Biological Systems Lab, Prof. Gary Bader
We study the organization and evolution of biological systems using computational biology and bioinformatics techniques. We seek to accurately predict links, such as specific molecular interactions, in eukaryotic cell signaling systems using comprehensive genomics data like genome sequence and transcript profiles. We are interested to find how these links are rewired by mutations to cause disease. This work is supported through the development of open-source biological pathway and network databases and visualization and analysis software.
- Predicting biologically relevant protein interactions and cellular network evolution
- Detection of cell type and stage active biological processes using molecular profiles
- Multiple perturbation analysis to map cellular systems
- Biological pathway and network databases and analysis tools
More about our research or view our research interests as art.
Non-expert explanation
Watch the Inner Life of the Cell movie from Harvard (45MB)
Affiliations:
The Donnelly Centre
Department of Molecular Genetics
Department of Computer Science
The Lunenfeld-Tanenbaum Research Institute at Sinai Health System
Princess Margaret Cancer Centre at University Health Network
Collaborative Graduate Program in Genome Biology and Bioinformatics
all associated with the University of Toronto
The MacMillan Multiscale Human Program, Canadian Institute for Advanced Research
Where we are: |
Contact: |
Support Open Access Publishing
