#acl All:read
= Positive Selection of Tyrosine Loss in Metazoan Evolution =
<<BR>><<BR>>
This page contain associated data used in:
<<BR>><<BR>>
''Positive Selection of Tyrosine Loss in Metazoan Evolution''
<<BR>><<BR>>
Chris S.H Tan^1,2^, Adrian Pasculescu^1^, Wendell A. Lim^4^, Tony Pawson^1,2*^, Gary D. Bader^1,2,3*^, Rune Linding^5*^
<<BR>><<BR>>
1. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

2. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada 

3. Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

4. Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA.


5. Cellular and Molecular Logic Team, Section of Cell and Molecular Biology, The Institute of Cancer Research (ICR), London, UK

* To whom correspondence should be addressed. E-mail: pawson@lunenfeld.ca (TP); gary.bader@utoronto.ca (GDB); linding@icr.ac.uk (RL)


== Supplemental Materials ==
 * [[attachment:Supplementary Materials.doc]] - Supplementary Notes 1-4 and Figure S1-6 with legends

== Supplemental Tables ==
 * [[attachment:MousePDZdomainpeptideMap.xls|Table S1]] - Quantitative Mouse PDZ Domain-peptide Interaction Matrix
 * [[attachment:SemiSVR_DifferentEncoding.xls|Table S2]] - Performance on Different Encoding
 * [[attachment:SemiSVR_Prediction_MousePDZ.xls|Table S7]] - Predicted Affinity Score for Putative Mouse PDZ Domain-peptide Pairs
 * [[attachment:SemiSVR_Prediction_HumanPDZ.xls|Table S8]] - Predicted Affinity Score for Putative Human PDZ Domain-peptide Pairs

== Semi-quantitative Support Vector Regression Code ==
 * [[attachment:SemiSVR_code.Zip]] - Matlab code for SemiSVR (compressed).

== PDZ Sequence ==
 * Mouse PDZ sequence : [[attachment:MousePDZSeq.fasta|MousePDZSequence.fasta]]
 * SemiSVR Predictable Human PDZ Sequence : [[attachment:SemiSVRpredictable_HumanPDZdomain.fa|SemiSVR_Predictable_HumanPDZSequence.fasta]]
 * SemiSVR Predictable Mouse PDZ Sequence : [[attachment:SemiSVRpredictable_MousePDZdomain.fa|SemiSVR_Predictable_MousePDZSequence.fasta]]