Goals
- Predict specificity of peptide recognition domain from the primary amino acid sequence.
- Analyze PDZ, WW and then SH3 domains
Strategy
Status
- [wiki:/Log Status Log]
Tasks
Learn SVN, Brain code (ResidueResidueCorrelation)
- Literature review related to domain specificity (background activity)
Run ResidueResidue correlation analysis on PDZ domain data: 1-1 version + try others e.g. 1-2 (Requires: PDZ profiles from Gary)
- Implement new feature: amino acid groups (learn amino acid groups) + run on PDZ data
- Think about new PDZ domain features that can be used for prediction.
Ideas
- Use of structural data (PDZ domain structures) (may require homology modeling)
- Use of machine learning methods (SVM for classification and boosting decision tree for interpretable learning model)
- Analysis of correlation within domain and peptide (inter-residue correlation) maybe correspondence analysis
Team
- Shirley Hui
- Gary Bader
Documents
Background Literature
More General
- The Structure and Function of Proline Recognition Domains, Zarrinpar A, Bhattacharyya RP, Lim WA., Sci STKE. 2003 Apr 22;2003(179):RE8.
- attachment:Structure_Function_Pro_Recog_Domains_Zarrinpar_et_al_2003.pdf
- Can we infer peptide recognition specificity mediated by SH3 domains?, Cesareni G, Panni S, Nardelli G, Castagnoli L., FEBS Lett. 2002 Feb 20;513(1):38-44.
- attachment:Can_we_infer_PR_specificity_med_by_SH3_Cesareni_et_al_2002.pdf
- Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits, Bhattacharyya RP, Remenyi A, Yeh BJ, Lim WA., Annu Rev Biochem. 2006;75:655-80.
- attachment:Domains_motifs_scaffolds_Bhattacharyya_et_al_2006.pdf
- Simplified amino acid alphabets for protein fold recognition and implications for folding, Murphy LR, Wallqvist A, Levy RM, Protein Eng. 2000 Mar;13(3):149-52.
PDZ Related
- PDZ domains-glue and guide., van Ham M, Hendriks W., Mol Biol Rep. 2003 Jun;30(2):69-82.
- attachment:PDZ_Domains_Glue_and_Guide_2003.pdf
- PDZ domains: structural modules for protein complex assembly., Hung AY, Sheng M., J Biol Chem. 2002 Feb 22;277(8):5699-702. Epub 2001 Dec 10.
- attachment:PDZ_Domains_Structural_Modules_2001.pdf