The human genome and drug discovery after a decade. Roads (still) not taken

This data is supplementary material for:

The human genome and drug discovery after a decade. Roads (still) not taken

Ruth Isserlin 1, Gary D. Bader 1 *, Aled Edwards 2 * ,Stephen Frye 3, Timothy Willson 4, Frank H. Yu 5

1. Donnelly Centre for Cellular and Biomolecular Research, Faculty of Medicine, University of Toronto, 160 College Street, Toronto, Ontario, Canada M5S 3E1
2. University of Toronto, Toronto, Ontario Canada, M5G 1L7
3. Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA 27599

4. GlaxoSmithKline, Research Triangle Park, North Caroline, USA 27709

5. Neurobiology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, South Korea, 110-749

Code

• If you are interested in seeing the citations for your set of genes please use the following script to query pubmed with your genes of interest.

Supplementary Figures

SupplementaryFigure1_highqualityProbes.pdf
Supplementary Figure 1: NR Growth curves with high quality probes
Individual Citation Growth curves for each Nuclear Hormone Receptor that has a high quality chemical tool associated with it. Citation growth is calculated for each time frame by taking the normalized citation count from the previous time frame and subtracting it from the current normalized citation count. Citation counts are normalized to the total number of citations for the entire NR group for the given time frame. Graphs are annotated with year of probe publication, year the receptor was cloned.

SupplementaryFigure2_unpublishedProbes.pdf
Supplementary Figure 2: NR Growth curves with unpublished or restricted probes
Individual Citation Growth curves for each Nuclear Hormone Receptor that has a probe but the probe might be unpublished, restricting it use.

SupplementaryFigure3_noProbes.pdf
Supplementary Figure 3: NR Growth curves with no probes
Individual Citation Growth curves for each Nuclear Hormone Receptor that does not have a probe.