18184-8.954-0.7097No
3351561"IL23A (interleukin 23, alpha subunit p19)"19029-17.353-0.7129Yes
345295"PIK3R1 (phosphoinositide-3-kinase, regulatory subunit 1 (alpha))"19422-26.295-0.6742Yes
356774STAT3 (signal transducer and activator of transcription 3 (acute-phase response factor))19451-27.002-0.6160Yes
364792"NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha)"20116-83.052-0.4654Yes
376772"STAT1 (signal transducer and activator of transcription 1, 91kDa)"20302-215.4320.0011Yes
Table: GSEA details [plain text format]



Fig 2: PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA|IL23-MEDIATED SIGNALING EVENTS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA|IL23-MEDIATED SIGNALING EVENTS: Random ES distribution   
Gene set null distribution of ES for PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA|IL23-MEDIATED SIGNALING EVENTS