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= Prediction of PDZ Domain-Peptide Binding Affinity from Primary Sequence =
This data is supplementary material for :

''Prediction of PDZ Domain-Peptide Binding Affinity from Primary Sequence''

Xiaojian Shao1,2,4, Chris S. H. Tan2,4, Courtney Voss3, Shawn S. C. Li3, Naiyang Deng1*, Gary D. Bader2*

1. College of Science, China Agricultural University, Beijing, China, 

2. Banting and Best Department of Medical Research, University of Toronto, Terrence Donnelly Centre for Cellular and Biomolecular Research, Toronto, Canada 

3. Department of Biochemistry, University of West Ontario, London, Ontario, Canada

4. These authors contributed equally to this work.

* To whom correspondence should be addressed. E-mail: gary.bader@utoronto.ca (GDB); dengnaiyang@cau.edu.cn (NYD)

== Supplemental Materials ==
 * [[attachment:Supplementary Materials.doc]] - Supplementary Method and Figure S1-5 with legends

== Supplemental Tables ==
 * [[attachment:MousePDZdomainpeptideMap.xls|Table S1]] - Quantitative Mouse PDZ Domain-peptide Interaction Matrix
 * [[attachment:SemiSVR_DifferentEncoding.xls|Table S2]] - Performance on Different Encoding
 * [[attachment:SemiSVR_RandomBindingSites.xls|Table S3]] - Performance on Random Binding Sites
 * [[attachment:SemiSVR_HumanScribbles.xls|Table S4]] -  Quantitative Human Scribble PDZ Domain-peptide Interaction Matrix
 * [[attachment:Worm_Fly_BlindTesting.xls|Table S5]] -  Blinding Testing on Worm and Fly 
 * [[attachment:SemiSVR_SemiQuantitativeAssessment.xls|Table S6]] - Performance of SemiSVR on Semi-Quantitative Assessment
 * [[attachment:SemiSVR_Prediction_HumanPDZ.xls|Table S7]] - Predicted Affinity Score for Putative Human PDZ Domain-peptide Pairs
 * [[attachment:SemiSVR_Prediction_MousePDZ.xls|Table S8]] - Predicted Affinity Score for Putative Mouse PDZ Domain-peptide Pairs

== Semi-quantitative Support Vector Regression Code ==
 * [[attachment:SemiSVR_code.Zip]] - Matlab code for SemiSVR (compressed). 

== PDZ Sequence ==
 * Mouse PDZ sequence : [[attachment:MousePDZSeq.fasta |MousePDZSequence.fasta]]
 * Human Scribble PDZ sequence : [[attachment:Human_PDZSeq.fasta | HumanScribblePDZSequence.fasta]]
 * ''C. elegens'' PDZ sequence : [[attachment:Celegans_PDZSeq.fasta |CelegansPDZSequence.fasta]]
 * ''D. melanogaster'' PDZ Sequence : [[attachment:Fly_PDZSeq.fasta | Fly_PDZSequence.fasta]]
 * SemiSVR Predictable Human PDZ Sequence : [[attachment:SemiSVRpredictable_HumanPDZdomain.fa |SemiSVR_Predictable_HumanPDZSequence.fasta]]
 * SemiSVR Predictable Mouse PDZ Sequence : [[attachment:SemiSVRpredictable_MousePDZdomain.fa |SemiSVR_Predictable_MousePDZSequence.fasta ]]