Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos
Phenotype | Phenotype.cls#treated_versus_cont_repos
Upregulated in class | cont
GeneSet | REACTOME|REACT_916.4
Enrichment Score (ES) | -0.9210093
Normalized Enrichment Score (NES) | -1.6275141
Nominal p-value | 0.008474576
FDR q-value | 0.2623402
FWER p-Value | 1.0
Table: GSEA Results Summary

Fig 1: Enrichment plot: REACTOME|REACT_916.4
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT
1 | 51166 | AADAT (aminoadipate aminotransferase) |  |  | 6430 | 1.850 | -0.3114 | No
2 | 56267 | CCBL2 (cysteine conjugate-beta lyase 2) |  |  | 7121 | 1.253 | -0.3419 | No
3 | 883 | "CCBL1 (cysteine conjugate-beta lyase, cytoplasmic)" |  |  | 7903 | 0.782 | -0.3782 | No
4 | 169355 | "INDOL1 (indoleamine-pyrrole 2,3 dioxygenase-like 1)" |  |  | 8133 | 0.681 | -0.3876 | No
5 | 6999 | "TDO2 (tryptophan 2,3-dioxygenase)" |  |  | 9210 | 0.331 | -0.4397 | No
6 | 130013 | ACMSD (aminocarboxymuconate semialdehyde decarboxylase) |  |  | 9401 | 0.279 | -0.4483 | No
7 | 3620 | "INDO (indoleamine-pyrrole 2,3 dioxygenase)" |  |  | 13182 | -0.662 | -0.6325 | No
8 | 125061 | AFMID (arylformamidase) |  |  | 14774 | -1.408 | -0.7070 | No
9 | 23498 | "HAAO (3-hydroxyanthranilate 3,4-dioxygenase)" |  |  | 14801 | -1.422 | -0.7043 | No
10 | 8564 | KMO (kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)) |  |  | 19162 | -19.956 | -0.8641 | Yes
11 | 8942 | KYNU (kynureninase (L-kynurenine hydrolase)) |  |  | 20320 | -334.884 | 0.0002 | Yes
Table: GSEA details [plain text format]

Fig 2: REACTOME|REACT_916.4
Blue-Pink O' Gram in the Space of the Analyzed GeneSet
Fig 3: REACTOME|REACT_916.4: Random ES distribution
Gene set null distribution of ES for REACTOME|REACT_916.4