Positive Selection of Tyrosine Loss in Metazoan Evolution

This page contain associated data used in:

Positive Selection of Tyrosine Loss in Metazoan Evolution

Chris S.H Tan^1,2, Adrian Pasculescu¹, Wendell A. Lim⁴, Tony Pawson^1,2*, Gary D. Bader^1,2,3*, Rune Linding^5*

1. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. 2. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada 3. Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada 4. Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA. 5. Cellular and Molecular Logic Team, Section of Cell and Molecular Biology, The Institute of Cancer Research (ICR), London, UK

* To whom correspondence should be addressed. E-mail: pawson@lunenfeld.ca (TP); gary.bader@utoronto.ca (GDB); linding@icr.ac.uk (RL)

Supplemental Materials

SupplementaryMaterials.pdf - Supplementary figure and methods
HumanTyrSite.csv - All human phospho-tyrosine sites collected
HumanTyrSiteWithAtLeast2Refs.csv - Subset of human phospho-tyrosine sites from at least 2 references/sources.
HumanYeastInferredOrthologs.txt - Output from Inparanoid algorithm for orthologous proteins between human and budding yeast.
Saccharomyces_cerevisiae.SGD1.01.51.pep.all.fasta - Protein sequences of budding yeast
Homo_sapiensLongestSpliced.NCBI36.51.fasta - Longest spliced variant of human proteins