Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | cont |
GeneSet | GO|GO:0031294 |
Enrichment Score (ES) | -0.68730354 |
Normalized Enrichment Score (NES) | -1.6180063 |
Nominal p-value | 0.0030487804 |
FDR q-value | 0.26264384 |
FWER p-Value | 1.0 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 5781 | "PTPN11 (protein tyrosine phosphatase, non-receptor type 11)" | 668 | 51.118 | 0.0216 | No | ||
2 | 1445 | CSK (c-src tyrosine kinase) | 1276 | 29.581 | 0.0231 | No | ||
3 | 79109 | MAPKAP1 (mitogen-activated protein kinase associated protein 1) | 1954 | 19.398 | 0.0104 | No | ||
4 | 7525 | YES1 (v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1) | 1987 | 18.910 | 0.0290 | No | ||
5 | 3123 | "HLA-DRB1 (major histocompatibility complex, class II, DR beta 1)" | 2579 | 13.655 | 0.0144 | No | ||
6 | 857 | "CAV1 (caveolin 1, caveolae protein, 22kDa)" | 3406 | 9.137 | -0.0166 | No | ||
7 | 2534 | "FYN (FYN oncogene related to SRC, FGR, YES)" | 4244 | 5.992 | -0.0515 | No | ||
8 | 28755 | TRAC (T cell receptor alpha constant) | 4249 | 5.969 | -0.0454 | No | ||
9 | 3126 | "HLA-DRB4 (major histocompatibility complex, class II, DR beta 4)" | 4371 | 5.560 | -0.0454 | No | ||
10 | 1326 | MAP3K8 (mitogen-activated protein kinase kinase kinase 8) | 5072 | 3.886 | -0.0758 | No | ||
11 | 2475 | FRAP1 (FK506 binding protein 12-rapamycin associated protein 1) | 5135 | 3.745 | -0.0749 | No | ||
12 | 3127 | "HLA-DRB5 (major histocompatibility complex, class II, DR beta 5)" | 6078 | 2.255 | -0.1189 | No | ||
13 | 8764 | "TNFRSF14 (tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator))" | 6083 | 2.252 | -0.1167 | No | ||
14 | 3113 | "HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)" | 6433 | 1.847 | -0.1320 | No | ||
15 | 5777 | "PTPN6 (protein tyrosine phosphatase, non-receptor type 6)" | 6958 | 1.373 | -0.1564 | No | ||
16 | 23308 | ICOSLG (inducible T-cell co-stimulator ligand) | 7081 | 1.283 | -0.1610 | No | ||
17 | 29126 | CD274 (CD274 molecule) | 7217 | 1.181 | -0.1664 | No | ||
18 | 1803 | DPP4 (dipeptidyl-peptidase 4) | 7351 | 1.095 | -0.1718 | No | ||
19 | 5058 | PAK1 (p21 protein (Cdc42/Rac)-activated kinase 1) | 7646 | 0.920 | -0.1854 | No | ||
20 | 22914 | "KLRK1 (killer cell lectin-like receptor subfamily K, member 1)" | 7672 | 0.900 | -0.1856 | No | ||
21 | 915 | "CD3D (CD3d molecule, delta (CD3-TCR complex))" | 8076 | 0.700 | -0.2048 | No | ||
22 | 3932 | LCK (lymphocyte-specific protein tyrosine kinase) | 8602 | 0.511 | -0.2301 | No | ||
23 | 3115 | "HLA-DPB1 (major histocompatibility complex, class II, DP beta 1)" | 8903 | 0.414 | -0.2445 | No | ||
24 | 919 | CD247 (CD247 molecule) | 9865 | 0.167 | -0.2918 | No | ||
25 | 942 | CD86 (CD86 molecule) | 10585 | -0.000 | -0.3272 | No | ||
26 | 6714 | SRC (v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)) | 11110 | -0.124 | -0.3530 | No | ||
27 | 940 | CD28 (CD28 molecule) | 12034 | -0.333 | -0.3982 | No | ||
28 | 920 | CD4 (CD4 molecule) | 12457 | -0.446 | -0.4185 | No | ||
29 | 6363 | CCL19 (chemokine (C-C motif) ligand 19) | 12834 | -0.556 | -0.4365 | No | ||
30 | 941 | CD80 (CD80 molecule) | 13279 | -0.692 | -0.4576 | No | ||
31 | 3112 | "HLA-DOB (major histocompatibility complex, class II, DO beta)" | 13515 | -0.781 | -0.4684 | No | ||
32 | 3108 | "HLA-DMA (major histocompatibility complex, class II, DM alpha)" | 13572 | -0.805 | -0.4703 | No | ||
33 | 151888 | BTLA (B and T lymphocyte associated) | 13780 | -0.890 | -0.4796 | No | ||
34 | 29851 | ICOS (inducible T-cell co-stimulator) | 13924 | -0.962 | -0.4856 | No | ||
35 | 9020 | MAP3K14 (mitogen-activated protein kinase kinase kinase 14) | 14010 | -1.000 | -0.4887 | No | ||
36 | 7409 | VAV1 (vav 1 guanine nucleotide exchange factor) | 14093 | -1.044 | -0.4917 | No | ||
37 | 6366 | CCL21 (chemokine (C-C motif) ligand 21) | 14126 | -1.061 | -0.4921 | No | ||
38 | 5133 | PDCD1 (programmed cell death 1) | 14292 | -1.129 | -0.4991 | No | ||
39 | 3109 | "HLA-DMB (major histocompatibility complex, class II, DM beta)" | 14469 | -1.219 | -0.5064 | No | ||
40 | 917 | "CD3G (CD3g molecule, gamma (CD3-TCR complex))" | 14522 | -1.255 | -0.5077 | No | ||
41 | 1236 | CCR7 (chemokine (C-C motif) receptor 7) | 14816 | -1.429 | -0.5206 | No | ||
42 | 84433 | "CARD11 (caspase recruitment domain family, member 11)" | 14839 | -1.444 | -0.5201 | No | ||
43 | 1493 | CTLA4 (cytotoxic T-lymphocyte-associated protein 4) | 15552 | -2.011 | -0.5531 | No | ||
44 | 80380 | PDCD1LG2 (programmed cell death 1 ligand 2) | 15782 | -2.243 | -0.5620 | No | ||
45 | 253260 | RICTOR (rapamycin-insensitive companion of mTOR) | 16150 | -2.699 | -0.5773 | No | ||
46 | 9402 | GRAP2 (GRB2-related adaptor protein 2) | 16323 | -2.949 | -0.5826 | No | ||
47 | 2885 | GRB2 (growth factor receptor-bound protein 2) | 16385 | -3.037 | -0.5824 | No | ||
48 | 916 | "CD3E (CD3e molecule, epsilon (CD3-TCR complex))" | 16842 | -3.845 | -0.6008 | No | ||
49 | 3111 | "HLA-DOA (major histocompatibility complex, class II, DO alpha)" | 17650 | -6.220 | -0.6340 | No | ||
50 | 64223 | GBL (G protein beta subunit-like) | 17731 | -6.592 | -0.6309 | No | ||
51 | 5290 | "PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide)" | 17764 | -6.773 | -0.6253 | No | ||
52 | 3122 | "HLA-DRA (major histocompatibility complex, class II, DR alpha)" | 17997 | -7.888 | -0.6283 | No | ||
53 | 4067 | LYN (v-yes-1 Yamaguchi sarcoma viral related oncogene homolog) | 18419 | -10.518 | -0.6379 | No | ||
54 | 5295 | "PIK3R1 (phosphoinositide-3-kinase, regulatory subunit 1 (alpha))" | 19422 | -26.295 | -0.6593 | Yes | ||
55 | 207 | AKT1 (v-akt murine thymoma viral oncogene homolog 1) | 19588 | -31.123 | -0.6342 | Yes | ||
56 | 5879 | "RAC1 (ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1))" | 19612 | -32.214 | -0.6010 | Yes | ||
57 | 5062 | PAK2 (p21 protein (Cdc42/Rac)-activated kinase 2) | 19777 | -40.918 | -0.5654 | Yes | ||
58 | 5170 | PDPK1 (3-phosphoinositide dependent protein kinase-1) | 19867 | -47.955 | -0.5187 | Yes | ||
59 | 5296 | "PIK3R2 (phosphoinositide-3-kinase, regulatory subunit 2 (beta))" | 19918 | -53.218 | -0.4644 | Yes | ||
60 | 998 | "CDC42 (cell division cycle 42 (GTP binding protein, 25kDa))" | 20112 | -82.496 | -0.3860 | Yes | ||
61 | 8503 | "PIK3R3 (phosphoinositide-3-kinase, regulatory subunit 3 (gamma))" | 20275 | -179.372 | -0.2027 | Yes | ||
62 | 100133941 | CD24 (CD24 molecule) | 20284 | -192.287 | 0.0020 | Yes |