Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | cont |
GeneSet | REACTOME|REACT_25229.1 |
Enrichment Score (ES) | -0.75266725 |
Normalized Enrichment Score (NES) | -1.8837374 |
Nominal p-value | 0.0 |
FDR q-value | 0.003330555 |
FWER p-Value | 0.011 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 818 | CAMK2G (calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma) | 328 | 82.541 | 0.0144 | No | ||
2 | 3716 | JAK1 (Janus kinase 1 (a protein tyrosine kinase)) | 606 | 54.842 | 0.0210 | No | ||
3 | 5781 | "PTPN11 (protein tyrosine phosphatase, non-receptor type 11)" | 668 | 51.118 | 0.0370 | No | ||
4 | 960 | CD44 (CD44 molecule (Indian blood group)) | 1122 | 33.175 | 0.0269 | No | ||
5 | 3669 | ISG20 (interferon stimulated exonuclease gene 20kDa) | 1486 | 25.675 | 0.0185 | No | ||
6 | 3717 | JAK2 (Janus kinase 2 (a protein tyrosine kinase)) | 1526 | 24.947 | 0.0258 | No | ||
7 | 3123 | "HLA-DRB1 (major histocompatibility complex, class II, DR beta 1)" | 2579 | 13.655 | -0.0212 | No | ||
8 | 5770 | "PTPN1 (protein tyrosine phosphatase, non-receptor type 1)" | 2646 | 13.099 | -0.0196 | No | ||
9 | 3661 | IRF3 (interferon regulatory factor 3) | 2655 | 13.086 | -0.0151 | No | ||
10 | 7341 | SUMO1 (SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)) | 3657 | 8.157 | -0.0616 | No | ||
11 | 3126 | "HLA-DRB4 (major histocompatibility complex, class II, DR beta 4)" | 4371 | 5.560 | -0.0948 | No | ||
12 | 3663 | IRF5 (interferon regulatory factor 5) | 5333 | 3.348 | -0.1410 | No | ||
13 | 3127 | "HLA-DRB5 (major histocompatibility complex, class II, DR beta 5)" | 6078 | 2.255 | -0.1770 | No | ||
14 | 3113 | "HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)" | 6433 | 1.847 | -0.1938 | No | ||
15 | 163351 | "GBP6 (guanylate binding protein family, member 6)" | 6454 | 1.813 | -0.1941 | No | ||
16 | 5777 | "PTPN6 (protein tyrosine phosphatase, non-receptor type 6)" | 6958 | 1.373 | -0.2185 | No | ||
17 | 5696 | "PSMB8 (proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7))" | 7219 | 1.180 | -0.2309 | No | ||
18 | 3443 | "IFNA6 (interferon, alpha 6)" | 7757 | 0.861 | -0.2571 | No | ||
19 | 8651 | SOCS1 (suppressor of cytokine signaling 1) | 7825 | 0.822 | -0.2602 | No | ||
20 | 3440 | "IFNA2 (interferon, alpha 2)" | 8144 | 0.676 | -0.2756 | No | ||
21 | 3460 | IFNGR2 (interferon gamma receptor 2 (interferon gamma transducer 1)) | 8264 | 0.626 | -0.2813 | No | ||
22 | 4684 | NCAM1 (neural cell adhesion molecule 1) | 8322 | 0.605 | -0.2839 | No | ||
23 | 3662 | IRF4 (interferon regulatory factor 4) | 8896 | 0.417 | -0.3120 | No | ||
24 | 3115 | "HLA-DPB1 (major histocompatibility complex, class II, DP beta 1)" | 8903 | 0.414 | -0.3122 | No | ||
25 | 4502 | MT2A (metallothionein 2A) | 9588 | 0.231 | -0.3459 | No | ||
26 | 7412 | VCAM1 (vascular cell adhesion molecule 1) | 9795 | 0.183 | -0.3560 | No | ||
27 | 3458 | "IFNG (interferon, gamma)" | 9835 | 0.174 | -0.3579 | No | ||
28 | 3442 | "IFNA5 (interferon, alpha 5)" | 9968 | 0.144 | -0.3644 | No | ||
29 | 5724 | PTAFR (platelet-activating factor receptor) | 10087 | 0.113 | -0.3702 | No | ||
30 | 115361 | GBP4 (guanylate binding protein 4) | 10398 | 0.039 | -0.3855 | No | ||
31 | 3446 | "IFNA10 (interferon, alpha 10)" | 10839 | -0.055 | -0.4072 | No | ||
32 | 3439 | "IFNA1 (interferon, alpha 1)" | 11441 | -0.201 | -0.4369 | No | ||
33 | 3445 | "IFNA8 (interferon, alpha 8)" | 11458 | -0.205 | -0.4376 | No | ||
34 | 9021 | SOCS3 (suppressor of cytokine signaling 3) | 12244 | -0.385 | -0.4762 | No | ||
35 | 3441 | "IFNA4 (interferon, alpha 4)" | 12451 | -0.445 | -0.4863 | No | ||
36 | 3449 | "IFNA16 (interferon, alpha 16)" | 12618 | -0.489 | -0.4943 | No | ||
37 | 3451 | "IFNA17 (interferon, alpha 17)" | 12711 | -0.517 | -0.4986 | No | ||
38 | 115362 | GBP5 (guanylate binding protein 5) | 12797 | -0.543 | -0.5027 | No | ||
39 | 2210 | "FCGR1B (Fc fragment of IgG, high affinity Ib, receptor (CD64))" | 12991 | -0.602 | -0.5120 | No | ||
40 | 4600 | MX2 (myxovirus (influenza virus) resistance 2 (mouse)) | 13084 | -0.634 | -0.5163 | No | ||
41 | 4599 | "MX1 (myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse))" | 13262 | -0.687 | -0.5248 | No | ||
42 | 3112 | "HLA-DOB (major histocompatibility complex, class II, DO beta)" | 13515 | -0.781 | -0.5370 | No | ||
43 | 3108 | "HLA-DMA (major histocompatibility complex, class II, DM alpha)" | 13572 | -0.805 | -0.5394 | No | ||
44 | 3444 | "IFNA7 (interferon, alpha 7)" | 13599 | -0.815 | -0.5404 | No | ||
45 | 1958 | EGR1 (early growth response 1) | 13634 | -0.827 | -0.5418 | No | ||
46 | 6041 | "RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent))" | 13797 | -0.896 | -0.5495 | No | ||
47 | 5580 | "PRKCD (protein kinase C, delta)" | 14205 | -1.089 | -0.5692 | No | ||
48 | 54739 | XAF1 (XIAP associated factor 1) | 14206 | -1.089 | -0.5688 | No | ||
49 | 3448 | "IFNA14 (interferon, alpha 14)" | 14278 | -1.122 | -0.5719 | No | ||
50 | 3452 | "IFNA21 (interferon, alpha 21)" | 14303 | -1.135 | -0.5726 | No | ||
51 | 3109 | "HLA-DMB (major histocompatibility complex, class II, DM beta)" | 14469 | -1.219 | -0.5803 | No | ||
52 | 3456 | "IFNB1 (interferon, beta 1, fibroblast)" | 14732 | -1.384 | -0.5928 | No | ||
53 | 2209 | "FCGR1A (Fc fragment of IgG, high affinity Ia, receptor (CD64))" | 15096 | -1.635 | -0.6101 | No | ||
54 | 816 | CAMK2B (calcium/calmodulin-dependent protein kinase (CaM kinase) II beta) | 15145 | -1.669 | -0.6119 | No | ||
55 | 3394 | IRF8 (interferon regulatory factor 8) | 15221 | -1.737 | -0.6149 | No | ||
56 | 3454 | "IFNAR1 (interferon (alpha, beta and omega) receptor 1)" | 15684 | -2.132 | -0.6370 | No | ||
57 | 815 | CAMK2A (calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha) | 16092 | -2.630 | -0.6561 | No | ||
58 | 4261 | "CIITA (class II, major histocompatibility complex, transactivator)" | 16562 | -3.334 | -0.6781 | No | ||
59 | 8638 | OASL (2'-5'-oligoadenylate synthetase-like) | 16666 | -3.527 | -0.6819 | No | ||
60 | 7297 | TYK2 (tyrosine kinase 2) | 16697 | -3.598 | -0.6820 | No | ||
61 | 6672 | SP100 (SP100 nuclear antigen) | 16717 | -3.632 | -0.6816 | No | ||
62 | 3433 | IFIT2 (interferon-induced protein with tetratricopeptide repeats 2) | 17164 | -4.656 | -0.7019 | No | ||
63 | 3660 | IRF2 (interferon regulatory factor 2) | 17207 | -4.758 | -0.7023 | No | ||
64 | 3111 | "HLA-DOA (major histocompatibility complex, class II, DO alpha)" | 17650 | -6.220 | -0.7218 | No | ||
65 | 3383 | ICAM1 (intercellular adhesion molecule 1) | 17688 | -6.391 | -0.7213 | No | ||
66 | 3664 | IRF6 (interferon regulatory factor 6) | 17986 | -7.831 | -0.7330 | No | ||
67 | 3122 | "HLA-DRA (major histocompatibility complex, class II, DR alpha)" | 17997 | -7.888 | -0.7306 | No | ||
68 | 3659 | IRF1 (interferon regulatory factor 1) | 18007 | -7.943 | -0.7281 | No | ||
69 | 8554 | "PIAS1 (protein inhibitor of activated STAT, 1)" | 18340 | -9.843 | -0.7409 | No | ||
70 | 5371 | PML (promyelocytic leukemia) | 18450 | -10.797 | -0.7423 | No | ||
71 | 2635 | GBP3 (guanylate binding protein 3) | 18501 | -11.136 | -0.7406 | No | ||
72 | 3665 | IRF7 (interferon regulatory factor 7) | 18746 | -13.575 | -0.7476 | Yes | ||
73 | 2633 | "GBP1 (guanylate binding protein 1, interferon-inducible, 67kDa)" | 18816 | -14.186 | -0.7458 | Yes | ||
74 | 11274 | USP18 (ubiquitin specific peptidase 18) | 18861 | -14.702 | -0.7425 | Yes | ||
75 | 2634 | "GBP2 (guanylate binding protein 2, interferon-inducible)" | 18868 | -14.825 | -0.7373 | Yes | ||
76 | 3430 | IFI35 (interferon-induced protein 35) | 19007 | -16.958 | -0.7378 | Yes | ||
77 | 3437 | IFIT3 (interferon-induced protein with tetratricopeptide repeats 3) | 19104 | -18.975 | -0.7355 | Yes | ||
78 | 3134 | "HLA-F (major histocompatibility complex, class I, F)" | 19233 | -21.099 | -0.7341 | Yes | ||
79 | 4939 | "OAS2 (2'-5'-oligoadenylate synthetase 2, 69/71kDa)" | 19395 | -25.501 | -0.7326 | Yes | ||
80 | 6773 | "STAT2 (signal transducer and activator of transcription 2, 113kDa)" | 19399 | -25.624 | -0.7232 | Yes | ||
81 | 3429 | "IFI27 (interferon, alpha-inducible protein 27)" | 19448 | -26.932 | -0.7156 | Yes | ||
82 | 3133 | "HLA-E (major histocompatibility complex, class I, E)" | 19478 | -27.797 | -0.7067 | Yes | ||
83 | 51447 | IHPK2 (inositol hexaphosphate kinase 2) | 19516 | -28.829 | -0.6978 | Yes | ||
84 | 817 | CAMK2D (calcium/calmodulin-dependent protein kinase (CaM kinase) II delta) | 19600 | -31.852 | -0.6901 | Yes | ||
85 | 2537 | "IFI6 (interferon, alpha-inducible protein 6)" | 19662 | -35.028 | -0.6802 | Yes | ||
86 | 10437 | "IFI30 (interferon, gamma-inducible protein 30)" | 19766 | -40.310 | -0.6703 | Yes | ||
87 | 3135 | "HLA-G (major histocompatibility complex, class I, G)" | 19863 | -47.478 | -0.6574 | Yes | ||
88 | 4938 | "OAS1 (2',5'-oligoadenylate synthetase 1, 40/46kDa)" | 19903 | -51.434 | -0.6403 | Yes | ||
89 | 3459 | IFNGR1 (interferon gamma receptor 1) | 19965 | -58.421 | -0.6217 | Yes | ||
90 | 10581 | IFITM2 (interferon induced transmembrane protein 2 (1-8D)) | 19970 | -58.782 | -0.6000 | Yes | ||
91 | 3105 | "HLA-A (major histocompatibility complex, class I, A)" | 20027 | -65.132 | -0.5787 | Yes | ||
92 | 3106 | "HLA-B (major histocompatibility complex, class I, B)" | 20100 | -78.491 | -0.5531 | Yes | ||
93 | 4940 | "OAS3 (2'-5'-oligoadenylate synthetase 3, 100kDa)" | 20125 | -86.843 | -0.5221 | Yes | ||
94 | 8519 | IFITM1 (interferon induced transmembrane protein 1 (9-27)) | 20204 | -117.578 | -0.4823 | Yes | ||
95 | 103 | "ADAR (adenosine deaminase, RNA-specific)" | 20231 | -134.677 | -0.4337 | Yes | ||
96 | 3107 | "HLA-C (major histocompatibility complex, class I, C)" | 20243 | -142.867 | -0.3812 | Yes | ||
97 | 10379 | IRF9 (interferon regulatory factor 9) | 20262 | -164.279 | -0.3212 | Yes | ||
98 | 10410 | IFITM3 (interferon induced transmembrane protein 3 (1-8U)) | 20271 | -173.958 | -0.2571 | Yes | ||
99 | 567 | B2M (beta-2-microglobulin) | 20305 | -220.982 | -0.1768 | Yes | ||
100 | 3434 | IFIT1 (interferon-induced protein with tetratricopeptide repeats 1) | 20306 | -233.172 | -0.0903 | Yes | ||
101 | 9636 | ISG15 (ISG15 ubiquitin-like modifier) | 20309 | -245.852 | 0.0008 | Yes |