Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classcont
GeneSetREACTOME|REACT_25229.1
Enrichment Score (ES)-0.75266725
Normalized Enrichment Score (NES)-1.8837374
Nominal p-value0.0
FDR q-value0.003330555
FWER p-Value0.011
Table: GSEA Results Summary



Fig 1: Enrichment plot: REACTOME|REACT_25229.1   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1818CAMK2G (calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma)32882.5410.0144No
23716JAK1 (Janus kinase 1 (a protein tyrosine kinase))60654.8420.0210No
35781"PTPN11 (protein tyrosine phosphatase, non-receptor type 11)"66851.1180.0370No
4960CD44 (CD44 molecule (Indian blood group))112233.1750.0269No
53669ISG20 (interferon stimulated exonuclease gene 20kDa)148625.6750.0185No
63717JAK2 (Janus kinase 2 (a protein tyrosine kinase))152624.9470.0258No
73123"HLA-DRB1 (major histocompatibility complex, class II, DR beta 1)"257913.655-0.0212No
85770"PTPN1 (protein tyrosine phosphatase, non-receptor type 1)"264613.099-0.0196No
93661IRF3 (interferon regulatory factor 3)265513.086-0.0151No
107341SUMO1 (SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae))36578.157-0.0616No
113126"HLA-DRB4 (major histocompatibility complex, class II, DR beta 4)"43715.560-0.0948No
123663IRF5 (interferon regulatory factor 5)53333.348-0.1410No
133127"HLA-DRB5 (major histocompatibility complex, class II, DR beta 5)"60782.255-0.1770No
143113"HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)"64331.847-0.1938No
15163351"GBP6 (guanylate binding protein family, member 6)"64541.813-0.1941No
165777"PTPN6 (protein tyrosine phosphatase, non-receptor type 6)"69581.373-0.2185No
175696"PSMB8 (proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7))"72191.180-0.2309No
183443"IFNA6 (interferon, alpha 6)"77570.861-0.2571No
198651SOCS1 (suppressor of cytokine signaling 1)78250.822-0.2602No
203440"IFNA2 (interferon, alpha 2)"81440.676-0.2756No
213460IFNGR2 (interferon gamma receptor 2 (interferon gamma transducer 1))82640.626-0.2813No
224684NCAM1 (neural cell adhesion molecule 1)83220.605-0.2839No
233662IRF4 (interferon regulatory factor 4)88960.417-0.3120No
243115"HLA-DPB1 (major histocompatibility complex, class II, DP beta 1)"89030.414-0.3122No
254502MT2A (metallothionein 2A)95880.231-0.3459No
267412VCAM1 (vascular cell adhesion molecule 1)97950.183-0.3560No
273458"IFNG (interferon, gamma)"98350.174-0.3579No
283442"IFNA5 (interferon, alpha 5)"99680.144-0.3644No
295724PTAFR (platelet-activating factor receptor)100870.113-0.3702No
30115361GBP4 (guanylate binding protein 4)103980.039-0.3855No
313446"IFNA10 (interferon, alpha 10)"10839-0.055-0.4072No
323439"IFNA1 (interferon, alpha 1)"11441-0.201-0.4369No
333445"IFNA8 (interferon, alpha 8)"11458-0.205-0.4376No
349021SOCS3 (suppressor of cytokine signaling 3)12244-0.385-0.4762No
353441"IFNA4 (interferon, alpha 4)"12451-0.445-0.4863No
363449"IFNA16 (interferon, alpha 16)"12618-0.489-0.4943No
373451"IFNA17 (interferon, alpha 17)"12711-0.517-0.4986No
38115362GBP5 (guanylate binding protein 5)12797-0.543-0.5027No
392210"FCGR1B (Fc fragment of IgG, high affinity Ib, receptor (CD64))"12991-0.602-0.5120No
404600MX2 (myxovirus (influenza virus) resistance 2 (mouse))13084-0.634-0.5163No
414599"MX1 (myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse))"13262-0.687-0.5248No
423112"HLA-DOB (major histocompatibility complex, class II, DO beta)"13515-0.781-0.5370No
433108"HLA-DMA (major histocompatibility complex, class II, DM alpha)"13572-0.805-0.5394No
443444"IFNA7 (interferon, alpha 7)"13599-0.815-0.5404No
451958EGR1 (early growth response 1)13634-0.827-0.5418No
466041"RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent))"13797-0.896-0.5495No
475580"PRKCD (protein kinase C, delta)"14205-1.089-0.5692No
4854739XAF1 (XIAP associated factor 1)14206-1.089-0.5688No
493448"IFNA14 (interferon, alpha 14)"14278-1.122-0.5719No
503452"IFNA21 (interferon, alpha 21)"14303-1.135-0.5726No
513109"HLA-DMB (major histocompatibility complex, class II, DM beta)"14469-1.219-0.5803No
523456"IFNB1 (interferon, beta 1, fibroblast)"14732-1.384-0.5928No
532209"FCGR1A (Fc fragment of IgG, high affinity Ia, receptor (CD64))"15096-1.635-0.6101No
54816CAMK2B (calcium/calmodulin-dependent protein kinase (CaM kinase) II beta)15145-1.669-0.6119No
553394IRF8 (interferon regulatory factor 8)15221-1.737-0.6149No
563454"IFNAR1 (interferon (alpha, beta and omega) receptor 1)"15684-2.132-0.6370No
57815CAMK2A (calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha)16092-2.630-0.6561No
584261"CIITA (class II, major histocompatibility complex, transactivator)"16562-3.334-0.6781No
598638OASL (2'-5'-oligoadenylate synthetase-like)16666-3.527-0.6819No
607297TYK2 (tyrosine kinase 2)16697-3.598-0.6820No
616672SP100 (SP100 nuclear antigen)16717-3.632-0.6816No
623433IFIT2 (interferon-induced protein with tetratricopeptide repeats 2)17164-4.656-0.7019No
633660IRF2 (interferon regulatory factor 2)17207-4.758-0.7023No
643111"HLA-DOA (major histocompatibility complex, class II, DO alpha)"17650-6.220-0.7218No
653383ICAM1 (intercellular adhesion molecule 1)17688-6.391-0.7213No
663664IRF6 (interferon regulatory factor 6)17986-7.831-0.7330No
673122"HLA-DRA (major histocompatibility complex, class II, DR alpha)"17997-7.888-0.7306No
683659IRF1 (interferon regulatory factor 1)18007-7.943-0.7281No
698554"PIAS1 (protein inhibitor of activated STAT, 1)"18340-9.843-0.7409No
705371PML (promyelocytic leukemia)18450-10.797-0.7423No
712635GBP3 (guanylate binding protein 3)18501-11.136-0.7406No
723665IRF7 (interferon regulatory factor 7)18746-13.575-0.7476Yes
732633"GBP1 (guanylate binding protein 1, interferon-inducible, 67kDa)"18816-14.186-0.7458Yes
7411274USP18 (ubiquitin specific peptidase 18)18861-14.702-0.7425Yes
752634"GBP2 (guanylate binding protein 2, interferon-inducible)"18868-14.825-0.7373Yes
763430IFI35 (interferon-induced protein 35)19007-16.958-0.7378Yes
773437IFIT3 (interferon-induced protein with tetratricopeptide repeats 3)19104-18.975-0.7355Yes
783134"HLA-F (major histocompatibility complex, class I, F)"19233-21.099-0.7341Yes
794939"OAS2 (2'-5'-oligoadenylate synthetase 2, 69/71kDa)"19395-25.501-0.7326Yes
806773"STAT2 (signal transducer and activator of transcription 2, 113kDa)"19399-25.624-0.7232Yes
813429"IFI27 (interferon, alpha-inducible protein 27)"19448-26.932-0.7156Yes
823133"HLA-E (major histocompatibility complex, class I, E)"19478-27.797-0.7067Yes
8351447IHPK2 (inositol hexaphosphate kinase 2)19516-28.829-0.6978Yes
84817CAMK2D (calcium/calmodulin-dependent protein kinase (CaM kinase) II delta)19600-31.852-0.6901Yes
852537"IFI6 (interferon, alpha-inducible protein 6)"19662-35.028-0.6802Yes
8610437"IFI30 (interferon, gamma-inducible protein 30)"19766-40.310-0.6703Yes
873135"HLA-G (major histocompatibility complex, class I, G)"19863-47.478-0.6574Yes
884938"OAS1 (2',5'-oligoadenylate synthetase 1, 40/46kDa)"19903-51.434-0.6403Yes
893459IFNGR1 (interferon gamma receptor 1)19965-58.421-0.6217Yes
9010581IFITM2 (interferon induced transmembrane protein 2 (1-8D))19970-58.782-0.6000Yes
913105"HLA-A (major histocompatibility complex, class I, A)"20027-65.132-0.5787Yes
923106"HLA-B (major histocompatibility complex, class I, B)"20100-78.491-0.5531Yes
934940"OAS3 (2'-5'-oligoadenylate synthetase 3, 100kDa)"20125-86.843-0.5221Yes
948519IFITM1 (interferon induced transmembrane protein 1 (9-27))20204-117.578-0.4823Yes
95103"ADAR (adenosine deaminase, RNA-specific)"20231-134.677-0.4337Yes
963107"HLA-C (major histocompatibility complex, class I, C)"20243-142.867-0.3812Yes
9710379IRF9 (interferon regulatory factor 9)20262-164.279-0.3212Yes
9810410IFITM3 (interferon induced transmembrane protein 3 (1-8U))20271-173.958-0.2571Yes
99567B2M (beta-2-microglobulin)20305-220.982-0.1768Yes
1003434IFIT1 (interferon-induced protein with tetratricopeptide repeats 1)20306-233.172-0.0903Yes
1019636ISG15 (ISG15 ubiquitin-like modifier)20309-245.8520.0008Yes
Table: GSEA details [plain text format]



Fig 2: REACTOME|REACT_25229.1   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: REACTOME|REACT_25229.1: Random ES distribution   
Gene set null distribution of ES for REACTOME|REACT_25229.1