Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | cont |
GeneSet | REACTOME|REACT_25162.1 |
Enrichment Score (ES) | -0.8207189 |
Normalized Enrichment Score (NES) | -1.9450018 |
Nominal p-value | 0.0 |
FDR q-value | 0.0024581559 |
FWER p-Value | 0.0020 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 3716 | JAK1 (Janus kinase 1 (a protein tyrosine kinase)) | 606 | 54.842 | -0.0036 | No | ||
2 | 5781 | "PTPN11 (protein tyrosine phosphatase, non-receptor type 11)" | 668 | 51.118 | 0.0179 | No | ||
3 | 3669 | ISG20 (interferon stimulated exonuclease gene 20kDa) | 1486 | 25.675 | -0.0101 | No | ||
4 | 5770 | "PTPN1 (protein tyrosine phosphatase, non-receptor type 1)" | 2646 | 13.099 | -0.0610 | No | ||
5 | 3661 | IRF3 (interferon regulatory factor 3) | 2655 | 13.086 | -0.0551 | No | ||
6 | 3663 | IRF5 (interferon regulatory factor 5) | 5333 | 3.348 | -0.1856 | No | ||
7 | 5777 | "PTPN6 (protein tyrosine phosphatase, non-receptor type 6)" | 6958 | 1.373 | -0.2651 | No | ||
8 | 5696 | "PSMB8 (proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7))" | 7219 | 1.180 | -0.2773 | No | ||
9 | 3443 | "IFNA6 (interferon, alpha 6)" | 7757 | 0.861 | -0.3034 | No | ||
10 | 8651 | SOCS1 (suppressor of cytokine signaling 1) | 7825 | 0.822 | -0.3063 | No | ||
11 | 3440 | "IFNA2 (interferon, alpha 2)" | 8144 | 0.676 | -0.3217 | No | ||
12 | 3662 | IRF4 (interferon regulatory factor 4) | 8896 | 0.417 | -0.3586 | No | ||
13 | 3442 | "IFNA5 (interferon, alpha 5)" | 9968 | 0.144 | -0.4114 | No | ||
14 | 3446 | "IFNA10 (interferon, alpha 10)" | 10839 | -0.055 | -0.4543 | No | ||
15 | 3439 | "IFNA1 (interferon, alpha 1)" | 11441 | -0.201 | -0.4838 | No | ||
16 | 3445 | "IFNA8 (interferon, alpha 8)" | 11458 | -0.205 | -0.4845 | No | ||
17 | 9021 | SOCS3 (suppressor of cytokine signaling 3) | 12244 | -0.385 | -0.5231 | No | ||
18 | 3441 | "IFNA4 (interferon, alpha 4)" | 12451 | -0.445 | -0.5330 | No | ||
19 | 3449 | "IFNA16 (interferon, alpha 16)" | 12618 | -0.489 | -0.5410 | No | ||
20 | 3451 | "IFNA17 (interferon, alpha 17)" | 12711 | -0.517 | -0.5453 | No | ||
21 | 4600 | MX2 (myxovirus (influenza virus) resistance 2 (mouse)) | 13084 | -0.634 | -0.5633 | No | ||
22 | 4599 | "MX1 (myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse))" | 13262 | -0.687 | -0.5717 | No | ||
23 | 3444 | "IFNA7 (interferon, alpha 7)" | 13599 | -0.815 | -0.5879 | No | ||
24 | 1958 | EGR1 (early growth response 1) | 13634 | -0.827 | -0.5892 | No | ||
25 | 6041 | "RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent))" | 13797 | -0.896 | -0.5968 | No | ||
26 | 54739 | XAF1 (XIAP associated factor 1) | 14206 | -1.089 | -0.6164 | No | ||
27 | 3448 | "IFNA14 (interferon, alpha 14)" | 14278 | -1.122 | -0.6193 | No | ||
28 | 3452 | "IFNA21 (interferon, alpha 21)" | 14303 | -1.135 | -0.6200 | No | ||
29 | 3456 | "IFNB1 (interferon, beta 1, fibroblast)" | 14732 | -1.384 | -0.6404 | No | ||
30 | 3394 | IRF8 (interferon regulatory factor 8) | 15221 | -1.737 | -0.6637 | No | ||
31 | 3454 | "IFNAR1 (interferon (alpha, beta and omega) receptor 1)" | 15684 | -2.132 | -0.6855 | No | ||
32 | 8638 | OASL (2'-5'-oligoadenylate synthetase-like) | 16666 | -3.527 | -0.7322 | No | ||
33 | 7297 | TYK2 (tyrosine kinase 2) | 16697 | -3.598 | -0.7319 | No | ||
34 | 3433 | IFIT2 (interferon-induced protein with tetratricopeptide repeats 2) | 17164 | -4.656 | -0.7527 | No | ||
35 | 3660 | IRF2 (interferon regulatory factor 2) | 17207 | -4.758 | -0.7525 | No | ||
36 | 3664 | IRF6 (interferon regulatory factor 6) | 17986 | -7.831 | -0.7871 | No | ||
37 | 3659 | IRF1 (interferon regulatory factor 1) | 18007 | -7.943 | -0.7843 | No | ||
38 | 3665 | IRF7 (interferon regulatory factor 7) | 18746 | -13.575 | -0.8142 | Yes | ||
39 | 11274 | USP18 (ubiquitin specific peptidase 18) | 18861 | -14.702 | -0.8128 | Yes | ||
40 | 2634 | "GBP2 (guanylate binding protein 2, interferon-inducible)" | 18868 | -14.825 | -0.8060 | Yes | ||
41 | 3430 | IFI35 (interferon-induced protein 35) | 19007 | -16.958 | -0.8046 | Yes | ||
42 | 3437 | IFIT3 (interferon-induced protein with tetratricopeptide repeats 3) | 19104 | -18.975 | -0.8003 | Yes | ||
43 | 3134 | "HLA-F (major histocompatibility complex, class I, F)" | 19233 | -21.099 | -0.7965 | Yes | ||
44 | 4939 | "OAS2 (2'-5'-oligoadenylate synthetase 2, 69/71kDa)" | 19395 | -25.501 | -0.7922 | Yes | ||
45 | 6773 | "STAT2 (signal transducer and activator of transcription 2, 113kDa)" | 19399 | -25.624 | -0.7800 | Yes | ||
46 | 3429 | "IFI27 (interferon, alpha-inducible protein 27)" | 19448 | -26.932 | -0.7695 | Yes | ||
47 | 3133 | "HLA-E (major histocompatibility complex, class I, E)" | 19478 | -27.797 | -0.7576 | Yes | ||
48 | 51447 | IHPK2 (inositol hexaphosphate kinase 2) | 19516 | -28.829 | -0.7456 | Yes | ||
49 | 2537 | "IFI6 (interferon, alpha-inducible protein 6)" | 19662 | -35.028 | -0.7359 | Yes | ||
50 | 3135 | "HLA-G (major histocompatibility complex, class I, G)" | 19863 | -47.478 | -0.7230 | Yes | ||
51 | 4938 | "OAS1 (2',5'-oligoadenylate synthetase 1, 40/46kDa)" | 19903 | -51.434 | -0.7002 | Yes | ||
52 | 10581 | IFITM2 (interferon induced transmembrane protein 2 (1-8D)) | 19970 | -58.782 | -0.6753 | Yes | ||
53 | 3105 | "HLA-A (major histocompatibility complex, class I, A)" | 20027 | -65.132 | -0.6468 | Yes | ||
54 | 3106 | "HLA-B (major histocompatibility complex, class I, B)" | 20100 | -78.491 | -0.6127 | Yes | ||
55 | 4940 | "OAS3 (2'-5'-oligoadenylate synthetase 3, 100kDa)" | 20125 | -86.843 | -0.5722 | Yes | ||
56 | 8519 | IFITM1 (interferon induced transmembrane protein 1 (9-27)) | 20204 | -117.578 | -0.5196 | Yes | ||
57 | 103 | "ADAR (adenosine deaminase, RNA-specific)" | 20231 | -134.677 | -0.4563 | Yes | ||
58 | 3107 | "HLA-C (major histocompatibility complex, class I, C)" | 20243 | -142.867 | -0.3883 | Yes | ||
59 | 10379 | IRF9 (interferon regulatory factor 9) | 20262 | -164.279 | -0.3104 | Yes | ||
60 | 10410 | IFITM3 (interferon induced transmembrane protein 3 (1-8U)) | 20271 | -173.958 | -0.2273 | Yes | ||
61 | 3434 | IFIT1 (interferon-induced protein with tetratricopeptide repeats 1) | 20306 | -233.172 | -0.1171 | Yes | ||
62 | 9636 | ISG15 (ISG15 ubiquitin-like modifier) | 20309 | -245.852 | 0.0008 | Yes |