Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | treated |
GeneSet | GO|GO:0060249 |
Enrichment Score (ES) | 0.70717853 |
Normalized Enrichment Score (NES) | 1.625557 |
Nominal p-value | 0.0027173914 |
FDR q-value | 0.043987695 |
FWER p-Value | 0.923 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 5111 | PCNA (proliferating cell nuclear antigen) | 102 | 146.221 | 0.0733 | Yes | ||
2 | 8364 | "HIST1H4C (histone cluster 1, H4c)" | 141 | 122.900 | 0.1372 | Yes | ||
3 | 1736 | "DKC1 (dyskeratosis congenita 1, dyskerin)" | 177 | 108.949 | 0.1938 | Yes | ||
4 | 4609 | MYC (v-myc myelocytomatosis viral oncogene homolog (avian)) | 186 | 106.854 | 0.2507 | Yes | ||
5 | 5983 | "RFC3 (replication factor C (activator 1) 3, 38kDa)" | 215 | 100.338 | 0.3030 | Yes | ||
6 | 226 | "ALDOA (aldolase A, fructose-bisphosphate)" | 229 | 97.359 | 0.3545 | Yes | ||
7 | 7520 | XRCC5 (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | 300 | 85.797 | 0.3970 | Yes | ||
8 | 2547 | XRCC6 (X-ray repair complementing defective repair in Chinese hamster cells 6) | 307 | 84.412 | 0.4419 | Yes | ||
9 | 2237 | FEN1 (flap structure-specific endonuclease 1) | 348 | 79.316 | 0.4824 | Yes | ||
10 | 12 | "SERPINA3 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3)" | 556 | 58.325 | 0.5034 | Yes | ||
11 | 5557 | "PRIM1 (primase, DNA, polypeptide 1 (49kDa))" | 756 | 47.079 | 0.5188 | Yes | ||
12 | 5425 | "POLD2 (polymerase (DNA directed), delta 2, regulatory subunit 50kDa)" | 912 | 40.218 | 0.5327 | Yes | ||
13 | 6584 | "SLC22A5 (solute carrier family 22 (organic cation/carnitine transporter), member 5)" | 1113 | 33.332 | 0.5406 | Yes | ||
14 | 5982 | "RFC2 (replication factor C (activator 1) 2, 40kDa)" | 1288 | 29.303 | 0.5477 | Yes | ||
15 | 6119 | "RPA3 (replication protein A3, 14kDa)" | 1289 | 29.297 | 0.5634 | Yes | ||
16 | 5213 | "PFKM (phosphofructokinase, muscle)" | 1329 | 28.252 | 0.5766 | Yes | ||
17 | 23649 | "POLA2 (polymerase (DNA directed), alpha 2 (70kD subunit))" | 1598 | 23.976 | 0.5762 | Yes | ||
18 | 5985 | "RFC5 (replication factor C (activator 1) 5, 36.5kDa)" | 1617 | 23.676 | 0.5880 | Yes | ||
19 | 4763 | NF1 (neurofibromin 1) | 1656 | 23.147 | 0.5985 | Yes | ||
20 | 4683 | NBN (nibrin) | 1706 | 22.316 | 0.6080 | Yes | ||
21 | 580 | BARD1 (BRCA1 associated RING domain 1) | 1756 | 21.556 | 0.6172 | Yes | ||
22 | 65057 | ACD (adrenocortical dysplasia homolog (mouse)) | 1788 | 21.255 | 0.6270 | Yes | ||
23 | 54386 | "TERF2IP (telomeric repeat binding factor 2, interacting protein)" | 1845 | 20.548 | 0.6352 | Yes | ||
24 | 5424 | "POLD1 (polymerase (DNA directed), delta 1, catalytic subunit 125kDa)" | 1866 | 20.334 | 0.6451 | Yes | ||
25 | 10728 | PTGES3 (prostaglandin E synthase 3 (cytosolic)) | 2000 | 18.771 | 0.6486 | Yes | ||
26 | 5558 | "PRIM2 (primase, DNA, polypeptide 2 (58kDa))" | 2031 | 18.485 | 0.6570 | Yes | ||
27 | 6118 | "RPA2 (replication protein A2, 32kDa)" | 2048 | 18.355 | 0.6661 | Yes | ||
28 | 7486 | WRN (Werner syndrome) | 2166 | 17.386 | 0.6696 | Yes | ||
29 | 5427 | "POLE2 (polymerase (DNA directed), epsilon 2 (p59 subunit))" | 2176 | 17.332 | 0.6784 | Yes | ||
30 | 5984 | "RFC4 (replication factor C (activator 1) 4, 37kDa)" | 2335 | 15.735 | 0.6790 | Yes | ||
31 | 10111 | RAD50 (RAD50 homolog (S. cerevisiae)) | 2396 | 15.188 | 0.6842 | Yes | ||
32 | 4361 | MRE11A (MRE11 meiotic recombination 11 homolog A (S. cerevisiae)) | 2457 | 14.716 | 0.6891 | Yes | ||
33 | 5981 | "RFC1 (replication factor C (activator 1) 1, 145kDa)" | 2519 | 14.098 | 0.6937 | Yes | ||
34 | 5422 | "POLA1 (polymerase (DNA directed), alpha 1, catalytic subunit)" | 2543 | 13.945 | 0.7000 | Yes | ||
35 | 6117 | "RPA1 (replication protein A1, 70kDa)" | 2549 | 13.888 | 0.7072 | Yes | ||
36 | 55277 | FGGY (FGGY carbohydrate kinase domain containing) | 2710 | 12.813 | 0.7061 | No | ||
37 | 79738 | BBS10 (Bardet-Biedl syndrome 10) | 2973 | 11.136 | 0.6991 | No | ||
38 | 10714 | "POLD3 (polymerase (DNA-directed), delta 3, accessory subunit)" | 3097 | 10.449 | 0.6986 | No | ||
39 | 64858 | "DCLRE1B (DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae))" | 3362 | 9.320 | 0.6906 | No | ||
40 | 26272 | FBXO4 (F-box protein 4) | 3456 | 8.909 | 0.6907 | No | ||
41 | 6647 | "SOD1 (superoxide dismutase 1, soluble)" | 3814 | 7.463 | 0.6771 | No | ||
42 | 2072 | "ERCC4 (excision repair cross-complementing rodent repair deficiency, complementation group 4)" | 3970 | 6.895 | 0.6731 | No | ||
43 | 85456 | "TNKS1BP1 (tankyrase 1 binding protein 1, 182kDa)" | 3983 | 6.858 | 0.6762 | No | ||
44 | 9215 | LARGE (like-glycosyltransferase) | 4321 | 5.712 | 0.6626 | No | ||
45 | 120071 | GYLTL1B (glycosyltransferase-like 1B) | 4339 | 5.652 | 0.6648 | No | ||
46 | 79991 | OBFC1 (oligonucleotide/oligosaccharide-binding fold containing 1) | 4538 | 5.134 | 0.6577 | No | ||
47 | 6662 | SOX9 (SRY (sex determining region Y)-box 9) | 5204 | 3.599 | 0.6268 | No | ||
48 | 25861 | "DFNB31 (deafness, autosomal recessive 31)" | 5754 | 2.677 | 0.6010 | No | ||
49 | 5426 | "POLE (polymerase (DNA directed), epsilon)" | 5878 | 2.520 | 0.5963 | No | ||
50 | 171392 | ZNF675 (zinc finger protein 675) | 5929 | 2.457 | 0.5951 | No | ||
51 | 8360 | "HIST1H4D (histone cluster 1, H4d)" | 6045 | 2.314 | 0.5907 | No | ||
52 | 1763 | DNA2 (DNA replication helicase 2 homolog (yeast)) | 6049 | 2.310 | 0.5918 | No | ||
53 | 9290 | GPR55 (G protein-coupled receptor 55) | 6663 | 1.620 | 0.5623 | No | ||
54 | 9607 | CARTPT (CART prepropeptide) | 6701 | 1.593 | 0.5613 | No | ||
55 | 8363 | "HIST1H4J (histone cluster 1, H4j)" | 6766 | 1.539 | 0.5590 | No | ||
56 | 7013 | TERF1 (telomeric repeat binding factor (NIMA-interacting) 1) | 7412 | 1.059 | 0.5277 | No | ||
57 | 8366 | "HIST1H4B (histone cluster 1, H4b)" | 7434 | 1.045 | 0.5272 | No | ||
58 | 8359 | "HIST1H4A (histone cluster 1, H4a)" | 7807 | 0.832 | 0.5092 | No | ||
59 | 1134 | "CHRNA1 (cholinergic receptor, nicotinic, alpha 1 (muscle))" | 8381 | 0.584 | 0.4812 | No | ||
60 | 5950 | "RBP4 (retinol binding protein 4, plasma)" | 9448 | 0.266 | 0.4286 | No | ||
61 | 8290 | "HIST3H3 (histone cluster 3, H3)" | 9524 | 0.249 | 0.4250 | No | ||
62 | 8600 | "TNFSF11 (tumor necrosis factor (ligand) superfamily, member 11)" | 9608 | 0.227 | 0.4211 | No | ||
63 | 101 | ADAM8 (ADAM metallopeptidase domain 8) | 9784 | 0.185 | 0.4125 | No | ||
64 | 201516 | ZSCAN4 (zinc finger and SCAN domain containing 4) | 9903 | 0.157 | 0.4067 | No | ||
65 | 25913 | POT1 (POT1 protection of telomeres 1 homolog (S. pombe)) | 10394 | 0.040 | 0.3825 | No | ||
66 | 3978 | "LIG1 (ligase I, DNA, ATP-dependent)" | 10691 | -0.024 | 0.3679 | No | ||
67 | 6714 | SRC (v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)) | 11110 | -0.124 | 0.3473 | No | ||
68 | 8294 | "HIST1H4I (histone cluster 1, H4i)" | 11396 | -0.190 | 0.3333 | No | ||
69 | 137868 | SGCZ (sarcoglycan zeta) | 11428 | -0.199 | 0.3319 | No | ||
70 | 5027 | "P2RX7 (purinergic receptor P2X, ligand-gated ion channel, 7)" | 12248 | -0.386 | 0.2916 | No | ||
71 | 51750 | RTEL1 (regulator of telomere elongation helicase 1) | 12358 | -0.416 | 0.2864 | No | ||
72 | 5741 | PTH (parathyroid hormone) | 12607 | -0.485 | 0.2744 | No | ||
73 | 57876 | "MUC3B (mucin 3B, cell surface associated)" | 12647 | -0.498 | 0.2727 | No | ||
74 | 3574 | IL7 (interleukin 7) | 13019 | -0.612 | 0.2547 | No | ||
75 | 8368 | "HIST1H4L (histone cluster 1, H4l)" | 13315 | -0.710 | 0.2405 | No | ||
76 | 4160 | MC4R (melanocortin 4 receptor) | 13545 | -0.793 | 0.2296 | No | ||
77 | 585 | BBS4 (Bardet-Biedl syndrome 4) | 13612 | -0.822 | 0.2268 | No | ||
78 | 7099 | TLR4 (toll-like receptor 4) | 14032 | -1.010 | 0.2066 | No | ||
79 | 6441 | SFTPD (surfactant protein D) | 14068 | -1.033 | 0.2054 | No | ||
80 | 80119 | PIF1 (PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)) | 14116 | -1.057 | 0.2036 | No | ||
81 | 4760 | NEUROD1 (neurogenic differentiation 1) | 14137 | -1.065 | 0.2032 | No | ||
82 | 5025 | "P2RX4 (purinergic receptor P2X, ligand-gated ion channel, 4)" | 14139 | -1.066 | 0.2037 | No | ||
83 | 8029 | CUBN (cubilin (intrinsic factor-cobalamin receptor)) | 14416 | -1.188 | 0.1907 | No | ||
84 | 6722 | SRF (serum response factor (c-fos serum response element-binding transcription factor)) | 14565 | -1.276 | 0.1841 | No | ||
85 | 7128 | "TNFAIP3 (tumor necrosis factor, alpha-induced protein 3)" | 14654 | -1.331 | 0.1804 | No | ||
86 | 23498 | "HAAO (3-hydroxyanthranilate 3,4-dioxygenase)" | 14801 | -1.422 | 0.1740 | No | ||
87 | 8370 | "HIST2H4A (histone cluster 2, H4a)" | 15149 | -1.673 | 0.1577 | No | ||
88 | 54106 | TLR9 (toll-like receptor 9) | 15160 | -1.682 | 0.1581 | No | ||
89 | 8361 | "HIST1H4F (histone cluster 1, H4f)" | 15444 | -1.911 | 0.1451 | No | ||
90 | 8367 | "HIST1H4E (histone cluster 1, H4e)" | 15478 | -1.939 | 0.1445 | No | ||
91 | 7011 | TEP1 (telomerase-associated protein 1) | 15540 | -2.005 | 0.1426 | No | ||
92 | 7015 | TERT (telomerase reverse transcriptase) | 15612 | -2.063 | 0.1402 | No | ||
93 | 3690 | "ITGB3 (integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61))" | 15709 | -2.159 | 0.1366 | No | ||
94 | 796 | CALCA (calcitonin-related polypeptide alpha) | 16176 | -2.725 | 0.1150 | No | ||
95 | 8658 | "TNKS (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase)" | 16951 | -4.120 | 0.0789 | No | ||
96 | 57804 | "POLD4 (polymerase (DNA-directed), delta 4)" | 17078 | -4.447 | 0.0751 | No | ||
97 | 2185 | PTK2B (PTK2B protein tyrosine kinase 2 beta) | 17444 | -5.452 | 0.0599 | No | ||
98 | 80169 | C17orf68 (chromosome 17 open reading frame 68) | 17913 | -7.441 | 0.0408 | No | ||
99 | 4584 | "MUC3A (mucin 3A, cell surface associated)" | 17916 | -7.462 | 0.0447 | No | ||
100 | 582 | BBS1 (Bardet-Biedl syndrome 1) | 17978 | -7.805 | 0.0458 | No | ||
101 | 23293 | "SMG6 (Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans))" | 18036 | -8.067 | 0.0473 | No | ||
102 | 8362 | "HIST1H4K (histone cluster 1, H4k)" | 18125 | -8.615 | 0.0476 | No | ||
103 | 7014 | TERF2 (telomeric repeat binding factor 2) | 18350 | -9.921 | 0.0418 | No | ||
104 | 4588 | "MUC6 (mucin 6, oligomeric mucus/gel-forming)" | 18361 | -9.957 | 0.0467 | No | ||
105 | 5371 | PML (promyelocytic leukemia) | 18450 | -10.797 | 0.0481 | No | ||
106 | 2067 | "ERCC1 (excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence))" | 18551 | -11.530 | 0.0493 | No | ||
107 | 80351 | "TNKS2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2)" | 18583 | -11.868 | 0.0542 | No | ||
108 | 8365 | "HIST1H4H (histone cluster 1, H4h)" | 18949 | -16.029 | 0.0447 | No | ||
109 | 1200 | TPP1 (tripeptidyl peptidase I) | 19050 | -17.858 | 0.0493 | No | ||
110 | 26277 | TINF2 (TERF1 (TRF1)-interacting nuclear factor 2) | 19397 | -25.602 | 0.0459 | No |