Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | cont |
GeneSet | PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA|IL23-MEDIATED SIGNALING EVENTS |
Enrichment Score (ES) | -0.75125384 |
Normalized Enrichment Score (NES) | -1.627747 |
Nominal p-value | 0.005899705 |
FDR q-value | 0.2668648 |
FWER p-Value | 1.0 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 3717 | JAK2 (Janus kinase 2 (a protein tyrosine kinase)) | 1526 | 24.947 | -0.0201 | No | ||
2 | 3675 | "ITGA3 (integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor))" | 4398 | 5.483 | -0.1495 | No | ||
3 | 4843 | "NOS2A (nitric oxide synthase 2A (inducible, hepatocytes))" | 5502 | 3.060 | -0.1971 | No | ||
4 | 29949 | IL19 (interleukin 19) | 6780 | 1.530 | -0.2567 | No | ||
5 | 8807 | IL18RAP (interleukin 18 receptor accessory protein) | 6802 | 1.511 | -0.2544 | No | ||
6 | 3606 | IL18 (interleukin 18 (interferon-gamma-inducing factor)) | 7146 | 1.235 | -0.2686 | No | ||
7 | 149233 | IL23R (interleukin 23 receptor) | 7228 | 1.174 | -0.2700 | No | ||
8 | 4353 | MPO (myeloperoxidase) | 7249 | 1.163 | -0.2684 | No | ||
9 | 11009 | IL24 (interleukin 24) | 7270 | 1.157 | -0.2668 | No | ||
10 | 6776 | STAT5A (signal transducer and activator of transcription 5A) | 7586 | 0.951 | -0.2803 | No | ||
11 | 112744 | IL17F (interleukin 17F) | 7746 | 0.868 | -0.2862 | No | ||
12 | 8809 | IL18R1 (interleukin 18 receptor 1) | 8158 | 0.671 | -0.3050 | No | ||
13 | 3558 | IL2 (interleukin 2) | 8365 | 0.590 | -0.3138 | No | ||
14 | 242 | "ALOX12B (arachidonate 12-lipoxygenase, 12R type)" | 9750 | 0.195 | -0.3816 | No | ||
15 | 3569 | "IL6 (interleukin 6 (interferon, beta 2))" | 9770 | 0.188 | -0.3821 | No | ||
16 | 3458 | "IFNG (interferon, gamma)" | 9835 | 0.174 | -0.3849 | No | ||
17 | 2919 | "CXCL1 (chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha))" | 9875 | 0.163 | -0.3865 | No | ||
18 | 3605 | IL17A (interleukin 17A) | 10238 | 0.077 | -0.4041 | No | ||
19 | 3593 | "IL12B (interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40))" | 11374 | -0.185 | -0.4597 | No | ||
20 | 3553 | "IL1B (interleukin 1, beta)" | 11912 | -0.304 | -0.4855 | No | ||
21 | 9021 | SOCS3 (suppressor of cytokine signaling 3) | 12244 | -0.385 | -0.5009 | No | ||
22 | 920 | CD4 (CD4 molecule) | 12457 | -0.446 | -0.5104 | No | ||
23 | 7124 | "TNF (tumor necrosis factor (TNF superfamily, member 2))" | 12777 | -0.537 | -0.5249 | No | ||
24 | 6347 | CCL2 (chemokine (C-C motif) ligand 2) | 14056 | -1.027 | -0.5856 | No | ||
25 | 4283 | CXCL9 (chemokine (C-X-C motif) ligand 9) | 15376 | -1.852 | -0.6466 | No | ||
26 | 3594 | "IL12RB1 (interleukin 12 receptor, beta 1)" | 15945 | -2.429 | -0.6692 | No | ||
27 | 6775 | STAT4 (signal transducer and activator of transcription 4) | 16188 | -2.744 | -0.6751 | No | ||
28 | 7297 | TYK2 (tyrosine kinase 2) | 16697 | -3.598 | -0.6922 | No | ||
29 | 916 | "CD3E (CD3e molecule, epsilon (CD3-TCR complex))" | 16842 | -3.845 | -0.6908 | No | ||
30 | 4790 | NFKB1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) | 17493 | -5.614 | -0.7104 | No | ||
31 | 5290 | "PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide)" | 17764 | -6.773 | -0.7088 | No | ||
32 | 5970 | RELA (v-rel reticuloendotheliosis viral oncogene homolog A (avian)) | 18184 | -8.954 | -0.7097 | No | ||
33 | 51561 | "IL23A (interleukin 23, alpha subunit p19)" | 19029 | -17.353 | -0.7129 | Yes | ||
34 | 5295 | "PIK3R1 (phosphoinositide-3-kinase, regulatory subunit 1 (alpha))" | 19422 | -26.295 | -0.6742 | Yes | ||
35 | 6774 | STAT3 (signal transducer and activator of transcription 3 (acute-phase response factor)) | 19451 | -27.002 | -0.6160 | Yes | ||
36 | 4792 | "NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha)" | 20116 | -83.052 | -0.4654 | Yes | ||
37 | 6772 | "STAT1 (signal transducer and activator of transcription 1, 91kDa)" | 20302 | -215.432 | 0.0011 | Yes |