Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | treated |
GeneSet | GO|GO:0006261 |
Enrichment Score (ES) | 0.7545145 |
Normalized Enrichment Score (NES) | 1.6576405 |
Nominal p-value | 0.0 |
FDR q-value | 0.026844855 |
FWER p-Value | 0.646 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 4175 | MCM6 (minichromosome maintenance complex component 6) | 78 | 163.812 | 0.0744 | Yes | ||
2 | 5111 | PCNA (proliferating cell nuclear antigen) | 102 | 146.221 | 0.1431 | Yes | ||
3 | 4176 | MCM7 (minichromosome maintenance complex component 7) | 145 | 121.439 | 0.1990 | Yes | ||
4 | 5983 | "RFC3 (replication factor C (activator 1) 3, 38kDa)" | 215 | 100.338 | 0.2436 | Yes | ||
5 | 8099 | CDK2AP1 (CDK2-associated protein 1) | 231 | 97.175 | 0.2892 | Yes | ||
6 | 4171 | MCM2 (minichromosome maintenance complex component 2) | 259 | 91.901 | 0.3318 | Yes | ||
7 | 2237 | FEN1 (flap structure-specific endonuclease 1) | 348 | 79.316 | 0.3653 | Yes | ||
8 | 51659 | GINS2 (GINS complex subunit 2 (Psf2 homolog)) | 424 | 69.284 | 0.3947 | Yes | ||
9 | 79892 | C10orf119 (chromosome 10 open reading frame 119) | 661 | 51.406 | 0.4076 | Yes | ||
10 | 9837 | GINS1 (GINS complex subunit 1 (Psf1 homolog)) | 731 | 47.833 | 0.4271 | Yes | ||
11 | 5557 | "PRIM1 (primase, DNA, polypeptide 1 (49kDa))" | 756 | 47.079 | 0.4484 | Yes | ||
12 | 4172 | MCM3 (minichromosome maintenance complex component 3) | 816 | 43.892 | 0.4664 | Yes | ||
13 | 5425 | "POLD2 (polymerase (DNA directed), delta 2, regulatory subunit 50kDa)" | 912 | 40.218 | 0.4809 | Yes | ||
14 | 54962 | TIPIN (TIMELESS interacting protein) | 927 | 39.532 | 0.4991 | Yes | ||
15 | 4174 | MCM5 (minichromosome maintenance complex component 5) | 954 | 38.341 | 0.5162 | Yes | ||
16 | 7884 | SLBP (stem-loop binding protein) | 966 | 37.985 | 0.5338 | Yes | ||
17 | 9126 | SMC3 (structural maintenance of chromosomes 3) | 998 | 37.097 | 0.5499 | Yes | ||
18 | 11177 | "BAZ1A (bromodomain adjacent to zinc finger domain, 1A)" | 1100 | 33.730 | 0.5611 | Yes | ||
19 | 7019 | "TFAM (transcription factor A, mitochondrial)" | 1267 | 29.727 | 0.5671 | Yes | ||
20 | 5982 | "RFC2 (replication factor C (activator 1) 2, 40kDa)" | 1288 | 29.303 | 0.5801 | Yes | ||
21 | 6119 | "RPA3 (replication protein A3, 14kDa)" | 1289 | 29.297 | 0.5941 | Yes | ||
22 | 8243 | SMC1A (structural maintenance of chromosomes 1A) | 1597 | 23.987 | 0.5904 | Yes | ||
23 | 23649 | "POLA2 (polymerase (DNA directed), alpha 2 (70kD subunit))" | 1598 | 23.976 | 0.6018 | Yes | ||
24 | 5985 | "RFC5 (replication factor C (activator 1) 5, 36.5kDa)" | 1617 | 23.676 | 0.6122 | Yes | ||
25 | 4998 | "ORC1L (origin recognition complex, subunit 1-like (yeast))" | 1658 | 23.133 | 0.6213 | Yes | ||
26 | 4683 | NBN (nibrin) | 1706 | 22.316 | 0.6297 | Yes | ||
27 | 81620 | CDT1 (chromatin licensing and DNA replication factor 1) | 1790 | 21.205 | 0.6357 | Yes | ||
28 | 5888 | "RAD51 (RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae))" | 1822 | 20.798 | 0.6441 | Yes | ||
29 | 4999 | "ORC2L (origin recognition complex, subunit 2-like (yeast))" | 1830 | 20.770 | 0.6537 | Yes | ||
30 | 5424 | "POLD1 (polymerase (DNA directed), delta 1, catalytic subunit 125kDa)" | 1866 | 20.334 | 0.6617 | Yes | ||
31 | 4173 | MCM4 (minichromosome maintenance complex component 4) | 1938 | 19.630 | 0.6675 | Yes | ||
32 | 84515 | MCM8 (minichromosome maintenance complex component 8) | 1949 | 19.444 | 0.6763 | Yes | ||
33 | 56897 | WRNIP1 (Werner helicase interacting protein 1) | 2028 | 18.501 | 0.6813 | Yes | ||
34 | 5001 | "ORC5L (origin recognition complex, subunit 5-like (yeast))" | 2030 | 18.486 | 0.6901 | Yes | ||
35 | 5558 | "PRIM2 (primase, DNA, polypeptide 2 (58kDa))" | 2031 | 18.485 | 0.6989 | Yes | ||
36 | 6118 | "RPA2 (replication protein A2, 32kDa)" | 2048 | 18.355 | 0.7069 | Yes | ||
37 | 8318 | CDC45L (CDC45 cell division cycle 45-like (S. cerevisiae)) | 2151 | 17.475 | 0.7102 | Yes | ||
38 | 7486 | WRN (Werner syndrome) | 2166 | 17.386 | 0.7178 | Yes | ||
39 | 5427 | "POLE2 (polymerase (DNA directed), epsilon 2 (p59 subunit))" | 2176 | 17.332 | 0.7256 | Yes | ||
40 | 5984 | "RFC4 (replication factor C (activator 1) 4, 37kDa)" | 2335 | 15.735 | 0.7254 | Yes | ||
41 | 4361 | MRE11A (MRE11 meiotic recombination 11 homolog A (S. cerevisiae)) | 2457 | 14.716 | 0.7264 | Yes | ||
42 | 56652 | C10orf2 (chromosome 10 open reading frame 2) | 2466 | 14.676 | 0.7330 | Yes | ||
43 | 5981 | "RFC1 (replication factor C (activator 1) 1, 145kDa)" | 2519 | 14.098 | 0.7372 | Yes | ||
44 | 5422 | "POLA1 (polymerase (DNA directed), alpha 1, catalytic subunit)" | 2543 | 13.945 | 0.7427 | Yes | ||
45 | 6117 | "RPA1 (replication protein A1, 70kDa)" | 2549 | 13.888 | 0.7491 | Yes | ||
46 | 222229 | LRWD1 (leucine-rich repeats and WD repeat domain containing 1) | 2573 | 13.695 | 0.7545 | Yes | ||
47 | 90381 | C15orf42 (chromosome 15 open reading frame 42) | 2769 | 12.370 | 0.7508 | No | ||
48 | 10714 | "POLD3 (polymerase (DNA-directed), delta 3, accessory subunit)" | 3097 | 10.449 | 0.7396 | No | ||
49 | 79736 | C17orf42 (chromosome 17 open reading frame 42) | 3331 | 9.427 | 0.7326 | No | ||
50 | 5813 | PURA (purine-rich element binding protein A) | 3372 | 9.274 | 0.7351 | No | ||
51 | 11232 | "POLG2 (polymerase (DNA directed), gamma 2, accessory subunit)" | 3427 | 9.064 | 0.7368 | No | ||
52 | 641 | BLM (Bloom syndrome) | 3552 | 8.583 | 0.7347 | No | ||
53 | 55294 | FBXW7 (F-box and WD repeat domain containing 7) | 3750 | 7.697 | 0.7287 | No | ||
54 | 84268 | RPAIN (RPA interacting protein) | 4212 | 6.053 | 0.7088 | No | ||
55 | 84296 | GINS4 (GINS complex subunit 4 (Sld5 homolog)) | 4413 | 5.461 | 0.7015 | No | ||
56 | 4796 | NFKBIL2 (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2) | 4844 | 4.371 | 0.6824 | No | ||
57 | 5980 | "REV3L (REV3-like, catalytic subunit of DNA polymerase zeta (yeast))" | 5145 | 3.721 | 0.6693 | No | ||
58 | 5426 | "POLE (polymerase (DNA directed), epsilon)" | 5878 | 2.520 | 0.6344 | No | ||
59 | 1763 | DNA2 (DNA replication helicase 2 homolog (yeast)) | 6049 | 2.310 | 0.6271 | No | ||
60 | 92797 | HELB (helicase (DNA) B) | 6386 | 1.895 | 0.6114 | No | ||
61 | 54617 | INO80 (INO80 homolog (S. cerevisiae)) | 6834 | 1.476 | 0.5901 | No | ||
62 | 7013 | TERF1 (telomeric repeat binding factor (NIMA-interacting) 1) | 7412 | 1.059 | 0.5621 | No | ||
63 | 29935 | "RPA4 (replication protein A4, 34kDa)" | 8120 | 0.684 | 0.5275 | No | ||
64 | 3978 | "LIG1 (ligase I, DNA, ATP-dependent)" | 10691 | -0.024 | 0.4006 | No | ||
65 | 5428 | "POLG (polymerase (DNA directed), gamma)" | 10805 | -0.048 | 0.3950 | No | ||
66 | 340533 | KIAA2022 (KIAA2022) | 13859 | -0.927 | 0.2447 | No | ||
67 | 5423 | "POLB (polymerase (DNA directed), beta)" | 15243 | -1.750 | 0.1772 | No | ||
68 | 3159 | HMGA1 (high mobility group AT-hook 1) | 16865 | -3.917 | 0.0991 | No | ||
69 | 57804 | "POLD4 (polymerase (DNA-directed), delta 4)" | 17078 | -4.447 | 0.0907 | No | ||
70 | 11284 | PNKP (polynucleotide kinase 3'-phosphatase) | 17615 | -6.077 | 0.0671 | No | ||
71 | 997 | CDC34 (cell division cycle 34 homolog (S. cerevisiae)) | 17810 | -6.960 | 0.0609 | No | ||
72 | 7014 | TERF2 (telomeric repeat binding factor 2) | 18350 | -9.921 | 0.0390 | No | ||
73 | 5000 | "ORC4L (origin recognition complex, subunit 4-like (yeast))" | 18666 | -12.706 | 0.0295 | No | ||
74 | 7153 | TOP2A (topoisomerase (DNA) II alpha 170kDa) | 19279 | -22.386 | 0.0100 | No | ||
75 | 7155 | TOP2B (topoisomerase (DNA) II beta 180kDa) | 19771 | -40.621 | 0.0052 | No | ||
76 | 10735 | STAG2 (stromal antigen 2) | 19852 | -46.380 | 0.0234 | No |