Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | treated |
GeneSet | GO|GO:0051168 |
Enrichment Score (ES) | 0.7351652 |
Normalized Enrichment Score (NES) | 1.6486042 |
Nominal p-value | 0.0 |
FDR q-value | 0.031643916 |
FWER p-Value | 0.747 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 5901 | "RAN (RAN, member RAS oncogene family)" | 27 | 250.127 | 0.0837 | Yes | ||
2 | 6432 | "SFRS7 (splicing factor, arginine/serine-rich 7, 35kDa)" | 38 | 213.976 | 0.1559 | Yes | ||
3 | 1984 | EIF5A (eukaryotic translation initiation factor 5A) | 68 | 172.120 | 0.2130 | Yes | ||
4 | 6426 | "SFRS1 (splicing factor, arginine/serine-rich 1)" | 119 | 133.017 | 0.2558 | Yes | ||
5 | 6209 | RPS15 (ribosomal protein S15) | 122 | 130.517 | 0.3001 | Yes | ||
6 | 10189 | THOC4 (THO complex 4) | 158 | 117.078 | 0.3381 | Yes | ||
7 | 9939 | RBM8A (RNA binding motif protein 8A) | 201 | 102.613 | 0.3709 | Yes | ||
8 | 80145 | THOC7 (THO complex 7 homolog (Drosophila)) | 243 | 94.098 | 0.4009 | Yes | ||
9 | 6427 | "SFRS2 (splicing factor, arginine/serine-rich 2)" | 273 | 90.107 | 0.4301 | Yes | ||
10 | 57122 | NUP107 (nucleoporin 107kDa) | 276 | 89.588 | 0.4605 | Yes | ||
11 | 6428 | "SFRS3 (splicing factor, arginine/serine-rich 3)" | 302 | 85.664 | 0.4883 | Yes | ||
12 | 1977 | EIF4E (eukaryotic translation initiation factor 4E) | 306 | 84.641 | 0.5170 | Yes | ||
13 | 8480 | RAE1 (RAE1 RNA export 1 homolog (S. pombe)) | 322 | 83.312 | 0.5446 | Yes | ||
14 | 11260 | "XPOT (exportin, tRNA (nuclear export receptor for tRNAs))" | 367 | 76.844 | 0.5685 | Yes | ||
15 | 7307 | U2AF1 (U2 small nuclear RNA auxiliary factor 1) | 509 | 61.555 | 0.5825 | Yes | ||
16 | 10772 | FUSIP1 (FUS interacting protein (serine/arginine-rich) 1) | 511 | 61.419 | 0.6033 | Yes | ||
17 | 8563 | THOC5 (THO complex 5) | 620 | 53.822 | 0.6163 | Yes | ||
18 | 811 | CALR (calreticulin) | 644 | 52.360 | 0.6329 | Yes | ||
19 | 55341 | LSG1 (large subunit GTPase 1 homolog (S. cerevisiae)) | 856 | 42.370 | 0.6369 | Yes | ||
20 | 4686 | "NCBP1 (nuclear cap binding protein subunit 1, 80kDa)" | 860 | 42.266 | 0.6511 | Yes | ||
21 | 7884 | SLBP (stem-loop binding protein) | 966 | 37.985 | 0.6588 | Yes | ||
22 | 22916 | "NCBP2 (nuclear cap binding protein subunit 2, 20kDa)" | 986 | 37.528 | 0.6707 | Yes | ||
23 | 4116 | "MAGOH (mago-nashi homolog, proliferation-associated (Drosophila))" | 1009 | 36.619 | 0.6820 | Yes | ||
24 | 9295 | "SFRS11 (splicing factor, arginine/serine-rich 11)" | 1042 | 35.388 | 0.6925 | Yes | ||
25 | 10921 | "RNPS1 (RNA binding protein S1, serine-rich domain)" | 1107 | 33.536 | 0.7007 | Yes | ||
26 | 11338 | U2AF2 (U2 small nuclear RNA auxiliary factor 2) | 1112 | 33.372 | 0.7119 | Yes | ||
27 | 10657 | "KHDRBS1 (KH domain containing, RNA binding, signal transduction associated 1)" | 1396 | 27.053 | 0.7071 | Yes | ||
28 | 23214 | XPO6 (exportin 6) | 1512 | 25.187 | 0.7099 | Yes | ||
29 | 51808 | "RNUXA (RNA U, small nuclear RNA export adaptor (phosphorylation regulated))" | 1660 | 23.100 | 0.7105 | Yes | ||
30 | 580 | BARD1 (BRCA1 associated RING domain 1) | 1756 | 21.556 | 0.7132 | Yes | ||
31 | 65109 | UPF3B (UPF3 regulator of nonsense transcripts homolog B (yeast)) | 1778 | 21.341 | 0.7194 | Yes | ||
32 | 23279 | NUP160 (nucleoporin 160kDa) | 1804 | 20.988 | 0.7253 | Yes | ||
33 | 6429 | "SFRS4 (splicing factor, arginine/serine-rich 4)" | 1970 | 19.104 | 0.7236 | Yes | ||
34 | 84934 | C12orf52 (chromosome 12 open reading frame 52) | 2023 | 18.536 | 0.7274 | Yes | ||
35 | 51362 | CDC40 (cell division cycle 40 homolog (S. cerevisiae)) | 2098 | 17.942 | 0.7298 | Yes | ||
36 | 6431 | "SFRS6 (splicing factor, arginine/serine-rich 6)" | 2113 | 17.800 | 0.7352 | Yes | ||
37 | 11269 | DDX19B (DEAD (Asp-Glu-Ala-As) box polypeptide 19B) | 2524 | 14.080 | 0.7197 | No | ||
38 | 29894 | "CPSF1 (cleavage and polyadenylation specific factor 1, 160kDa)" | 2720 | 12.711 | 0.7144 | No | ||
39 | 55746 | NUP133 (nucleoporin 133kDa) | 2787 | 12.281 | 0.7153 | No | ||
40 | 10482 | NXF1 (nuclear RNA export factor 1) | 2811 | 12.145 | 0.7183 | No | ||
41 | 57187 | THOC2 (THO complex 2) | 3035 | 10.817 | 0.7109 | No | ||
42 | 9984 | THOC1 (THO complex 1) | 3123 | 10.355 | 0.7102 | No | ||
43 | 23049 | SMG1 (PI-3-kinase-related kinase SMG-1) | 3211 | 9.906 | 0.7092 | No | ||
44 | 51692 | "CPSF3 (cleavage and polyadenylation specific factor 3, 73kDa)" | 3299 | 9.533 | 0.7082 | No | ||
45 | 10250 | SRRM1 (serine/arginine repetitive matrix 1) | 3484 | 8.795 | 0.7021 | No | ||
46 | 2010 | EMD (emerin) | 3549 | 8.598 | 0.7018 | No | ||
47 | 7040 | "TGFB1 (transforming growth factor, beta 1)" | 3665 | 8.104 | 0.6989 | No | ||
48 | 5976 | UPF1 (UPF1 regulator of nonsense transcripts homolog (yeast)) | 4148 | 6.283 | 0.6772 | No | ||
49 | 79228 | THOC6 (THO complex 6 homolog (Drosophila)) | 4206 | 6.072 | 0.6765 | No | ||
50 | 23381 | "SMG5 (Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans))" | 4285 | 5.861 | 0.6746 | No | ||
51 | 23039 | XPO7 (exportin 7) | 4783 | 4.527 | 0.6516 | No | ||
52 | 57154 | SMURF1 (SMAD specific E3 ubiquitin protein ligase 1) | 4836 | 4.388 | 0.6505 | No | ||
53 | 80824 | DUSP16 (dual specificity phosphatase 16) | 4923 | 4.181 | 0.6477 | No | ||
54 | 10892 | MALT1 (mucosa associated lymphoid tissue lymphoma translocation gene 1) | 5886 | 2.511 | 0.6010 | No | ||
55 | 3087 | HHEX (hematopoietically expressed homeobox) | 6095 | 2.232 | 0.5915 | No | ||
56 | 56001 | NXF2 (nuclear RNA export factor 2) | 6582 | 1.692 | 0.5680 | No | ||
57 | 23144 | ZC3H3 (zinc finger CCCH-type containing 3) | 7516 | 0.986 | 0.5223 | No | ||
58 | 2932 | GSK3B (glycogen synthase kinase 3 beta) | 8018 | 0.725 | 0.4978 | No | ||
59 | 55998 | NXF5 (nuclear RNA export factor 5) | 8043 | 0.713 | 0.4968 | No | ||
60 | 56000 | NXF3 (nuclear RNA export factor 3) | 8688 | 0.482 | 0.4652 | No | ||
61 | 8106 | "PABPN1 (poly(A) binding protein, nuclear 1)" | 9866 | 0.167 | 0.4071 | No | ||
62 | 7248 | TSC1 (tuberous sclerosis 1) | 10179 | 0.089 | 0.3917 | No | ||
63 | 1959 | "EGR2 (early growth response 2 (Krox-20 homolog, Drosophila))" | 11293 | -0.162 | 0.3367 | No | ||
64 | 29118 | DDX25 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 25) | 11315 | -0.167 | 0.3357 | No | ||
65 | 3553 | "IL1B (interleukin 1, beta)" | 11912 | -0.304 | 0.3064 | No | ||
66 | 10212 | DDX39 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 39) | 12643 | -0.497 | 0.2705 | No | ||
67 | 9785 | DHX38 (DEAH (Asp-Glu-Ala-His) box polypeptide 38) | 14908 | -1.491 | 0.1591 | No | ||
68 | 26019 | UPF2 (UPF2 regulator of nonsense transcripts homolog (yeast)) | 14958 | -1.532 | 0.1572 | No | ||
69 | 53981 | "CPSF2 (cleavage and polyadenylation specific factor 2, 100kDa)" | 15120 | -1.654 | 0.1498 | No | ||
70 | 3267 | HRB (HIV-1 Rev binding protein) | 15546 | -2.007 | 0.1295 | No | ||
71 | 8021 | NUP214 (nucleoporin 214kDa) | 16014 | -2.513 | 0.1073 | No | ||
72 | 2733 | GLE1 (GLE1 RNA export mediator homolog (yeast)) | 16723 | -3.644 | 0.0735 | No | ||
73 | 1029 | "CDKN2A (cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4))" | 17223 | -4.794 | 0.0505 | No | ||
74 | 92335 | LYK5 (protein kinase LYK5) | 17393 | -5.272 | 0.0440 | No | ||
75 | 55437 | "ALS2CR2 (amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2)" | 17797 | -6.909 | 0.0264 | No | ||
76 | 23293 | "SMG6 (Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans))" | 18036 | -8.067 | 0.0174 | No | ||
77 | 3178 | HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) | 18139 | -8.691 | 0.0153 | No | ||
78 | 11097 | NUPL2 (nucleoporin like 2) | 18164 | -8.850 | 0.0171 | No | ||
79 | 9887 | "SMG7 (Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans))" | 18182 | -8.946 | 0.0193 | No | ||
80 | 127933 | UHMK1 (U2AF homology motif (UHM) kinase 1) | 18381 | -10.154 | 0.0130 | No | ||
81 | 6310 | ATXN1 (ataxin 1) | 18704 | -13.104 | 0.0015 | No | ||
82 | 8683 | "SFRS9 (splicing factor, arginine/serine-rich 9)" | 18964 | -16.250 | -0.0058 | No | ||
83 | 11163 | NUDT4 (nudix (nucleoside diphosphate linked moiety X)-type motif 4) | 19126 | -19.371 | -0.0071 | No | ||
84 | 3921 | RPSA (ribosomal protein SA) | 19315 | -23.344 | -0.0085 | No | ||
85 | 84248 | FYTTD1 (forty-two-three domain containing 1) | 19338 | -23.934 | -0.0014 | No | ||
86 | 7919 | BAT1 (HLA-B associated transcript 1) | 19345 | -24.118 | 0.0065 | No | ||
87 | 6659 | SOX4 (SRY (sex determining region Y)-box 4) | 19584 | -30.987 | 0.0052 | No | ||
88 | 6934 | "TCF7L2 (transcription factor 7-like 2 (T-cell specific, HMG-box))" | 19726 | -38.340 | 0.0113 | No | ||
89 | 6430 | "SFRS5 (splicing factor, arginine/serine-rich 5)" | 19923 | -53.636 | 0.0199 | No |