Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
Phenotype | Phenotype.cls#treated_versus_cont_repos |
Upregulated in class | treated |
GeneSet | KEGG|HSA03008 |
Enrichment Score (ES) | 0.83452326 |
Normalized Enrichment Score (NES) | 1.8097132 |
Nominal p-value | 0.0 |
FDR q-value | 0.0018137803 |
FWER p-Value | 0.0020 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | 55651 | "NOLA2 (nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs))" | 16 | 288.767 | 0.0991 | Yes | ||
2 | 5901 | "RAN (RAN, member RAS oncogene family)" | 27 | 250.127 | 0.1850 | Yes | ||
3 | 51602 | NOP5/NOP58 (nucleolar protein NOP5/NOP58) | 106 | 143.574 | 0.2308 | Yes | ||
4 | 4809 | NHP2L1 (NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)) | 162 | 113.700 | 0.2674 | Yes | ||
5 | 1736 | "DKC1 (dyskeratosis congenita 1, dyskerin)" | 177 | 108.949 | 0.3044 | Yes | ||
6 | 51096 | "UTP18 (UTP18, small subunit (SSU) processome component, homolog (yeast))" | 178 | 108.854 | 0.3420 | Yes | ||
7 | 92856 | "IMP4 (IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast))" | 255 | 92.309 | 0.3702 | Yes | ||
8 | 84916 | "CIRH1A (cirrhosis, autosomal recessive 1A (cirhin))" | 298 | 85.973 | 0.3979 | Yes | ||
9 | 3692 | EIF6 (eukaryotic translation initiation factor 6) | 338 | 80.958 | 0.4239 | Yes | ||
10 | 2091 | FBL (fibrillarin) | 349 | 79.165 | 0.4508 | Yes | ||
11 | 10528 | NOL5A (nucleolar protein 5A (56kDa with KKE/D repeat)) | 353 | 78.890 | 0.4779 | Yes | ||
12 | 7514 | "XPO1 (exportin 1 (CRM1 homolog, yeast))" | 539 | 59.462 | 0.4893 | Yes | ||
13 | 29107 | NXT1 (NTF2-like export factor 1) | 572 | 57.245 | 0.5076 | Yes | ||
14 | 10799 | RPP40 (ribonuclease P/MRP 40kDa subunit) | 654 | 51.912 | 0.5215 | Yes | ||
15 | 55272 | "IMP3 (IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast))" | 683 | 50.430 | 0.5376 | Yes | ||
16 | 10885 | WDR3 (WD repeat domain 3) | 698 | 49.508 | 0.5540 | Yes | ||
17 | 10248 | "POP7 (processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae))" | 699 | 49.475 | 0.5711 | Yes | ||
18 | 23560 | GTPBP4 (GTP binding protein 4) | 722 | 48.168 | 0.5867 | Yes | ||
19 | 1460 | "CSNK2B (casein kinase 2, beta polypeptide)" | 744 | 47.339 | 0.6020 | Yes | ||
20 | 55127 | HEATR1 (HEAT repeat containing 1) | 798 | 44.950 | 0.6149 | Yes | ||
21 | 55505 | "NOLA3 (nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs))" | 826 | 43.588 | 0.6287 | Yes | ||
22 | 55341 | LSG1 (large subunit GTPase 1 homolog (S. cerevisiae)) | 856 | 42.370 | 0.6419 | Yes | ||
23 | 10813 | "UTP14A (UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast))" | 880 | 41.274 | 0.6550 | Yes | ||
24 | 55781 | RIOK2 (RIO kinase 2 (yeast)) | 922 | 39.956 | 0.6668 | Yes | ||
25 | 84128 | WDR75 (WD repeat domain 75) | 947 | 38.592 | 0.6790 | Yes | ||
26 | 55131 | RBM28 (RNA binding motif protein 28) | 960 | 38.181 | 0.6916 | Yes | ||
27 | 9790 | "BMS1 (BMS1 homolog, ribosome assembly protein (yeast))" | 1014 | 36.493 | 0.7016 | Yes | ||
28 | 55226 | NAT10 (N-acetyltransferase 10) | 1101 | 33.729 | 0.7090 | Yes | ||
29 | 10171 | RCL1 (RNA terminal phosphate cyclase-like 1) | 1109 | 33.479 | 0.7202 | Yes | ||
30 | 51119 | SBDS (Shwachman-Bodian-Diamond syndrome) | 1120 | 33.204 | 0.7312 | Yes | ||
31 | 29889 | GNL2 (guanine nucleotide binding protein-like 2 (nucleolar)) | 1137 | 32.745 | 0.7417 | Yes | ||
32 | 28987 | NOB1 (NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)) | 1166 | 32.001 | 0.7514 | Yes | ||
33 | 51367 | "POP5 (processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae))" | 1200 | 31.164 | 0.7606 | Yes | ||
34 | 10199 | MPHOSPH10 (M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)) | 1285 | 29.380 | 0.7666 | Yes | ||
35 | 26354 | GNL3 (guanine nucleotide binding protein-like 3 (nucleolar)) | 1343 | 27.914 | 0.7734 | Yes | ||
36 | 54913 | RPP25 (ribonuclease P/MRP 25kDa subunit) | 1434 | 26.482 | 0.7781 | Yes | ||
37 | 23160 | WDR43 (WD repeat domain 43) | 1458 | 26.096 | 0.7860 | Yes | ||
38 | 6880 | "TAF9 (TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa)" | 1501 | 25.350 | 0.7927 | Yes | ||
39 | 51077 | FCF1 (FCF1 small subunit (SSU) processome component homolog (S. cerevisiae)) | 1765 | 21.473 | 0.7871 | Yes | ||
40 | 27341 | RRP7A (ribosomal RNA processing 7 homolog A (S. cerevisiae)) | 1817 | 20.826 | 0.7918 | Yes | ||
41 | 5822 | PWP2 (PWP2 periodic tryptophan protein homolog (yeast)) | 1886 | 20.099 | 0.7954 | Yes | ||
42 | 6949 | TCOF1 (Treacher Collins-Franceschetti syndrome 1) | 1905 | 19.872 | 0.8014 | Yes | ||
43 | 55813 | "UTP6 (UTP6, small subunit (SSU) processome component, homolog (yeast))" | 1910 | 19.860 | 0.8081 | Yes | ||
44 | 10557 | RPP38 (ribonuclease P/MRP 38kDa subunit) | 2029 | 18.491 | 0.8086 | Yes | ||
45 | 83732 | RIOK1 (RIO kinase 1 (yeast)) | 2052 | 18.302 | 0.8139 | Yes | ||
46 | 84135 | "UTP15 (UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae))" | 2089 | 18.020 | 0.8183 | Yes | ||
47 | 1457 | "CSNK2A1 (casein kinase 2, alpha 1 polypeptide)" | 2136 | 17.608 | 0.8221 | Yes | ||
48 | 54552 | GNL3L (guanine nucleotide binding protein-like 3 (nucleolar)-like) | 2146 | 17.516 | 0.8277 | Yes | ||
49 | 134430 | WDR36 (WD repeat domain 36) | 2184 | 17.255 | 0.8319 | Yes | ||
50 | 10607 | TBL3 (transducin (beta)-like 3) | 2248 | 16.640 | 0.8345 | Yes | ||
51 | 54433 | "NOLA1 (nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs))" | 2604 | 13.436 | 0.8216 | No | ||
52 | 29102 | "RNASEN (ribonuclease type III, nuclear)" | 2674 | 12.996 | 0.8227 | No | ||
53 | 10482 | NXF1 (nuclear RNA export factor 1) | 2811 | 12.145 | 0.8202 | No | ||
54 | 55916 | NXT2 (nuclear transport factor 2-like export factor 2) | 3010 | 10.977 | 0.8142 | No | ||
55 | 65083 | NOL6 (nucleolar protein family 6 (RNA-associated)) | 3192 | 9.999 | 0.8087 | No | ||
56 | 54464 | XRN1 (5'-3' exoribonuclease 1) | 3263 | 9.667 | 0.8086 | No | ||
57 | 10775 | "POP4 (processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae))" | 3400 | 9.154 | 0.8051 | No | ||
58 | 1459 | "CSNK2A2 (casein kinase 2, alpha prime polypeptide)" | 3532 | 8.638 | 0.8016 | No | ||
59 | 10940 | "POP1 (processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae))" | 3570 | 8.468 | 0.8027 | No | ||
60 | 10556 | RPP30 (ribonuclease P/MRP 30kDa subunit) | 3660 | 8.138 | 0.8011 | No | ||
61 | 23195 | "MDN1 (MDN1, midasin homolog (yeast))" | 3822 | 7.421 | 0.7957 | No | ||
62 | 166378 | SPATA5 (spermatogenesis associated 5) | 3892 | 7.117 | 0.7948 | No | ||
63 | 138716 | C9orf23 (chromosome 9 open reading frame 23) | 3927 | 7.006 | 0.7955 | No | ||
64 | 9724 | "UTP14C (UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast))" | 4335 | 5.671 | 0.7774 | No | ||
65 | 25996 | "REXO2 (REX2, RNA exonuclease 2 homolog (S. cerevisiae))" | 5627 | 2.878 | 0.7146 | No | ||
66 | 56001 | NXF2 (nuclear RNA export factor 2) | 6582 | 1.692 | 0.6681 | No | ||
67 | 55998 | NXF5 (nuclear RNA export factor 5) | 8043 | 0.713 | 0.5963 | No | ||
68 | 56000 | NXF3 (nuclear RNA export factor 3) | 8688 | 0.482 | 0.5646 | No | ||
69 | 57455 | "REXO1 (REX1, RNA exonuclease 1 homolog (S. cerevisiae))" | 14805 | -1.424 | 0.2631 | No | ||
70 | 254958 | "REXO1L1 (REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1)" | 15101 | -1.637 | 0.2491 | No | ||
71 | 22803 | XRN2 (5'-3' exoribonuclease 2) | 15213 | -1.732 | 0.2443 | No | ||
72 | 79631 | EFTUD1 (elongation factor Tu GTP binding domain containing 1) | 16673 | -3.548 | 0.1734 | No | ||
73 | 51068 | NMD3 (NMD3 homolog (S. cerevisiae)) | 18108 | -8.476 | 0.1056 | No | ||
74 | 4931 | NVL (nuclear VCP-like) | 18502 | -11.140 | 0.0900 | No |