Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classtreated
GeneSetGO|GO:0000723
Enrichment Score (ES)0.7472158
Normalized Enrichment Score (NES)1.5857714
Nominal p-value0.0014771048
FDR q-value0.074371405
FWER p-Value0.999
Table: GSEA Results Summary



Fig 1: Enrichment plot: GO|GO:0000723   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
15111PCNA (proliferating cell nuclear antigen)102146.2210.0937Yes
28364"HIST1H4C (histone cluster 1, H4c)"141122.9000.1748Yes
31736"DKC1 (dyskeratosis congenita 1, dyskerin)"177108.9490.2467Yes
44609MYC (v-myc myelocytomatosis viral oncogene homolog (avian))186106.8540.3185Yes
55983"RFC3 (replication factor C (activator 1) 3, 38kDa)"215100.3380.3848Yes
67520XRCC5 (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))30085.7970.4386Yes
72547XRCC6 (X-ray repair complementing defective repair in Chinese hamster cells 6)30784.4120.4953Yes
82237FEN1 (flap structure-specific endonuclease 1)34879.3160.5469Yes
95557"PRIM1 (primase, DNA, polypeptide 1 (49kDa))"75647.0790.5586Yes
105425"POLD2 (polymerase (DNA directed), delta 2, regulatory subunit 50kDa)"91240.2180.5781Yes
115982"RFC2 (replication factor C (activator 1) 2, 40kDa)"128829.3030.5794Yes
126119"RPA3 (replication protein A3, 14kDa)"128929.2970.5992Yes
1323649"POLA2 (polymerase (DNA directed), alpha 2 (70kD subunit))"159823.9760.6002Yes
145985"RFC5 (replication factor C (activator 1) 5, 36.5kDa)"161723.6760.6153Yes
154683NBN (nibrin)170622.3160.6260Yes
1665057ACD (adrenocortical dysplasia homolog (mouse))178821.2550.6364Yes
1754386"TERF2IP (telomeric repeat binding factor 2, interacting protein)"184520.5480.6475Yes
185424"POLD1 (polymerase (DNA directed), delta 1, catalytic subunit 125kDa)"186620.3340.6602Yes
1910728PTGES3 (prostaglandin E synthase 3 (cytosolic))200018.7710.6664Yes
205558"PRIM2 (primase, DNA, polypeptide 2 (58kDa))"203118.4850.6774Yes
216118"RPA2 (replication protein A2, 32kDa)"204818.3550.6890Yes
227486WRN (Werner syndrome)216617.3860.6949Yes
235427"POLE2 (polymerase (DNA directed), epsilon 2 (p59 subunit))"217617.3320.7062Yes
245984"RFC4 (replication factor C (activator 1) 4, 37kDa)"233515.7350.7090Yes
2510111RAD50 (RAD50 homolog (S. cerevisiae))239615.1880.7163Yes
264361MRE11A (MRE11 meiotic recombination 11 homolog A (S. cerevisiae))245714.7160.7233Yes
275981"RFC1 (replication factor C (activator 1) 1, 145kDa)"251914.0980.7298Yes
285422"POLA1 (polymerase (DNA directed), alpha 1, catalytic subunit)"254313.9450.7381Yes
296117"RPA1 (replication protein A1, 70kDa)"254913.8880.7472Yes
3010714"POLD3 (polymerase (DNA-directed), delta 3, accessory subunit)"309710.4490.7273No
3164858"DCLRE1B (DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae))"33629.3200.7205No
3226272FBXO4 (F-box protein 4)34568.9090.7220No
332072"ERCC4 (excision repair cross-complementing rodent repair deficiency, complementation group 4)"39706.8950.7013No
3485456"TNKS1BP1 (tankyrase 1 binding protein 1, 182kDa)"39836.8580.7053No
3579991OBFC1 (oligonucleotide/oligosaccharide-binding fold containing 1)45385.1340.6815No
365426"POLE (polymerase (DNA directed), epsilon)"58782.5200.6171No
378360"HIST1H4D (histone cluster 1, H4d)"60452.3140.6104No
381763DNA2 (DNA replication helicase 2 homolog (yeast))60492.3100.6119No
398363"HIST1H4J (histone cluster 1, H4j)"67661.5390.5776No
407013TERF1 (telomeric repeat binding factor (NIMA-interacting) 1)74121.0590.5464No
418366"HIST1H4B (histone cluster 1, H4b)"74341.0450.5461No
428359"HIST1H4A (histone cluster 1, H4a)"78070.8320.5283No
438290"HIST3H3 (histone cluster 3, H3)"95240.2490.4438No
44201516ZSCAN4 (zinc finger and SCAN domain containing 4)99030.1570.4252No
4525913POT1 (POT1 protection of telomeres 1 homolog (S. pombe))103940.0400.4011No
463978"LIG1 (ligase I, DNA, ATP-dependent)"10691-0.0240.3865No
478294"HIST1H4I (histone cluster 1, H4i)"11396-0.1900.3518No
4851750RTEL1 (regulator of telomere elongation helicase 1)12358-0.4160.3047No
498368"HIST1H4L (histone cluster 1, H4l)"13315-0.7100.2580No
5080119PIF1 (PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae))14116-1.0570.2192No
518370"HIST2H4A (histone cluster 2, H4a)"15149-1.6730.1694No
528361"HIST1H4F (histone cluster 1, H4f)"15444-1.9110.1562No
538367"HIST1H4E (histone cluster 1, H4e)"15478-1.9390.1559No
547011TEP1 (telomerase-associated protein 1)15540-2.0050.1542No
557015TERT (telomerase reverse transcriptase)15612-2.0630.1521No
568658"TNKS (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase)"16951-4.1200.0888No
5757804"POLD4 (polymerase (DNA-directed), delta 4)"17078-4.4470.0856No
5880169C17orf68 (chromosome 17 open reading frame 68)17913-7.4410.0495No
5923293"SMG6 (Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans))"18036-8.0670.0489No
608362"HIST1H4K (histone cluster 1, H4k)"18125-8.6150.0504No
617014TERF2 (telomeric repeat binding factor 2)18350-9.9210.0460No
625371PML (promyelocytic leukemia)18450-10.7970.0484No
632067"ERCC1 (excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence))"18551-11.5300.0513No
6480351"TNKS2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2)"18583-11.8680.0578No
658365"HIST1H4H (histone cluster 1, H4h)"18949-16.0290.0506No
6626277TINF2 (TERF1 (TRF1)-interacting nuclear factor 2)19397-25.6020.0458No
Table: GSEA details [plain text format]



Fig 2: GO|GO:0000723   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: GO|GO:0000723: Random ES distribution   
Gene set null distribution of ES for GO|GO:0000723