Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos
Phenotype | Phenotype.cls#treated_versus_cont_repos
Upregulated in class | cont
GeneSet | MSIGDB_C2|BIOCARTA_AGPCR_PATHWAY
Enrichment Score (ES) | -0.8582323
Normalized Enrichment Score (NES) | -1.5732524
Nominal p-value | 0.014409222
FDR q-value | 0.3047703
FWER p-Value | 1.0
Table: GSEA Results Summary

Fig 1: Enrichment plot: MSIGDB_C2|BIOCARTA_AGPCR_PATHWAY
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT
1 | 5576 | "PRKAR2A (protein kinase, cAMP-dependent, regulatory, type II, alpha)" |  |  | 1787 | 21.278 | -0.0415 | No
2 | 5577 | "PRKAR2B (protein kinase, cAMP-dependent, regulatory, type II, beta)" |  |  | 3542 | 8.613 | -0.1091 | No
3 | 408 | "ARRB1 (arrestin, beta 1)" |  |  | 4928 | 4.173 | -0.1682 | No
4 | 5578 | "PRKCA (protein kinase C, alpha)" |  |  | 6827 | 1.483 | -0.2584 | No
5 | 5579 | "PRKCB (protein kinase C, beta)" |  |  | 7021 | 1.335 | -0.2650 | No
6 | 2868 | GRK4 (G protein-coupled receptor kinase 4) |  |  | 7782 | 0.847 | -0.3005 | No
7 | 5568 | "PRKACG (protein kinase, cAMP-dependent, catalytic, gamma)" |  |  | 8565 | 0.525 | -0.3379 | No
8 | 5575 | "PRKAR1B (protein kinase, cAMP-dependent, regulatory, type I, beta)" |  |  | 11757 | -0.272 | -0.4944 | No
9 | 2792 | "GNGT1 (guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1)" |  |  | 12761 | -0.531 | -0.5426 | No
10 | 2782 | "GNB1 (guanine nucleotide binding protein (G protein), beta polypeptide 1)" |  |  | 17381 | -5.227 | -0.7586 | No
11 | 5567 | "PRKACB (protein kinase, cAMP-dependent, catalytic, beta)" |  |  | 19040 | -17.599 | -0.8018 | Yes
12 | 5573 | "PRKAR1A (protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1))" |  |  | 20187 | -109.195 | -0.6200 | Yes
13 | 2778 | GNAS (GNAS complex locus) |  |  | 20315 | -287.233 | 0.0005 | Yes
Table: GSEA details [plain text format]

Fig 2: MSIGDB_C2|BIOCARTA_AGPCR_PATHWAY
Blue-Pink O' Gram in the Space of the Analyzed GeneSet
Fig 3: MSIGDB_C2|BIOCARTA_AGPCR_PATHWAY: Random ES distribution
Gene set null distribution of ES for MSIGDB_C2|BIOCARTA_AGPCR_PATHWAY