#acl All:read DanieleMerico:write,delete,revert
= Neurobiological Gene-sets =
== Phenotypes and Expression Specificity ==
'''Last update: May 2011'''<
>
Text files
* [[attachment:Neuro_ExpHsBr.txt|ExpHsBr: Human Brain-Specific Expression]]
* [[attachment:Neuro_PhMmAll.txt|PhMmAll: Mouse Neurological Phenotypes converted to Human]]
* [[attachment:Neuro_PhHsPsy.txt|PhHsPsy: Human Neuropsychiatric Disorders]]
* [[attachment:Neuro_PhHsDev.txt|PhHsDev: Human Neurodevelopmental Disorders and Intellectual Disability]]
* [[attachment:Neuro_PhHsMsc.txt|PhHsMsc: Human Other Neurological Disorders]]
R Workspace
* [[attachment:coreNeuroLists.RData|All gene-sets Rws]]
'''Details'''
* __ID System__: human Entrez-Gene
* __Documentation__
* [[attachment:Documentation_v01.pdf|PDF]]
* [[attachment:Documentation_v01.pptx|pptx]]
* __Notes on use__
* All gene-sets have good quality with respect to enrichment in neuropsychological functions and phenotypes
* ''!ExpHsBr'' and ''!PhMmAll'' are the ones I found of higher quality when overlapping with my autism gene-set analysis results
* ''!PhHsPsy'' probably includes several genes from candidate gene studies, but is otherwise of good quality
* The distinction between ''!PhHsPsy'' and ''!PhHsDev'' is a bit loose, these two gene-sets could be collapsed
* ''!PhHsMsc'' is quite heterogeneous, and its neurovascular and neurodegenerative auto-immune components are probably source of bad candidates for researchers working on autism, schizophrenia or ADHD
* ''!PhMmAll'' is not completely unbiased, as investigators will make KO mouse models for genes of interest
* ''!ExpHsBr'' may be partially biased towards well characterized genes
== From Gene Ontology ==
'''Last update: April 2011'''<
>
Text files
* [[attachment:GO_neuro_dev.txt|Human Nervous System Development (GO:0007399)]]
* [[attachment:GO_neuro_process.txt|Human Nervous System Process (without sensory receptors)]]
* Cognition (GO:0050890), Neuronal action potential propagation (GO:0019227), Transmission of nerve impulse (GO:0019226)