Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | cont |
GeneSet | GO|GO:0051607 |
Enrichment Score (ES) | -0.649058 |
Normalized Enrichment Score (NES) | -1.5661181 |
Nominal p-value | 0.012861736 |
FDR q-value | 0.3214722 |
FWER p-Value | 1.0 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 664 | BNIP3 (BCL2/adenovirus E1B 19kDa interacting protein 3) | 228 | 97.404 | 0.0538 | No | ||
2 | 8772 | FADD (Fas (TNFRSF6)-associated via death domain) | 808 | 44.495 | 0.0549 | No | ||
3 | 596 | BCL2 (B-cell CLL/lymphoma 2) | 1760 | 21.505 | 0.0223 | No | ||
4 | 1175 | "AP2S1 (adaptor-related protein complex 2, sigma 1 subunit)" | 1777 | 21.343 | 0.0358 | No | ||
5 | 162 | "AP1B1 (adaptor-related protein complex 1, beta 1 subunit)" | 2020 | 18.565 | 0.0362 | No | ||
6 | 8905 | "AP1S2 (adaptor-related protein complex 1, sigma 2 subunit)" | 2240 | 16.745 | 0.0366 | No | ||
7 | 6895 | TARBP2 (TAR (HIV-1) RNA binding protein 2) | 2251 | 16.637 | 0.0472 | No | ||
8 | 163 | "AP2B1 (adaptor-related protein complex 2, beta 1 subunit)" | 2511 | 14.197 | 0.0439 | No | ||
9 | 161 | "AP2A2 (adaptor-related protein complex 2, alpha 2 subunit)" | 2544 | 13.921 | 0.0516 | No | ||
10 | 4277 | MICB (MHC class I polypeptide-related sequence B) | 2688 | 12.937 | 0.0532 | No | ||
11 | 8907 | "AP1M1 (adaptor-related protein complex 1, mu 1 subunit)" | 3145 | 10.205 | 0.0375 | No | ||
12 | 130340 | "AP1S3 (adaptor-related protein complex 1, sigma 3 subunit)" | 3774 | 7.615 | 0.0115 | No | ||
13 | 51191 | HERC5 (hect domain and RLD 5) | 4140 | 6.303 | -0.0023 | No | ||
14 | 2534 | "FYN (FYN oncogene related to SRC, FGR, YES)" | 4244 | 5.992 | -0.0034 | No | ||
15 | 7187 | TRAF3 (TNF receptor-associated factor 3) | 4328 | 5.691 | -0.0037 | No | ||
16 | 255520 | ELMOD2 (ELMO/CED-12 domain containing 2) | 4514 | 5.198 | -0.0093 | No | ||
17 | 1174 | "AP1S1 (adaptor-related protein complex 1, sigma 1 subunit)" | 4682 | 4.756 | -0.0144 | No | ||
18 | 160 | "AP2A1 (adaptor-related protein complex 2, alpha 1 subunit)" | 4698 | 4.725 | -0.0120 | No | ||
19 | 60489 | "APOBEC3G (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G)" | 5820 | 2.589 | -0.0656 | No | ||
20 | 2150 | F2RL1 (coagulation factor II (thrombin) receptor-like 1) | 5923 | 2.465 | -0.0690 | No | ||
21 | 282618 | "IL29 (interleukin 29 (interferon, lambda 1))" | 6786 | 1.527 | -0.1105 | No | ||
22 | 149233 | IL23R (interleukin 23 receptor) | 7228 | 1.174 | -0.1315 | No | ||
23 | 340061 | TMEM173 (transmembrane protein 173) | 7361 | 1.090 | -0.1373 | No | ||
24 | 83737 | ITCH (itchy E3 ubiquitin protein ligase homolog (mouse)) | 7590 | 0.949 | -0.1480 | No | ||
25 | 3932 | LCK (lymphocyte-specific protein tyrosine kinase) | 8602 | 0.511 | -0.1975 | No | ||
26 | 5551 | PRF1 (perforin 1 (pore forming protein)) | 9314 | 0.302 | -0.2324 | No | ||
27 | 3569 | "IL6 (interleukin 6 (interferon, beta 2))" | 9770 | 0.188 | -0.2548 | No | ||
28 | 54476 | RNF216 (ring finger protein 216) | 9832 | 0.174 | -0.2577 | No | ||
29 | 919 | CD247 (CD247 molecule) | 9865 | 0.167 | -0.2592 | No | ||
30 | 51284 | TLR7 (toll-like receptor 7) | 10492 | 0.016 | -0.2901 | No | ||
31 | 1130 | LYST (lysosomal trafficking regulator) | 10863 | -0.062 | -0.3083 | No | ||
32 | 5788 | "PTPRC (protein tyrosine phosphatase, receptor type, C)" | 11206 | -0.144 | -0.3251 | No | ||
33 | 3593 | "IL12B (interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40))" | 11374 | -0.185 | -0.3332 | No | ||
34 | 7098 | TLR3 (toll-like receptor 3) | 11911 | -0.304 | -0.3595 | No | ||
35 | 940 | CD28 (CD28 molecule) | 12034 | -0.333 | -0.3653 | No | ||
36 | 920 | CD4 (CD4 molecule) | 12457 | -0.446 | -0.3858 | No | ||
37 | 10060 | "ABCC9 (ATP-binding cassette, sub-family C (CFTR/MRP), member 9)" | 12798 | -0.543 | -0.4022 | No | ||
38 | 200315 | "APOBEC3A (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A)" | 12811 | -0.548 | -0.4025 | No | ||
39 | 50489 | "CD207 (CD207 molecule, langerin)" | 13390 | -0.738 | -0.4305 | No | ||
40 | 51311 | TLR8 (toll-like receptor 8) | 13682 | -0.846 | -0.4443 | No | ||
41 | 6041 | "RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent))" | 13797 | -0.896 | -0.4493 | No | ||
42 | 163702 | "IL28RA (interleukin 28 receptor, alpha (interferon, lambda receptor))" | 13920 | -0.961 | -0.4547 | No | ||
43 | 1794 | DOCK2 (dedicator of cytokinesis 2) | 14135 | -1.064 | -0.4646 | No | ||
44 | 926 | CD8B (CD8b molecule) | 14383 | -1.176 | -0.4760 | No | ||
45 | 9844 | ELMO1 (engulfment and cell motility 1) | 14392 | -1.178 | -0.4756 | No | ||
46 | 7128 | "TNFAIP3 (tumor necrosis factor, alpha-induced protein 3)" | 14654 | -1.331 | -0.4876 | No | ||
47 | 3456 | "IFNB1 (interferon, beta 1, fibroblast)" | 14732 | -1.384 | -0.4905 | No | ||
48 | 3594 | "IL12RB1 (interleukin 12 receptor, beta 1)" | 15945 | -2.429 | -0.5487 | No | ||
49 | 3055 | HCK (hemopoietic cell kinase) | 16018 | -2.517 | -0.5506 | No | ||
50 | 84166 | "NLRC5 (NLR family, CARD domain containing 5)" | 16156 | -2.702 | -0.5555 | No | ||
51 | 81844 | TRIM56 (tripartite motif-containing 56) | 16172 | -2.721 | -0.5545 | No | ||
52 | 91543 | RSAD2 (radical S-adenosyl methionine domain containing 2) | 16978 | -4.199 | -0.5914 | No | ||
53 | 200316 | "APOBEC3F (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F)" | 17527 | -5.737 | -0.6146 | No | ||
54 | 10053 | "AP1M2 (adaptor-related protein complex 1, mu 2 subunit)" | 17870 | -7.186 | -0.6267 | No | ||
55 | 665 | BNIP3L (BCL2/adenovirus E1B 19kDa interacting protein 3-like) | 18121 | -8.583 | -0.6333 | No | ||
56 | 5970 | RELA (v-rel reticuloendotheliosis viral oncogene homolog A (avian)) | 18184 | -8.954 | -0.6304 | No | ||
57 | 25939 | SAMHD1 (SAM domain and HD domain 1) | 18307 | -9.649 | -0.6300 | No | ||
58 | 5371 | PML (promyelocytic leukemia) | 18450 | -10.797 | -0.6298 | No | ||
59 | 51606 | "ATP6V1H (ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H)" | 18782 | -13.854 | -0.6369 | No | ||
60 | 51561 | "IL23A (interleukin 23, alpha subunit p19)" | 19029 | -17.353 | -0.6375 | Yes | ||
61 | 684 | BST2 (bone marrow stromal cell antigen 2) | 19237 | -21.251 | -0.6335 | Yes | ||
62 | 23586 | DDX58 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 58) | 19385 | -25.182 | -0.6239 | Yes | ||
63 | 375 | ARF1 (ADP-ribosylation factor 1) | 19469 | -27.515 | -0.6097 | Yes | ||
64 | 55690 | PACS1 (phosphofurin acidic cluster sorting protein 1) | 19567 | -30.534 | -0.5941 | Yes | ||
65 | 5879 | "RAC1 (ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1))" | 19612 | -32.214 | -0.5747 | Yes | ||
66 | 57506 | VISA (virus-induced signaling adapter) | 19622 | -32.677 | -0.5534 | Yes | ||
67 | 5062 | PAK2 (p21 protein (Cdc42/Rac)-activated kinase 2) | 19777 | -40.918 | -0.5336 | Yes | ||
68 | 164 | "AP1G1 (adaptor-related protein complex 1, gamma 1 subunit)" | 19805 | -42.696 | -0.5065 | Yes | ||
69 | 1173 | "AP2M1 (adaptor-related protein complex 2, mu 1 subunit)" | 19821 | -43.932 | -0.4779 | Yes | ||
70 | 4938 | "OAS1 (2',5'-oligoadenylate synthetase 1, 40/46kDa)" | 19903 | -51.434 | -0.4475 | Yes | ||
71 | 5094 | PCBP2 (poly(rC) binding protein 2) | 20076 | -73.183 | -0.4072 | Yes | ||
72 | 4940 | "OAS3 (2'-5'-oligoadenylate synthetase 3, 100kDa)" | 20125 | -86.843 | -0.3515 | Yes | ||
73 | 5359 | PLSCR1 (phospholipid scramblase 1) | 20126 | -86.908 | -0.2935 | Yes | ||
74 | 567 | B2M (beta-2-microglobulin) | 20305 | -220.982 | -0.1548 | Yes | ||
75 | 3434 | IFIT1 (interferon-induced protein with tetratricopeptide repeats 1) | 20306 | -233.172 | 0.0009 | Yes |