Memoranda Directory

Organized by Seminar Date

• Adrian Dobra - Biostats Seminars - Lebovic Building - Thur 13 Nov 2007 BR Since I did not take part to the previous formal seminar, but just to the open discussion, I was almost clueless about the statistical model proposed. However, it was interesting to discuss the problem of searching genetic markers, and how to use prior information (e.g. known physical interaction) to enhance the search effectivity. Here follows a more general discussion on why the search of genetic markers is not such a straightforward process, because of context-dependence.BR [:DanieleMerico/MemorandaDirectory/MarkersAndContext: The search for Genetic Markers and the Context-dependence problem]

Organized by Paper Reviewing Date

• Wed 14 Nov 2007 BR Lehar J & al., Nature Systems Biology, Feb 2007 [http://www.nature.com/msb/journal/v3/n1/full/msb4100116.html Chemical combination effects predict connectivity in biological systems]

  • issue: relations between the curve-shape of drug binary-combination effects and connectivity in metabolic pathawys
  • understanding of the genral message: 90%
  • understanding of details: 40%

  • [:DanieleMerico/MemorandaDirectory/ChemCombConnectPath: more detailed review]

=== Organized by Issue === (listed under this category only if not appearing in the Work Logs)

• Problems in the search for Disease Markers

  • [:DanieleMerico/MemorandaDirectory/MarkersAndContext: The search for Genetic Markers and the Context-dependence problem]