Datasetexpression_12hrs.Phenotype.cls
#treated_versus_cont.Phenotype.cls
#treated_versus_cont_repos
PhenotypePhenotype.cls#treated_versus_cont_repos
Upregulated in classtreated
GeneSetREACTOME|REACT_125.2
Enrichment Score (ES)0.75536203
Normalized Enrichment Score (NES)1.767303
Nominal p-value0.0
FDR q-value0.0016435173
FWER p-Value0.011
Table: GSEA Results Summary



Fig 1: Enrichment plot: REACTOME|REACT_125.2   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
16432"SFRS7 (splicing factor, arginine/serine-rich 7, 35kDa)"38213.9760.0385Yes
26635SNRPE (small nuclear ribonucleoprotein polypeptide E)43207.4330.0775Yes
34904YBX1 (Y box binding protein 1)52184.1770.1119Yes
46627SNRPA1 (small nuclear ribonucleoprotein polypeptide A')87156.3830.1398Yes
53187HNRNPH1 (heterogeneous nuclear ribonucleoprotein H1 (H))89155.6030.1691Yes
66636SNRPF (small nuclear ribonucleoprotein polypeptide F)93154.3880.1981Yes
73184"HNRNPD (heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa))"114136.8580.2230Yes
86426"SFRS1 (splicing factor, arginine/serine-rich 1)"119133.0170.2479Yes
910189THOC4 (THO complex 4)158117.0780.2682Yes
104809NHP2L1 (NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae))162113.7000.2895Yes
112521FUS (fusion (involved in t(12;16) in malignant liposarcoma))182107.3020.3088Yes
126634SNRPD3 (small nuclear ribonucleoprotein D3 polypeptide 18kDa)196103.4340.3277Yes
139939RBM8A (RNA binding motif protein 8A)201102.6130.3469Yes
1451639"SF3B14 (splicing factor 3B, 14 kDa subunit)"23296.6860.3637Yes
155431"POLR2B (polymerase (RNA) II (DNA directed) polypeptide B, 140kDa)"24893.7050.3806Yes
166427"SFRS2 (splicing factor, arginine/serine-rich 2)"27390.1070.3965Yes
1757122NUP107 (nucleoporin 107kDa)27689.5880.4133Yes
1810907TXNL4A (thioredoxin-like 4A)28388.4840.4297Yes
196428"SFRS3 (splicing factor, arginine/serine-rich 3)"30285.6640.4450Yes
201977EIF4E (eukaryotic translation initiation factor 4E)30684.6410.4608Yes
218480RAE1 (RAE1 RNA export 1 homolog (S. pombe))32283.3120.4758Yes
226632SNRPD1 (small nuclear ribonucleoprotein D1 polypeptide 16kDa)35278.9030.4893Yes
236629SNRPB2 (small nuclear ribonucleoprotein polypeptide B'')42169.8440.4991Yes
245436POLR2G (polymerase (RNA) II (DNA directed) polypeptide G)43967.7680.5111Yes
253192HNRNPU (heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A))45066.4000.5231Yes
26129401NUP35 (nucleoporin 35kDa)50261.8730.5323Yes
277307U2AF1 (U2 small nuclear RNA auxiliary factor 1)50961.5550.5436Yes
286633SNRPD2 (small nuclear ribonucleoprotein D2 polypeptide 16.5kDa)52860.4710.5542Yes
295435POLR2F (polymerase (RNA) II (DNA directed) polypeptide F)53160.3460.5655Yes
309128PRPF4 (PRP4 pre-mRNA processing factor 4 homolog (yeast))55858.1800.5752Yes
3183443"SF3B5 (splicing factor 3b, subunit 5, 10kDa)"60554.8530.5832Yes
3284844PHF5A (PHD finger protein 5A)61654.0600.5930Yes
335441"POLR2L (polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa)"65551.8330.6009Yes
346628SNRPB (small nuclear ribonucleoprotein polypeptides B and B1)69749.7170.6082Yes
3523450"SF3B3 (splicing factor 3b, subunit 3, 130kDa)"71148.6050.6168Yes
361479"CSTF3 (cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa)"76746.2720.6228Yes
3779023NUP37 (nucleoporin 37kDa)77046.1890.6314Yes
3810236HNRNPR (heterogeneous nuclear ribonucleoprotein R)80344.7120.6383Yes
394686"NCBP1 (nuclear cap binding protein subunit 1, 80kDa)"86042.2660.6435Yes
4010262"SF3B4 (splicing factor 3b, subunit 4, 49kDa)"88241.2580.6502Yes
416626SNRPA (small nuclear ribonucleoprotein polypeptide A)92040.0410.6560Yes
429972NUP153 (nucleoporin 153kDa)92439.6720.6633Yes
437884SLBP (stem-loop binding protein)96637.9850.6685Yes
4423636NUP62 (nucleoporin 62kDa)98037.6920.6749Yes
4522916"NCBP2 (nuclear cap binding protein subunit 2, 20kDa)"98637.5280.6818Yes
464116"MAGOH (mago-nashi homolog, proliferation-associated (Drosophila))"100936.6190.6876Yes
4756339METTL3 (methyltransferase like 3)101236.5450.6944Yes
489295"SFRS11 (splicing factor, arginine/serine-rich 11)"104235.3880.6997Yes
4910921"RNPS1 (RNA binding protein S1, serine-rich domain)"110733.5360.7028Yes
5011338U2AF2 (U2 small nuclear RNA auxiliary factor 2)111233.3720.7089Yes
5110762NUP50 (nucleoporin 50kDa)113232.8600.7142Yes
5227316"RBMX (RNA binding motif protein, X-linked)"114232.6050.7199Yes
5323165NUP205 (nucleoporin 205kDa)114332.6050.7261Yes
544927NUP88 (nucleoporin 88kDa)114932.4550.7320Yes
555438"POLR2I (polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa)"115732.2490.7377Yes
563185HNRNPF (heterogeneous nuclear ribonucleoprotein F)121730.7320.7406Yes
573188HNRNPH2 (heterogeneous nuclear ribonucleoprotein H2 (H'))126529.7600.7439Yes
585434"POLR2E (polymerase (RNA) II (DNA directed) polypeptide E, 25kDa)"132828.2680.7461Yes
598243SMC1A (structural maintenance of chromosomes 1A)159723.9870.7374Yes
6053371NUP54 (nucleoporin 54kDa)160423.8590.7416Yes
619631NUP155 (nucleoporin 155kDa)164123.3600.7442Yes
625433POLR2D (polymerase (RNA) II (DNA directed) polypeptide D)174721.7110.7431Yes
635432"POLR2C (polymerase (RNA) II (DNA directed) polypeptide C, 33kDa)"177221.3890.7460Yes
6465109UPF3B (UPF3 regulator of nonsense transcripts homolog B (yeast))177821.3410.7498Yes
6523279NUP160 (nucleoporin 160kDa)180420.9880.7525Yes
666429"SFRS4 (splicing factor, arginine/serine-rich 4)"197019.1040.7479Yes
672963"GTF2F2 (general transcription factor IIF, polypeptide 2, 30kDa)"205618.2640.7472Yes
6851362CDC40 (cell division cycle 40 homolog (S. cerevisiae))209817.9420.7485Yes
696431"SFRS6 (splicing factor, arginine/serine-rich 6)"211317.8000.7512Yes
706625SNRP70 (small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen))215917.4430.7523Yes
715903RANBP2 (RAN binding protein 2)216417.3990.7554Yes
721660DHX9 (DEAH (Asp-Glu-Ala-His) box polypeptide 9)225816.5210.7539No
739410WDR57 (WD repeat domain 57 (U5 snRNP specific))243414.8490.7480No
745093PCBP1 (poly(rC) binding protein 1)260613.4290.7421No
7523511NUP188 (nucleoporin 188kDa)262313.2560.7438No
769416DDX23 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 23)265313.0870.7448No
7755749CCAR1 (cell division cycle and apoptosis regulator 1)268412.9530.7458No
789688NUP93 (nucleoporin 93kDa)270912.8140.7470No
7929894"CPSF1 (cleavage and polyadenylation specific factor 1, 160kDa)"272012.7110.7489No
8055746NUP133 (nucleoporin 133kDa)278712.2810.7480No
8110482NXF1 (nuclear RNA export factor 1)281112.1450.7491No
8210946"SF3A3 (splicing factor 3a, subunit 3, 60kDa)"290611.6230.7467No
8357819"LSM2 (LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae))"313610.2510.7373No
8411051NUDT21 (nudix (nucleoside diphosphate linked moiety X)-type motif 21)313910.2330.7391No
8579902NUP85 (nucleoporin 85kDa)32899.5860.7335No
8651692"CPSF3 (cleavage and polyadenylation specific factor 3, 73kDa)"32999.5330.7349No
87348995NUP43 (nucleoporin 43kDa)33559.3500.7339No
8823225NUP210 (nucleoporin 210kDa)33969.1690.7337No
8979869"FLJ12529 (pre-mRNA cleavage factor I, 59 kDa subunit)"34828.7990.7311No
9010250SRRM1 (serine/arginine repetitive matrix 1)34848.7950.7327No
9110291"SF3A1 (splicing factor 3a, subunit 1, 120kDa)"35978.3600.7288No
929343EFTUD2 (elongation factor Tu GTP binding domain containing 2)36178.2800.7294No
935430"POLR2A (polymerase (RNA) II (DNA directed) polypeptide A, 220kDa)"36268.2310.7306No
9410914PAPOLA (poly(A) polymerase alpha)38757.1870.7196No
953191HNRNPL (heterogeneous nuclear ribonucleoprotein L)40066.7660.7145No
965437POLR2H (polymerase (RNA) II (DNA directed) polypeptide H)45965.0000.6862No
979883POM121 (POM121 membrane glycoprotein (rat))50273.9780.6657No
9810421CD2BP2 (CD2 (cytoplasmic tail) binding protein 2)53573.3070.6500No
991478"CSTF2 (cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa)"54943.0740.6439No
10010978"CLP1 (CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae))"57832.6370.6301No
1015440"POLR2K (polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa)"63211.9700.6039No
1022962"GTF2F1 (general transcription factor IIF, polypeptide 1, 74kDa)"63881.8940.6010No
103652147"LOC652147 (similar to U5 snRNP-specific protein, 200 kDa)"65321.7500.5942No
10457794SF4 (splicing factor 4)66911.5970.5867No
10510949HNRNPA0 (heterogeneous nuclear ribonucleoprotein A0)79900.7410.5226No
1068106"PABPN1 (poly(A) binding protein, nuclear 1)"98660.1670.4297No
1073181HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1)13361-0.7270.2568No
1089785DHX38 (DEAH (Asp-Glu-Ala-His) box polypeptide 38)14908-1.4910.1805No
10953981"CPSF2 (cleavage and polyadenylation specific factor 2, 100kDa)"15120-1.6540.1704No
1108175"SF3A2 (splicing factor 3a, subunit 2, 66kDa)"15425-1.8930.1557No
11123451"SF3B1 (splicing factor 3b, subunit 1, 155kDa)"15886-2.3480.1334No
1128021NUP214 (nucleoporin 214kDa)16014-2.5130.1275No
1138086"AAAS (achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A))"16985-4.2110.0803No
11411100HNRNPUL1 (heterogeneous nuclear ribonucleoprotein U-like 1)17403-5.3000.0606No
1157175TPR (translocated promoter region (to activated MET oncogene))17416-5.3360.0611No
11610181RBM5 (RNA binding motif protein 5)17795-6.8970.0436No
11710594PRPF8 (PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae))17881-7.2460.0408No
1184670HNRNPM (heterogeneous nuclear ribonucleoprotein M)17936-7.5870.0396No
1191477"CSTF1 (cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa)"18059-8.1900.0351No
1205439"POLR2J (polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa)"18134-8.6610.0330No
1213178HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)18139-8.6910.0345No
12211097NUPL2 (nucleoporin like 2)18164-8.8500.0350No
1233190HNRNPK (heterogeneous nuclear ribonucleoprotein K)18557-11.6200.0177No
12424148PRPF6 (PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae))18644-12.5100.0158No
12522826"DNAJC8 (DnaJ (Hsp40) homolog, subfamily C, member 8)"18654-12.5950.0178No
1268683"SFRS9 (splicing factor, arginine/serine-rich 9)"18964-16.2500.0055No
12710992"SF3B2 (splicing factor 3b, subunit 2, 145kDa)"19037-17.5760.0053No
1286637SNRPG (small nuclear ribonucleoprotein polypeptide G)19107-18.9860.0055No
1295725PTBP1 (polypyrimidine tract binding protein 1)19275-22.2900.0014No
13051585"PCF11 (PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae))"19324-23.5840.0035No
13123020ASCC3L1 (activating signal cointegrator 1 complex subunit 3-like 1)19614-32.261-0.0047No
132220988HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3)19789-41.609-0.0055No
1333183HNRNPC (heterogeneous nuclear ribonucleoprotein C (C1/C2))19797-42.0220.0021No
1346430"SFRS5 (splicing factor, arginine/serine-rich 5)"19923-53.6360.0060No
1355094PCBP2 (poly(rC) binding protein 2)20076-73.1830.0123No
Table: GSEA details [plain text format]



Fig 2: REACTOME|REACT_125.2   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: REACTOME|REACT_125.2: Random ES distribution   
Gene set null distribution of ES for REACTOME|REACT_125.2