##master-page:HomepageTemplate #format wiki #acl All:read DanieleMerico:write,delete,revert = Daniele Merico = === Contact === __Location__: Common Lab Area, 6th Floor (CCBR)[[BR]] __Email__: [[MailTo(daniele DOT merico AT gmail DOT com)]][[BR]] __Skype__: the-amerigo[[BR]] __Linked-In__: [http://www.linkedin.com/profile?viewProfile=&key=4048991&goback=%2Econ-*3conbro*40*4*051*4false*4*02*40%2Ebcc_2220874_1/ Daniele Merico][[BR]] == Research Projects == === Present Reasearch Projects === __Projects @CCBR__: [[BR]] * '''Mouse Heart Pathway Project''' ([:MouseHeartPathwayProject/NetworkProfilingTrack:Main Directory of my work])[[BR]] With: [:RuthIsserlin:Ruth Isserlin]. Supervised by: [http://lambda.med.utoronto.ca/Emili.htm/ Andrew Emili] and [:GaryBader:Gary Bader]. [[BR]] I am specifically working on the gene expression analysis using: * Improved set-enrichment methods * Pathway profiling * Network profiling * Identification of miRNA candidates, [[BR]] integrating predictions and miRNA expression patterns with taregt expression patterns * '''Active Cell Map''' (pathway & network: topology, expression profiling, activity patterns, etc...) [[BR]] Supervised by: [:GaryBader:Gary Bader]. __Ongoing Collaborative Projects__: [[BR]] * [:DanieleMerico/OntoBioMed: Biomedical Ontologies], bridging clinics and molecular biosciences === Past Research Projects === __Projects @UNIMIB__: * Analysis of Time-course Microarray Data[[BR]] With Italo Zoppis. Supervised by: Marco Antoniotti. * enahncements of the GOALIE approach to time-course data analysis * the PIFS data-set analysis (with the CDC of Atlanta & University of South Wales) * Clinical Phenotype Ontology for Cerebrovascular Disorders (NEUROWEB Project) With Gianluca Colombo, Giuseppe "Beppe" Frisoni, Flavio De Paoli, Marco Antoniotti. Supervised by: Giancarlo Mauri.[[BR]] Ref & Links: * [http://www.nettab.org/2007/slides/SemanticWeb_Frisoni.pdf NETTAB 2007 presentation]; * [http://nuke.neurowebkc.eu/Dissemination/tabid/66/Default.aspx/ published papers & proceedings]. __Projects @UNIMI__: * The p63 Network With Alessandra Viganò. Supervised by: Roberto Mantovani.[[BR]] Ref & Links: [http://www.nature.com/emboj/journal/v25/n21/pdf/7601375a.pdf p63 EMBO Paper] * The Landscape of NF-Y Binding[[BR]] With: Michele Ceribelli, Diletta Dolfini. Supervised by: Roberto Mantovani.[[BR]] Ref & Links: * [http://mcb.asm.org/cgi/reprint/MCB.01861-07v1?view=long&pmid=18212061 The histone like NF-Y is a bifunctional transcription factor.] * [http://nar.oxfordjournals.org/cgi/content/full/gkm1046v2 A balance between NF-Y and p53 governs the pro- and anti-apoptotic transcriptional response.] === Activity Reports === [:DanieleMerico/WorkLogDirectory: Work logs], concerning on-going reserach activity, will be visible only to lab members.[[BR]] [:DanieleMerico/MemorandaDirectory: Memoranda], concerning paper and seminar summaries, or more general considerations, will be kept more open. === Knowledge Sharing === Here's the knowledge & expertise I wish to share with anybody who wants to. __Computational techniques & resources__: * PCA (Principal Correspondence Analysis) & CA (Correspondence Analysis) * Correlation Measures (Pearson, Spearman) * [:DanieleMerico/HowtoDirectory/PearsonDotP: Pearson Correlation and the Dot Product] * Distance Measures (continuous data: Euclidean, correlation-based; binary data: Hamming, Jaccard-based; sets: Jaccard-based)[[BR]] * [:DanieleMerico/HowtoDirectory/Distances: a few tips on distances] (especially for binary strings) * Standard Affymetrix Microarray Analysis (CEL files handling, Normalization, Signal computation (e.g. rma), Exploratory Analysis, Differentially Expressed Genes) * Clustering (hierarchical, K-means, CLICK, etc...) * Statistical tests (t-test, Fisher's, Kolmogorov-Smirnov) * Gene Ontology I usually program with: * [http://cran.r-project.org/ R] (see also [http://www.bioconductor.org/ Bioconductor]) Go to my [:DanieleMerico/HowtoDirectory: How To Directory] for tips with R programming. [:DanieleMerico/CytoMemo: Cytoscape Memos] __Biological Systems and Pathologies__ I've been working on (in order of confidence): * Mammalian Immune System (focus on Dendritic Cells) * Ischemic Stroke & Atherosclerosis * Mammalian Chromatin Modification * Yeast Cell Cycle === Resume & CV === I was born in Saronno (VA, Italy) in 29/07/1981. I lived, studied and worked in the Milan metropolitan area till November 2007. I got my BSc in Molecular Biotechnologies (July 2003) and my MSc Bioinformatics (July 2005) at Università di Milano-Bicocca. I started my PhD in Molecular and Cellular Biology at Università di Milano in 2005.[[BR]] My scientific interests are: * Pathways and Networks * Human Phenotypes * Expression Data and Transcriptional Regulation * Biomedical Knowledge Engineering & Representation * Philosophy and Sociology of Science For more details, please have a look at my CV: [attachment:DanieleMericoCV.PDF CV.PDF]. === Affiliations === * CCBR - Banting & Best Dept. of Medical Research Visiting PhD student * Università di Milano ([http://www.unimi.it UNIMI]) - Dipartimento di Scienze Biomolecolari e Biotecnologie ([http://www.sbb.unimi.it/ DSBB]) PhD student (Program of Cellular and Molecular Biology)[[BR]] [http://www.bsb.unimi.it/gene_expression.htm Roberto Mantovani's Lab] * Università di Milano-Bicocca ([http://www.unimib.it UNIMIB]) - Dipartimento di Informatica ([http://www.disco.unimib.it/ DISCo]) External PhD student[[BR]] [http://bimib.disco.unimib.it/ BiMIB Group] (Bioinformatics at Milano-Bicocca) === Trivia & Amenities === The [http://en.wikipedia.org/wiki/Celestial_Emporium_of_Benevolent_Recognition Celestial Emporium of Benevolent Knowledge's Taxonomy]: how not to build an ontology I like to... * travel, and discover new cultures * meet people * discuss ideas * take more than 45' to have lunch or dinner * swim, walk, trek * write [http://en.wikipedia.org/wiki/Tengwar/ runes] (still have to learn ideograms...) * drink beer * throw snowballs (look out...) * laugh :D ---- CategoryHomepage