The human genome and drug discovery after a decade. Roads (still) not taken

This data is supplementary material for:

''The human genome and drug discovery after a decade. Roads (still) not taken''

Ruth Isserlin 1, Gary D. Bader 1 *, Aled Edwards 2 * ,Stephen Frye 3, Timothy Willson 4, Frank H. Yu 5

  1. Donnelly Centre for Cellular and Biomolecular Research, Faculty of Medicine, University of Toronto, 160 College Street, Toronto, Ontario, Canada M5S 3E1
  2. University of Toronto, Toronto, Ontario Canada, M5G 1L7
  3. Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA 27599
  4. GlaxoSmithKline, Research Triangle Park, North Caroline, USA 27709

  5. Neurobiology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, South Korea, 110-749

Also, see Too many roads not taken, a companion paper published in Nature. 2011 Feb 10;470(7333):163-5

Code

Supplementary Figures

SupplementaryFigure1_highqualityProbes.pdf
Supplementary Figure 1: NR Growth curves with high quality probes
Individual Citation Growth curves for each Nuclear Hormone Receptor that has a high quality chemical tool associated with it. The growth at one year is shown relative to the previous year. Citation growth is calculated for each time frame by taking the normalized citation count from the previous time frame and subtracting it from the current normalized citation count. Citation counts are normalized to the total number of citations for the entire NR group for the given time frame. The formula is ((|nc2 - nc1|)/nc1) * 100, where nc1 is the fraction of citations for a given gene in year n compared to all citations for the gene family and nc2 is the fraction of citations for a given gene in year n+1. Graphs are annotated with year of probe publication and the year the receptor was cloned.

SupplementaryFigure2_unpublishedProbes.pdf
Supplementary Figure 2: NR Growth curves with unpublished or restricted probes
Individual Citation Growth curves for each Nuclear Hormone Receptor that has a probe but the probe might be unpublished, restricting it use.

SupplementaryFigure3_noProbes.pdf
Supplementary Figure 3: NR Growth curves with no probes
Individual Citation Growth curves for each Nuclear Hormone Receptor that does not have a probe.

Supplementary Tables

High Resolution Figures

figure1_NR_19502009.pdf
Figure 1: Human NR Citations (1950-2009)

figure2_kinases_19502009.pdf
Figure 2: Human Protein Kinase Publications 1950-2009

figure3_NR_19501995_vs2009.pdf
Figure 3: Human NR Citations 1950-1995 vs. 2009

figure4_NR_2009_probes.pdf
Figure 4: Chemical Tools associated with Human Nuclear Hormone Receptors

figure5_Ionchannels_19502009_vs2009.pdf
Figure 5: Ion Channel Citations 1950-2000 vs. 2009

Original PubMed Query Results

  1. NuclearHormoneReceptors.xlsx

  2. Kinases.xlsx

  3. IonChannels.xlsx

  4. MethylTransferases.xls

Data/RoadsNotTaken (last edited 2011-10-31 19:40:41 by GaryBader)

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